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mTPO recombinant protein :: Thrombopoietin Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS142223 mTPO recombinant protein
Unit / Price
0.002 mg  /  $140 +1 FREE 8GB USB
0.01 mg  /  $205 +1 FREE 8GB USB
1 mg  /  $3,760 +4 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Thrombopoietin (mTPO), Recombinant Protein

★Popular Item★
 Also Known As   

Recombinant Mouse Thrombopoietin

 Product Synonym Names    TPO Mouse; Thrombopoietin Mouse Recombinant; Megakaryocyte colony-stimulating factor; Myeloproliferative leukemia virus oncogene ligand; C-mpl ligand; ML; Megakaryocyte growth and development factor; MGDF; TPO; MKCSF; MPLLG; MGC163194; THPO
 Product Gene Name   

mTPO recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence    SPVAPACDPR LLNKLLRDSH LLHSRLSQCP DVDPLSIPVL LPAVDFSLGE WKTQTEQSKA QDILGAVSLL LEGVMAARGQ LEPSCLSSLL GQLSGQVRLL LGALQGLLGT QLPLQGRTTA HKDPNALFLS LQQLLRGKVR FLLLVEGPTL CVRRTLPTTA VPSSTSQLLT LNKF
 3D Structure    ModBase 3D Structure for P40226
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 Host    E Coli
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 Purity/Purification    Greater than 95.0% as determined by SDS-PAGE.
 Form/Format    Lyophilized from a concentrated (1mg/ml) solution in water containing no additives.
Sterile Filtered White lyophilized (freeze-dried) powder.
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 Solubility    It is recommended to reconstitute the lyophilized Thrombopoietin in sterile 18M Omega -cm H2O not less than 100 ug/ml, which can then be further diluted to other aqueous solutions.
 Biological Activity    ED50 range is less than 0.8 ng/ml as determined by the dose dependent stimulation of Mo7e cells.
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 Preparation and Storage    Lyophilized Thrombopoietin although stable at room temperature for 3 weeks, should be stored desiccated below -18 degree C. Upon reconstitution TPO Mouse should be stored at 4 degree C between 2-7 days and for future use below -18 degree C.For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please prevent freeze-thaw cycles.
 Other Notes    Small volumes of mTPO recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for mTPO recombinant protein

   Description: Thrombopoietin Mouse Recombinant produced in E Coli is a single, non-glycosylated soluble polypeptide chain containing 174 amino acids and having a molecular mass of 18704 Dalton. The TPO is purified by proprietary chromatographic techniques.

Introduction: Thrombopoietin is a glycoprotein hormone produced mainly by the liver and the kidneyt hat regulates the production of platelets by the bone marrow. It stimulates the production and differentiation of megakaryocytes, the bone marrow cells that fragment into large numbers of platelets.
 Product Categories/Family for mTPO recombinant protein    CYTOKINES AND GROWTH FACTORS; Cytokines; Thrombopoietin
NCBI/Uniprot data below describe general gene information for mTPO. It may not necessarily be applicable to this product.
 NCBI GI #    291045237
 NCBI GeneID    21832
 NCBI Accession #    NP_001166976.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001173505.1 [Other Products]
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 UniProt Primary Accession #    P40226 [Other Products]
 UniProt Related Accession #    P40226; JC4227 [Other Products]
 Molecular Weight    37,384 Da
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 NCBI Official Full Name    thrombopoietin isoform 1
 NCBI Official Synonym Full Names    thrombopoietin
 NCBI Official Symbol    Thpo [Similar Products]
 NCBI Official Synonym Symbols   
Ml; Tpo; Mgdf; Mpllg
[Similar Products]
 NCBI Protein Information    thrombopoietin; C-mpl ligand; megakaryocyte colony-stimulating factor; megakaryocyte growth and development factor; myeloproliferative leukemia virus oncogene ligand
 UniProt Protein Name    Thrombopoietin
 UniProt Synonym Protein Names   
C-mpl ligand; ML; Megakaryocyte colony-stimulating factor; Megakaryocyte growth and development factor; MGDF; Myeloproliferative leukemia virus oncogene ligand
 Protein Family    Thrombopoietin
 UniProt Gene Name    Thpo [Similar Products]
 UniProt Synonym Gene Names    ML; MGDF [Similar Products]
 UniProt Entry Name    TPO_MOUSE
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 NCBI Summary for mTPO    This gene encodes a humoral growth factor necessary for megakaryocyte proliferation and maturation, as well as for thrombopoiesis. The encoded protein is a ligand for the product of the myeloproliferative leukemia virus oncogene. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2010]
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 UniProt Comments for mTPO    THPO: Lineage-specific cytokine affecting the proliferation and maturation of megakaryocytes from their committed progenitor cells. It acts at a late stage of megakaryocyte development. It may be the major physiological regulator of circulating platelets. Defects in THPO are the cause of thrombocythemia type 1 (THCYT1). A myeloproliferative disorder characterized by elevated platelet levels due to sustained proliferation of megakaryocytes, and frequently lead to thrombotic and haemorrhagic complications. Belongs to the EPO/TPO family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Cytokine; Secreted; Cell cycle regulation; Secreted, signal peptide

Cellular Component: extracellular space; extracellular region

Molecular Function: hormone activity; cytokine activity; receptor binding

Biological Process: positive regulation of protein kinase B signaling cascade; cell proliferation; myeloid cell differentiation; positive regulation of megakaryocyte differentiation; positive regulation of protein amino acid phosphorylation
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 Research Articles on mTPO    1. Mpl expression, but not Tpo, is fundamental in the development of JAK2V617F(+) myeloproliferative neoplasms
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with mTPO recombinant proteinPathways associated with mTPO recombinant protein
 Reference Product  PubMed Publications
 Mpl recombinant protein  >28 publications with mTPO and Mpl
 Cd34 recombinant protein  >2 publications with mTPO and Cd34
 Il3 recombinant protein  >1 publications with mTPO and Il3
 Selp recombinant protein  >1 publications with mTPO and Selp
 Products by Pathway  Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Hematopoietic Cell Lineage Pathway antibodies  Hematopoietic Cell Lineage Pathway Diagram
 Hematopoietic Cell Lineage Pathway antibodies  Hematopoietic Cell Lineage Pathway Diagram
 Hemostasis Pathway antibodies  Hemostasis Pathway Diagram
 Jak-STAT Signaling Pathway antibodies  Jak-STAT Signaling Pathway Diagram
 Jak-STAT Signaling Pathway antibodies  Jak-STAT Signaling Pathway Diagram
 Platelet Aggregation (Plug Formation) Pathway antibodies  Platelet Aggregation (Plug Formation) Pathway Diagram
 Platelet Activation, Signaling And Aggregation Pathway antibodies  Platelet Activation, Signaling And Aggregation Pathway Diagram
Diseases associated with mTPO recombinant proteinOrgans/Tissues associated with mTPO recombinant protein
 Disease Name  Pubmed Publications
 Thrombocytosis Antibodies  >10 publications with mTPO and Thrombocytosis
 Anemia Antibodies  >7 publications with mTPO and Anemia
 Cardiovascular Diseases Antibodies  >5 publications with mTPO and Cardiovascular Diseases
 Lung Neoplasms Antibodies  >3 publications with mTPO and Lung Neoplasms
 Congenital Abnormalities Antibodies  >3 publications with mTPO and Congenital Abnormalities
 Hemorrhage Antibodies  >2 publications with mTPO and Hemorrhage
 Carcinoma, Squamous Cell Antibodies  >2 publications with mTPO and Carcinoma, Squamous Cell
 Pain Antibodies  >2 publications with mTPO and Pain
 Thrombocythemia, Essential Antibodies  >2 publications with mTPO and Thrombocythemia, Essential
 Precancerous Conditions Antibodies  >1 publications with mTPO and Precancerous Conditions
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >39 publications with mTPO and Brain
 Kidney Antibodies  >7 publications with mTPO and Kidney
 Liver Antibodies  >6 publications with mTPO and Liver
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