NP_057700.3
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
67,270 Da
NCBI Official Full Name
thioredoxin domain-containing protein 3
NCBI Official Synonym Full Names
NME/NM23 family member 8
NCBI Official Synonym Symbols
CILD6; SPTRX2; TXNDC3; NM23-H8; sptrx-2; HEL-S-99 [Similar Products]
NCBI Protein Information
thioredoxin domain-containing protein 3
UniProt Protein Name
Thioredoxin domain-containing protein 3
UniProt Synonym Protein Names
NM23-H8; NME/NM23 family member 8; Spermatid-specific thioredoxin-2; Sptrx-2
UniProt Synonym Gene Names
NCBI Summary for TXNDC3
This gene encodes a protein with an N-terminal thioredoxin domain and three C-terminal nucleoside diphosphate kinase (NDK) domains, but the NDK domains are thought to be catalytically inactive. The sea urchin ortholog of this gene encodes a component of sperm outer dynein arms, and the protein is implicated in ciliary function. Mutations in this gene are implicated in primary ciliary dyskinesia type 6.[provided by RefSeq, Nov 2009]
UniProt Comments for TXNDC3
Probably required during the final stages of sperm tail maturation in the testis and/or epididymis, where extensive disulfide bonding of fibrous sheath (FS) proteins occurs. May be involved in the reduction of disulfide bonds within the sperm FS components. In vitro, it has neither NDP kinase nor reducing activity on disulfide bonds.
Research Articles on TXNDC3
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Products associated with TXNDC3 recombinant protein
Diseases associated with TXNDC3 recombinant protein
Organs/Tissues associated with TXNDC3 recombinant protein
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