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Tg recombinant protein :: Thyroglobulin (Tg), partial Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS1258460 Tg recombinant protein
Unit / Price
0.5 mg (E-Coli)  /  $1,035 +1 FREE 8GB USB
0.05 mg (Baculovirus)  /  $1,035 +1 FREE 8GB USB
0.5 mg (Yeast)  /  $1,265 +1 FREE 8GB USB
0.05 mg (Mammalian-Cell)  /  $1,265 +1 FREE 8GB USB
1 mg (E-Coli)  /  $1,575 +1 FREE 8GB USB
0.1 mg (Baculovirus)  /  $1,575 +1 FREE 8GB USB
1 mg (Yeast)  /  $2,035 +2 FREE 8GB USB
0.1 mg (Mammalian-Cell)  /  $2,035 +2 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Thyroglobulin (Tg), partial, Recombinant Protein

 Also Known As   

Recombinant Mouse Thyroglobulin (Tg), partial

 Product Synonym Names    Thyroglobulin; Tg
 Product Gene Name   

Tg recombinant protein

[Similar Products]
 Product Synonym Gene Name    Tg; Tgn [Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence Positions    21-300; Fragment at the N-terminal;
 Sequence    NIFEYQVDAQ PLRPCELQRE KAFLKQAEYV PQCSEDGSFQ TVQCQNDGQS CWCVDSDGRE VPGSRQLGRP TVCLSFCQLH KQRILLGSYI NSTDALYLPQ CQDSGNYAPV QCDLQRVQCW CVDTEGMEVY GTRQQGRPTR CPRSCEIRNR RLLHGVGDRS PPQCTADGEF MPVQCKFVNT TDMMIFDLIH NYNRFPDAFV TFSSFRGRFP EVSGYCYCAD SQGRELAETG LELLLDEIYD TIFAGLDQAS TFTQSTMYRI LQRRFLAIQL VISGRFRCPT
 3D Structure    ModBase 3D Structure for O08710
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 Host    E Coli or Yeast or Baculovirus or Mammalian Cell
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 Purity/Purification    >90%
 Form/Format    Liquid containing glycerol
 Tag Information    This protein contains an N-terminal tag and may also contain a C-terminal Myc-tag. N-terminal host tags may vary (His, His-SUMO, His-B2M, GST). Tag types are determined by various factors including tag-protein stability and, therefore, are subject to change; please inquire for tag information.
 Sterility    Sterile filter available upon request.
 Endotoxin    Low endotoxin available upon request.
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 Species    Mus musculus (Mouse)
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 Preparation and Storage    Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of Tg recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for Tg recombinant protein

   Thyroglobulin (Tg) is a glycoprotein homodimer produced predominantly by the thryroid gland. It acts as a substrate for the synthesis of thyroxine and triiodothyronine as well as the storage of the inactive forms of thyroid hormone and iodine. Thyroglobulin is secreted from the endoplasmic reticulum to its site of iodination, and subsequent thyroxine biosynthesis, in the follicular lumen. Mutations in this gene cause thyroid dyshormonogenesis, manifested as goiter, and are associated with moderate to severe congenital hypothyroidism. Polymorphisms in this gene are associated with susceptibility to autoimmune thyroid diseases (AITD) such as Graves disease and Hashimoto thryoiditis.
NCBI/Uniprot data below describe general gene information for Tg. It may not necessarily be applicable to this product.
 NCBI GI #    124430576
 NCBI GeneID    21819
 NCBI Accession #    NP_033401.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_009375.2 [Other Products]
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 UniProt Primary Accession #    O08710 [Other Products]
 UniProt Secondary Accession #    O88590; Q2NKY1; Q9QWY7 [Other Products]
 UniProt Related Accession #    O08710 [Other Products]
 Molecular Weight    304,473 Da
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 NCBI Official Full Name    thyroglobulin
 NCBI Official Synonym Full Names    thyroglobulin
 NCBI Official Symbol    Tg [Similar Products]
 NCBI Official Synonym Symbols   
Tgn; cog
[Similar Products]
 NCBI Protein Information    thyroglobulin; congenital goiter
 UniProt Protein Name    Thyroglobulin
 Protein Family    Thyroglobulin
 UniProt Gene Name    Tg [Similar Products]
 UniProt Synonym Gene Names    Tgn; Tg [Similar Products]
 UniProt Entry Name    THYG_MOUSE
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 UniProt Comments for Tg    TG: Precursor of the iodinated thyroid hormones thyroxine (T4) and triiodothyronine (T3). Defects in TG are the cause of thyroid dyshormonogenesis 3 (TDH3). A disorder due to thyroid dyshormonogenesis, causing large goiters of elastic and soft consistency in the majority of patients. Although the degree of thyroid dysfunction varies considerably among patients with defective thyroglobulin synthesis, patients usually have a relatively high serum free triiodothyronine (T3) concentration with disproportionately low free tetraiodothyronine (T4) level. The maintenance of relatively high free T3 levels prevents profound tissue hypothyroidism except in brain and pituitary, which are dependent on T4 supply, resulting in neurologic and intellectual defects in some cases. Variations in TG are associated with susceptibility to autoimmune thyroid disease type 3 (AITD3). AITDs including Graves disease (GD) and Hashimoto thyroiditis (HT), are among the most common human autoimmune diseases. They are complex diseases, which are caused by an interaction between susceptibility genes and nongenetic factors, such as infection. Belongs to the type-B carboxylesterase/lipase family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Secreted; Secreted, signal peptide

Cellular Component: Golgi apparatus; extracellular space; protein complex; endoplasmic reticulum; perinuclear region of cytoplasm; extracellular region

Molecular Function: protein homodimerization activity; anion binding; hormone activity; chaperone binding; protein complex binding; receptor binding

Biological Process: regulation of myelination; iodide transport; thyroid hormone generation; transcytosis; hormone biosynthetic process; thyroid hormone metabolic process; response to pH
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 Research Articles on Tg    1. these data identify for the first time a Tg T cell epitope as a spontaneous target in ISAT.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with Tg recombinant proteinPathways associated with Tg recombinant protein
 Reference Product  PubMed Publications
 APCS recombinant protein  >28 publications with Tg and APCS
 HSPA5 recombinant protein  >4 publications with Tg and HSPA5
 LRP2 recombinant protein  >3 publications with Tg and LRP2
 CTSL1 recombinant protein  >3 publications with Tg and CTSL1
 Products by Pathway  Pathway Diagram
 Autoimmune Thyroid Disease Pathway antibodies  Autoimmune Thyroid Disease Pathway Diagram
 Autoimmune Thyroid Disease Pathway antibodies  Autoimmune Thyroid Disease Pathway Diagram
 Thyroid Hormone Synthesis Pathway antibodies  Thyroid Hormone Synthesis Pathway Diagram
 Thyroid Hormone Synthesis Pathway antibodies  Thyroid Hormone Synthesis Pathway Diagram
Diseases associated with Tg recombinant proteinOrgans/Tissues associated with Tg recombinant protein
 Disease Name  Pubmed Publications
 Thyroid Diseases Antibodies  >2336 publications with Tg and Thyroid Diseases
 Fatty Liver Antibodies  >1593 publications with Tg and Fatty Liver
 Inflammation Antibodies  >1359 publications with Tg and Inflammation
 Liver Diseases Antibodies  >1352 publications with Tg and Liver Diseases
 Hypertension Antibodies  >1289 publications with Tg and Hypertension
 Thyroid Neoplasms Antibodies  >1172 publications with Tg and Thyroid Neoplasms
 Necrosis Antibodies  >818 publications with Tg and Necrosis
 Mental Disorders Antibodies  >807 publications with Tg and Mental Disorders
 Kidney Diseases Antibodies  >769 publications with Tg and Kidney Diseases
 Goiter Antibodies  >633 publications with Tg and Goiter
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >13142 publications with Tg and Blood
 Liver Antibodies  >2906 publications with Tg and Liver
 Thyroid Antibodies  >2605 publications with Tg and Thyroid
 Muscle Antibodies  >1845 publications with Tg and Muscle
 Brain Antibodies  >1632 publications with Tg and Brain
 Kidney Antibodies  >992 publications with Tg and Kidney
 Connective Tissue Antibodies  >860 publications with Tg and Connective Tissue
 Lymph Node Antibodies  >551 publications with Tg and Lymph Node
 Intestine Antibodies  >467 publications with Tg and Intestine
 Pancreas Antibodies  >333 publications with Tg and Pancreas
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