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TSHR recombinant protein :: Thyrotropin receptor (TSHR) Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS949648 TSHR recombinant protein
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 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Thyrotropin receptor (TSHR), Recombinant Protein

 Also Known As   

Recombinant Sheep Thyrotropin receptor (TSHR)

 Product Synonym Names    Recombinant Thyrotropin receptor (TSHR); Thyrotropin receptor; Thyroid-stimulating hormone receptor; TSH-R
 Product Gene Name   

TSHR recombinant protein

[Similar Products]
 Product Synonym Gene Name    TSHR [Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence Positions    22-413aa; Fragment at the N-terminal, provide the extracellular domain.
 Sequence    ERCPSPPCEC RQEDDFRVTC KDIQRIPSLP PSTQTLKFIE THLKTIPSRA FSNLPNISRI YLSIDATLQQ LESHSFYNLS KVTHIEIRNT RSLTYIDSGA LKELPLLKFL GIFNTGLRVF PDLTKIYSTD VFFILEITDN PYMTSVPANA FQGLSNETLT LKLYNNGFTS IQGHAFNGTK LDAVYLNKNK YLTVIDQDAF AGVYSGPTLL DISYTSVTAL PSKGLEHLKE LIARNTWTLK KLPLSLSFLH LTRADLSYPS HCCAFKNQKN IRGILQSLMC NESSIWGLRQ RKSASALNGP FYQEYEEDLG DGSAGYKENS KFQDTHSNSH YYVFFEDQED EIIGFGQELK NPQEETLQAF DNHYDYTVCG GSEEMVCTPK SDEFNPCEDI MG
 Chromosome Location    Chromosome: 7; NC_019464.1 (89258689..89433026). Location: chromosome: 7
 3D Structure    ModBase 3D Structure for P56495
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 Host    E Coli or Yeast or Baculovirus or Mammalian Cell
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 Purity/Purification    >=90% (lot specific)
 Form/Format    Liquid containing glycerol
 Tag Information    This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
 Sterility    Sterile filter available upon request.
 Endotoxin    Low endotoxin available upon request.
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 Species    Ovis aries (Sheep)
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 Preparation and Storage    Store at -20 degree C. For extended storage, store at -20 or -80 degree C.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of TSHR recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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NCBI/Uniprot data below describe general gene information for TSHR. It may not necessarily be applicable to this product.
 NCBI GI #    57164277
 NCBI GeneID    443428
 NCBI Accession #    NP_001009410.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001009410.1 [Other Products]
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 UniProt Primary Accession #    P56495 [Other Products]
 UniProt Related Accession #    P56495 [Other Products]
 Molecular Weight    86,674 Da [Similar Products]
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 NCBI Official Full Name    thyrotropin receptor
 NCBI Official Symbol    TSHR [Similar Products]
 NCBI Protein Information    thyrotropin receptor; TSH-R; thyroid-stimulating hormone receptor
 UniProt Protein Name    Thyrotropin receptor
 UniProt Synonym Protein Names   
Thyroid-stimulating hormone receptor
 Protein Family    Thyrotropin receptor
 UniProt Gene Name    TSHR [Similar Products]
 UniProt Synonym Gene Names    TSH-R [Similar Products]
 UniProt Entry Name    TSHR_SHEEP
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 UniProt Comments for TSHR    Function: Receptor for thyrothropin. Plays a central role in controlling thyroid cell metabolism. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Also acts as a receptor for thyrostimulin (GPA2+GPB5).

Subunit structure: Interacts (via the PDZ-binding motif) with SCRIB; regulates TSHR trafficking and function

By similarity.

Subcellular location: Cell membrane; Multi-pass membrane protein.

Sequence similarities: Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily.Contains 6 LRR (leucine-rich) repeats.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Diseases associated with TSHR recombinant protein
 Disease Name  Pubmed Publications
 Hyperthyroidism Antibodies  >431 publications with TSHR and Hyperthyroidism
 Graves Disease Antibodies  >401 publications with TSHR and Graves Disease
 Neoplasms Antibodies  >153 publications with TSHR and Neoplasms
 Thyroid Neoplasms Antibodies  >145 publications with TSHR and Thyroid Neoplasms
 Thyroiditis, Autoimmune Antibodies  >91 publications with TSHR and Thyroiditis, Autoimmune
 Carcinoma Antibodies  >76 publications with TSHR and Carcinoma
 Disease Models, Animal Antibodies  >69 publications with TSHR and Disease Models, Animal
 Congenital Hypothyroidism Antibodies  >61 publications with TSHR and Congenital Hypothyroidism
 Adenoma Antibodies  >45 publications with TSHR and Adenoma
 Thyrotoxicosis Antibodies  >34 publications with TSHR and Thyrotoxicosis
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