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Tyms recombinant protein :: Thymidylate synthase (Tyms) Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS962575 Tyms recombinant protein
Unit / Price
0.05 mg (E-Coli)  /  $710 +1 FREE 8GB USB
0.05 mg (Yeast)  /  $840 +1 FREE 8GB USB
0.2 mg (E-Coli)  /  $960 +1 FREE 8GB USB
0.05 mg (Baculovirus)  /  $980 +1 FREE 8GB USB
0.5 mg (E-Coli)  /  $1,050 +1 FREE 8GB USB
0.2 mg (Yeast)  /  $1,130 +1 FREE 8GB USB
0.05 mg (Mammalian-Cell)  /  $1,220 +1 FREE 8GB USB
0.1 mg (Baculovirus)  /  $1,235 +1 FREE 8GB USB
0.5 mg (Yeast)  /  $1,275 +1 FREE 8GB USB
1 mg (E-Coli)  /  $1,490 +1 FREE 8GB USB
0.5 mg (Baculovirus)  /  $1,780 +2 FREE 8GB USB
0.1 mg (Mammalian-Cell)  /  $1,855 +2 FREE 8GB USB
1 mg (Yeast)  /  $1,940 +2 FREE 8GB USB
1 mg (Baculovirus)  /  $2,375 +2 FREE 8GB USB
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Thymidylate synthase (Tyms), Recombinant Protein

 Also Known As   

Recombinant Rat Thymidylate synthase (Tyms)

 Product Synonym Names    Thymidylate synthase; TS; TSase; EC=
 Product Gene Name   

Tyms recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence Positions    2-307aa; Full length protein
 3D Structure    ModBase 3D Structure for P45352
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 Host    E Coli or Yeast or Baculovirus or Mammalian Cell
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 Purity/Purification    >=90% (lot specific)
 Form/Format    Liquid containing glycerol
 Tag Information    This protein contains an N-terminal tag and may also contain a C-terminal Myc-tag. N-terminal host tags may vary (His, His-SUMO, His-B2M, GST). Tag types are determined by various factors including tag-protein stability and, therefore, are subject to change; please inquire for tag information.
 Sterility    Sterile filter available upon request.
 Endotoxin    Low endotoxin available upon request.
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 Species    Rattus norvegicus (Rat)
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 Preparation and Storage    Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of Tyms recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for Tyms recombinant protein

   Thymidylate synthase catalyzes the methylation of deoxyuridylate to deoxythymidylate using 5,10-methylenetetrahydrofolate (methylene-THF) as a cofactor. This function maintains the dTMP (thymidine-5-prime monophosphate) pool critical for DNA replication and repair. The enzyme has been of interest as a target for cancer chemotherapeutic agents. It is considered to be the primary site of action for 5-fluorouracil, 5-fluoro-2-prime-deoxyuridine, and some folate analogs. Expression of this gene and that of a naturally occuring antisense transcript rTSalpha (GeneID:55556) vary inversely when cell-growth progresses from late-log to plateau phase.
NCBI/Uniprot data below describe general gene information for Tyms. It may not necessarily be applicable to this product.
 NCBI GI #    9507217
 NCBI GeneID    29261
 NCBI Accession #    NP_062052.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_019179.1 [Other Products]
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 UniProt Primary Accession #    P45352 [Other Products]
 UniProt Secondary Accession #    A0JN23 [Other Products]
 UniProt Related Accession #    P45352 [Other Products]
 Molecular Weight    35,017 Da
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 NCBI Official Full Name    thymidylate synthase
 NCBI Official Synonym Full Names    thymidylate synthetase
 NCBI Official Symbol    Tyms [Similar Products]
 NCBI Protein Information    thymidylate synthase; TS; TSase
 UniProt Protein Name    Thymidylate synthase
 UniProt Gene Name    Tyms [Similar Products]
 UniProt Synonym Gene Names    TS; TSase [Similar Products]
 UniProt Entry Name    TYSY_RAT
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 NCBI Summary for Tyms    catalyzes the reductive methylation of dUMP to dTMP using CH2H4PteGlu as both the methyl donor and reductant [RGD, Feb 2006]
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 UniProt Comments for Tyms    TYMS: an enzyme in the thymidylate synthase family. Polymorphisms serve as prognostic markers for determining modality of treatment in certain cancers. Genotyping helps predict toxicity to 5-FU-based chemotherapy in patients with colorectal cancer and the response to platinum-based chemotherapy in advanced NSCLC. A common polymorphism is a determinant of red blood cell folate and homocysteine concentrations. Homodimer.

Protein type: DNA repair, damage; EC; Cofactor and Vitamin Metabolism - one carbon pool by folate; Methyltransferase; Nucleotide Metabolism - pyrimidine; Mitochondrial

Cellular Component: mitochondrion; mitochondrial matrix; cytoplasm; mitochondrial inner membrane; nucleolus; nucleus

Molecular Function: mRNA binding; protein homodimerization activity; nucleotide binding; drug binding; cofactor binding; thymidylate synthase activity; folic acid binding

Biological Process: circadian rhythm; tetrahydrofolate metabolic process; immortalization of host cell by virus; response to drug; methylation; uracil metabolic process; developmental growth; response to organophosphorus; organ regeneration; response to toxin; response to glucocorticoid stimulus; dTTP biosynthetic process; dTMP biosynthetic process; response to organic cyclic substance; response to vitamin A; response to ethanol; pyrimidine base metabolic process; response to folic acid; cartilage development; response to cytokine stimulus; dUMP metabolic process; response to progesterone stimulus; aging
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with Tyms recombinant proteinDiseases associated with Tyms recombinant protein
 Products by Pathway  Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram
 Cell Cycle, Mitotic Pathway antibodies  Cell Cycle, Mitotic Pathway Diagram
 E2F Mediated Regulation Of DNA Replication Pathway antibodies  E2F Mediated Regulation Of DNA Replication Pathway Diagram
 G1/S Transition Pathway antibodies  G1/S Transition Pathway Diagram
 G1/S-Specific Transcription Pathway antibodies  G1/S-Specific Transcription Pathway Diagram
 Metabolic Pathways antibodies  Metabolic Pathways Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram
 Metabolism Of Nucleotides Pathway antibodies  Metabolism Of Nucleotides Pathway Diagram
 Mitotic G1-G1/S Phases Pathway antibodies  Mitotic G1-G1/S Phases Pathway Diagram
 One Carbon Metabolism Pathway antibodies  One Carbon Metabolism Pathway Diagram
 Disease Name  Pubmed Publications
 Digestive System Neoplasms Antibodies  >82 publications with Tyms and Digestive System Neoplasms
 Colorectal Neoplasms Antibodies  >60 publications with Tyms and Colorectal Neoplasms
 Carcinoma Antibodies  >60 publications with Tyms and Carcinoma
 Adenocarcinoma Antibodies  >30 publications with Tyms and Adenocarcinoma
 Breast Neoplasms Antibodies  >26 publications with Tyms and Breast Neoplasms
 Neoplasms, Experimental Antibodies  >17 publications with Tyms and Neoplasms, Experimental
 Lung Neoplasms Antibodies  >17 publications with Tyms and Lung Neoplasms
 Carcinoma, Squamous Cell Antibodies  >15 publications with Tyms and Carcinoma, Squamous Cell
 Nervous System Diseases Antibodies  >14 publications with Tyms and Nervous System Diseases
 Diarrhea Antibodies  >12 publications with Tyms and Diarrhea
Organs/Tissues associated with Tyms recombinant protein
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >4 publications with Tyms and Brain
 Pancreas Antibodies  >4 publications with Tyms and Pancreas
 Embryonic Tissue Antibodies  >1 publications with Tyms and Embryonic Tissue
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