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| Product Name
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TREM2, Recombinant Protein ★Popular Item★
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| Also Known As
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Recombinant Mouse TREM2 Protein (His tag)
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| Product Synonym Names
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Trem2a, Trem2b, Trem2c
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| Product Gene Name
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[Similar Products]
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| Research Use Only
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For Research Use Only. Not for use in diagnostic procedures.
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| 3D Structure
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ModBase 3D Structure for Q99NH8
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| Host
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Human Cells
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| Purity/Purification
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> 95 % as determined by SDS-PAGE
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| Form/Format
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Lyophilized from sterile PBS, pH 7.4
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| Predicted N Terminal
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Leu 19
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| Endotoxin
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< 1.0 EU per mug of the protein as determined by the LAL method
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| Preparation and Storage
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Samples are stable for up to twelve months from date of receipt at -70 degree C
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| ISO Certification
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Manufactured in an ISO 9001:2008 Certified Laboratory.
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| Other Notes
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Small volumes of TREM2 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Background: Triggering receptor expressed on myeloid cells 2 (TREM2) is a single Ig domain receptor. It is expressed on macrophages and dendritic cells but not on granulocytes or monocytes. Its expression is most abundant in the basal ganglia, corpus callosum, medulla oblongata and spinal cord, and microglial cells are the major TREM2-producing cell type in the central nervous system (CNS). TREM2 may play a role in chronic inflammations and may stimulate production of constitutive rather than inflammatory chemokines and cytokines. TREM2 forms a receptor signaling complex with TYROBP and triggers activation of the immune responses in macrophages and dendritic cells. It also associates with the signal adapter protein, DAP12, which has a cytoplasmic ITAM, leading to the subsequent activation of cytoplasmic tyrosine kinases. TREM2 is both required and sufficient for competent uptake of apoptotic neuronal cells. TREM2 and TREM2-L form a receptor-ligand pair connecting microglia with apoptotic neurons, directing removal of damaged cells to allow repair. Deficiency of the adapter protein DAP12 or its associated receptor TREM2 is associated with abnormal osteoclast development in humans. Defects in TREM2 are causes of PLOSL, also known as NHD. In addition, TREM2 signaling is also an important pathway to promote healing of wounds in the colon where stem cell replacement is necessary.
Description: A DNA sequence encoding the mouse TREM2 (NP_112544.1) extracellular domain (Met 1-Pro 168) was expressed, with a C-terminal polyhistidine tag.
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| Application Notes for TREM2 recombinant protein
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The recombinant mouse TREM2 consists of 161 amino acids with the predicted molecular mass of 18 kDa. As a result of glycosylation, the apparent molecular mass of rmTREM2 is approximately 30-40 kDa in SDS-PAGE under reducing conditions.
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| NCBI/Uniprot data below describe general gene information for TREM2. It may not necessarily be applicable to this product. |
| NCBI GI #
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13994125
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| NCBI GeneID
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83433
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| NCBI Accession #
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NP_112544.1
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[Other Products]
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| NCBI GenBank Nucleotide #
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NM_031254.3
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[Other Products]
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| UniProt Primary Accession #
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Q99NH8
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[Other Products]
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| UniProt Secondary Accession #
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Q8CGK4; Q8CIA6; Q99NH9; Q9JL34
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[Other Products]
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| UniProt Related Accession #
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Q99NH8
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[Other Products]
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| Molecular Weight
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27,304 Da
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| NCBI Official Full Name
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triggering receptor expressed on myeloid cells 2 isoform 1
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| NCBI Official Synonym Full Names
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triggering receptor expressed on myeloid cells 2
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| NCBI Official Symbol
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Trem2
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[Similar Products]
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| NCBI Official Synonym Symbols
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TREM-2; Trem2a; Trem2b; Trem2c
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[Similar Products]
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| NCBI Protein Information
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triggering receptor expressed on myeloid cells 2
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| UniProt Protein Name
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Triggering receptor expressed on myeloid cells 2
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| UniProt Synonym Protein Names
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Triggering receptor expressed on monocytes 2
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| Protein Family
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Triggering receptor expressed on myeloid cells
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| UniProt Gene Name
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Trem2
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[Similar Products]
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| UniProt Synonym Gene Names
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Trem2a; Trem2b; Trem2c; TREM-2
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[Similar Products]
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| NCBI Summary for TREM2
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The protein encoded by this gene is part of the immunoglobulin and lectin-like superfamily and functions as part of the innate immune system. This gene forms part of a cluster of genes on mouse chromosome 17 thought to be involved in innate immunity. This protein associates with the adaptor protein Dap-12 and recruits several factors, such as kinases and phospholipase C-gamma, to form a receptor signaling complex that activates myeloid cells, including dendritic cells and microglia. In humans homozygous loss-of-function mutations in this gene cause Nasu-Hakola disease and mutations in this gene may be risk factors to the development of Alzheimer's disease. In mouse mutations of this gene serve as a pathophysiological model for polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy (Nasu-Hakola disease) and for inflammatory bowel disease. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Jan 2013]
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| UniProt Comments for TREM2
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TREM2: May have a role in chronic inflammations and may stimulate production of constitutive rather than inflammatory chemokines and cytokines. Forms a receptor signaling complex with TYROBP and triggers activation of the immune responses in macrophages and dendritic cells. Defects in TREM2 are a cause of polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy (PLOSL); also known as presenile dementia with bone cysts or Nasu-Hakola disease (NHD). PLOSL is a recessively inherited disease characterized by a combination of psychotic symptoms rapidly progressing to presenile dementia and bone cysts restricted to wrists and ankles. PLOSL has a global distribution, although most of the patients have been diagnosed in Finland and Japan, with an estimated population prevalence of 2x10(-6) in the Finns. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: Membrane protein, integral
Chromosomal Location of Human Ortholog: 17|17 C
Cellular Component: integral to membrane; intracellular membrane-bound organelle
Molecular Function: lipopolysaccharide binding; peptidoglycan binding; protein binding; transmembrane receptor activity
Biological Process: detection of lipopolysaccharide; detection of peptidoglycan; innate immune response; lipopolysaccharide-mediated signaling pathway; phagocytosis, engulfment; positive regulation of antigen processing and presentation of peptide antigen via MHC class II; positive regulation of calcium-mediated signaling; positive regulation of peptidyl-tyrosine phosphorylation
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| Research Articles on TREM2
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1. TREM2 attenuates tau kinase activity through restriction of neuroinflammation, and thus protects against tau pathology.
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| Precautions
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All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
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| Disclaimer
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While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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| Products associated with TREM2 recombinant protein | Pathways associated with TREM2 recombinant protein |
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| Diseases associated with TREM2 recombinant protein | Organs/Tissues associated with TREM2 recombinant protein |
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Recombinant Protein 
