NP_003320
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
thioredoxin isoform 1
NCBI Official Synonym Full Names
thioredoxin
NCBI Protein Information
thioredoxin
UniProt Protein Name
Thioredoxin
UniProt Synonym Protein Names
ATL-derived factor; ADF; Surface-associated sulphydryl protein; SASP
UniProt Synonym Gene Names
NCBI Summary for TXN
The protein encoded by this gene acts as a homodimer and is involved in many redox reactions. The encoded protein is active in the reversible S-nitrosylation of cysteines in certain proteins, which is part of the response to intracellular nitric oxide. This protein is found in the cytoplasm. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]
UniProt Comments for TXN
Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions. Plays a role in the reversible S-nitrosylation of cysteine residues in target proteins, and thereby contributes to the response to intracellular nitric oxide. Nitrosylates the active site Cys of CASP3 in response to nitric oxide (NO), and thereby inhibits caspase-3 activity. Induces the FOS/JUN AP-1 DNA-binding activity in ionizing radiation (IR) cells through its oxidation/reduction status and stimulates AP-1 transcriptional activity.
Product References and Citations for TXN active protein
Pigiet VP., et al. (1986) Proc. Natl.Acad.Sci. uSA 83 (20):7643-7.; Lundstrom J., et al. (1990) J.Biol.Chem. 265 (16):9114-20.; Laurent TC., et al. (1964) J Biol Chem. 239:3436-44.;
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Products associated with TXN active protein
Pathways associated with TXN active protein
Diseases associated with TXN active protein
Organs/Tissues associated with TXN active protein
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