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TRAF6 recombinant protein :: TNF receptor-associated factor 6 Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS9420773 TRAF6 recombinant protein
Unit / Price
0.01 mg  /  $180 +1 FREE 8GB USB
0.05 mg  /  $225 +1 FREE 8GB USB
0.1 mg  /  $320 +1 FREE 8GB USB
0.2 mg  /  $500 +1 FREE 8GB USB
0.5 mg  /  $800 +1 FREE 8GB USB
1 mg  /  $1,235 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

TNF receptor-associated factor 6 (TRAF6), Recombinant Protein

★Popular Item★
 Also Known As   

Recombinant Human TNF receptor-associated factor 6

 Product Synonym Names    E3 ubiquitin-protein ligase TRAF6Interleukin-1 signal transducerRING finger protein 85
 Product Gene Name   

TRAF6 recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence Positions    Full Length, 1-522aa
 Sequence    MSLLNCENSC GSSQSESDCC VAMASSCSAV TKDDSVGGTA STGNLSSSFM EEIQGYDVEF DPPLESKYEC PICLMALREA VQTPCGHRFC KACIIKSIRD AGHKCPVDNE ILLENQLFPD NFAKREILSL MVKCPNEGCL HKMELRHLED HQAHCEFALM DCPQCQRPFQ KFHINIHILK DCPRRQVSCD NCAASMAFED KEIHDQNCPL ANVICEYCNT ILIREQMPNH YDLDCPTAPI PCTFSTFGCH EKMQRNHLAR HLQENTQSHM RMLAQAVHSL SVIPDSGYIS EVRNFQETIH QLEGRLVRQD HQIRELTAKM ETQSMYVSEL KRTIRTLEDK VAEIEAQQCN GIYIWKIGNF GMHLKCQEEE KPVVIHSPGF YTGKPGYKLC MRLHLQLPTA QRCANYISLF VHTMQGEYDS HLPWPFQGTI RLTILDQSEA PVRQNHEEIM DAKPELLAFQ RPTIPRNPKG FGYVTFMHLE ALRQRTFIKD DTLLVRCEVS TRFDMGSLRR EGFQPRSTDA GV
 OMIM    U78798 mRNA
 3D Structure    ModBase 3D Structure for Q9Y4K3
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 Host    E Coli
 Species Reactivity    Human
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 Purity/Purification    Greater than 90% as determined by SDS-PAGE.
 Form/Format    Tris-based buffer 50% glycerol
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 Immunogen Description    Expression Region:1-522aaSequence Info:Full Length
 Tag Info    N-terminal 6xHis-SUMO-tagged
 Calculated MW    75.6 kDa
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 Preparation and Storage    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20C,-80C. The shelf life of lyophilized form is 12 months at -20C,-80C.

Notes:Repeated freezing and thawing is not recommended. Store working aliquots at 4C for up to one week.
 Other Notes    Small volumes of TRAF6 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for TRAF6 recombinant protein

   Recombinant protein

E3 ubiquitin ligase that, together with UBE2N and UBE2V1, mediates the synthesis of 'Lys-63'-linked-polyubiquitin chains conjugated to proteins, such as IKBKG, IRAK1, AKT1 and AKT2. Also mediates ubiquitination of free,unanchored polyubiquitin chain that leads to MAP3K7 activation. Leads to the activation of NF-kappa-B and JUN. May be essential for the formation of functional osteoclasts. Ses to also play a role in dendritic cells (DCs) maturation and,or activation. Represses c-Myb-mediated transactivation, in B-lymphocytes. Adapter protein that ses to play a role in signal transduction initiated via TNF receptor, IL-1 receptor and IL-17 receptor. Regulates osteoclast differentiation by mediating the activation of adapter protein complex 1 (AP-1) and NF-kappa-B, in response to RANK-L stimulation. Together with MAP3K8, mediates CD40 signals that activate ERK in B-cells and macrophages, and thus may play a role in the regulation of immunoglobulin production .
NCBI/Uniprot data below describe general gene information for TRAF6. It may not necessarily be applicable to this product.
 NCBI GI #    4759254
 NCBI GeneID    7189
 NCBI Accession #    NP_004611.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_004620.3 [Other Products]
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 UniProt Primary Accession #    Q9Y4K3 [Other Products]
 UniProt Secondary Accession #    Q8NEH5; A6NKI7; A8KAB3; D3DR16 [Other Products]
 UniProt Related Accession #    Q9Y4K3 [Other Products]
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 NCBI Official Full Name    TNF receptor-associated factor 6
 NCBI Official Synonym Full Names    TNF receptor associated factor 6
 NCBI Official Symbol    TRAF6 [Similar Products]
 NCBI Official Synonym Symbols   
RNF85; MGC:3310
[Similar Products]
 NCBI Protein Information    TNF receptor-associated factor 6
 UniProt Protein Name    TNF receptor-associated factor 6
 UniProt Synonym Protein Names   
E3 ubiquitin-protein ligase TRAF6; Interleukin-1 signal transducer; RING finger protein 85; RING-type E3 ubiquitin transferase TRAF6Curated
 Protein Family    TNF receptor-associated factor
 UniProt Gene Name    TRAF6 [Similar Products]
 UniProt Synonym Gene Names    RNF85 [Similar Products]
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 NCBI Summary for TRAF6    The protein encoded by this gene is a member of the TNF receptor associated factor (TRAF) protein family. TRAF proteins are associated with, and mediate signal transduction from, members of the TNF receptor superfamily. This protein mediates signaling from members of the TNF receptor superfamily as well as the Toll/IL-1 family. Signals from receptors such as CD40, TNFSF11/RANCE and IL-1 have been shown to be mediated by this protein. This protein also interacts with various protein kinases including IRAK1/IRAK, SRC and PKCzeta, which provides a link between distinct signaling pathways. This protein functions as a signal transducer in the NF-kappaB pathway that activates IkappaB kinase (IKK) in response to proinflammatory cytokines. The interaction of this protein with UBE2N/UBC13, and UBE2V1/UEV1A, which are ubiquitin conjugating enzymes catalyzing the formation of polyubiquitin chains, has been found to be required for IKK activation by this protein. This protein also interacts with the transforming growth factor (TGF) beta receptor complex and is required for Smad-independent activation of the JNK and p38 kinases. This protein has an amino terminal RING domain which is followed by four zinc-finger motifs, a central coiled-coil region and a highly conserved carboxyl terminal domain, known as the TRAF-C domain. Two alternatively spliced transcript variants, encoding an identical protein, have been reported. [provided by RefSeq, Feb 2012]
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 UniProt Comments for TRAF6    TRAF6: E3 ubiquitin ligase that, together with UBE2N and UBE2V1, mediates the synthesis of 'Lys-63'-linked-polyubiquitin chains conjugated to proteins, such as IKBKG, AKT1 and AKT2. Also mediates ubiquitination of free/unanchored polyubiquitin chain that leads to MAP3K7 activation. Leads to the activation of NF- kappa-B and JUN. May be essential for the formation of functional osteoclasts. Seems to also play a role in dendritic cells (DCs) maturation and/or activation. Represses c-Myb-mediated transactivation, in B-lymphocytes. Adapter protein that seems to play a role in signal transduction initiated via TNF receptor, IL- 1 receptor and IL-17 receptor. Regulates osteoclast differentiation by mediating the activation of adapter protein complex 1 (AP-1) and NF-kappa-B, in response to RANK-L stimulation. Homotrimer. Homooligomer. N-terminal region is dimeric while C-terminal region is trimeric; maybe providing a mode of oligomerization. Binds to TNFRSF5/CD40 and TNFRSF11A/RANK. Associates with NGFR, TNFRSF17, IRAK1, IRAK2, IRAK3, IRAK4, RIPK2, MAP3K1, MAP3K5, MAP3K14, CSK, TRAF, TRAF-interacting protein TRIP and TNF receptor associated protein TDP2. Interacts with IL17R. Interacts with SQSTM1 bridging NTRK1 and NGFR. Forms a ternary complex with SQSTM1 and PRKCZ. Interacts with PELI1, PELI2 and PELI3. Binds UBE2V1. Interacts with MAVS/IPS1. Interacts with TAX1BP1. Interacts with IL1RL1. Interacts with TRAFD1. Interacts with ZNF675. Interacts with AJUBA. Interacts with TICAM1 and TICAM2. Interacts with ZFAND5. Interacts with ARRB1 and ARRB2. Interacts with MAP3K7 and TAB1/MAP3K7IP1; during IL-1 signaling. Interacts with UBE2N. Interacts with TGFBR1, HDAC1 and RANGAP1. Interacts with AKT1, AKT2 and AKT3. Interacts (via TRAF domains) with NUMBL (via C-terminal). Interacts (via TRAF domains) with WDR34 (via WD domains). Interacts with RBCK1. Interacts with TRAF3IP2. Interacts with LIMD1 (via LIM domains). Expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. Belongs to the TNF receptor-associated factor family. A subfamily.

Protein type: EC 6.3.2.-; Ligase; Ubiquitin conjugating system; Ubiquitin ligase

Chromosomal Location of Human Ortholog: 11p12

Cellular Component: cytoplasm; cytosol; endosome membrane; internal side of plasma membrane; lipid particle; nucleus; perinuclear region of cytoplasm; plasma membrane; protein complex

Molecular Function: histone deacetylase binding; identical protein binding; mitogen-activated protein kinase kinase kinase binding; protein binding; protein kinase B binding; protein kinase binding; protein N-terminus binding; thioesterase binding; tumor necrosis factor receptor binding; ubiquitin conjugating enzyme binding; ubiquitin protein ligase binding; ubiquitin-protein ligase activity

Biological Process: activation of MAPK activity; activation of NF-kappaB transcription factor; activation of NF-kappaB-inducing kinase; activation of protein kinase activity; I-kappaB kinase/NF-kappaB cascade; JNK cascade; membrane protein intracellular domain proteolysis; MyD88-dependent toll-like receptor signaling pathway; MyD88-independent toll-like receptor signaling pathway; negative regulation of apoptosis; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; positive regulation of apoptosis; positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of interleukin-2 production; positive regulation of JNK activity; positive regulation of osteoclast differentiation; positive regulation of T cell activation; positive regulation of T cell cytokine production; positive regulation of transcription factor activity; positive regulation of transcription from RNA polymerase II promoter; protein autoubiquitination; protein deubiquitination; protein polyubiquitination; stimulatory C-type lectin receptor signaling pathway; T cell receptor signaling pathway; toll-like receptor 9 signaling pathway; toll-like receptor signaling pathway
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 Research Articles on TRAF6    1. Results suggest that overexpression of miR-146a could promote IDD through the TRAF/NF-kappaB pathway.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with TRAF6 recombinant proteinPathways associated with TRAF6 recombinant protein
 Reference Product  PubMed Publications
 CD40 recombinant protein  >100 publications with TRAF6 and CD40
 IRAK1 recombinant protein  >97 publications with TRAF6 and IRAK1
 TNFRSF11A recombinant protein  >61 publications with TRAF6 and TNFRSF11A
 TAB2 recombinant protein  >43 publications with TRAF6 and TAB2
 TAB1 recombinant protein  >24 publications with TRAF6 and TAB1
 SQSTM1 recombinant protein  >16 publications with TRAF6 and SQSTM1
 IKBKG recombinant protein  >13 publications with TRAF6 and IKBKG
 UBE2N recombinant protein  >12 publications with TRAF6 and UBE2N
 UBC recombinant protein  >5 publications with TRAF6 and UBC
 MAP3K7 recombinant protein  >4 publications with TRAF6 and MAP3K7
 Products by Pathway  Pathway Diagram
 Activated TLR4 Signalling Pathway antibodies  Activated TLR4 Signalling Pathway Diagram
 Adaptive Immune System Pathway antibodies  Adaptive Immune System Pathway Diagram
 Apoptosis Modulation And Signaling Pathway antibodies  Apoptosis Modulation And Signaling Pathway Diagram
 BCR Signaling Pathway antibodies  BCR Signaling Pathway Diagram
 BDNF Signaling Pathway antibodies  BDNF Signaling Pathway Diagram
 CD40/CD40L Signaling Pathway antibodies  CD40/CD40L Signaling Pathway Diagram
 Canonical NF-kappaB Pathway antibodies  Canonical NF-kappaB Pathway Diagram
 Cell Death Signalling Via NRAGE, NRIF And NADE Pathway antibodies  Cell Death Signalling Via NRAGE, NRIF And NADE Pathway Diagram
 Chagas Disease (American Trypanosomiasis) Pathway antibodies  Chagas Disease (American Trypanosomiasis) Pathway Diagram
 Chagas Disease (American Trypanosomiasis) Pathway antibodies  Chagas Disease (American Trypanosomiasis) Pathway Diagram
Diseases associated with TRAF6 recombinant proteinOrgans/Tissues associated with TRAF6 recombinant protein
 Disease Name  Pubmed Publications
 Necrosis Antibodies  >574 publications with TRAF6 and Necrosis
 Inflammation Antibodies  >243 publications with TRAF6 and Inflammation
 Neoplasms Antibodies  >96 publications with TRAF6 and Neoplasms
 Immune System Diseases Antibodies  >82 publications with TRAF6 and Immune System Diseases
 Arthritis, Rheumatoid Antibodies  >38 publications with TRAF6 and Arthritis, Rheumatoid
 Cardiovascular Diseases Antibodies  >32 publications with TRAF6 and Cardiovascular Diseases
 Lung Diseases Antibodies  >20 publications with TRAF6 and Lung Diseases
 Cell Transformation, Neoplastic Antibodies  >17 publications with TRAF6 and Cell Transformation, Neoplastic
 Atherosclerosis Antibodies  >14 publications with TRAF6 and Atherosclerosis
 Fibrosis Antibodies  >12 publications with TRAF6 and Fibrosis
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >208 publications with TRAF6 and Blood
 Brain Antibodies  >38 publications with TRAF6 and Brain
 Kidney Antibodies  >37 publications with TRAF6 and Kidney
 Thymus Antibodies  >17 publications with TRAF6 and Thymus
 Lymph Node Antibodies  >16 publications with TRAF6 and Lymph Node
 Uterus Antibodies  >4 publications with TRAF6 and Uterus
 Placenta Antibodies  >3 publications with TRAF6 and Placenta
 Trachea Antibodies  >3 publications with TRAF6 and Trachea
 Cervix Antibodies  >1 publications with TRAF6 and Cervix
 Testis Antibodies  >1 publications with TRAF6 and Testis
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