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Thbs1 recombinant protein :: Thrombospondin-1 Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS1265139
SDS-PAGE
Unit / Price
0.01 mg (Yeast)  /  $110 +1 FREE 8GB USB
0.05 mg (Yeast)  /  $190 +1 FREE 8GB USB
0.1 mg (Yeast)  /  $285 +1 FREE 8GB USB
0.2 mg (Yeast)  /  $460 +1 FREE 8GB USB
0.05 mg (E-Coli)  /  $740 +1 FREE 8GB USB
0.5 mg (Yeast)  /  $750 +1 FREE 8GB USB
0.2 mg (E-Coli)  /  $990 +1 FREE 8GB USB
0.05 mg (Baculovirus)  /  $995 +1 FREE 8GB USB
0.5 mg (E-Coli)  /  $1,090 +1 FREE 8GB USB
1 mg (Yeast)  /  $1,180 +1 FREE 8GB USB
0.05 mg (Mammalian-Cell)  /  $1,240 +1 FREE 8GB USB
0.1 mg (Baculovirus)  /  $1,265 +1 FREE 8GB USB
1 mg (E-Coli)  /  $1,550 +1 FREE 8GB USB
0.5 mg (Baculovirus)  /  $1,820 +2 FREE 8GB USB
0.1 mg (Mammalian-Cell)  /  $1,885 +2 FREE 8GB USB
1 mg (Baculovirus)  /  $2,420 +3 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Thrombospondin-1 (Thbs1), Recombinant Protein

★Popular Item★
 Also Known As   

Recombinant Mouse Thrombospondin-1

 Product Gene Name   

Thbs1 recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence Positions    19-350aa; Partial
 Sequence    NRIPESGGDN GVFDIFELIG GARRGPGRRL VKGQDLSSPA FRIENANLIP AVPDDKFQDL LDAVWADKGF IFLASLRQMK KTRGTLLAVE RKDNTGQIFS VVSNGKAGTL DLSLSLPGKQ QVVSVEEALL ATGQWKSITL FVQEDRAQLY IDCDKMESAE LDVPIQSIFT RDLASVARLR VAKGDVNDNF QGVLQNVRFV FGTTPEDILR NKGCSSSATN VLLTLDNNVV NGSSPAIRTN YIGHKTKDLQ AICGLSCDEL SSMVLELKGL RTIVTTLQDS IRKVTEENRE LVSELKRPPL CFHNGVQYKN NEEWTVDSCT ECHCQNSVTI CK
 3D Structure    ModBase 3D Structure for P35441
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 Host    E Coli or Yeast or Baculovirus or Mammalian Cell
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 Purity/Purification    Greater than 90% as determined by SDS-PAGE.
 Form/Format    Liquid containing glycerol
 Tag Information    This protein contains an N-terminal tag and may also contain a C-terminal Myc-tag. N-terminal host tags may vary (His, His-SUMO, His-B2M, GST). Tag types are determined by various factors including tag-protein stability and, therefore, are subject to change; please inquire for tag information.
 Sterility    Sterile filter available upon request.
 Endotoxin    Low endotoxin available upon request.
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 Preparation and Storage    Store at -20 degree C, for extended storage, conserve at -20 degree C or -80 degree C.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of Thbs1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for Thbs1 recombinant protein

   Adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. Binds heparin. May play a role in dentinogenesis and/or maintenance of dentin and dental pulp. Ligand for CD36 mediating antiangiogenic properties. Plays a role in ER stress response, via its interaction with the activating transcription factor 6 alpha (ATF6) which produces adaptive ER stress response factors. 1 Publication
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 SDS-PAGE of Thbs1 recombinant protein    Thbs1 recombinant protein SDS-PAGE image
(Note: Representative image, actual molecular weight may vary depending on Tag type and expression host)
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NCBI/Uniprot data below describe general gene information for Thbs1. It may not necessarily be applicable to this product.
 NCBI GI #    549134
 NCBI GeneID    21825
 NCBI Accession #    P35441.1 [Other Products]
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 UniProt Primary Accession #    P35441 [Other Products]
 UniProt Related Accession #    P35441 [Other Products]
 Molecular Weight    40.7kD
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 NCBI Official Full Name    Thrombospondin-1
 NCBI Official Synonym Full Names    thrombospondin 1
 NCBI Official Symbol    Thbs1 [Similar Products]
 NCBI Official Synonym Symbols   
TSP1; TSP-1; tbsp1; Thbs-1
[Similar Products]
 NCBI Protein Information    thrombospondin-1
 UniProt Protein Name    Thrombospondin-1
 Protein Family    Thrombospondin
 UniProt Gene Name    Thbs1 [Similar Products]
 UniProt Synonym Gene Names    Tsp1 [Similar Products]
 UniProt Entry Name    TSP1_MOUSE
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 NCBI Summary for Thbs1    The protein encoded by this gene is a subunit of a disulfide-linked homotrimeric protein. This protein is an adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. This protein can bind to fibrinogen, fibronectin, laminin, type V collagen and integrins alpha-V/beta-1. This protein has been shown to play roles in platelet aggregation, angiogenesis, and tumorigenesis. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2015]
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 UniProt Comments for Thbs1    THBS1: Adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. Binds heparin. May play a role in dentinogenesis and/or maintenance of dentin and dental pulp. Ligand for CD36 mediating antiangiogenic properties. Belongs to the thrombospondin family.

Protein type: Motility/polarity/chemotaxis; Inhibitor

Cellular Component: cell surface; cytoplasm; endoplasmic reticulum; external side of plasma membrane; extracellular matrix; extracellular region; extracellular space; fibrinogen complex; sarcoplasmic reticulum; secretory granule

Molecular Function: calcium ion binding; extracellular matrix binding; fibroblast growth factor binding; fibronectin binding; heparin binding; integrin binding; laminin binding; low-density lipoprotein binding; phosphatidylserine binding; protein binding; transforming growth factor beta binding

Biological Process: activation of MAPK activity; behavioral response to pain; blood vessel morphogenesis; cell adhesion; cell cycle arrest; cell migration; engulfment of apoptotic cell; inflammatory response; negative regulation of angiogenesis; negative regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II; negative regulation of apoptosis; negative regulation of blood vessel endothelial cell migration; negative regulation of caspase activity; negative regulation of cell-matrix adhesion; negative regulation of dendritic cell antigen processing and presentation; negative regulation of endothelial cell proliferation; negative regulation of fibrinolysis; negative regulation of fibroblast growth factor receptor signaling pathway; negative regulation of interleukin-12 production; peptide cross-linking; positive regulation of angiogenesis; positive regulation of blood coagulation; positive regulation of blood vessel endothelial cell migration; positive regulation of cell migration; positive regulation of chemotaxis; positive regulation of macrophage activation; positive regulation of phosphorylation; positive regulation of protein kinase B signaling cascade; positive regulation of transforming growth factor beta receptor signaling pathway; positive regulation of translation; positive regulation of tumor necrosis factor biosynthetic process; regulation of cGMP metabolic process; response to calcium ion; response to glucose stimulus; response to magnesium ion; response to mechanical stimulus; response to unfolded protein; sprouting angiogenesis
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Product References and Citations for Thbs1 recombinant protein

   Characterization of the murine thrombospondin gene.Lawler J., Duquette M., Ferro P., Copeland N.G., Gilbert D.J., Jenkins N.A.Genomics 11:587-600(1991) Characterization of mouse thrombospondin 2 sequence and expression during cell growth and development.Laherty C.D., O'Rourke K., Wolf F.W., Katz R., Seldin M.F., Dixit V.M.J. Biol. Chem. 267:3274-3281(1992) Characterization of the mouse thrombospondin gene and evaluation of the role of the first intron in human gene expression.Bornstein P., Alfi D., Devarayalu S., Framson P., Li P.J. Biol. Chem. 265:16691-16698(1990) Expression and initial characterization of recombinant mouse thrombospondin 1 and thrombospondin 3.Chen H., Aeschlimann D., Nowlen J., Mosher D.F.FEBS Lett. 387:36-41(1996) The mouse C2C12 myoblast cell surface N-linked glycoproteome identification, glycosite occupancy, and membrane orientation.Gundry R.L., Raginski K., Tarasova Y., Tchernyshyov I., Bausch-Fluck D., Elliott S.T., Boheler K.R., Van Eyk J.E., Wollscheid B.Mol. Cell. Proteomics 8:2555-2569(2009) A thrombospondin-dependent pathway for a protective ER stress response.Lynch J.M., Maillet M., Vanhoutte D., Schloemer A., Sargent M.A., Blair N.S., Lynch K.A., Okada T., Aronow B.J., Osinska H., Prywes R., Lorenz J.N., Mori K., Lawler J., Robbins J., Molkentin J.D.Cell 149:1257-1268(2012)
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 Research Articles on Thbs1    1. It mediates PGE2-induced angiogenesis in Alzheimer's disease.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with Thbs1 recombinant proteinPathways associated with Thbs1 recombinant protein
 Reference Product  PubMed Publications
 Cd36 recombinant protein  >192 publications with Thbs1 and Cd36
 Cd47 recombinant protein  >157 publications with Thbs1 and Cd47
 Mmp9 recombinant protein  >26 publications with Thbs1 and Mmp9
 Mmp2 recombinant protein  >18 publications with Thbs1 and Mmp2
 Thbs2 recombinant protein  >17 publications with Thbs1 and Thbs2
 Id1 recombinant protein  >9 publications with Thbs1 and Id1
 Pofut2 recombinant protein  >5 publications with Thbs1 and Pofut2
 Itgb3 recombinant protein  >5 publications with Thbs1 and Itgb3
 Itgb1 recombinant protein  >3 publications with Thbs1 and Itgb1
 Itga2b recombinant protein  >1 publications with Thbs1 and Itga2b
 Products by Pathway  Pathway Diagram
 Bladder Cancer Pathway antibodies  Bladder Cancer Pathway Diagram
 Bladder Cancer Pathway antibodies  Bladder Cancer Pathway Diagram
 ECM-receptor Interaction Pathway antibodies  ECM-receptor Interaction Pathway Diagram
 ECM-receptor Interaction Pathway antibodies  ECM-receptor Interaction Pathway Diagram
 Extracellular Matrix Organization Pathway antibodies  Extracellular Matrix Organization Pathway Diagram
 Focal Adhesion Pathway antibodies  Focal Adhesion Pathway Diagram
 Focal Adhesion Pathway antibodies  Focal Adhesion Pathway Diagram
 Focal Adhesion Pathway antibodies  Focal Adhesion Pathway Diagram
 Hemostasis Pathway antibodies  Hemostasis Pathway Diagram
 Inflammatory Response Pathway antibodies  Inflammatory Response Pathway Diagram
Organs/Tissues associated with Thbs1 recombinant protein
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >980 publications with Thbs1 and Blood
 Muscle Antibodies  >280 publications with Thbs1 and Muscle
 Eye Antibodies  >170 publications with Thbs1 and Eye
 Kidney Antibodies  >168 publications with Thbs1 and Kidney
 Lung Antibodies  >165 publications with Thbs1 and Lung
 Brain Antibodies  >157 publications with Thbs1 and Brain
 Bone Antibodies  >145 publications with Thbs1 and Bone
 Heart Antibodies  >135 publications with Thbs1 and Heart
 Skin Antibodies  >127 publications with Thbs1 and Skin
 Connective Tissue Antibodies  >122 publications with Thbs1 and Connective Tissue
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