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TSHR recombinant protein

Scan QR to view Datasheet Catalog #    MBS355600 TSHR recombinant protein
Unit / Price
0.1 mg  /  $465 +1 FREE 8GB USB
1 mg  /  $1,890 +2 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

TSHR, Recombinant Protein

★Popular Item★
 Also Known As   

TSHR Protein (Active)

 Product Synonym Names    Thyrotropin receptor, Thyroid-stimulating hormone receptor, TSH-R, TSHR, LGR3
 Product Gene Name   

TSHR recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 14; NC_000014.8 (81421333..81612646). Location: 14q31
 OMIM    275200
 3D Structure    ModBase 3D Structure for P16473
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 Purity/Purification    >90% by SDS-PAGE
 Form/Format    Liquid
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 Preparation and Storage    Ship at 4 degree C. Upon receipt, aliquot and store at -20 degree C or -80 degree C for long term.
Avoid repeated freeze and thaw cycles.
 Other Notes    Small volumes of TSHR recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for TSHR recombinant protein

   Background/Introduction: Thyroid stimulating hormone receptor (TSHR), also known as Thyrotropin receptor is a member of the leucine-rich repeat-containing G protein-coupled receptors. G protein-coupled receptors (GPCRs) are the largest family of plasma membrane receptors. They mediate the effects of several endogenous cues and serve as important pharmacological targets. TSHR is primarily found on the surface of the thyroid epithelial cells. Both TSHR and its ligand TSH have evolved to acquire specificity, minimize cross-reaction to other glycoprotein hormone receptors, and modulate cognate interaction (and thereby thyrotropic activity).
 Applications Tested/Suitable for TSHR recombinant protein   

ELISA (EIA), SDS-PAGE

Other applications have not been tested. The optimal dilutions should be determined by end user.

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NCBI/Uniprot data below describe general gene information for TSHR. It may not necessarily be applicable to this product.
 NCBI GI #    217330610
 NCBI GeneID    7253
 NCBI Accession #    NP_001136098.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001142626.2 [Other Products]
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 UniProt Primary Accession #    P16473 [Other Products]
 UniProt Secondary Accession #    Q16503; Q8TB90; Q96GT6; Q9P1V4; Q9ULA3; Q9UPH3; A0PJU7; G3V2A9 [Other Products]
 UniProt Related Accession #    P16473 [Other Products]
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 NCBI Official Full Name    thyrotropin receptor isoform 3
 NCBI Official Synonym Full Names    thyroid stimulating hormone receptor
 NCBI Official Symbol    TSHR [Similar Products]
 NCBI Official Synonym Symbols   
LGR3; CHNG1; hTSHR-I
[Similar Products]
 NCBI Protein Information    thyrotropin receptor; thyrotropin receptor-I, hTSHR-I; seven transmembrane helix receptor; thyroid stimulating hormone receptor, isoform 2
 UniProt Protein Name    Thyrotropin receptor
 UniProt Synonym Protein Names   
Thyroid-stimulating hormone receptor
 Protein Family    Thyrotropin receptor
 UniProt Gene Name    TSHR [Similar Products]
 UniProt Synonym Gene Names    LGR3; TSH-R [Similar Products]
 UniProt Entry Name    TSHR_HUMAN
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 NCBI Summary for TSHR    The protein encoded by this gene is a membrane protein and a major controller of thyroid cell metabolism. The encoded protein is a receptor for thyrothropin and thyrostimulin, and its activity is mediated by adenylate cyclase. Defects in this gene are a cause of several types of hyperthyroidism. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2008]
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 UniProt Comments for TSHR    Function: Receptor for thyrothropin. Plays a central role in controlling thyroid cell metabolism. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Also acts as a receptor for thyrostimulin (GPA2+GPB5). Ref.11

Subunit structure: Interacts (via the PDZ-binding motif) with SCRIB; regulates TSHR trafficking and function. Ref.11 Ref.12

Subcellular location: Cell membrane; Multi-pass membrane protein.

Tissue specificity: Expressed in the thyroid. Ref.2

Polymorphism: The Asp727Glu polymorphism is associated with Graves disease in a Russian population. The Glu727 allele and the heterozygous Asp727Glu genotype are related to higher risk of the disease. The Asp727Glu polymorphism significantly ameliorates G(s)alpha protein activation in the presence of the gain-of-function mutation Ala593Asn although it is functionally inert in the context of the wild-type TSHR.

Involvement in disease: Defects in TSHR are found in patients affected by hyperthyroidism with different etiologies. Somatic, constitutively activating TSHR mutations and/or constitutively activating G(s)alpha mutations have been identified in toxic thyroid nodules (TTNs) that are the predominant cause of hyperthyroidism in iodine deficient areas. These mutations lead to TSH independent activation of the cAMP cascade resulting in thyroid growth and hormone production. TSHR mutations are found in autonomously functioning thyroid nodules (AFTN), toxic multinodular goiter (TMNG) and hyperfunctioning thyroid adenomas (HTA). TMNG encompasses a spectrum of different clinical entities, ranging from a single hyperfunctioning nodule within an enlarged thyroid, to multiple hyperfunctioning areas scattered throughout the gland. HTA are discrete encapsulated neoplasms characterized by TSH-independent autonomous growth, hypersecretion of thyroid hormones, and TSH suppression. Defects in TSHR are also a cause of thyroid neoplasms (papillary and follicular cancers). Ref.15 Ref.16 Ref.17Autoantibodies against TSHR are directly responsible for the pathogenesis and hyperthyroidism of Graves disease. Antibody interaction with TSHR results in an uncontrolled receptor stimulation. Ref.15 Ref.16 Ref.17Hypothyroidism, congenital, non-goitrous, 1 (CHNG1) [MIM:275200]: A non-autoimmune condition characterized by resistance to thyroid-stimulating hormone (TSH) leading to increased levels of plasma TSH and low levels of thyroid hormone. It presents variable severity depending on the completeness of the defect. Most patients are euthyroid and asymptomatic, with a normal sized thyroid gland. Only a subset of patients develop hypothyroidism and present a hypoplastic thyroid gland.Note: The disease is caused by mutations affecting the gene represented in this entry. Ref.15 Ref.16 Ref.17 Ref.27 Ref.32 Ref.34 Ref.36 Ref.39 Ref.50 Ref.53 Ref.61 Ref.63 Ref.67 Ref.69Familial gestational hyperthyroidism (HTFG) [MIM:603373]: A condition characterized by abnormally high levels of serum thyroid hormones occurring during early pregnancy.Note: The disease is caused by mutations affecting the gene represented in this entry. Ref.15 Ref.16 Ref.17 Ref.43Hyperthyroidism, non-autoimmune (HTNA) [MIM:609152]: A condition characterized by abnormally high levels of serum thyroid hormones, thyroid hyperplasia, goiter and lack of anti-thyroid antibodies. Typical features of Graves disease such as exophthalmia, myxedema, antibodies anti-TSH receptor and lymphocytic infiltration of the thyroid gland are absent.Note: The disease is caused by mutations affecting the gene represented in this entry. Ref.15 Ref.16 Ref.17 Ref.24 Ref.26 Ref.30 Ref.31 Ref.37 Ref.38 Ref.41 Ref.42 Ref.44 Ref.51 Ref.54 Ref.55 Ref.57 Ref.58 Ref.59 Ref.68

Sequence similarities: Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily.Contains 7 LRR (leucine-rich) repeats.

Sequence caution: The sequence AAA70232.1 differs from that shown. Reason: Frameshift at positions 130, 135 and 612.
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 Research Articles on TSHR    1. Loss-of-function mutations in the thyrotropin receptor gene is associated with congenital hypothyroidism.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with TSHR recombinant proteinPathways associated with TSHR recombinant protein
 Reference Product  PubMed Publications
 GNAS recombinant protein  >16 publications with TSHR and GNAS
 TSHB recombinant protein  >7 publications with TSHR and TSHB
 LHCGR recombinant protein  >5 publications with TSHR and LHCGR
 NKX2-1 recombinant protein  >4 publications with TSHR and NKX2-1
 PTH recombinant protein  >4 publications with TSHR and PTH
 CALCA recombinant protein  >2 publications with TSHR and CALCA
 POMC recombinant protein  >1 publications with TSHR and POMC
 Products by Pathway  Pathway Diagram
 Arf6 Signaling Events Pathway antibodies  Arf6 Signaling Events Pathway Diagram
 Arf6 Trafficking Events Pathway antibodies  Arf6 Trafficking Events Pathway Diagram
 Autoimmune Thyroid Disease Pathway antibodies  Autoimmune Thyroid Disease Pathway Diagram
 Autoimmune Thyroid Disease Pathway antibodies  Autoimmune Thyroid Disease Pathway Diagram
 Class A/1 (Rhodopsin-like Receptors) Pathway antibodies  Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
 G Alpha (s) Signalling Events Pathway antibodies  G Alpha (s) Signalling Events Pathway Diagram
 GPCR Downstream Signaling Pathway antibodies  GPCR Downstream Signaling Pathway Diagram
 GPCR Ligand Binding Pathway antibodies  GPCR Ligand Binding Pathway Diagram
 Hormone Ligand-binding Receptors Pathway antibodies  Hormone Ligand-binding Receptors Pathway Diagram
 Neuroactive Ligand-receptor Interaction Pathway antibodies  Neuroactive Ligand-receptor Interaction Pathway Diagram
Diseases associated with TSHR recombinant proteinOrgans/Tissues associated with TSHR recombinant protein
 Disease Name  Pubmed Publications
 Hyperthyroidism Antibodies  >465 publications with TSHR and Hyperthyroidism
 Graves Disease Antibodies  >435 publications with TSHR and Graves Disease
 Thyroid Neoplasms Antibodies  >154 publications with TSHR and Thyroid Neoplasms
 Thyroiditis, Autoimmune Antibodies  >98 publications with TSHR and Thyroiditis, Autoimmune
 Carcinoma Antibodies  >89 publications with TSHR and Carcinoma
 Congenital Hypothyroidism Antibodies  >66 publications with TSHR and Congenital Hypothyroidism
 Adenoma Antibodies  >48 publications with TSHR and Adenoma
 Thyrotoxicosis Antibodies  >38 publications with TSHR and Thyrotoxicosis
 Kidney Diseases Antibodies  >35 publications with TSHR and Kidney Diseases
 Hyperthyroidism, Nonautoimmune Antibodies  >34 publications with TSHR and Hyperthyroidism, Nonautoimmune
 Organ/Tissue Name  Pubmed Publications
 Thyroid Antibodies  >976 publications with TSHR and Thyroid
 Blood Antibodies  >321 publications with TSHR and Blood
 Ovary Antibodies  >75 publications with TSHR and Ovary
 Connective Tissue Antibodies  >52 publications with TSHR and Connective Tissue
 Muscle Antibodies  >38 publications with TSHR and Muscle
 Brain Antibodies  >26 publications with TSHR and Brain
 Thymus Antibodies  >12 publications with TSHR and Thymus
 Lung Antibodies  >10 publications with TSHR and Lung
 Embryonic Tissue Antibodies  >6 publications with TSHR and Embryonic Tissue
 Placenta Antibodies  >2 publications with TSHR and Placenta
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