NP_001029082.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
TNF receptor-associated factor 5 isoform b
NCBI Official Synonym Full Names
TNF receptor associated factor 5
NCBI Protein Information
TNF receptor-associated factor 5
UniProt Protein Name
TNF receptor-associated factor 5
UniProt Synonym Protein Names
RING finger protein 84
UniProt Synonym Gene Names
NCBI Summary for TRAF5
The scaffold protein encoded by this gene is a member of the tumor necrosis factor receptor-associated factor (TRAF) protein family and contains a meprin and TRAF homology (MATH) domain, a RING-type zinc finger, and two TRAF-type zinc fingers. TRAF proteins are associated with, and mediate signal transduction from members of the TNF receptor superfamily. This protein is one of the components of a multiple protein complex which binds to tumor necrosis factor (TNF) receptor cytoplasmic domains and mediates TNF-induced activation. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2016]
UniProt Comments for TRAF5
TRAF5: Adapter protein and signal transducer that links members of the tumor necrosis factor receptor family to different signaling pathways by association with the receptor cytoplasmic domain and kinases. Mediates activation of NF-kappa-B and probably JNK. Seems to be involved in apoptosis. Belongs to the TNF receptor-associated factor family. A subfamily.
Protein type: Adaptor/scaffold; Ubiquitin conjugating system
Chromosomal Location of Human Ortholog: 1q32.3
Cellular Component: centrosome; cytosol; internal side of plasma membrane
Molecular Function: identical protein binding; protein binding; thioesterase binding; ubiquitin protein ligase binding
Biological Process: activation of NF-kappaB transcription factor; positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of transcription factor activity
Research Articles on TRAF5
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Products associated with TRAF5 recombinant protein
Pathways associated with TRAF5 recombinant protein
Diseases associated with TRAF5 recombinant protein
Organs/Tissues associated with TRAF5 recombinant protein
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