Antibody Protein ELISA Kit from MyBioSource header Telephone 1.858.633.0165          
1.855.MyBioSource
Fax 1.858.633.0166    Email sales@mybiosource.com 
tel/fax
menu1 Home Products Ordering Company Help menu7
bottom
   MyBioSource rightarrow Recombinant Protein rightarrow TLR8  rightarrow LOG IN  rightarrow MY ACCOUNT  rightarrow CART CONTENTS  rightarrow CHECKOUT 
horiz bar
MyBioSource Menu separator
separator
ELISA Kit ELISA Kit
CLIA Kit CLIA Kit
PCR Kit PCR Kit
Monoclonal Antibody Monoclonal Antibody
Polyclonal Antibody Polyclonal Antibody
Secondary Antibody Secondary Antibody
Antigen Antigen
Biochemical Biochemical
cDNA Clone cDNA Clone
siRNA siRNA
Peptide Peptide
Recombinant/Purified Protein Rec./Purified Protein

Custom ELISA Kit Custom ELISA Kit
Custom Protein Custom Protein
Custom Antibody Custom Antibody
Antibody Matched Pairs Antibody Matched Pairs
Antibody & Corresponding Blocking Peptide Pairs Antibody Peptide Pairs
Phospho-Specific Antibodies Phospho Antibodies
Products by Disease Products by Disease
Products by Pathway Products by Pathway
Products by Tissue Products by Tissue

arrow Advanced Search
arrow Submit Technical Q&A
arrow International Distributors
arrow Contact Us
separator
Our Best Sellers moreseparator
separator
 • Apolipoprotein CIII (Apo CIII) Antibody
 • Alpha Fetoprotein, Ig Fraction- F(ab)'2 Fragment (AFP) Antibody
 • 4-Hydroxyphenylpyruvate Dioxygenase (HPD) ELISA Kit
 • CD8 ELISA Kit
 • Uncharacterized protein yjbL (yjbL) Recombinant Protein
 • CITED4 Antibody
 • Aquaporin 2 (AQP2) Antibody
 • Salmonellae sp. Antibody
 • TNFRSF17 Recombinant Protein
 • DACH1 cDNA Clone
 • Early growth response protein 3 (Egr3) Recombinant Protein
 • ATM Antibody
 • Cholera Toxin beta subunit Antibody
 • KCND2 cDNA Clone
 downarrow more ...
separator
separator
DatasheetFull DatasheetPrinter Friendly DatasheetPrint This DatasheetAdd to Compare ListHave Questions? Ask UsRequest for a Quotation today

TLR8 recombinant protein :: Toll Like Receptor 8 (TLR8) Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS2009495 (SPECIAL PROMOTION: Get FREE $5 Starbucks gift card (Maximum 5 gift cards/product). Gift card(s) will be included with shipment)
Unit / Price
0.01 mg  /  $130 +1 FREE 8GB USB
0.05 mg  /  $225 +1 FREE 8GB USB
0.1 mg  /  $340 +1 FREE 8GB USB
0.2 mg  /  $415 +1 FREE 8GB USB
0.5 mg  /  $800 +1 FREE 8GB USB
1 mg  /  $1,180 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Toll Like Receptor 8 (TLR8), Recombinant Protein

★Popular Item★
 Also Known As   

Recombinant Toll Like Receptor 8 (TLR8)

 Product Gene Name   

TLR8 recombinant protein

[Similar Products]
 Matching Pairs    Antibody: Toll Like Receptor 8 (TLR8) (MBS2007048)
Antigen: Toll Like Receptor 8 (TLR8) (MBS2009495)
 Matching Pairs    Antibody: Toll Like Receptor 8 (TLR8) (MBS2085923)
Antigen: Toll Like Receptor 8 (TLR8) (MBS2009495)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
Table BarTOPTable Bar
 Chromosome Location    Chromosome: X; NC_000023.10 (12924739..12941288). Location: Xp22
 OMIM    300366
 3D Structure    ModBase 3D Structure for Q9NR97
Section Bar
 Host    E.coli
 Species Reactivity    Human
Section Bar
 Purity/Purification    > 95%
 Form/Format    PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
 Concentration    Original Concentration: 200@g/mL (lot specific)
Section Bar
 Source    Prokaryotic expression
 Tags    N-terminal His Tag
 Tissue Specificity    Membrane
 Traits    Freeze-dried powder
 Predicted isoelectric point    6.1
 Predicted Molecular Mass    30.0kDa
 Accurate Molecular Mass    29kDa as determined by SDS-PAGE reducing conditions
 Usage    Reconstitute in PBS (pH7.4) to a concentration of 0.1-1.0 mg/mL. Do not vortex.
Section Bar
 Preparation and Storage    Storage: Avoid repeated freeze/thaw cycles.
Store at 2-8C for one month.
Aliquot and store at -80C for 12 months.
Stability Test: The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.
 ISO Certification    Manufactured in an ISO 9001:2015 and ISO 13485:2016 Certified Laboratory.
 Supply Chain Verification    Manufactured in a lab with traceable raw materials manufactured on site. Coordinated product portfolio of antibodies, pairs, conjugates, recombinant proteins, and immunoassay materials available. Please inquire.
 Other Notes    Small volumes of TLR8 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Table BarTOPTable Bar
 Applications Tested/Suitable for TLR8 recombinant protein   

Positive Control, Immunogen, SDS-PAGE, WB
(May be suitable for use in other assays to be determined by the end user.)

Section Bar
 Sequence of TLR8 recombinant protein    TLR8 recombinant protein Sequence image
Section Bar
 SDS-PAGE of TLR8 recombinant protein    TLR8 recombinant protein SDS-PAGE image
Table BarTOPTable Bar
NCBI/Uniprot data below describe general gene information for TLR8. It may not necessarily be applicable to this product.
 NCBI GI #    20302168
 NCBI GeneID    51311
 NCBI Accession #    NP_619542.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_138636.5 [Other Products]
Section Bar
 UniProt Primary Accession #    Q9NR97 [Other Products]
 UniProt Secondary Accession #    Q495P4; Q6UXL6; Q9NYG9; B3Y654; D1CS70; D1CS76 [Other Products]
 UniProt Related Accession #    Q9NR97 [Other Products]
Table BarTOPTable Bar
 NCBI Official Full Name    toll-like receptor 8
 NCBI Official Synonym Full Names    toll-like receptor 8
 NCBI Official Symbol    TLR8 [Similar Products]
 NCBI Official Synonym Symbols   
CD288
[Similar Products]
 NCBI Protein Information    toll-like receptor 8
 UniProt Protein Name    Toll-like receptor 8
 Protein Family    Toll-like receptor
 UniProt Gene Name    TLR8 [Similar Products]
 UniProt Entry Name    TLR8_HUMAN
Section Bar
 NCBI Summary for TLR8    The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This gene is predominantly expressed in lung and peripheral blood leukocytes, and lies in close proximity to another family member, TLR7, on chromosome X. [provided by RefSeq, Jul 2008]
Section Bar
 UniProt Comments for TLR8    TLR8: Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Belongs to the Toll-like receptor family.

Protein type: Membrane protein, integral; Receptor, misc.

Chromosomal Location of Human Ortholog: Xp22

Cellular Component: Golgi membrane; endoplasmic reticulum membrane; integral to membrane; endosome membrane

Molecular Function: single-stranded RNA binding; DNA binding; RNA binding; double-stranded RNA binding; drug binding; receptor activity

Biological Process: I-kappaB kinase/NF-kappaB cascade; regulation of cytokine secretion; response to virus; microglial cell activation; positive regulation of interleukin-8 biosynthetic process; positive regulation of interferon-alpha biosynthetic process; toll-like receptor 8 signaling pathway; MyD88-dependent toll-like receptor signaling pathway; positive regulation of interferon-beta biosynthetic process; positive regulation of innate immune response; toll-like receptor signaling pathway; innate immune response; immunoglobulin mediated immune response; toll-like receptor 9 signaling pathway; inflammatory response; defense response to virus; positive regulation of interferon-gamma biosynthetic process
Table BarTOPTable Bar
 Research Articles on TLR8    1. Data indicate that TLR-induced IL-1beta overproduction in FANCA- and FANCC-deficient mononuclear phagocyte cell lines and primary cells requires activation of the inflammasome.
Table BarTOPTable Bar
 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Table BarTOPTable Bar
Products associated with TLR8 recombinant proteinPathways associated with TLR8 recombinant protein
 Reference Product  PubMed Publications
 TLR7 recombinant protein  >399 publications with TLR8 and TLR7
 TLR9 recombinant protein  >203 publications with TLR8 and TLR9
 TLR3 recombinant protein  >203 publications with TLR8 and TLR3
 MYD88 recombinant protein  >60 publications with TLR8 and MYD88
 CD40 recombinant protein  >16 publications with TLR8 and CD40
 UNC93B1 recombinant protein  >7 publications with TLR8 and UNC93B1
 Products by Pathway  Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram
 Innate Immune System Pathway antibodies  Innate Immune System Pathway Diagram
 MyD88 Dependent Cascade Initiated On Endosome Pathway antibodies  MyD88 Dependent Cascade Initiated On Endosome Pathway Diagram
 Regulation Of Toll-like Receptor Signaling Pathway antibodies  Regulation Of Toll-like Receptor Signaling Pathway Diagram
 TRAF6 Mediated IRF7 Activation In TLR7/8 Or 9 Signaling Pathway antibodies  TRAF6 Mediated IRF7 Activation In TLR7/8 Or 9 Signaling Pathway Diagram
 TRAF6 Mediated Induction Of NFkB And MAP Kinases Upon TLR7/8 Or 9 Activation Pathway antibodies  TRAF6 Mediated Induction Of NFkB And MAP Kinases Upon TLR7/8 Or 9 Activation Pathway Diagram
 Toll Like Receptor 7/8 (TLR7/8) Cascade Pathway antibodies  Toll Like Receptor 7/8 (TLR7/8) Cascade Pathway Diagram
 Toll Like Receptor 9 (TLR9) Cascade Pathway antibodies  Toll Like Receptor 9 (TLR9) Cascade Pathway Diagram
 Toll-Like Receptors Cascades Pathway antibodies  Toll-Like Receptors Cascades Pathway Diagram
 Toll-like Receptor Signaling Pathway antibodies  Toll-like Receptor Signaling Pathway Diagram
Diseases associated with TLR8 recombinant proteinOrgans/Tissues associated with TLR8 recombinant protein
 Disease Name  Pubmed Publications
 Immune System Diseases Antibodies  >95 publications with TLR8 and Immune System Diseases
 Inflammation Antibodies  >94 publications with TLR8 and Inflammation
 Necrosis Antibodies  >79 publications with TLR8 and Necrosis
 Neoplasms Antibodies  >56 publications with TLR8 and Neoplasms
 Skin Diseases Antibodies  >23 publications with TLR8 and Skin Diseases
 Lung Diseases Antibodies  >19 publications with TLR8 and Lung Diseases
 Brain Diseases Antibodies  >9 publications with TLR8 and Brain Diseases
 Skin Neoplasms Antibodies  >9 publications with TLR8 and Skin Neoplasms
 Lung Neoplasms Antibodies  >8 publications with TLR8 and Lung Neoplasms
 Kidney Diseases Antibodies  >8 publications with TLR8 and Kidney Diseases
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >268 publications with TLR8 and Blood
 Lung Antibodies  >33 publications with TLR8 and Lung
 Spleen Antibodies  >24 publications with TLR8 and Spleen
 Kidney Antibodies  >19 publications with TLR8 and Kidney
 Brain Antibodies  >19 publications with TLR8 and Brain
 Intestine Antibodies  >15 publications with TLR8 and Intestine
 Vascular Antibodies  >9 publications with TLR8 and Vascular
 Uterus Antibodies  >6 publications with TLR8 and Uterus
 Placenta Antibodies  >4 publications with TLR8 and Placenta
 Connective Tissue Antibodies  >3 publications with TLR8 and Connective Tissue
Table BarTOPTable Bar
horiz bar
 SSL   Follow us on Facebook Follow us onTwitter Follow us on Google Plus Connect us on LinkedIn Subscribe to our RSS Feed for latest products and special promotions