NP_001107227.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
50,405 Da
NCBI Official Full Name
thymidine phosphorylase isoform 1 proprotein
NCBI Official Synonym Full Names
thymidine phosphorylase
NCBI Official Synonym Symbols
TP; ECGF; ECGF1; MNGIE; MEDPS1; MTDPS1; PDECGF; hPD-ECGF [Similar Products]
NCBI Protein Information
thymidine phosphorylase; gliostatin; tdRPase
UniProt Protein Name
Thymidine phosphorylase
UniProt Synonym Protein Names
Gliostatin; Platelet-derived endothelial cell growth factor; PD-ECGF; TdRPase
UniProt Synonym Gene Names
UniProt Entry Name
TYPH_HUMAN
NCBI Summary for TYMP
This gene encodes an angiogenic factor which promotes angiogenesis in vivo and stimulates the in vitro growth of a variety of endothelial cells. It has a highly restricted target cell specificity acting only on endothelial cells. Mutations in this gene have been associated with mitochondrial neurogastrointestinal encephalomyopathy. Multiple alternatively spliced transcript variants have been identified. [provided by RefSeq, Apr 2012]
UniProt Comments for TYMP
ECGF1: May have a role in maintaining the integrity of the blood vessels. Has growth promoting activity on endothelial cells, angiogenic activity in vivo and chemotactic activity on endothelial cells in vitro. Homodimer. Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family.
Protein type: Xenobiotic Metabolism - drug metabolism - other enzymes; Phosphorylase; Nucleotide Metabolism - pyrimidine; Cytokine; EC 2.4.2.4; Motility/polarity/chemotaxis; DNA replication; Transferase
Chromosomal Location of Human Ortholog: 22q13.33
Cellular Component: cytosol
Molecular Function: thymidine phosphorylase activity; growth factor activity; phosphorylase activity; transferase activity, transferring pentosyl groups; pyrimidine-nucleoside phosphorylase activity; platelet-derived growth factor receptor binding
Biological Process: pyrimidine nucleoside catabolic process; mitochondrial genome maintenance; pyrimidine base metabolic process; pyrimidine nucleotide metabolic process; nucleobase, nucleoside and nucleotide metabolic process; pyrimidine nucleoside salvage; angiogenesis; DNA replication; cell differentiation; chemotaxis
Disease: Mitochondrial Dna Depletion Syndrome 1 (mngie Type)
Research Articles on TYMP
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Products associated with TYMP recombinant protein
Pathways associated with TYMP recombinant protein
Diseases associated with TYMP recombinant protein
Organs/Tissues associated with TYMP recombinant protein
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