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THRA recombinant protein :: Thyroid hormone receptor alpha (THRA) Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS959459
SDS-PAGE
Unit / Price
0.05 mg (E-Coli)  /  $910 +1 FREE 8GB USB
0.05 mg (Yeast)  /  $990 +1 FREE 8GB USB
0.05 mg (Baculovirus)  /  $1,120 +1 FREE 8GB USB
0.2 mg (E-Coli)  /  $1,220 +1 FREE 8GB USB
0.2 mg (Yeast)  /  $1,340 +1 FREE 8GB USB
0.5 mg (E-Coli)  /  $1,345 +1 FREE 8GB USB
0.05 mg (Mammalian-Cell)  /  $1,370 +1 FREE 8GB USB
0.1 mg (Baculovirus)  /  $1,420 +1 FREE 8GB USB
0.5 mg (Yeast)  /  $1,515 +1 FREE 8GB USB
1 mg (E-Coli)  /  $1,915 +2 FREE 8GB USB
0.5 mg (Baculovirus)  /  $2,035 +2 FREE 8GB USB
0.1 mg (Mammalian-Cell)  /  $2,065 +2 FREE 8GB USB
1 mg (Yeast)  /  $2,305 +2 FREE 8GB USB
1 mg (Baculovirus)  /  $2,680 +3 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Thyroid hormone receptor alpha (THRA), Recombinant Protein

★Popular Item★
 Also Known As   

Recombinant Human Thyroid hormone receptor alpha (THRA)

 Product Synonym Names    Thyroid hormone receptor alpha; Nuclear receptor subfamily 1 group A member 1; V-erbA-related protein 7; EAR-7; c-erbA-1; c-erbA-alpha
 Product Gene Name   

THRA recombinant protein

[Similar Products]
 Product Synonym Gene Name    THRA; EAR7; ERBA1; NR1A1; THRA1; THRA2 [Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence Positions    1-490aa; Full length protein
 Sequence    MEQKPSKVEC GSDPEENSAR SPDGKRKRKN GQCSLKTSMS GYIPSYLDKD EQCVVCGDKA TGYHYRCITC EGCKGFFRRT IQKNLHPTYS CKYDSCCVID KITRNQCQLC RFKKCIAVGM AMDLVLDDSK RVAKRKLIEQ NRERRRKEEM IRSLQQRPEP TPEEWDLIHI ATEAHRSTNA QGSHWKQRRK FLPDDIGQSP IVSMPDGDKV DLEAFSEFTK IITPAITRVV DFAKKLPMFS ELPCEDQIIL LKGCCMEIMS LRAAVRYDPE SDTLTLSGEM AVKREQLKNG GLGVVSDAIF ELGKSLSAFN LDDTEVALLQ AVLLMSTDRS GLLCVDKIEK SQEAYLLAFE HYVNHRKHNI PHFWPKLLMK EREVQSSILY KGAAAEGRPG GSLGVHPEGQ QLLGMHVVQG PQVRQLEQQL GEAGSLQGPV LQHQSPKSPQ QRLLELLHRS GILHARAVCG EDDSSEADSP SSSEEEPEVC EDLAGNAASP
 OMIM    gene 614450
 3D Structure    ModBase 3D Structure for P10827
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 Host    E Coli or Yeast or Baculovirus or Mammalian Cell
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 Purity/Purification    >=90% (lot specific)
 Form/Format    Liquid containing glycerol
 Tag Information    This protein contains an N-terminal tag and may also contain a C-terminal Myc-tag. N-terminal host tags may vary (His, His-SUMO, His-B2M, GST). Tag types are determined by various factors including tag-protein stability and, therefore, are subject to change; please inquire for tag information.
 Sterility    Sterile filter available upon request.
 Endotoxin    Low endotoxin available upon request.
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 Species    Homo sapiens (Human)
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 Preparation and Storage    Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of THRA recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for THRA recombinant protein

   Nuclear hormone receptor that can act as a repressor or activator of transcription. High affinity receptor for thyroid hormones, including triiodothyronine and thyroxine.
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 SDS-PAGE of THRA recombinant protein    THRA recombinant protein SDS-PAGE image
(Note: Representative image, actual molecular weight may vary depending on Tag type and expression host)
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NCBI/Uniprot data below describe general gene information for THRA. It may not necessarily be applicable to this product.
 NCBI GI #    300116307
 NCBI GeneID    7067
 NCBI Accession #    NP_001177847.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001190918.1 [Other Products]
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 UniProt Primary Accession #    P10827 [Other Products]
 UniProt Secondary Accession #    P21205; Q8N6A1; Q96H73; A8K3B5 [Other Products]
 UniProt Related Accession #    P10827 [Other Products]
 Molecular Weight    50,465 Da
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 NCBI Official Full Name    thyroid hormone receptor alpha isoform 3
 NCBI Official Synonym Full Names    thyroid hormone receptor, alpha
 NCBI Official Symbol    THRA [Similar Products]
 NCBI Official Synonym Symbols   
AR7; EAR7; ERBA; CHNG6; ERBA1; NR1A1; THRA1; THRA2; ERB-T-1; c-ERBA-1
[Similar Products]
 NCBI Protein Information    thyroid hormone receptor alpha; EAR-7; c-erbA-alpha; ERBA-related 7; V-erbA-related protein 7; triiodothyronine receptor; nuclear receptor subfamily 1 group A member 1; thyroid normone nuclear receptor alpha variant 1; thyroid hormone receptor, alpha (erythroblastic leukemia viral (v-erb-a) oncogene homolog, avian)
 UniProt Protein Name    Thyroid hormone receptor alpha
 UniProt Synonym Protein Names   
Nuclear receptor subfamily 1 group A member 1; V-erbA-related protein 7; EAR-7; c-erbA-1; c-erbA-alpha
 Protein Family    Thyroid hormone receptor
 UniProt Gene Name    THRA [Similar Products]
 UniProt Synonym Gene Names    EAR7; ERBA1; NR1A1; THRA1; THRA2; EAR-7 [Similar Products]
 UniProt Entry Name    THA_HUMAN
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 NCBI Summary for THRA    The protein encoded by this gene is a nuclear hormone receptor for triiodothyronine. It is one of the several receptors for thyroid hormone, and has been shown to mediate the biological activities of thyroid hormone. Knockout studies in mice suggest that the different receptors, while having certain extent of redundancy, may mediate different functions of thyroid hormone. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]
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 UniProt Comments for THRA    TR-alpha: nuclear hormone receptor and transcription factor. High affinity receptor for triiodothyronine. Interacts with SRC-3 and NCOA6 coactivators, leading to a strong increase of transcription of target genes. Four splice variant isoforms have been described.

Protein type: Transcription factor; Nuclear receptor; DNA-binding

Chromosomal Location of Human Ortholog: 17q11.2

Cellular Component: nucleoplasm; cytosol; nucleus

Molecular Function: protein domain specific binding; protein binding; zinc ion binding; sequence-specific DNA binding; chromatin DNA binding; TATA-binding protein binding; protein complex binding; steroid hormone receptor activity; thyroid hormone receptor activity; transcription factor binding; transcription factor activity

Biological Process: transcription from RNA polymerase II promoter; transcription initiation from RNA polymerase II promoter; negative regulation of transcriptional preinitiation complex assembly; cytoplasmic sequestering of transcription factor; ossification; intracellular receptor-mediated signaling pathway; hormone-mediated signaling; positive regulation of female receptivity; regulation of myeloid cell apoptosis; regulation of lipid catabolic process; regulation of heart contraction; regulation of transcription from RNA polymerase II promoter; learning and/or memory; female courtship behavior; thyroid gland development; erythrocyte differentiation; gene expression; steroid hormone mediated signaling; positive regulation of transcription from RNA polymerase II promoter; response to cold; negative regulation of transcription, DNA-dependent; cartilage condensation

Disease: Hypothyroidism, Congenital, Nongoitrous, 6
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 Research Articles on THRA    1. THRA gene polymorphisms are associated with obesity development. This is a novel observation linking the THRA locus to metabolic phenotypes.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with THRA recombinant proteinPathways associated with THRA recombinant protein
 Reference Product  PubMed Publications
 CCND1 recombinant protein  >3 publications with THRA and CCND1
 MED1 recombinant protein  >2 publications with THRA and MED1
 RXRG recombinant protein  >1 publications with THRA and RXRG
 RXRB recombinant protein  >1 publications with THRA and RXRB
 RXRA recombinant protein  >1 publications with THRA and RXRA
 NCOR1 recombinant protein  >1 publications with THRA and NCOR1
 ESR1 recombinant protein  >1 publications with THRA and ESR1
 CREBBP recombinant protein  >1 publications with THRA and CREBBP
 Products by Pathway  Pathway Diagram
 Endochondral Ossification Pathway antibodies  Endochondral Ossification Pathway Diagram
 Gene Expression Pathway antibodies  Gene Expression Pathway Diagram
 Generic Transcription Pathway antibodies  Generic Transcription Pathway Diagram
 Neuroactive Ligand-receptor Interaction Pathway antibodies  Neuroactive Ligand-receptor Interaction Pathway Diagram
 Neuroactive Ligand-receptor Interaction Pathway antibodies  Neuroactive Ligand-receptor Interaction Pathway Diagram
 Nuclear Receptor Transcription Pathway antibodies  Nuclear Receptor Transcription Pathway Diagram
 Nuclear Receptors Pathway antibodies  Nuclear Receptors Pathway Diagram
Diseases associated with THRA recombinant proteinOrgans/Tissues associated with THRA recombinant protein
 Disease Name  Pubmed Publications
 Cardiovascular Diseases Antibodies  >17 publications with THRA and Cardiovascular Diseases
 Thyroid Diseases Antibodies  >12 publications with THRA and Thyroid Diseases
 Nervous System Diseases Antibodies  >4 publications with THRA and Nervous System Diseases
 Brain Diseases Antibodies  >3 publications with THRA and Brain Diseases
 Liver Diseases Antibodies  >3 publications with THRA and Liver Diseases
 Kidney Diseases Antibodies  >2 publications with THRA and Kidney Diseases
 Drug Toxicity Antibodies  >2 publications with THRA and Drug Toxicity
 Weight Loss Antibodies  >2 publications with THRA and Weight Loss
 Heart Diseases Antibodies  >2 publications with THRA and Heart Diseases
 Fatty Liver Antibodies  >2 publications with THRA and Fatty Liver
 Organ/Tissue Name  Pubmed Publications
 Thyroid Antibodies  >43 publications with THRA and Thyroid
 Blood Antibodies  >21 publications with THRA and Blood
 Bone Antibodies  >14 publications with THRA and Bone
 Brain Antibodies  >11 publications with THRA and Brain
 Liver Antibodies  >9 publications with THRA and Liver
 Muscle Antibodies  >5 publications with THRA and Muscle
 Ear Antibodies  >4 publications with THRA and Ear
 Heart Antibodies  >4 publications with THRA and Heart
 Testis Antibodies  >3 publications with THRA and Testis
 Eye Antibodies  >3 publications with THRA and Eye
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