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TXNDC12 recombinant protein :: Thioredoxin domain-containing protein 12 Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS1064185
SDS-PAGE
Unit / Price
0.01 mg (E-Coli)  /  $110 +1 FREE 8GB USB
0.05 mg (E-Coli)  /  $190 +1 FREE 8GB USB
0.1 mg (E-Coli)  /  $285 +1 FREE 8GB USB
0.2 mg (E-Coli)  /  $460 +1 FREE 8GB USB
0.05 mg (Yeast)  /  $705 +1 FREE 8GB USB
0.5 mg (E-Coli)  /  $750 +1 FREE 8GB USB
0.05 mg (Baculovirus)  /  $855 +1 FREE 8GB USB
0.2 mg (Yeast)  /  $950 +1 FREE 8GB USB
0.5 mg (Yeast)  /  $1,065 +1 FREE 8GB USB
0.1 mg (Baculovirus)  /  $1,075 +1 FREE 8GB USB
0.05 mg (Mammalian-Cell)  /  $1,095 +1 FREE 8GB USB
1 mg (E-Coli)  /  $1,180 +1 FREE 8GB USB
0.5 mg (Baculovirus)  /  $1,560 +1 FREE 8GB USB
1 mg (Yeast)  /  $1,620 +2 FREE 8GB USB
0.1 mg (Mammalian-Cell)  /  $1,670 +2 FREE 8GB USB
1 mg (Baculovirus)  /  $2,090 +2 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Thioredoxin domain-containing protein 12 (TXNDC12), Recombinant Protein

 Also Known As   

Recombinant Human Thioredoxin domain-containing protein 12

 Product Synonym Names    Endoplasmic reticulum resident protein 18; ER protein 18; ERp18; Endoplasmic reticulum resident protein 19; ER protein 19; ERp19; Thioredoxin-like protein p19h; TLP19
 Product Gene Name   

TXNDC12 recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence Positions    27-172aa; Full Length
 Sequence    HNGLGKGFGD HIHWRTLEDG KKEAAASGLP LMVIIHKSWC GACKALKPKF AESTEISELS HNFVMVNLED EEEPKDEDFS PDGGYIPRIL FLDPSGKVHP EIINENGNPS YKYFYVSAEQ VVQGMKEAQE RLTGDAFRKK HLEDEL
 OMIM    609448
 3D Structure    ModBase 3D Structure for O95881
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 Host    E Coli or Yeast or Baculovirus or Mammalian Cell
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 Purity/Purification    Greater than 90% as determined by SDS-PAGE. (lot specific)
 Form/Format    Liquid containing glycerol
 Tag Information    This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
 Sterility    Sterile filter available upon request.
 Endotoxin    Low endotoxin available upon request.
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 Preparation and Storage    Store at -20 degree C, for extended storage, conserve at -20 degree C or -80 degree C.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of TXNDC12 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for TXNDC12 recombinant protein

   Possesses significant protein thiol-disulfide oxidase activity.
 Product Categories/Family for TXNDC12 recombinant protein    Signal Transduction
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 SDS-PAGE of TXNDC12 recombinant protein    TXNDC12 recombinant protein SDS-PAGE image
(Note: Representative image, actual molecular weight may vary depending on Tag type and expression host)
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NCBI/Uniprot data below describe general gene information for TXNDC12. It may not necessarily be applicable to this product.
 NCBI GI #    7705696
 NCBI GeneID    51060
 NCBI Accession #    NP_056997.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_015913.3 [Other Products]
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 UniProt Primary Accession #    O95881 [Other Products]
 UniProt Secondary Accession #    Q5T1T4; Q96H50; B3KQS0 [Other Products]
 UniProt Related Accession #    O95881 [Other Products]
 Molecular Weight    32.42kD
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 NCBI Official Full Name    thioredoxin domain-containing protein 12
 NCBI Official Synonym Full Names    thioredoxin domain containing 12 (endoplasmic reticulum)
 NCBI Official Symbol    TXNDC12 [Similar Products]
 NCBI Official Synonym Symbols   
AG1; AGR1; ERP16; ERP18; ERP19; TLP19; hAG-1; PDIA16; hTLP19
[Similar Products]
 NCBI Protein Information    thioredoxin domain-containing protein 12
 UniProt Protein Name    Thioredoxin domain-containing protein 12
 UniProt Synonym Protein Names   
Endoplasmic reticulum resident protein 18; ER protein 18; ERp18; Endoplasmic reticulum resident protein 19; ER protein 19; ERp19; Thioredoxin-like protein p19; hTLP19
 Protein Family    Thioredoxin domain-containing protein
 UniProt Gene Name    TXNDC12 [Similar Products]
 UniProt Synonym Gene Names    TLP19; ER protein 18; ERp18; ER protein 19; ERp19 [Similar Products]
 UniProt Entry Name    TXD12_HUMAN
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 NCBI Summary for TXNDC12    This gene encodes a member of the thioredoxin superfamily. Members of this family are characterized by a conserved active motif called the thioredoxin fold that catalyzes disulfide bond formation and isomerization. This protein localizes to the endoplasmic reticulum and has a single atypical active motif. The encoded protein is mainly involved in catalyzing native disulfide bond formation and displays activity similar to protein-disulfide isomerases. This protein may play a role in defense against endoplasmic reticulum stress. Alternate splicing results in both coding and non-coding variants. [provided by RefSeq, Mar 2012]
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 UniProt Comments for TXNDC12    TXNDC12: Possesses significant protein thiol-disulfide oxidase activity.

Protein type: Secreted, signal peptide; Other Amino Acids Metabolism - glutathione; Secreted; Oxidoreductase; EC 1.8.4.2

Chromosomal Location of Human Ortholog: 1p32.3

Cellular Component: endoplasmic reticulum lumen

Molecular Function: peptide disulfide oxidoreductase activity; protein binding; protein-disulfide reductase (glutathione) activity

Biological Process: cell redox homeostasis
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Product References and Citations for TXNDC12 recombinant protein

   Isolation and characterization of a novel human thioredoxin-like gene hTLP19 encoding a secretory protein.Liu F., Rong Y.P., Zeng L.C., Zhang X., Han Z.G.Gene 315:71-78(2003) Mei G., Yu W., Gibbs R.A. The secreted protein discovery initiative (SPDI) , a large-scale effort to identify novel human secreted and transmembrane proteins a bioinformatics assessment.Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E., Heldens S., Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M.Genome Res. 13:2265-2270(2003) Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries.Otsuki T., Ota T., Nishikawa T., Hayashi K., Suzuki Y., Yamamoto J., Wakamatsu A., Kimura K., Sakamoto K., Hatano N., Kawai Y., Ishii S., Saito K., Kojima S., Sugiyama T., Ono T., Okano K., Yoshikawa Y., Aotsuka S., Sasaki N., Hattori A., Okumura K., Nagai K., Sugano S., Isogai T.DNA Res. 12:117-126(2005) The DNA sequence and biological annotation of human chromosome 1.Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K., Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.Nature 441:315-321(2006) Signal peptide prediction based on analysis of experimentally verified cleavage sites.Zhang Z., Henzel W.J.Protein Sci. 13:2819-2824(2004) Functional characterization of ERp18, a new endoplasmic reticulum-located thioredoxin superfamily member.Alanen H.I., Williamson R.A., Howard M.J., Lappi A.-K., Jaentti H.P., Rautio S.M., Kellokumpu S., Ruddock L.W.J. Biol. Chem. 278:28912-28920(2003) Initial characterization of the human central proteome.Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.BMC Syst. Biol. 5:17-17(2011) An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L., Ye M., Zou H.J. Proteomics 96:253-262(2014) Solution structure and dynamics of ERp18, a small endoplasmic reticulum resident oxidoreductase.Rowe M.L., Ruddock L.W., Kelly G., Schmidt J.M., Williamson R.A., Howard M.J.Biochemistry 48:4596-4606(2009)
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 Research Articles on TXNDC12    1. ERp18 shows specificity towards a component of the complement cascade, pentraxin-related protein PTX3.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with TXNDC12 recombinant proteinDiseases associated with TXNDC12 recombinant protein
 Products by Pathway  Pathway Diagram
 Glutathione Metabolism Pathway antibodies  Glutathione Metabolism Pathway Diagram
 Glutathione Metabolism Pathway antibodies  Glutathione Metabolism Pathway Diagram
 Disease Name  Pubmed Publications
 Cell Transformation, Neoplastic Antibodies  >1 publications with TXNDC12 and Cell Transformation, Neoplastic
 Lung Neoplasms Antibodies  >1 publications with TXNDC12 and Lung Neoplasms
 Obesity Antibodies  >1 publications with TXNDC12 and Obesity
 Breast Neoplasms Antibodies  >1 publications with TXNDC12 and Breast Neoplasms
Organs/Tissues associated with TXNDC12 recombinant protein
 Organ/Tissue Name  Pubmed Publications
 Muscle Antibodies  >2 publications with TXNDC12 and Muscle
 Liver Antibodies  >2 publications with TXNDC12 and Liver
 Heart Antibodies  >1 publications with TXNDC12 and Heart
 Spleen Antibodies  >1 publications with TXNDC12 and Spleen
 Lung Antibodies  >1 publications with TXNDC12 and Lung
 Placenta Antibodies  >1 publications with TXNDC12 and Placenta
 Brain Antibodies  >1 publications with TXNDC12 and Brain
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