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TYMS recombinant protein :: Thymidylate synthase Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS203615
SDS-Page
Unit / Price
0.1 mg  /  $285 +1 FREE 8GB USB
0.5 mg  /  $640 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Thymidylate synthase (TYMS), Recombinant Protein

★Popular Item★
 Also Known As   

Thymidylate synthase, 1-313aa, Human, His tag, E Coli

 Product Synonym Names    HST422; TMS; TS; d TMP synthase; EC 2.1.1.45; MGC88736; Thymidylate synthase; Thymidylate synthetase; Tsase; TYMS; TYMS protein; Tyms thymidylate synthetase
 Product Gene Name   

TYMS recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence    MGSSHHHHHH SSGLVPRGSH MPVAGSELPR RPLPPAAQER DAEPRPPHGE LQYLGQIQHI LRCGVRKDDR TGTGTLSVFG MQARYSLRDE FPLLTTKRVF WKGVLEELLW FIKGSTNAKE LSSKGVKIWD ANGSRDFLDS LGFSTREEGD LGPVYGFQWR HFGAEYRDME SDYSGQGVDQ LQRVIDTIKT NPDDRRIIMC AWNPRDLPLM ALPPCHALCQ FYVVNSELSC QLYQRSGDMG LGVPFNIASY ALLTYMIAHI TGLKPGDFIH TLGDAHIYLN HIEPLKIQLQ REPRPFPKLR ILRKVEKIDD FKAEDFQIEG YNPHPTIKME MAV
 OMIM    X02308 mRNA
 3D Structure    ModBase 3D Structure for P04818
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 Host    E Coli
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 Purity/Purification    > 95% by SDS-PAGE
 Form/Format    Liquid. In 20mM Tris-HCl Buffer (pH 8.0) containing 10% glycerol, 1mM DTT, 0.1 M NaCl.
 Concentration    1 mg/ml (determined by Bradford assay) (lot specific)
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 Antigen Species    Human
 Tag Information    His-tag
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 Preparation and Storage    Can be stored at 4 degree C short term (1-2 weeks).
For long term storage, aliquot and store at -20 degree C or -70 degree C.
Avoid repeated freezing and thawing cycles.
 Other Notes    Small volumes of TYMS recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for TYMS recombinant protein

   Thymidylate synthase is an intracellular enzyme critical for de novo synthesis of DNA. This function maintains the dTMP (thymidine-5-prime monophosphate) pool critical for DNA replication and repair. In cancer, expression of this protein is often elevated and becomes further elevated as a result of treatment with the most commonly used chemotherapeutic, 5-fluorouracil (5-Fu). Resistance or lack of response to 5-Fu is attributed to the elevation of thymidylate synthase activity. Recombinant human Thymidylate synthase protein, fused to His-tag at N-terminus, was expressed in E Coli and purified by using conventional chromatography techniques.
 Product Categories/Family for TYMS recombinant protein    Enzymes & Proteases
 Applications Tested/Suitable for TYMS recombinant protein   

SDS-PAGE

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 SDS-Page of TYMS recombinant protein    TYMS recombinant protein SDS-Page image
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NCBI/Uniprot data below describe general gene information for TYMS. It may not necessarily be applicable to this product.
 NCBI GI #    4507751
 NCBI GeneID    7298
 NCBI Accession #    NP_001062 [Other Products]
 NCBI GenBank Nucleotide #    NM_001071.2 [Other Products]
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 UniProt Primary Accession #    P04818 [Other Products]
 UniProt Secondary Accession #    Q8WYK3; Q8WYK4 [Other Products]
 UniProt Related Accession #    P04818 [Other Products]
 Molecular Weight    37.8 kDa (333aa), confirmed by MALDI-TOF. [Similar Products]
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 NCBI Official Full Name    thymidylate synthase
 NCBI Official Synonym Full Names    thymidylate synthetase
 NCBI Official Symbol    TYMS [Similar Products]
 NCBI Official Synonym Symbols   
TS; TMS; HST422
[Similar Products]
 NCBI Protein Information    thymidylate synthase
 UniProt Protein Name    Thymidylate synthase
 Protein Family    Thymidylate synthase
 UniProt Gene Name    TYMS [Similar Products]
 UniProt Synonym Gene Names    TS; TS; TSase [Similar Products]
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 NCBI Summary for TYMS    Thymidylate synthase catalyzes the methylation of deoxyuridylate to deoxythymidylate using, 10-methylenetetrahydrofolate (methylene-THF) as a cofactor. This function maintains the dTMP (thymidine-5-prime monophosphate) pool critical for DNA replication and repair. The enzyme has been of interest as a target for cancer chemotherapeutic agents. It is considered to be the primary site of action for 5-fluorouracil, 5-fluoro-2-prime-deoxyuridine, and some folate analogs. Expression of this gene and that of a naturally occurring antisense transcript, mitochondrial enolase superfamily member 1 (GeneID:55556), vary inversely when cell-growth progresses from late-log to plateau phase. Polymorphisms in this gene may be associated with etiology of neoplasia, including breast cancer, and response to chemotherapy. [provided by RefSeq, Aug 2017]
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 UniProt Comments for TYMS    Contributes to the de novo mitochondrial thymidylate biosynthesis pathway.
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Product References and Citations for TYMS recombinant protein

   Chiu TH., et al. (2009) Anticancer Res. 29 (11):4503-11. ; Pena MM., et al. (2009) J Biol Chem. 284 (46):31597-607.;
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 Research Articles on TYMS    1. High expression level of TYMS is associated with neuroendocrine lung tumors.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with TYMS recombinant proteinPathways associated with TYMS recombinant protein
 Reference Product  PubMed Publications
 DHFR recombinant protein  >48 publications with TYMS and DHFR
 SHMT1 recombinant protein  >32 publications with TYMS and SHMT1
 MTHFD1 recombinant protein  >28 publications with TYMS and MTHFD1
 FPGS recombinant protein  >15 publications with TYMS and FPGS
 TK1 recombinant protein  >7 publications with TYMS and TK1
 DTYMK recombinant protein  >3 publications with TYMS and DTYMK
 RRM2 recombinant protein  >2 publications with TYMS and RRM2
 DCTD recombinant protein  >2 publications with TYMS and DCTD
 DHFRL1 recombinant protein  >1 publications with TYMS and DHFRL1
 DUT recombinant protein  >1 publications with TYMS and DUT
 Products by Pathway  Pathway Diagram
 Antifolate Resistance Pathway antibodies  Antifolate Resistance Pathway Diagram
 Antifolate Resistance Pathway antibodies  Antifolate Resistance Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram
 Cell Cycle, Mitotic Pathway antibodies  Cell Cycle, Mitotic Pathway Diagram
 Circadian Rythm Related Genes Pathway antibodies  Circadian Rythm Related Genes Pathway Diagram
 E2F Mediated Regulation Of DNA Replication Pathway antibodies  E2F Mediated Regulation Of DNA Replication Pathway Diagram
 E2F Transcription Factor Network Pathway antibodies  E2F Transcription Factor Network Pathway Diagram
 Fluoropyrimidine Activity Pathway antibodies  Fluoropyrimidine Activity Pathway Diagram
 G1/S Transition Pathway antibodies  G1/S Transition Pathway Diagram
 G1/S-Specific Transcription Pathway antibodies  G1/S-Specific Transcription Pathway Diagram
Diseases associated with TYMS recombinant proteinOrgans/Tissues associated with TYMS recombinant protein
 Disease Name  Pubmed Publications
 Digestive System Neoplasms Antibodies  >121 publications with TYMS and Digestive System Neoplasms
 Colorectal Neoplasms Antibodies  >87 publications with TYMS and Colorectal Neoplasms
 Adenocarcinoma Antibodies  >44 publications with TYMS and Adenocarcinoma
 Breast Neoplasms Antibodies  >42 publications with TYMS and Breast Neoplasms
 Lung Neoplasms Antibodies  >39 publications with TYMS and Lung Neoplasms
 Carcinoma, Squamous Cell Antibodies  >26 publications with TYMS and Carcinoma, Squamous Cell
 Neoplasms, Experimental Antibodies  >23 publications with TYMS and Neoplasms, Experimental
 Head and Neck Neoplasms Antibodies  >22 publications with TYMS and Head and Neck Neoplasms
 Diarrhea Antibodies  >19 publications with TYMS and Diarrhea
 Stomach Neoplasms Antibodies  >18 publications with TYMS and Stomach Neoplasms
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >92 publications with TYMS and Blood
 Lung Antibodies  >50 publications with TYMS and Lung
 Stomach Antibodies  >18 publications with TYMS and Stomach
 Liver Antibodies  >12 publications with TYMS and Liver
 Vascular Antibodies  >10 publications with TYMS and Vascular
 Heart Antibodies  >9 publications with TYMS and Heart
 Pancreas Antibodies  >8 publications with TYMS and Pancreas
 Lymph Antibodies  >7 publications with TYMS and Lymph
 Lymph Node Antibodies  >7 publications with TYMS and Lymph Node
 Bladder Antibodies  >6 publications with TYMS and Bladder
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