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TXN1 recombinant protein :: Thioredoxin Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS144064 TXN1 recombinant protein
Unit / Price
0.005 mg  /  $140 +1 FREE 8GB USB
0.025 mg  /  $205 +1 FREE 8GB USB
1 mg  /  $2,235 +2 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Thioredoxin (TXN1), Recombinant Protein

 Also Known As   

Recombinant Human Thioredoxin His Tag

 Product Synonym Names    TXN1 Human, His; Thioredoxin Human Recombinant, His Tag; Thioredoxin; ATL-derived factor; ADF; Surface-associated sulphydryl protein; SASP; TXN; TRDX; TRX; TRX1; MGC61975; DKFZp686B1993; TXN1, His
 Product Gene Name   

TXN1 recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence    MGSSHHH HHH SSGLVPRGSH MVKQIESKTA FQEALDAAGD KLVVVDFSAT WCGPCKMIKP FFHSLSEKYS NVIFLEVDVD DCQDVASECE VKCMPTFQFF KKGQKVGEFS GANKEKLEAT INELV
 OMIM    165090
 3D Structure    ModBase 3D Structure for P10301
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 Host    E Coli
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 Purity/Purification    Greater than 95.0% as determined by SDS-PAGE.
 Form/Format    TXN1 solution containing 1x PBS pH 7.4.
Sterile filtered colorless solution.
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 Biological Activity    Specific activity is 7-10 A650/min/mg, obtained by measuring the increase of insulin precipitation in absorbance at 650 nm resulting from the reduction of insulin.
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 Preparation and Storage    Store at 4 degree C if entire vial will be used within 2-4 weeks. Store, frozen at -20 degree C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
 Other Notes    Small volumes of TXN1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for TXN1 recombinant protein

   Description: Thioredoxin Human Recombinant produced in E Coli is a single, non-glycosylated, polypeptide chain containing 125 amino acids (1-105 a.a.) and having a molecular mass of 13.9 kDa (Molecular weight on SDS-PAGE will appear higher). TXN protein is fused to a 20 amino acid His-Tag at N-terminus and purified by standard chromatography.

Introduction: Thioredoxins are small disulphide-containing redox proteins (within the conserved Cys-Gly-Pro-Cys active site) that have been found in all the kingdoms of living organisms. Thioredoxin contains a single disulfide active site and serves as a general protein disulphide oxidoreductase. Thioredoxins are involved in the first unique step in DNA synthesis. It interacts with a broad range of proteins by a redox mechanism based on reversible oxidation of two cysteine thiol groups to a disulphide, accompanied by the transfer of two electrons and two protons. The net result is the covalent interconversion of a disulphide and a dithiol. It has been suggested that thioredoxin may catalyze the formation of correct disulfides during protein folding because of its ability to act as an efficient oxidoreductant. Trx also provides control over a number of transcription factors affecting cell proliferation and death through a mechanism referred to as redox regulation.
 Product Categories/Family for TXN1 recombinant protein    RECOMBINANT & NATURAL PROTEINS; Recombinant Proteins; Thioredoxin
NCBI/Uniprot data below describe general gene information for TXN1. It may not necessarily be applicable to this product.
 NCBI GI #    5454028
 NCBI GeneID    6237
 NCBI Accession #    NP_006261.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_006270.3 [Other Products]
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 UniProt Primary Accession #    P10301 [Other Products]
 UniProt Secondary Accession #    Q6FH12 [Other Products]
 UniProt Related Accession #    P10301 [Other Products]
 Molecular Weight    23,480 Da
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 NCBI Official Full Name    ras-related protein R-Ras
 NCBI Official Synonym Full Names    related RAS viral (r-ras) oncogene homolog
 NCBI Official Symbol    RRAS [Similar Products]
 NCBI Protein Information    ras-related protein R-Ras; Oncogene RRAS; p23
 UniProt Protein Name    Ras-related protein R-Ras
 UniProt Synonym Protein Names   
p23
 Protein Family    Thioredoxin
 UniProt Gene Name    RRAS [Similar Products]
 UniProt Entry Name    RRAS_HUMAN
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 NCBI Summary for TXN1    The protein encoded by this gene is a small GTPase involved in diverse processes including angiogenesis, vascular homeostasis and regeneration, cell adhesion, and neuronal axon guidance. Mutations in this gene are found in many invasive cancers. [provided by RefSeq, Jul 2015]
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 UniProt Comments for TXN1    RRas: a small G protein of the Ras family. Promotes focal adhesion formation by signaling to FAK and p130(Cas). Promotes tumor growth of cervical epithelial cells and increases their migration potential over collagen through a pathway that involves PI 3-K.

Protein type: G protein, monomeric, Ras; Motility/polarity/chemotaxis; G protein; G protein, monomeric

Chromosomal Location of Human Ortholog: 19q13.33

Cellular Component: focal adhesion; plasma membrane

Molecular Function: GTPase activity; protein binding; GDP binding; GTP binding; protein complex binding

Biological Process: axon guidance; synaptic transmission; positive regulation of angiogenesis; metabolic process; leukocyte differentiation; Ras protein signal transduction; regulation of protein kinase B signaling cascade; negative regulation of cell migration
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 Research Articles on TXN1    1. Contradicting the positive association reported in previous studies, our results indicate that R-Ras activation may negatively regulate the transformation of breast epithelial cells.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with TXN1 recombinant proteinPathways associated with TXN1 recombinant protein
 Reference Product  PubMed Publications
 SRC recombinant protein  >5 publications with TXN1 and SRC
 SEMA4D recombinant protein  >3 publications with TXN1 and SEMA4D
 RAF1 recombinant protein  >3 publications with TXN1 and RAF1
 EPHB2 recombinant protein  >1 publications with TXN1 and EPHB2
 Products by Pathway  Pathway Diagram
 Activation Of NMDA Receptor Upon Glutamate Binding And Postsynaptic Events Pathway antibodies  Activation Of NMDA Receptor Upon Glutamate Binding And Postsynaptic Events Pathway Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
 CREB Phosphorylation Through The Activation Of Ras Pathway antibodies  CREB Phosphorylation Through The Activation Of Ras Pathway Diagram
 Developmental Biology Pathway antibodies  Developmental Biology Pathway Diagram
 EPHB Forward Signaling Pathway antibodies  EPHB Forward Signaling Pathway Diagram
 G Protein Signaling Pathways antibodies  G Protein Signaling Pathways Diagram
 HTLV-I Infection Pathway antibodies  HTLV-I Infection Pathway Diagram
 HTLV-I Infection Pathway antibodies  HTLV-I Infection Pathway Diagram
 Integrated Breast Cancer Pathway antibodies  Integrated Breast Cancer Pathway Diagram
 MAPK Cascade Pathway antibodies  MAPK Cascade Pathway Diagram
Diseases associated with TXN1 recombinant proteinOrgans/Tissues associated with TXN1 recombinant protein
 Disease Name  Pubmed Publications
 Cell Transformation, Neoplastic Antibodies  >11 publications with TXN1 and Cell Transformation, Neoplastic
 Nervous System Diseases Antibodies  >7 publications with TXN1 and Nervous System Diseases
 Breast Neoplasms Antibodies  >6 publications with TXN1 and Breast Neoplasms
 Brain Diseases Antibodies  >6 publications with TXN1 and Brain Diseases
 Inflammation Antibodies  >5 publications with TXN1 and Inflammation
 Neoplasm Metastasis Antibodies  >4 publications with TXN1 and Neoplasm Metastasis
 Neoplasms, Experimental Antibodies  >3 publications with TXN1 and Neoplasms, Experimental
 Liver Neoplasms Antibodies  >2 publications with TXN1 and Liver Neoplasms
 Uterine Cervical Neoplasms Antibodies  >2 publications with TXN1 and Uterine Cervical Neoplasms
 Fibrosis Antibodies  >2 publications with TXN1 and Fibrosis
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >15 publications with TXN1 and Brain
 Muscle Antibodies  >9 publications with TXN1 and Muscle
 Testis Antibodies  >7 publications with TXN1 and Testis
 Bone Antibodies  >7 publications with TXN1 and Bone
 Heart Antibodies  >6 publications with TXN1 and Heart
 Connective Tissue Antibodies  >4 publications with TXN1 and Connective Tissue
 Embryonic Tissue Antibodies  >4 publications with TXN1 and Embryonic Tissue
 Prostate Antibodies  >4 publications with TXN1 and Prostate
 Lymph Antibodies  >3 publications with TXN1 and Lymph
 Kidney Antibodies  >3 publications with TXN1 and Kidney
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