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THBS1 recombinant protein :: Thrombospondin Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS142844 THBS1 recombinant protein
Unit / Price
0.002 mg  /  $140 +1 FREE 8GB USB
0.01 mg  /  $265 +1 FREE 8GB USB
0.1 mg  /  $1,800 +2 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Thrombospondin (THBS1), Recombinant Protein

 Also Known As   

Recombinant Human Thrombospondin

 Product Synonym Names    THBS1 Human; Thrombospondin-1 Human Recombinant; Thrombospondin-1; THBS1; TSP; TSP1; THBS; THBS-1
 Product Gene Name   

THBS1 recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    188060
 3D Structure    ModBase 3D Structure for P07996
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 Host    Baculovirus Insect Cells
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 Purity/Purification    Greater than 90.0% as determined by: (a) Analysis by RP-HPLC. (b) Analysis by SDS-PAGE.
 Form/Format    The sterile protein solution contains 20mM Sodium phosphate, pH 6.0 and 300mM NaCl.
Sterile Filtered clear solution.
 Concentration    87ug/ml (lot specific)
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 Preparation and Storage    Recombinant Human TSP should be stored between 2 degree C- 8 degree C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).
 Other Notes    Small volumes of THBS1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
 Searchable Terms for THBS1 purchase    Multifunctional and widely expressed, human thrombospondin 1 THBS1 plays physiological roles from synapse formation to immune regulation. The list of receptors grows everyday, which is why our human recombinant thrombospondin 1 protein is a top selling product. Creative Biomart has carefully selected appropriate TSP gene sequences for human not mouse rat THBS1 genes for expression in animal free insect cell systems to generate the ideal recombinant human THBS proteins to study pathways interactions, functional genomics, screen drugs compounds, primary antibody generation, analyze signaling disorders or analyze by IHC; induction of cancer / carcinoma pathway. Due to precise Kda size analysis, 90% SDS PAGE confirmation, you can be sure this, and similar products proteins, are excellent choices for antibody controls on assay section (s) or for WB ELISA IP applications. Ordering your human THBS1 is easy with MyBiosource.com and includes Pubmed derived box summaries transcripts and additional products proteins publications.
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Product Description specifically for THBS1 recombinant protein

   Description: Recombinant Human THBS1 is glycosylated with N-linked sugars and produced using baculovirus vectors in insect cells. Recombinant Human THBS1 is Reactive with A4.1 anti-TSP mAb and its Mw is 140,000 Dalton.

Introduction: Thrombospondin-1 (TSP1) is a member of the Thrombospondin family and is encoded by the gene THBS1 which is a subunit of a disulfide-linked homotrimeric protein. Thrombospondin-1 is an adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. Thrombospondin-1 can bind to fibrinogen, fibronectin, laminin, type V collagen and integrins alpha-V/beta-1. TSP1 has been shown to play roles in platelet aggregation, angiogenesis, and tumorigenesis. TSP1 has been shown to be a natural inhibitor of neovascularization and tumorigenesis in healthy tissue. TSP1 interacts with no less than 12 cell adhesion receptors, including CD36, av integrins, b1 integrins, syndecan, and integrin-associated protein (IAP or CD47). It also interacts with various proteases involved in angiogenesis, including plasminogen, urokinase, matrix metalloproteinase, thrombin, cathepsin, and elastase. Positive and negative modulation of endothelial cell adhesion, motility, and growth are attributed to TSP1. Recently, thrombospondin-1 was found to bind to the reelin receptors, ApoER2 and VLDLR, in so doing affecting neuronal migration in the rostral migratory stream.
 Product Categories/Family for THBS1 recombinant protein    RECOMBINANT & NATURAL PROTEINS; Recombinant Proteins
NCBI/Uniprot data below describe general gene information for THBS1. It may not necessarily be applicable to this product.
 NCBI GI #    40317626
 NCBI GeneID    7057
 NCBI Accession #    NP_003237.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_003246.2 [Other Products]
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 UniProt Primary Accession #    P07996 [Other Products]
 UniProt Secondary Accession #    Q15667; Q59E99; A8K6H4; B4E3J7; B9EGH6 [Other Products]
 UniProt Related Accession #    P07996 [Other Products]
 Molecular Weight    120,148 Da
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 NCBI Official Full Name    thrombospondin-1
 NCBI Official Synonym Full Names    thrombospondin 1
 NCBI Official Symbol    THBS1 [Similar Products]
 NCBI Official Synonym Symbols   
TSP; THBS; TSP1; TSP-1; THBS-1
[Similar Products]
 NCBI Protein Information    thrombospondin-1; thrombospondin-1p180
 UniProt Protein Name    Thrombospondin-1
 Protein Family    Thrombospondin
 UniProt Gene Name    THBS1 [Similar Products]
 UniProt Synonym Gene Names    TSP; TSP1 [Similar Products]
 UniProt Entry Name    TSP1_HUMAN
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 NCBI Summary for THBS1    The protein encoded by this gene is a subunit of a disulfide-linked homotrimeric protein. This protein is an adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. This protein can bind to fibrinogen, fibronectin, laminin, type V collagen and integrins alpha-V/beta-1. This protein has been shown to play roles in platelet aggregation, angiogenesis, and tumorigenesis. [provided by RefSeq, Jul 2008]
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 UniProt Comments for THBS1    THBS1: Adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. Binds heparin. May play a role in dentinogenesis and/or maintenance of dentin and dental pulp. Ligand for CD36 mediating antiangiogenic properties. Belongs to the thrombospondin family.

Protein type: Motility/polarity/chemotaxis; Inhibitor

Chromosomal Location of Human Ortholog: 15q15

Cellular Component: extracellular matrix; extracellular space; cell surface; sarcoplasmic reticulum; endoplasmic reticulum; endoplasmic reticulum lumen; fibrinogen complex; extracellular region; external side of plasma membrane; secretory granule

Molecular Function: heparin binding; identical protein binding; laminin binding; calcium ion binding; integrin binding; proteoglycan binding; protein binding; fibroblast growth factor binding; phosphatidylserine binding; transforming growth factor beta binding; fibronectin binding; low-density lipoprotein binding; glycoprotein binding

Biological Process: extracellular matrix organization and biogenesis; activation of MAPK activity; response to magnesium ion; negative regulation of fibrinolysis; response to glucose stimulus; cell cycle arrest; cell adhesion; positive regulation of macrophage activation; response to drug; platelet activation; negative regulation of interleukin-12 production; positive regulation of chemotaxis; positive regulation of blood vessel endothelial cell migration; response to testosterone stimulus; negative regulation of blood vessel endothelial cell migration; negative regulation of cell-matrix adhesion; response to unfolded protein; positive regulation of angiogenesis; response to mechanical stimulus; negative regulation of endothelial cell proliferation; regulation of cGMP metabolic process; peptide cross-linking; response to calcium ion; response to progesterone stimulus; negative regulation of apoptosis; positive regulation of blood coagulation; positive regulation of translation; negative regulation of fibroblast growth factor receptor signaling pathway; negative regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II; negative regulation of caspase activity; behavioral response to pain; platelet degranulation; positive regulation of tumor necrosis factor biosynthetic process; protein amino acid O-linked glycosylation; positive regulation of transforming growth factor-beta1 production; chronic inflammatory response; cell migration; negative regulation of focal adhesion formation; positive regulation of transforming growth factor beta receptor signaling pathway; engulfment of apoptotic cell; post-translational protein modification; positive regulation of protein kinase B signaling cascade; negative regulation of angiogenesis; cellular protein metabolic process; negative regulation of dendritic cell antigen processing and presentation; response to hypoxia; immune response; sprouting angiogenesis; blood coagulation; positive regulation of phosphorylation; positive regulation of cell migration
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 Research Articles on THBS1    1. Elevated postinjury thrombospondin 1-CD47 triggering aids differentiation of patients' defective inflammatory CD1a+dendritic cells.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with THBS1 recombinant proteinPathways associated with THBS1 recombinant protein
 Reference Product  PubMed Publications
 CD36 recombinant protein  >180 publications with THBS1 and CD36
 TGFB1 recombinant protein  >169 publications with THBS1 and TGFB1
 CD47 recombinant protein  >145 publications with THBS1 and CD47
 VEGFA recombinant protein  >55 publications with THBS1 and VEGFA
 MMP9 recombinant protein  >22 publications with THBS1 and MMP9
 PDGFB recombinant protein  >15 publications with THBS1 and PDGFB
 LRP1 recombinant protein  >12 publications with THBS1 and LRP1
 FN1 recombinant protein  >8 publications with THBS1 and FN1
 SCARB2 recombinant protein  >1 publications with THBS1 and SCARB2
 ITGA6 recombinant protein  >1 publications with THBS1 and ITGA6
 Products by Pathway  Pathway Diagram
 Bladder Cancer Pathway antibodies  Bladder Cancer Pathway Diagram
 Bladder Cancer Pathway antibodies  Bladder Cancer Pathway Diagram
 ECM-receptor Interaction Pathway antibodies  ECM-receptor Interaction Pathway Diagram
 ECM-receptor Interaction Pathway antibodies  ECM-receptor Interaction Pathway Diagram
 Extracellular Matrix Organization Pathway antibodies  Extracellular Matrix Organization Pathway Diagram
 Focal Adhesion Pathway antibodies  Focal Adhesion Pathway Diagram
 Focal Adhesion Pathway antibodies  Focal Adhesion Pathway Diagram
 Focal Adhesion Pathway antibodies  Focal Adhesion Pathway Diagram
 Hemostasis Pathway antibodies  Hemostasis Pathway Diagram
 Inflammatory Response Pathway antibodies  Inflammatory Response Pathway Diagram
Diseases associated with THBS1 recombinant proteinOrgans/Tissues associated with THBS1 recombinant protein
 Disease Name  Pubmed Publications
 Carcinoma Antibodies  >308 publications with THBS1 and Carcinoma
 Cardiovascular Diseases Antibodies  >224 publications with THBS1 and Cardiovascular Diseases
 Inflammation Antibodies  >206 publications with THBS1 and Inflammation
 Disease Models, Animal Antibodies  >204 publications with THBS1 and Disease Models, Animal
 Fibrosis Antibodies  >140 publications with THBS1 and Fibrosis
 Neoplasms, Experimental Antibodies  >123 publications with THBS1 and Neoplasms, Experimental
 Breast Neoplasms Antibodies  >119 publications with THBS1 and Breast Neoplasms
 Neoplasm Metastasis Antibodies  >112 publications with THBS1 and Neoplasm Metastasis
 Necrosis Antibodies  >100 publications with THBS1 and Necrosis
 Kidney Diseases Antibodies  >93 publications with THBS1 and Kidney Diseases
 Organ/Tissue Name  Pubmed Publications
 Vascular Antibodies  >962 publications with THBS1 and Vascular
 Blood Antibodies  >918 publications with THBS1 and Blood
 Muscle Antibodies  >261 publications with THBS1 and Muscle
 Kidney Antibodies  >163 publications with THBS1 and Kidney
 Eye Antibodies  >156 publications with THBS1 and Eye
 Lung Antibodies  >151 publications with THBS1 and Lung
 Brain Antibodies  >147 publications with THBS1 and Brain
 Bone Antibodies  >134 publications with THBS1 and Bone
 Heart Antibodies  >123 publications with THBS1 and Heart
 Skin Antibodies  >120 publications with THBS1 and Skin
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