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TAC3 recombinant protein :: Tachykinin-3 Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS143502 TAC3 recombinant protein
Unit / Price
0.005 mg  /  $140 +1 FREE 8GB USB
0.025 mg  /  $205 +1 FREE 8GB USB
1 mg  /  $2,665 +3 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Tachykinin-3 (TAC3), Recombinant Protein

 Also Known As   

Recombinant Human Tachykinin-3

 Product Synonym Names    TAC3 Human; Tachykinin-3 Human Recombinant; Tachykinin-3; ZNEUROK1; Neurokinin-B; NKB; Neuromedin-K; TAC3; NKNB; PRO1155
 Product Gene Name   

TAC3 recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence    MGSSHHH HHH SSGLVPRGSH QSFGAVCKEP QEEVVPGGGR SKRDPDLYQL LQRLFKSHSS LEGLLKALSQ ASTDPKESTS PEKRDMHDFF VGLMGKRSVQ PDSPTDVNQE NVPSFGILKY PPRAE
 OMIM    162330
 3D Structure    ModBase 3D Structure for Q9UHF0
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 Host    E Coli
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 Purity/Purification    Greater than 95.0% as determined by SDS-PAGE.
 Form/Format    The TAC3 solution contains 20mM Tris-HCl buffer (pH 8.0) and 20% glycerol.
Sterile Filtered colorless solution.
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 Preparation and Storage    TAC3 although stable 4 degree C for 4 weeks, should be stored desiccated below -18 degree C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please prevent freeze-thaw cycles.
 Other Notes    Small volumes of TAC3 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for TAC3 recombinant protein

   Description: TAC3 Human Recombinant fused with 20 amino acid His tag at N-terminus produced in E Coli is a single, non-glycosylated, polypeptide chain containing 125 amino acids (17-121 a.a.) and having a molecular mass of 13.8kDa.The TAC3 is purified by proprietary chromatographic techniques.

Introduction: Tachykinin-3 belongs to the substance P-related tachykinin family. Tachykinins are active peptides that stimulate neurons, induce behavioral responses, are effective vasodilators and secretagogues, and contract (directly or indirectly) many smooth muscles. TAC3 and its receptor are essential switches of regulator of human puberty, regulated by the brain through the release of the GnRH which starts a chain of processes which eventually lead to the production of sex hormones. During pregnancy, the expression of TAC3 is restricted to the outer syncytiotrophoblast of the placenta, significant concentrations of TAC3 can be identified in plasma as early as week 9, and plasma concentrations of TAC3 are grossly elevated in pregnancy-induced hypertension and pre-eclampsia. Higher Tachykinin-3 concentrations in normotensive pregnant women may be caused by the advanced gestational age and/or the result of a negative interaction of other vasoactive substances. TAC3 has a role in the continuance of high placental blood flow in normal pregnancy.
 Product Categories/Family for TAC3 recombinant protein    RECOMBINANT & NATURAL PROTEINS; Recombinant Proteins
NCBI/Uniprot data below describe general gene information for TAC3. It may not necessarily be applicable to this product.
 NCBI GI #    295849290
 NCBI GeneID    6866
 NCBI Accession #    NP_001171525.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001178054.1 [Other Products]
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 UniProt Primary Accession #    Q9UHF0 [Other Products]
 UniProt Secondary Accession #    Q6IAG2; Q71BC6; Q71BC9 [Other Products]
 UniProt Related Accession #    Q9UHF0 [Other Products]
 Molecular Weight    11,358 Da
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 NCBI Official Full Name    tachykinin-3 isoform 2 preproprotein
 NCBI Official Synonym Full Names    tachykinin 3
 NCBI Official Symbol    TAC3 [Similar Products]
 NCBI Official Synonym Symbols   
NKB; HH10; NKNB; PRO1155; ZNEUROK1
[Similar Products]
 NCBI Protein Information    tachykinin-3; gamma tachykinin 3; neurokinin b; neuromedin K; preprotachykinin B; preprotachykinin-B
 UniProt Protein Name    Tachykinin-3
 UniProt Synonym Protein Names   
ZNEUROK1Neurokinin-B; NKBAlternative name(s):Neuromedin-K
 Protein Family    Tachykinin
 UniProt Gene Name    TAC3 [Similar Products]
 UniProt Synonym Gene Names    NKNB; NKB [Similar Products]
 UniProt Entry Name    TKNK_HUMAN
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 NCBI Summary for TAC3    This gene encodes a member of the tachykinin family of secreted neuropeptides. The encoded protein is primarily expressed in the central and peripheral nervous system and functions as a neurotransmitter. This protein is the ligand for the neurokinin-3 receptor. This protein is also expressed in the outer syncytiotrophoblast of the placenta and may be associated with pregnancy-induced hypertension and pre-eclampsia. Mutations in this gene are associated with normosmic hypogonadotropic hypogonadism. Alternate splicing results in multiple transcript variants. [provided by RefSeq, May 2010]
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 UniProt Comments for TAC3    TAC3: Tachykinins are active peptides which excite neurons, evoke behavioral responses, are potent vasodilators and secretagogues, and contract (directly or indirectly) many smooth muscles. Belongs to the tachykinin family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 12q13.3

Cellular Component: extracellular space; extracellular region

Molecular Function: protein binding; receptor binding

Biological Process: tachykinin signaling pathway; neuropeptide signaling pathway; female pregnancy

Disease: Hypogonadotropic Hypogonadism 10 With Or Without Anosmia
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 Research Articles on TAC3    1. SP may influence the KP and NKB secretory output via additional autocrine/paracrine mechanisms or regulate GnRH neurosecretion directly.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with TAC3 recombinant proteinPathways associated with TAC3 recombinant protein
 Reference Product  PubMed Publications
 TACR3 recombinant protein  >39 publications with TAC3 and TACR3
 PROKR2 recombinant protein  >17 publications with TAC3 and PROKR2
 KISS1R recombinant protein  >16 publications with TAC3 and KISS1R
 GNRH1 recombinant protein  >11 publications with TAC3 and GNRH1
 TAC1 recombinant protein  >8 publications with TAC3 and TAC1
 TACR1 recombinant protein  >3 publications with TAC3 and TACR1
 TACR2 recombinant protein  >2 publications with TAC3 and TACR2
 Products by Pathway  Pathway Diagram
 Class A/1 (Rhodopsin-like Receptors) Pathway antibodies  Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
 Defective ACTH Causes Obesity And Pro-opiomelanocortinin Deficiency (POMCD) Pathway antibodies  Defective ACTH Causes Obesity And Pro-opiomelanocortinin Deficiency (POMCD) Pathway Diagram
 Disease Pathway antibodies  Disease Pathway Diagram
 G Alpha (q) Signalling Events Pathway antibodies  G Alpha (q) Signalling Events Pathway Diagram
 GPCR Downstream Signaling Pathway antibodies  GPCR Downstream Signaling Pathway Diagram
 GPCR Ligand Binding Pathway antibodies  GPCR Ligand Binding Pathway Diagram
 Gastrin-CREB Signalling Pathway Via PKC And MAPK antibodies  Gastrin-CREB Signalling Pathway Via PKC And MAPK Diagram
 Metabolic Disorders Of Biological Oxidation Enzymes Pathway antibodies  Metabolic Disorders Of Biological Oxidation Enzymes Pathway Diagram
 Peptide Ligand-binding Receptors Pathway antibodies  Peptide Ligand-binding Receptors Pathway Diagram
 Signal Transduction Pathway antibodies  Signal Transduction Pathway Diagram
Diseases associated with TAC3 recombinant proteinOrgans/Tissues associated with TAC3 recombinant protein
 Disease Name  Pubmed Publications
 Hypogonadism Antibodies  >33 publications with TAC3 and Hypogonadism
 Congenital Abnormalities Antibodies  >12 publications with TAC3 and Congenital Abnormalities
 Idiopathic Hypogonadotropic Hypogonadism Antibodies  >11 publications with TAC3 and Idiopathic Hypogonadotropic Hypogonadism
 Pregnancy Complications Antibodies  >3 publications with TAC3 and Pregnancy Complications
 Epilepsy Antibodies  >1 publications with TAC3 and Epilepsy
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >13 publications with TAC3 and Brain
 Placenta Antibodies  >3 publications with TAC3 and Placenta
 Uterus Antibodies  >1 publications with TAC3 and Uterus
 Connective Tissue Antibodies  >1 publications with TAC3 and Connective Tissue
 Embryonic Tissue Antibodies  >1 publications with TAC3 and Embryonic Tissue
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