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TST recombinant protein :: Thiosulfate Sulfurtransferase Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS143776 TST recombinant protein
Unit / Price
0.005 mg  /  $140 +1 FREE 8GB USB
0.02 mg  /  $205 +1 FREE 8GB USB
1 mg  /  $3,515 +4 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Thiosulfate Sulfurtransferase (TST), Recombinant Protein

 Also Known As   

Recombinant Human Thiosulfate Sulfurtransferase

 Product Synonym Names    Rhodanese Human; Thiosulfate Sulfurtransferase Human Recombinant; EC 2.8.1.1; TST; MGC19578; RDS; Thiosulfate sulfurtransferase; Rhodanese; Rhodanese
 Product Gene Name   

TST recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence    MGSSHHH HHH SSGLVPRGSH MVHQVLYRAL VSTKWLAESI RTGKLGPGLR VLDASWYSPG TREARKEYLE RHVPGASFFD IEECRDTASP YEMMLPSEAG FAEYVGRLGI SNHTHVVVYD GEHLGSFYAP RVWWMFRVFG HRTVSVLNGG FRNWLKEGHP VTSEPSRPEP AVFKATLDRS LLKTYEQVLE NLESKRFQLV DSRSQGRFLG TEPEPDAVGL DSGHIRGAVN MPFMDFLTED GFEKGPEELR ALFQTKKVDL SQPLIATCRK GVTACHVALA AYLCGKPDVA VYDGSWSEWF RRAPPESRVS QGKSEKA
 OMIM    180370
 3D Structure    ModBase 3D Structure for Q16762
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 Host    E Coli
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 Purity/Purification    Greater than 95.0% as determined by SDS-PAGE.
 Form/Format    The Rhodanese protein solution contains 20mM Tris-HCl, pH-8 and 10% Glycerol.
Sterile filtered colorless solution.
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 Preparation and Storage    Store at 4 degree C if entire vial will be used within 2-4 weeks. Store, frozen at -20 degree C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Avoid multiple freeze-thaw cycles.
 Other Notes    Small volumes of TST recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for TST recombinant protein

   Description: Recombinant Human Rhodanese produced in E Coli is a single, non-glycosylated polypeptide chain containing 317 amino acids (1-297 a.a) and having a molecular mass of 35.6 kDa. Rhodanese is fused to a 20 amino acid His-Tag at N-terminus and purified by conventional chromatography techniques.

Introduction: Rhodanese is a mitochondrial matrix enzyme that is encoded by the nucleus. Rhodanese is involved in cyanide detoxification, the formation of iron-sulfur proteins, and the modification of sulfur-containing enzymes. Rhodanese catalyzes the chemical reaction of thiosulfate & cyanide to sulfite & thiocyanate (detoxification). Rhodanese is part of the transferase family of proteins. Rhodanese includes two highly conservative domains, identified as rhodanese homology domains. In mammals, the majority of cyanide is converted to thiocyanate. Rhodanese has weak mercaptopyruvate sulfurtransferase activity.
 Product Categories/Family for TST recombinant protein    ENZYMES; Enzymes; Transferase
NCBI/Uniprot data below describe general gene information for TST. It may not necessarily be applicable to this product.
 NCBI GI #    395394071
 NCBI GeneID    7263
 NCBI Accession #    NP_001257412.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001270483.1 [Other Products]
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 UniProt Primary Accession #    Q16762 [Other Products]
 UniProt Secondary Accession #    Q6IB06; B3KRM1 [Other Products]
 UniProt Related Accession #    Q16762 [Other Products]
 Molecular Weight    33,429 Da [Similar Products]
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 NCBI Official Full Name    thiosulfate sulfurtransferase
 NCBI Official Synonym Full Names    thiosulfate sulfurtransferase (rhodanese)
 NCBI Official Symbol    TST [Similar Products]
 NCBI Official Synonym Symbols   
RDS
[Similar Products]
 NCBI Protein Information    thiosulfate sulfurtransferase
 UniProt Protein Name    Thiosulfate sulfurtransferase
 UniProt Synonym Protein Names   
Rhodanese
 Protein Family    Toxic shock syndrome toxin
 UniProt Gene Name    TST [Similar Products]
 UniProt Entry Name    THTR_HUMAN
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 NCBI Summary for TST    This is one of two neighboring genes encoding similar proteins that each contain two rhodanese domains. The encoded protein is localized to the mitochondria and catalyzes the conversion of thiosulfate and cyanide to thiocyanate and sulfite. In addition, the protein interacts with 5S ribosomal RNA and facilitates its import into the mitochondria. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2012]
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 UniProt Comments for TST    TST: Formation of iron-sulfur complexes, cyanide detoxification or modification of sulfur-containing enzymes. Other thiol compounds, besides cyanide, can act as sulfur ion acceptors. Also has weak mercaptopyruvate sulfurtransferase (MST) activity. Together with MRPL18, acts as a mitochondrial import factor for the cytosolic 5S rRNA. Only the nascent unfolded cytoplasmic form is able to bind to the 5S rRNA.

Protein type: Transferase; Mitochondrial; EC 2.8.1.1

Chromosomal Location of Human Ortholog: 22q13.1

Cellular Component: extracellular space; mitochondrion; mitochondrial matrix; mitochondrial inner membrane

Molecular Function: thiosulfate sulfurtransferase activity; 5S rRNA binding

Biological Process: cyanate catabolic process; epithelial cell differentiation; rRNA transport; sulfur amino acid metabolic process; sulfur amino acid catabolic process
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 Research Articles on TST    1. Loss of Thiosulfate Sulfurtransferase is associated with decreased mucosal sulfide detoxification capacity in patients with Crohn's disease
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with TST recombinant proteinPathways associated with TST recombinant protein
 Reference Product  PubMed Publications
 ETHE1 recombinant protein  >3 publications with TST and ETHE1
 Products by Pathway  Pathway Diagram
 Cysteine And Methionine Metabolism Pathway antibodies  Cysteine And Methionine Metabolism Pathway Diagram
 Cysteine And Methionine Metabolism Pathway antibodies  Cysteine And Methionine Metabolism Pathway Diagram
 Degradation Of Cysteine And Homocysteine Pathway antibodies  Degradation Of Cysteine And Homocysteine Pathway Diagram
 Metabolic Pathways antibodies  Metabolic Pathways Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram
 Metabolism Of Amino Acids And Derivatives Pathway antibodies  Metabolism Of Amino Acids And Derivatives Pathway Diagram
 Sulfide Oxidation To Sulfate Pathway antibodies  Sulfide Oxidation To Sulfate Pathway Diagram
 Sulfur Amino Acid Metabolism Pathway antibodies  Sulfur Amino Acid Metabolism Pathway Diagram
 Sulfur Metabolism Pathway antibodies  Sulfur Metabolism Pathway Diagram
 Sulfur Metabolism Pathway antibodies  Sulfur Metabolism Pathway Diagram
Diseases associated with TST recombinant proteinOrgans/Tissues associated with TST recombinant protein
 Disease Name  Pubmed Publications
 Necrosis Antibodies  >161 publications with TST and Necrosis
 Inflammation Antibodies  >94 publications with TST and Inflammation
 Cardiovascular Diseases Antibodies  >91 publications with TST and Cardiovascular Diseases
 Kidney Diseases Antibodies  >58 publications with TST and Kidney Diseases
 Heart Diseases Antibodies  >44 publications with TST and Heart Diseases
 Liver Diseases Antibodies  >25 publications with TST and Liver Diseases
 Weight Loss Antibodies  >23 publications with TST and Weight Loss
 Hypertension Antibodies  >22 publications with TST and Hypertension
 Weight Gain Antibodies  >22 publications with TST and Weight Gain
 Cognition Disorders Antibodies  >18 publications with TST and Cognition Disorders
 Organ/Tissue Name  Pubmed Publications
 Skin Antibodies  >1505 publications with TST and Skin
 Brain Antibodies  >333 publications with TST and Brain
 Lung Antibodies  >283 publications with TST and Lung
 Muscle Antibodies  >114 publications with TST and Muscle
 Eye Antibodies  >95 publications with TST and Eye
 Nerve Antibodies  >79 publications with TST and Nerve
 Kidney Antibodies  >72 publications with TST and Kidney
 Heart Antibodies  >66 publications with TST and Heart
 Liver Antibodies  >61 publications with TST and Liver
 Lymph Node Antibodies  >26 publications with TST and Lymph Node
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