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TGM2 Sf9 recombinant protein :: Tissue Transglutaminase Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS142444 TGM2 Sf9 recombinant protein
Unit / Price
0.005 mg  /  $140 +1 FREE 8GB USB
0.02 mg  /  $205 +1 FREE 8GB USB
1 mg  /  $4,380 +5 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Tissue Transglutaminase (TGM2 Sf9), Recombinant Protein

★Popular Item★
 Also Known As   

Recombinant Human Tissue Transglutaminase, Sf9

 Product Synonym Names    TGM2 Human, Sf9; Tissue Transglutaminase Human Recombinant, Sf9; Protein-glutamine gamma-glutamyltransferase 2; EC 2.3.2.13; Tissue transglutaminase; TGase C; TGC; TG(C); Transglutaminase-2; TGase-H; TG2; TGM2
 Product Gene Name   

TGM2 Sf9 recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    190196
 3D Structure    ModBase 3D Structure for P21980
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 Host    Sf9 Insect Cells
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 Purity/Purification    Greater than 95% as determined by SDS-PAGE.
 Form/Format    TGM2 is supplied in 16mM HEPES buffer pH-8.0, 320mM NaCl, and 20% glycerol.
 Concentration    Coating Concentration: 0.6-1.4 ug/ml (depending on the type of ELISA plate and coating buffer).Suitable for biotinylation and iodination. (lot specific)
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 Preparation and Storage    Store at 4 degree C if entire vial will be used within 2-4weeks. Store, frozen at -20 degree C for longer periods of time. Avoid multiple freeze-thaw cycles.
 Other Notes    Small volumes of TGM2 Sf9 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for TGM2 Sf9 recombinant protein

   Description: Tissue Transglutaminase Human Recombinant produced in SF9 is a glycosylated, polypeptide chain having a molecular mass of 78,018 Dalton. tTG is expressed with a -6xHis tag and purified by proprietary chromatographic techniques. By point mutation of the active center the catalytic transglutaminase activity has been eliminated, resulting in increased stability during storage and coating.

Introduction: Celiac disease is an enteropathy that is characterized by intestinal lesions of variable severity. Tissue-type transglutaminase (tTG) is believed to be the predominant autoantigen for celiac disease and the corresponding autoantibodies show higher sensitivity and specificity than anti-gliadin antibodies. Highly pure recombinant human tTG is now available to replace the traditionally used tTG fraction from guinea pig.Tissue-type transglutaminase antigens have been specifically modified for improved handling: exchange of an active site amino acid eliminates the protein cross-linking activity of the enzyme, while maintaining the native three-dimensional structure and the enzyme's secondary GTPase activity. This engineering assures reproducible properties of the antigen preparations through the absence of variable and ill-defined covalent aggregates of tTG antigen and host cell proteins.
 Product Categories/Family for TGM2 Sf9 recombinant protein    ENZYMES; Enzymes
NCBI/Uniprot data below describe general gene information for TGM2 Sf9. It may not necessarily be applicable to this product.
 NCBI GI #    39777597
 NCBI GeneID    7052
 NCBI Accession #    NP_004604.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_004613.2 [Other Products]
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 UniProt Primary Accession #    P21980 [Other Products]
 UniProt Secondary Accession #    Q16436; Q6B838; Q9BTN7; Q9UH35; E1P5V9 [Other Products]
 UniProt Related Accession #    P21980 [Other Products]
 Molecular Weight    38,671 Da
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 NCBI Official Full Name    protein-glutamine gamma-glutamyltransferase 2 isoform a
 NCBI Official Synonym Full Names    transglutaminase 2
 NCBI Official Symbol    TGM2 [Similar Products]
 NCBI Official Synonym Symbols   
TG2; TGC; GNAH; HEL-S-45; G-ALPHA-h
[Similar Products]
 NCBI Protein Information    protein-glutamine gamma-glutamyltransferase 2; C polypeptide, protein-glutamine-gamma-glutamyltransferase; TG(C); TGase C; TGase H; TGase-2; TGase-H; epididymis secretory protein Li 45; tissue transglutaminase; transglutaminase C; transglutaminase H; transglutaminase-2
 UniProt Protein Name    Protein-glutamine gamma-glutamyltransferase 2
 UniProt Synonym Protein Names   
Tissue transglutaminase; Transglutaminase C; TG(C); TGC; TGase C; Transglutaminase H; TGase H; Transglutaminase-2; TGase-2
 UniProt Gene Name    TGM2 [Similar Products]
 UniProt Synonym Gene Names    TG(C); TGC; TGase C; TGase H; TGase-2 [Similar Products]
 UniProt Entry Name    TGM2_HUMAN
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 NCBI Summary for TGM2 Sf9    Transglutaminases are enzymes that catalyze the crosslinking of proteins by epsilon-gamma glutamyl lysine isopeptide bonds. While the primary structure of transglutaminases is not conserved, they all have the same amino acid sequence at their active sites and their activity is calcium-dependent. The protein encoded by this gene acts as a monomer, is induced by retinoic acid, and appears to be involved in apoptosis. Finally, the encoded protein is the autoantigen implicated in celiac disease. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
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 UniProt Comments for TGM2 Sf9    TGM2: an enzyme of the transglutaminase family that catalyzes the crosslinking of proteins and the conjugation of polyamines to proteins. While the primary structure of transglutaminases is not conserved, they all have the same amino acid sequence at their active sites and their activity is calcium-dependent. The protein encoded by this gene acts as a monomer, is induced by retinoic acid, and appears to be involved in apoptosis. . Is the autoantigen in coeliac disease and plays a role in apoptosis, cellular differentiation and matrix stabilisation. Three alternatively spliced isoforms have been described.

Protein type: Transferase; EC 2.3.2.13

Chromosomal Location of Human Ortholog: 20q12

Cellular Component: focal adhesion; mitochondrion; plasma membrane; cytosol

Molecular Function: protein domain specific binding; protein binding; GTP binding; protein-glutamine gamma-glutamyltransferase activity; metal ion binding

Biological Process: elevation of cytosolic calcium ion concentration during G-protein signaling, coupled to IP3 second messenger (phospholipase C activating); positive regulation of cell adhesion; positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of apoptosis; isopeptide cross-linking via N6-(L-isoglutamyl)-L-lysine; reduction of endoplasmic reticulum calcium ion concentration; positive regulation of smooth muscle cell proliferation; blood vessel remodeling; protein homooligomerization; apoptotic cell clearance; positive regulation of inflammatory response; elevation of mitochondrial calcium ion concentration
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 Research Articles on TGM2 Sf9    1. perturbed transglutaminase 2 activity has a role in the arrested alveolarisation associated with BPD
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with TGM2 Sf9 recombinant proteinPathways associated with TGM2 Sf9 recombinant protein
 Reference Product  PubMed Publications
 ITGB1 recombinant protein  >1 publications with TGM2 Sf9 and ITGB1
 FN1 recombinant protein  >1 publications with TGM2 Sf9 and FN1
 Products by Pathway  Pathway Diagram
 Huntington's Disease Pathway antibodies  Huntington's Disease Pathway Diagram
 Huntington's Disease Pathway antibodies  Huntington's Disease Pathway Diagram
 Thromboxane A2 Receptor Signaling Pathway antibodies  Thromboxane A2 Receptor Signaling Pathway Diagram
Diseases associated with TGM2 Sf9 recombinant proteinOrgans/Tissues associated with TGM2 Sf9 recombinant protein
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >9 publications with TGM2 Sf9 and Inflammation
 Necrosis Antibodies  >6 publications with TGM2 Sf9 and Necrosis
 Disease Models, Animal Antibodies  >6 publications with TGM2 Sf9 and Disease Models, Animal
 Lung Neoplasms Antibodies  >6 publications with TGM2 Sf9 and Lung Neoplasms
 Fibrosis Antibodies  >5 publications with TGM2 Sf9 and Fibrosis
 Cardiovascular Diseases Antibodies  >5 publications with TGM2 Sf9 and Cardiovascular Diseases
 Breast Neoplasms Antibodies  >5 publications with TGM2 Sf9 and Breast Neoplasms
 Brain Neoplasms Antibodies  >4 publications with TGM2 Sf9 and Brain Neoplasms
 Kidney Diseases Antibodies  >4 publications with TGM2 Sf9 and Kidney Diseases
 Carcinoma, Hepatocellular Antibodies  >4 publications with TGM2 Sf9 and Carcinoma, Hepatocellular
 Organ/Tissue Name  Pubmed Publications
 Lung Antibodies  >11 publications with TGM2 Sf9 and Lung
 Brain Antibodies  >10 publications with TGM2 Sf9 and Brain
 Liver Antibodies  >9 publications with TGM2 Sf9 and Liver
 Blood Antibodies  >9 publications with TGM2 Sf9 and Blood
 Eye Antibodies  >7 publications with TGM2 Sf9 and Eye
 Bone Antibodies  >7 publications with TGM2 Sf9 and Bone
 Skin Antibodies  >7 publications with TGM2 Sf9 and Skin
 Connective Tissue Antibodies  >5 publications with TGM2 Sf9 and Connective Tissue
 Vascular Antibodies  >5 publications with TGM2 Sf9 and Vascular
 Muscle Antibodies  >5 publications with TGM2 Sf9 and Muscle
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