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TGM2 recombinant protein :: Tissue Transglutaminase Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS836701 TGM2 recombinant protein
Unit / Price
0.1 mg  /  $515 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Tissue Transglutaminase (TGM2), Recombinant Protein

★Popular Item★
 Also Known As   

Tissue Transglutaminase Ag

 Product Synonym Names    Human TTG protein
 Product Gene Name   

TGM2 recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 3D Structure    ModBase 3D Structure for Q9BXQ0
 Host    Human
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 Purity/Purification    > 95% pure
 Form/Format    Lyophilzed from 10mM Tris-HCl buffer, pH 8.1, with 150mM NaCl, 5mM DDT, 1mM EDTA, an d189mg/ml Maltodextrin.
 Concentration    100ug, lyophilized (lot specific)
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 Protein Type    Recombinant
 Biological Significance    Tissue transglutaminase is an enzyme of the transglutaminase family. Like other transglutaminases, it crosslinks proteins between an epsilon-amino group of a lysine residue and a gamma-carboxamide group of glutamine residue, creating an inter- or intramolecular bond that is highly resistant to proteolysis (protein degradation). It is particularly notable for being the autoantigen in coeliac disease, but is also known to play a role in apoptosis, cellular differentiation and matrix stabilisation.
 Expression System    Human cell line
 Biohazard    Use standard laboratory precautions when handling this material.
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 Preparation and Storage    4 degree C short term, -20 degree C for long term. Avoid repeated freeze/thaw cycles.
 Other Notes    Small volumes of TGM2 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for TGM2 recombinant protein

   Purified recombinant Human Tissue Transglutaminase protein
 Product Categories/Family for TGM2 recombinant protein    Nutrition & Metabolism
 Applications Tested/Suitable for TGM2 recombinant protein   

User optimized

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NCBI/Uniprot data below describe general gene information for TGM2. It may not necessarily be applicable to this product.
 NCBI GI #    13183616
 NCBI GeneID    7052
 NCBI Accession #    AAK15272.1 [Other Products]
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 UniProt Primary Accession #    Q9BXQ0 [Other Products]
 UniProt Related Accession #    P21980 [Other Products]
 Molecular Weight    1,641 Da [Similar Products]
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 NCBI Official Full Name    tissue transglutaminase, partial
 NCBI Official Synonym Full Names    transglutaminase 2
 NCBI Official Symbol    TGM2 [Similar Products]
 NCBI Official Synonym Symbols   
TG2; TGC; GNAH; HEL-S-45; G-ALPHA-h
[Similar Products]
 NCBI Protein Information    protein-glutamine gamma-glutamyltransferase 2
 UniProt Protein Name    Tissue transglutaminase
 UniProt Synonym Protein Names   
Tissue transglutaminase
 Protein Family    Protein-glutamine gamma-glutamyltransferase
 UniProt Gene Name    TGM2 [Similar Products]
 UniProt Entry Name    Q9BXQ0_HUMAN
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 NCBI Summary for TGM2    Transglutaminases are enzymes that catalyze the crosslinking of proteins by epsilon-gamma glutamyl lysine isopeptide bonds. While the primary structure of transglutaminases is not conserved, they all have the same amino acid sequence at their active sites and their activity is calcium-dependent. The protein encoded by this gene acts as a monomer, is induced by retinoic acid, and appears to be involved in apoptosis. Finally, the encoded protein is the autoantigen implicated in celiac disease. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
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 UniProt Comments for TGM2    TGM2: an enzyme of the transglutaminase family that catalyzes the crosslinking of proteins and the conjugation of polyamines to proteins. While the primary structure of transglutaminases is not conserved, they all have the same amino acid sequence at their active sites and their activity is calcium-dependent. The protein encoded by this gene acts as a monomer, is induced by retinoic acid, and appears to be involved in apoptosis. . Is the autoantigen in coeliac disease and plays a role in apoptosis, cellular differentiation and matrix stabilisation. Three alternatively spliced isoforms have been described.

Protein type: EC 2.3.2.13; Transferase

Chromosomal Location of Human Ortholog: 20q12

Cellular Component: focal adhesion; mitochondrion; plasma membrane; cytosol

Molecular Function: protein domain specific binding; protein binding; GTP binding; protein-glutamine gamma-glutamyltransferase activity; metal ion binding

Biological Process: elevation of cytosolic calcium ion concentration during G-protein signaling, coupled to IP3 second messenger (phospholipase C activating); positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of cell adhesion; positive regulation of apoptosis; isopeptide cross-linking via N6-(L-isoglutamyl)-L-lysine; reduction of endoplasmic reticulum calcium ion concentration; positive regulation of smooth muscle cell proliferation; blood vessel remodeling; apoptotic cell clearance; protein homooligomerization; positive regulation of inflammatory response; elevation of mitochondrial calcium ion concentration
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 Research Articles on TGM2    1. our results show, for the first time, that eEF-2K is involved in regulation of the invasive phenotype of PaCa cells through promoting a new signalling pathway, which is mediated by TG2/b1 integrin/Src/uPAR/MMP-2
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with TGM2 recombinant proteinOrgans/Tissues associated with TGM2 recombinant protein
 Products by Pathway  Pathway Diagram
 Huntington's Disease Pathway antibodies  Huntington's Disease Pathway Diagram
 Huntington's Disease Pathway antibodies  Huntington's Disease Pathway Diagram
 Thromboxane A2 Receptor Signaling Pathway antibodies  Thromboxane A2 Receptor Signaling Pathway Diagram
 Organ/Tissue Name  Pubmed Publications
 Lung Antibodies  >11 publications with TGM2 and Lung
 Brain Antibodies  >11 publications with TGM2 and Brain
 Liver Antibodies  >10 publications with TGM2 and Liver
 Blood Antibodies  >10 publications with TGM2 and Blood
 Bone Antibodies  >8 publications with TGM2 and Bone
 Eye Antibodies  >7 publications with TGM2 and Eye
 Skin Antibodies  >7 publications with TGM2 and Skin
 Vascular Antibodies  >6 publications with TGM2 and Vascular
 Connective Tissue Antibodies  >5 publications with TGM2 and Connective Tissue
 Bone Marrow Antibodies  >5 publications with TGM2 and Bone Marrow
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