Antibody Protein ELISA Kit from MyBioSource header Telephone 1.858.633.0165          
1.855.MyBioSource
Fax 1.858.633.0166    Email sales@mybiosource.com 
tel/fax
menu1 Home Products Ordering Company Help menu7
bottom
   MyBioSource rightarrow Recombinant Protein rightarrow TNIP1  rightarrow LOG IN  rightarrow MY ACCOUNT  rightarrow CART CONTENTS  rightarrow CHECKOUT 
horiz bar
MyBioSource Menu separator
separator
ELISA Kit ELISA Kit
CLIA Kit CLIA Kit
PCR Kit PCR Kit
Monoclonal Antibody Monoclonal Antibody
Polyclonal Antibody Polyclonal Antibody
Secondary Antibody Secondary Antibody
Antigen Antigen
Biochemical Biochemical
cDNA Clone cDNA Clone
siRNA siRNA
Peptide Peptide
Recombinant/Purified Protein Rec./Purified Protein

Custom ELISA Kit Custom ELISA Kit
Custom Protein Custom Protein
Custom Antibody Custom Antibody
Antibody Matched Pairs Antibody Matched Pairs
Antibody & Corresponding Blocking Peptide Pairs Antibody Peptide Pairs
Phospho-Specific Antibodies Phospho Antibodies
Products by Disease Products by Disease
Products by Pathway Products by Pathway
Products by Tissue Products by Tissue

arrow Advanced Search
arrow Submit Technical Q&A
arrow International Distributors
arrow Contact Us
separator
Our Best Sellers moreseparator
separator
 • Asparagine--tRNA ligase (asnS) Recombinant Protein
 • Galactose Mutarotase (GALM) Recombinant Protein
 • PDI Antibody
 • 17-BETA-ESTRADIOL Antibody
 • A Disintegrin And Metalloprotease 8 (ADAM8) ELISA Kit
 • Galactosidase Alpha (GLa) Antibody
 • Interferon Alpha-Beta Receptor 1 (IFNa-bR1) Antibody
 • C-Terminal Connective Tissue Growth Factor (CCTGF) ELISA Kit
 • IRAK2 - IRAK-2 Antibody
 • Myoglobin (MB) Antibody
 • Lymphotoxin alpha (LTA) ELISA Kit
 • Fucosidase, Alpha L1, Tissue (FUCA1) ELISA Kit
 • Cholinergic Receptor, Nicotinic, Alpha 5 (CHRNa5) ELISA Kit
 • Acetyl Histone H3 (Acetyl-H3) ELISA Kit
 downarrow more ...
separator
separator
DatasheetFull DatasheetPrinter Friendly DatasheetPrint This DatasheetAdd to Compare ListHave Questions? Ask UsRequest for a Quotation today

TNIP1 recombinant protein :: TNFAIP3 Interacting Protein 1 Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS144197 TNIP1 recombinant protein
Unit / Price
0.001 mg  /  $140 +1 FREE 8GB USB
0.005 mg  /  $205 +1 FREE 8GB USB
0.05 mg  /  $1,125 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

TNFAIP3 Interacting Protein 1 (TNIP1), Recombinant Protein

 Also Known As   

Recombinant Human TNFAIP3 Interacting Protein 1

 Product Synonym Names    TNIP1 Human; TNFAIP3 Interacting Protein 1 Human Recombinant; TNFAIP3-interacting protein 1; HIV-1 Nef-interacting protein; Nef-associated factor 1; Naf1; Nip40-1; Virion-associated nuclear shuttling protein; VAN; hVAN; TNIP1; KIAA0113; NAF1; ABIN-1
 Product Gene Name   

TNIP1 recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
Table BarTOPTable Bar
 Sequence    MGSSHHH HHH SSGLVPRGSH MSNVTASPTA PACPSDKPAP VQKPPSSGTS SEFEVVTPEE QNSPESSSHA NAMALGPLPR EDGNLMLHLQ RLETTLSVCA EEPDHGQLFT HLGRMALEFN RLASKVHKNE QRTSILQTLC EQLRKENEAL KAKLDKGLEQ RDQAAERLRE ENLELKKLLM SNGNKEGASG RPGSPKMEGT GKKAVAGQQQ ASVTAGKVPE VVALGAAEKK VKMLEQQRSE LLEVNKQWDQ HFRSMKQQYE QKITELRQKL ADLQKQVTDL EAEREQKQRD FDRKLLLAKS KIEMEETDKE QLTAEAKELR QKVKYLQDQL SPLTRQREYQ EKEIQRLNKA LEEALSIQTP PSSPPTAFGS PEGAGALLRK QELVTQNELL KQQVKIFEED FQRERSDRER MNEEKEELKK QVEKLQAQVT LSNAQLKAFK DEEKAREALR QQKRKAKA
 OMIM    607714
 3D Structure    ModBase 3D Structure for Q15025
Section Bar
 Host    E Coli
Section Bar
 Purity/Purification    Greater than 75.0% as determined by SDS-PAGE.
 Form/Format    The TNIP1 solution (0.25 mg/ml) contains 20mM Tris-HCl buffer (pH7.5), 20% glycerol, 5mM DTT and 200mM NaCl.
Sterile Filtered colorless solution.
Section Bar
Section Bar
 Preparation and Storage    TNIP1 should be stored desiccated below -18 degree C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please prevent freeze-thaw cycles.
 Other Notes    Small volumes of TNIP1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Table BarTOPTable Bar
 

Related Product Information for TNIP1 recombinant protein

   Description: TNIP1 Human Recombinant fused with a 20 amino acid His tag at N-terminus produced in E Coli is a single, non-glycosylated, polypeptide chain containing 458 amino acids (94-530 a.a.) and having a molecular mass of 51.8kDa. The TNIP1 is purified by proprietary chromatographic techniques.

Introduction: TNFAIP3-interacting protein 1 (TNIP1) interacts with zinc finger protein A20/TNFAIP3 and inhibits TNF-induced NF-kappa-B-dependent gene expression by interfering with a RIP- or TRAF2-mediated transactivation signal. Furthermore, TNIP1 interacts with HIV-1 matrix protein and is packaged into virions and its overexpression can inhibit viral replication. TNIP1 can regulate matrix nuclear localization, both nuclear import of Preintegration complex (PIC) and export of GAG polyprotein and viral genomic RNA during virion production.
 Product Categories/Family for TNIP1 recombinant protein    RECOMBINANT & NATURAL PROTEINS; Recombinant Proteins
NCBI/Uniprot data below describe general gene information for TNIP1. It may not necessarily be applicable to this product.
 NCBI GI #    356874786
 NCBI GeneID    10318
 NCBI Accession #    NP_001239314.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001252385.1 [Other Products]
Section Bar
 UniProt Primary Accession #    Q15025 [Other Products]
 UniProt Secondary Accession #    A4F1W8; A4F1W9; A4F1X2; A4F1X4; A4F1X5; A4F1X6; A4F1X7; A4F1X9; B7Z699; E7EPY1; E7ET96 [Other Products]
 UniProt Related Accession #    Q15025 [Other Products]
 Molecular Weight    62,103 Da
Table BarTOPTable Bar
 NCBI Official Full Name    TNFAIP3-interacting protein 1 isoform 1
 NCBI Official Synonym Full Names    TNFAIP3 interacting protein 1
 NCBI Official Symbol    TNIP1 [Similar Products]
 NCBI Official Synonym Symbols   
VAN; NAF1; ABIN-1; nip40-1
[Similar Products]
 NCBI Protein Information    TNFAIP3-interacting protein 1; A20-binding inhibitor of NF-kappa-B activation 1; HIV-1 Nef-interacting protein; Nef-associated factor 1 SNP; virion-associated nuclear shuttling protein
 UniProt Protein Name    TNFAIP3-interacting protein 1
 UniProt Synonym Protein Names   
A20-binding inhibitor of NF-kappa-B activation 1; ABIN-1; HIV-1 Nef-interacting protein; Nef-associated factor 1; Naf1; Nip40-1; Virion-associated nuclear shuttling protein; VAN; hVAN
 Protein Family    TNFAIP3-interacting protein
 UniProt Gene Name    TNIP1 [Similar Products]
 UniProt Synonym Gene Names    KIAA0113; NAF1; ABIN-1; Naf1; VAN; hVAN [Similar Products]
 UniProt Entry Name    TNIP1_HUMAN
Section Bar
 NCBI Summary for TNIP1    This gene encodes an A20-binding protein which plays a role in autoimmunity and tissue homeostasis through the regulation of nuclear factor kappa-B activation. Mutations in this gene have been associated with psoriatic arthritis, rheumatoid arthritis, and systemic lupus erythematosus. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]
Section Bar
 UniProt Comments for TNIP1    TNIP1: Interacts with zinc finger protein A20/TNFAIP3 and inhibits TNF-induced NF-kappa-B-dependent gene expression by interfering with an RIP- or TRAF2-mediated transactivation signal; however, binding to A20/TNFAIP3 seems not to be required for this function. Inhibits NF-kappa-B activation by regulating A20/TNFAIP3-mediated deubiquitination of IKBKG; proposed to link A20/TNFAIP3 to ubiquitinated IKBKG. Involved in regulation of EGF-induced ERK1/ERK2 signaling pathway; blocks MAPK3/MAPK1 nuclear translocation and MAPK1-dependent transcricption. Increases cell surface CD4(T4) antigen expression. Involved in the anti-inflammatory response of macrophages and positively regulates TLR-induced activation of CEBPB. Involved in the prevention of autoimmunity; this function implicates binding to polyubiquitin. Involved in leukocyte integrin activation during inflamation; this function is mediated by association with SELPLG and dependent on phosohorylation by SRC-family kinases. Interacts with HIV-1 matrix protein and is packaged into virions and overexpression can inhibit viral replication. May regulate matrix nuclear localization, both nuclear import of PIC (Preintegration complex) and export of GAG polyprotein and viral genomic RNA during virion production. In case of infection, promotes association of IKBKG with Shigella flexneri E3 ubiquitin-protein ligase ipah9.8 p which in turn promotes polyubiquitination of IKBKG leading to its proteasome-dependent degradation and thus is perturbing NF-kappa-B activation during bacterial infection. Interacts with TNFAIP3 and IKBKG; facilitates TNFAIP3- mediated de-ubiquitination of NEMO/IKBKG. Interacts with HIV-1 matrix protein. Interacts with Shigella flexneri ipah9.8; the interaction promotes polyubiquitination of IKBKG. Interacts with polyubiquitin. Interacts with MAPK1, SELPLG and PIK3CD. Interacts with IKBKG (polyubiquitinated). Interacts with IRAK1 (polyubiquitinated). Interacts with MYD88; the interaction is indicative for participation in an activated TLR-signaling complex. Ubiquitous. Strongly expressed in peripheral blood lymphocytes, spleen and skeletal muscle, and is weakly expressed in the brain. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Transcription regulation

Chromosomal Location of Human Ortholog: 5q32-q33.1

Cellular Component: cytoplasm; intracellular; nucleus

Molecular Function: protein binding; ubiquitin-specific protease activity; mitogen-activated protein kinase binding

Biological Process: MyD88-dependent toll-like receptor signaling pathway; leukocyte adhesion; negative regulation of viral genome replication; translation; glycoprotein biosynthetic process; defense response; positive regulation of transcription from RNA polymerase II promoter; negative regulation of I-kappaB kinase/NF-kappaB cascade; inflammatory response; positive regulation of inflammatory response
Table BarTOPTable Bar
 Research Articles on TNIP1    1. HSPA6 regulation by TNIP1 occurs in promoter regions lacking binding sites for known TNIP1-repressed transcription factors
Table BarTOPTable Bar
 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Table BarTOPTable Bar
Products associated with TNIP1 recombinant proteinPathways associated with TNIP1 recombinant protein
 Reference Product  PubMed Publications
 TNFAIP3 recombinant protein  >49 publications with TNIP1 and TNFAIP3
 NFKB1 recombinant protein  >5 publications with TNIP1 and NFKB1
 UHRF1BP1 recombinant protein  >3 publications with TNIP1 and UHRF1BP1
 TRAF3 recombinant protein  >2 publications with TNIP1 and TRAF3
 MAPK1 recombinant protein  >2 publications with TNIP1 and MAPK1
 TAX1BP1 recombinant protein  >2 publications with TNIP1 and TAX1BP1
 SRC recombinant protein  >2 publications with TNIP1 and SRC
 IKBKG recombinant protein  >2 publications with TNIP1 and IKBKG
 Products by Pathway  Pathway Diagram
 EGFR1 Signaling Pathway antibodies  EGFR1 Signaling Pathway Diagram
 TNF-alpha/NF-kB Signaling Pathway antibodies  TNF-alpha/NF-kB Signaling Pathway Diagram
Diseases associated with TNIP1 recombinant proteinOrgans/Tissues associated with TNIP1 recombinant protein
 Disease Name  Pubmed Publications
 Psoriasis Antibodies  >30 publications with TNIP1 and Psoriasis
 Lupus Erythematosus, Systemic Antibodies  >22 publications with TNIP1 and Lupus Erythematosus, Systemic
 Necrosis Antibodies  >21 publications with TNIP1 and Necrosis
 Inflammation Antibodies  >17 publications with TNIP1 and Inflammation
 Scleroderma, Systemic Antibodies  >4 publications with TNIP1 and Scleroderma, Systemic
 Lung Diseases Antibodies  >4 publications with TNIP1 and Lung Diseases
 Kidney Diseases Antibodies  >3 publications with TNIP1 and Kidney Diseases
 Cardiovascular Diseases Antibodies  >3 publications with TNIP1 and Cardiovascular Diseases
 Sjogren's Syndrome Antibodies  >2 publications with TNIP1 and Sjogren's Syndrome
 Heart Diseases Antibodies  >2 publications with TNIP1 and Heart Diseases
 Organ/Tissue Name  Pubmed Publications
 Skin Antibodies  >16 publications with TNIP1 and Skin
 Blood Antibodies  >15 publications with TNIP1 and Blood
 Liver Antibodies  >5 publications with TNIP1 and Liver
 Nerve Antibodies  >3 publications with TNIP1 and Nerve
 Vascular Antibodies  >3 publications with TNIP1 and Vascular
 Lung Antibodies  >3 publications with TNIP1 and Lung
 Heart Antibodies  >2 publications with TNIP1 and Heart
 Spleen Antibodies  >2 publications with TNIP1 and Spleen
 Bone Antibodies  >2 publications with TNIP1 and Bone
 Bone Marrow Antibodies  >2 publications with TNIP1 and Bone Marrow
Table BarTOPTable Bar
horiz bar
 SSL   Follow us on Facebook Follow us onTwitter Follow us on Google Plus Connect us on LinkedIn Subscribe to our RSS Feed for latest products and special promotions