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TLR4 recombinant protein :: Toll-like receptor 4 (TLR4) Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS956975 TLR4 recombinant protein
Unit / Price
1 mg (E-Coli)  /  $2,310 +2 FREE 8GB USB
1 mg (Yeast)  /  $2,770 +3 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Toll-like receptor 4 (TLR4), Recombinant Protein

 Also Known As   

Recombinant Cat Toll-like receptor 4 (TLR4)

 Product Gene Name   

TLR4 recombinant protein

[Similar Products]
 Product Synonym Gene Name    Recombinant Toll-like receptor 4 (TLR4); Toll-like receptor 4; CD_antigen= CD284 [Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence Positions    24-632
 Sequence    ESWDPCVEVV PNITYQCMDL NLHKIPDNIP SSTKDLDMSF NPLRNLGSHS FSNFPELQVL DLSRCEIQII EDDAYQGLNH LSILILTGNP IQRLFPGAFS GLSSLQTLVA VETNIASLED FPIGHLKTLK ELNVAHNLIH SFKLPEYFSN MSNLEYLDLS NNKIQNIYHK DLQVLHQKPL LNLSLDLSLN PLDFIQPGAF KEVKLRELTL RSNFNSTDVM KASIQGLAGL QIHQLVLGEF KNERNLGRFD KSILEGLCNL IIEKFRIAYF DKFSEDAIDS FNCLANVSTI SLVHLYFKGL KQLPKNLGWQ RLELVNCEFE QFPTWKLDPL KELVFSANEV RNAFTQVKLE SLEFLDLSRN DFSLKSCCSE RDLGTTRLKH LDLSFNNIIT ISSNFLGLEQ LEYLDFQHSS LKQVSDFSVF LPLKNLRYLD ISYTHTQVAF HGIFNGLISL QILKMAGNSF QDNFLPNIFM ELTNLTILDL SDCQLEQVSQ VAFNSLPKLQ LLNMSHNHLL SLDTLPYEPL HSLQTLDCSF NRIVASKEQE LRHFPSNLSS LNLTRNDFAC VCEHQSFLQW VKDQRQLLVE VEQMVCAKPL DMQGMPMLNF RNATCQVRK
 3D Structure    ModBase 3D Structure for P58727
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 Host    E Coli or Yeast or Baculovirus or Mammalian Cell
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 Purity/Purification    >90%
 Form/Format    Liquid containing glycerol; lyophilization may be available upon request.
 Tag Information    This protein contains an N-terminal tag and may also contain a C-terminal Myc-tag. N-terminal host tags may vary (His, His-SUMO, His-B2M, GST). Tag types are determined by various factors including tag-protein stability and, therefore, are subject to change; please inquire for tag information. Additional charge for Tag removal. Tag removal service standardly refers to removal of N-terminal Tag. Any C-terminal Myc-tag may remain intact unless removal of the C-terminal Myc-tag is specifically requested. In most cases tags can be successfully removed. If the lab concludes the protein is no longer stable after tag removal then your protein will be supplied with the tag intact, and you will not be charged for tag removal service.
 Sterility    Sterile filter available upon request.
 Endotoxin    Low endotoxin available upon request.
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 Species    Felis catus (Cat) (Felis silvestris catus)
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 Preparation and Storage    Store at -20 degree C. For extended storage, store at -20 or -80 degree C.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of TLR4 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for TLR4 recombinant protein

   TLR4
NCBI/Uniprot data below describe general gene information for TLR4. It may not necessarily be applicable to this product.
 NCBI GI #    57163761
 NCBI GeneID    493698
 NCBI Accession #    NP_001009223.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001009223.1 [Other Products]
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 UniProt Primary Accession #    P58727 [Other Products]
 UniProt Related Accession #    P58727 [Other Products]
 Molecular Weight    95,592 Da [Similar Products]
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 NCBI Official Full Name    toll-like receptor 4
 NCBI Official Symbol    TLR4 [Similar Products]
 NCBI Protein Information    toll-like receptor 4
 UniProt Protein Name    Toll-like receptor 4
 Protein Family    Toll-like receptor
 UniProt Gene Name    TLR4 [Similar Products]
 UniProt Entry Name    TLR4_FELCA
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 UniProt Comments for TLR4    Function: Cooperates with LY96 and CD14 to mediate the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MYD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response

By similarity.

Subunit structure: Belongs to the lipopolysaccharide (LPS) receptor, a multi-protein complex containing at least CD14, LY96 and TLR4. Binding to bacterial LPS leads to homodimerization. Interacts with LY96 via the extracellular domain. Interacts with MYD88 and TIRAP via their respective TIR domains. Interacts with NOX4

By similarity. Interacts with CNPY3 and HSP90B1; this interaction is required for proper folding in the endoplasmic reticulum. Interacts with MLK4; this interaction leads to negative regulation of TLR4 signaling

By similarity.

Subcellular location: Membrane; Single-pass type I membrane protein

By similarity.

Domain: The TIR domain mediates interaction with NOX4

By similarity.

Sequence similarities: Belongs to the Toll-like receptor family.Contains 17 LRR (leucine-rich) repeats.Contains 1 LRRCT domain.Contains 1 LRRNT domain.Contains 1 TIR domain.
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 Research Articles on TLR4    1. The overexpression of TLR-2 and TLR-4 mRNAs in stimulated feline PMNs suggests that these receptors are involved in the host immune response through the recognition of M. canis pathogen associated molecular patterns.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with TLR4 recombinant proteinPathways associated with TLR4 recombinant protein
 Reference Product  PubMed Publications
 FLNA recombinant protein  >12 publications with TLR4 and FLNA
 Products by Pathway  Pathway Diagram
 Focal Adhesion Pathway antibodies  Focal Adhesion Pathway Diagram
 Focal Adhesion Pathway antibodies  Focal Adhesion Pathway Diagram
 MAPK Signaling Pathway antibodies  MAPK Signaling Pathway Diagram
 MAPK Signaling Pathway antibodies  MAPK Signaling Pathway Diagram
 Salmonella Infection Pathway antibodies  Salmonella Infection Pathway Diagram
 Salmonella Infection Pathway antibodies  Salmonella Infection Pathway Diagram
Diseases associated with TLR4 recombinant protein
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >2467 publications with TLR4 and Inflammation
 Necrosis Antibodies  >1812 publications with TLR4 and Necrosis
 Sepsis Antibodies  >577 publications with TLR4 and Sepsis
 Cardiovascular Diseases Antibodies  >576 publications with TLR4 and Cardiovascular Diseases
 Disease Models, Animal Antibodies  >570 publications with TLR4 and Disease Models, Animal
 Vascular Diseases Antibodies  >506 publications with TLR4 and Vascular Diseases
 Lung Diseases Antibodies  >469 publications with TLR4 and Lung Diseases
 Neoplasms Antibodies  >395 publications with TLR4 and Neoplasms
 Intestinal Diseases Antibodies  >367 publications with TLR4 and Intestinal Diseases
 Nervous System Diseases Antibodies  >318 publications with TLR4 and Nervous System Diseases
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