NP_066932.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
thymosin beta-4
NCBI Official Synonym Full Names
thymosin beta 4, X-linked
NCBI Protein Information
thymosin beta-4
UniProt Protein Name
Thymosin beta-4
UniProt Synonym Protein Names
Fx
UniProt Synonym Gene Names
NCBI Summary for TMSB4X
This gene encodes an actin sequestering protein which plays a role in regulation of actin polymerization. The protein is also involved in cell proliferation, migration, and differentiation. This gene escapes X inactivation and has a homolog on chromosome Y. [provided by RefSeq, Jul 2008]
UniProt Comments for TMSB4X
TMSB4X: Plays an important role in the organization of the cytoskeleton. Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization. Belongs to the thymosin beta family.
Protein type: Cytoskeletal; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: Xp22.2
Cellular Component: cytoplasm; cytosol; extracellular region; intracellular; nucleus
Molecular Function: actin monomer binding; enzyme binding; protein binding; RNA binding
Biological Process: cytoplasmic sequestering of NF-kappaB; inhibition of NF-kappaB transcription factor; platelet degranulation; positive regulation of blood vessel endothelial cell migration; regulation of inflammatory response; sequestering of actin monomers; tumor necrosis factor-mediated signaling pathway
Research Articles on TMSB4X
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Pathways associated with TMSB4X active protein
Diseases associated with TMSB4X active protein
Organs/Tissues associated with TMSB4X active protein
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