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Trex1 recombinant protein :: Three prime repair exonuclease 1 (Trex1) Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS1449982 Trex1 recombinant protein
Unit / Price
0.05 mg (E-Coli)  /  $720 +1 FREE 8GB USB
0.05 mg (Yeast)  /  $845 +1 FREE 8GB USB
0.2 mg (E-Coli)  /  $970 +1 FREE 8GB USB
0.05 mg (Baculovirus)  /  $990 +1 FREE 8GB USB
0.5 mg (E-Coli)  /  $1,060 +1 FREE 8GB USB
0.2 mg (Yeast)  /  $1,140 +1 FREE 8GB USB
0.05 mg (Mammalian-Cell)  /  $1,230 +1 FREE 8GB USB
0.1 mg (Baculovirus)  /  $1,245 +1 FREE 8GB USB
0.5 mg (Yeast)  /  $1,285 +1 FREE 8GB USB
1 mg (E-Coli)  /  $1,505 +1 FREE 8GB USB
0.5 mg (Baculovirus)  /  $1,795 +2 FREE 8GB USB
0.1 mg (Mammalian-Cell)  /  $1,865 +2 FREE 8GB USB
1 mg (Yeast)  /  $1,955 +2 FREE 8GB USB
1 mg (Baculovirus)  /  $2,385 +2 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Three prime repair exonuclease 1 (Trex1), Recombinant Protein

 Also Known As   

Recombinant Mouse Three prime repair exonuclease 1 (Trex1)

 Product Synonym Names    Three prime repair exonuclease 1; EC=3.1.11.2; 3'-5' exonuclease TREX1
 Product Gene Name   

Trex1 recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence Positions    1-314. Full length
 Sequence    MGSQTLPHGH MQTLIFLDLE ATGLPSSRPE VTELCLLAVH RRALENTSIS QGHPPPVPRP PRVVDKLSLC IAPGKACSPG ASEITGLSKA ELEVQGRQRF DDNLAILLRA FLQRQPQPCC LVAHNGDRYD FPLLQTELAR LSTPSPLDGT FCVDSIAALK ALEQASSPSG NGSRKSYSLG SIYTRLYWQA PTDSHTAEGD VLTLLSICQW KPQALLQWVD EHARPFSTVK PMYGTPATTG TTNLRPHAAT ATTPLATANG SPSNGRSRRP KSPPPEKVPE APSQEGLLAP LSLLTLLTLA IATLYGLFLA SPGQ
 3D Structure    ModBase 3D Structure for Q91XB0
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 Host    E Coli or Yeast or Baculovirus or Mammalian Cell
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 Purity/Purification    >90%
 Form/Format    Liquid containing glycerol; lyophilization may be available upon request.
 Tag Information    This protein contains an N-terminal tag and may also contain a C-terminal Myc-tag. N-terminal host tags may vary (His, His-SUMO, His-B2M, GST). Tag types are determined by various factors including tag-protein stability and, therefore, are subject to change; please inquire for tag information.
 Sterility    Sterile filter available upon request.
 Endotoxin    Low endotoxin available upon request.
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 Species    Mus musculus (Mouse)
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 Preparation and Storage    Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of Trex1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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NCBI/Uniprot data below describe general gene information for Trex1. It may not necessarily be applicable to this product.
 NCBI GI #    59624981
 NCBI GeneID    22040
 NCBI Accession #    NP_001012236.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001012236.1 [Other Products]
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 UniProt Primary Accession #    Q91XB0 [Other Products]
 UniProt Secondary Accession #    Q3TAD7; Q9D6W2; Q9R1B0 [Other Products]
 UniProt Related Accession #    Q91XB0 [Other Products]
 Molecular Weight    33,675 Da
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 NCBI Official Full Name    three-prime repair exonuclease 1
 NCBI Official Synonym Full Names    three prime repair exonuclease 1
 NCBI Official Symbol    Trex1 [Similar Products]
 NCBI Official Synonym Symbols   
1661; AU041952
[Similar Products]
 NCBI Protein Information    three-prime repair exonuclease 1; DNase III; 3'-5' exonuclease TREX1; trophoblast expressed 1; three prime exonuclease 1
 UniProt Protein Name    Three-prime repair exonuclease 1
 UniProt Synonym Protein Names   
3'-5' exonuclease TREX1; DNase III
 Protein Family    Three-prime repair exonuclease
 UniProt Gene Name    Trex1 [Similar Products]
 UniProt Entry Name    TREX1_MOUSE
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 UniProt Comments for Trex1    TREX1: the major 3' DNA exonuclease in mammalian cells. Normally associates with the endoplasmic reticulum (ER). Translocates to the nucleus at S phase after DNA damage by gamma-irradiation or hydroxyurea. Trex1-deficient cells show defective G1/S transition, with single-stranded DNA molecules persisting after S phase and accumulating in the ER. Degrades ssDNA. Prevents chronic checkpoint activation and inappropriate immune activation. Mutations cause Aicardi-Goutieres syndrome, an autoimmune disorder. Trex1a(-/-) mice have autoinflammatory responses. The gene for this protein is either identical to or adjacent to that of ATRIP. Some of the mRNAs that encode TREX1 also encode ATRIP in another reading frame. Three alternatively spliced human isoforms have been reported.

Protein type: EC 3.1.11.2; Deoxyribonuclease; DNA-binding; Cell cycle regulation; DNA repair, damage

Cellular Component: membrane; endoplasmic reticulum; cytoplasm; nucleolus; nucleus

Molecular Function: protein homodimerization activity; nuclease activity; hydrolase activity; metal ion binding; 3'-5'-exodeoxyribonuclease activity; adenyl deoxyribonucleotide binding; protein binding; nucleic acid binding; exonuclease activity; double-stranded DNA binding; exodeoxyribonuclease III activity; MutLalpha complex binding; 3'-5' exonuclease activity; MutSalpha complex binding; single-stranded DNA binding

Biological Process: DNA catabolic process, exonucleolytic; DNA metabolic process
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 Research Articles on Trex1    1. DC activation induced by TLR3, -4, -7, and -9 ligands also augments Trex1 expression through autocrine IFN-beta production and triggering of the IFN signaling pathway
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with Trex1 recombinant proteinDiseases associated with Trex1 recombinant protein
 Products by Pathway  Pathway Diagram
 Cytosolic DNA-sensing Pathway antibodies  Cytosolic DNA-sensing Pathway Diagram
 Cytosolic DNA-sensing Pathway antibodies  Cytosolic DNA-sensing Pathway Diagram
 Cytosolic Sensors Of Pathogen-associated DNA Pathway antibodies  Cytosolic Sensors Of Pathogen-associated DNA Pathway Diagram
 IRF3-mediated Induction Of Type I IFN Pathway antibodies  IRF3-mediated Induction Of Type I IFN Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram
 Innate Immune System Pathway antibodies  Innate Immune System Pathway Diagram
 Regulation By TREX1 Pathway antibodies  Regulation By TREX1 Pathway Diagram
 Regulation Of Innate Immune Responses To Cytosolic DNA Pathway antibodies  Regulation Of Innate Immune Responses To Cytosolic DNA Pathway Diagram
 STING Mediated Induction Of Host Immune Responses Pathway antibodies  STING Mediated Induction Of Host Immune Responses Pathway Diagram
 Disease Name  Pubmed Publications
 Aicardi-Goutieres syndrome Antibodies  >51 publications with Trex1 and Aicardi-Goutieres syndrome
 Nervous System Diseases Antibodies  >45 publications with Trex1 and Nervous System Diseases
 Lupus Erythematosus, Systemic Antibodies  >39 publications with Trex1 and Lupus Erythematosus, Systemic
 Brain Diseases Antibodies  >26 publications with Trex1 and Brain Diseases
 Congenital Abnormalities Antibodies  >23 publications with Trex1 and Congenital Abnormalities
 Chilblain lupus Antibodies  >21 publications with Trex1 and Chilblain lupus
 Inflammation Antibodies  >13 publications with Trex1 and Inflammation
 Vasculopathy, Retinal, With Cerebral Leukodystrophy Antibodies  >9 publications with Trex1 and Vasculopathy, Retinal, With Cerebral Leukodystrophy
 Disease Models, Animal Antibodies  >4 publications with Trex1 and Disease Models, Animal
 Heart Diseases Antibodies  >3 publications with Trex1 and Heart Diseases
Organs/Tissues associated with Trex1 recombinant protein
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >23 publications with Trex1 and Brain
 Skin Antibodies  >4 publications with Trex1 and Skin
 Liver Antibodies  >3 publications with Trex1 and Liver
 Bone Marrow Antibodies  >3 publications with Trex1 and Bone Marrow
 Spleen Antibodies  >2 publications with Trex1 and Spleen
 Thymus Antibodies  >2 publications with Trex1 and Thymus
 Kidney Antibodies  >1 publications with Trex1 and Kidney
 Mammary Gland Antibodies  >1 publications with Trex1 and Mammary Gland
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