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Tlr7 recombinant protein :: Toll-like receptor 7 Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS951025
SDS-PAGE
Unit / Price
0.01 mg (E-Coli)  /  $195 +1 FREE 8GB USB
0.05 mg (E-Coli)  /  $255 +1 FREE 8GB USB
0.01 mg (Mammalian-Cell)  /  $315 +1 FREE 8GB USB
0.1 mg (E-Coli)  /  $420 +1 FREE 8GB USB
0.02 mg (Mammalian-Cell)  /  $485 +1 FREE 8GB USB
0.2 mg (E-Coli)  /  $665 +1 FREE 8GB USB
0.05 mg (Yeast)  /  $850 +1 FREE 8GB USB
0.05 mg (Mammalian-Cell)  /  $940 +1 FREE 8GB USB
0.05 mg (Baculovirus)  /  $995 +1 FREE 8GB USB
0.5 mg (E-Coli)  /  $1,090 +1 FREE 8GB USB
0.2 mg (Yeast)  /  $1,145 +1 FREE 8GB USB
0.1 mg (Baculovirus)  /  $1,250 +1 FREE 8GB USB
0.5 mg (Yeast)  /  $1,295 +1 FREE 8GB USB
0.1 mg (Mammalian-Cell)  /  $1,300 +1 FREE 8GB USB
1 mg (E-Coli)  /  $1,725 +2 FREE 8GB USB
0.5 mg (Baculovirus)  /  $1,805 +2 FREE 8GB USB
1 mg (Yeast)  /  $1,970 +2 FREE 8GB USB
1 mg (Baculovirus)  /  $2,400 +3 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Toll-like receptor 7 (Tlr7), Recombinant Protein

★Popular Item★
 Also Known As   

Recombinant Mouse Toll-like receptor 7

 Product Gene Name   

Tlr7 recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 MBS951025 COA    COA PDF
 Sequence Positions    27-348. Provide the fragment of the extracellular domain at the N-terminal.
 Sequence    FRWFPKTLPC EVKVNIPEAH VIVDCTDKHL TEIPEGIPTN TTNLTLTINH IPSISPDSFR RLNHLEEIDL RCNCVPVLLG SKANVCTKRL QIRPGSFSGL SDLKALYLDG NQLLEIPQDL PSSLHLLSLE ANNIFSITKE NLTELVNIET LYLGQNCYYR NPCNVSYSIE KDAFLVMRNL KVLSLKDNNV TAVPTTLPPN LLELYLYNNI IKKIQENDFN NLNELQVLDL SGNCPRCYNV PYPCTPCENN SPLQIHDNAF NSLTELKVLR LHSNSLQHVP PTWFKNMRNL QELDLSQNYL AREIEEAKFL HFLPNLVELD FS
 3D Structure    ModBase 3D Structure for P58681
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 Host    E Coli or Yeast or Baculovirus or Mammalian Cell
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 Purity/Purification    Greater than 90% as determined by SDS-PAGE. (lot specific)
 Form/Format    Liquid containing glycerol
 Tag Information    This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
 Sterility    Sterile filter available upon request.
 Endotoxin    Low endotoxin available upon request.
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 Preparation and Storage    Store at -20 degree C, for extended storage, conserve at -20 degree C or -80 degree C.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of Tlr7 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for Tlr7 recombinant protein

   Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. TLR7 is a nucleotide-sensing TLR which is activated by single-stranded RNA. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response.
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 SDS-PAGE of Tlr7 recombinant protein    Tlr7 recombinant protein SDS-PAGE image
(Note: Representative image, actual molecular weight may vary depending on Tag type and expression host)
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NCBI/Uniprot data below describe general gene information for Tlr7. It may not necessarily be applicable to this product.
 NCBI GI #    595582289
 NCBI GeneID    170743
 NCBI Accession #    NP_001277684.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001290755.1 [Other Products]
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 UniProt Primary Accession #    P58681 [Other Products]
 UniProt Secondary Accession #    Q923I1 [Other Products]
 UniProt Related Accession #    P58681 [Other Products]
 Molecular Weight    64.2kD
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 NCBI Official Full Name    toll-like receptor 7 isoform a
 NCBI Official Synonym Full Names    toll-like receptor 7
 NCBI Official Symbol    Tlr7 [Similar Products]
 NCBI Protein Information    toll-like receptor 7
 UniProt Protein Name    Toll-like receptor 7
 Protein Family    Toll-like receptor
 UniProt Gene Name    Tlr7 [Similar Products]
 UniProt Entry Name    TLR7_MOUSE
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 UniProt Comments for Tlr7    TLR7: Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. TLR7 is a nucleotide-sensing TLR which is activated by single-stranded RNA. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Interacts with MYD88 via their respective TIR domains. Interacts with UNC93B1. Detected in brain, placenta, spleen, stomach, small intestine, lung and in plasmacytoid pre-dendritic cells. Belongs to the Toll-like receptor family.

Protein type: Membrane protein, integral

Cellular Component: cytoplasm; cytoplasmic vesicle; endoplasmic reticulum; endosome; integral to membrane; lysosome; membrane; plasma membrane; receptor complex

Molecular Function: double-stranded RNA binding; drug binding; protein binding; single-stranded RNA binding; siRNA binding; transmembrane receptor activity

Biological Process: defense response to virus; I-kappaB phosphorylation; immune response; immune system process; inflammatory response; innate immune response; microglial cell activation; MyD88-dependent toll-like receptor signaling pathway; positive regulation of chemokine production; positive regulation of interferon-alpha biosynthetic process; positive regulation of interferon-beta biosynthetic process; positive regulation of interferon-gamma biosynthetic process; positive regulation of interleukin-6 production; positive regulation of interleukin-8 biosynthetic process; positive regulation of interleukin-8 production; positive regulation of NF-kappaB import into nucleus; regulation of protein amino acid phosphorylation; signal transduction; toll-like receptor 7 signaling pathway; toll-like receptor signaling pathway
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Product References and Citations for Tlr7 recombinant protein

   Molecular cloning of murine Toll-like receptor 7.Heil F.J., Lipford G.B., Wagner H., Bauer S.M. Innate antiviral responses by means of TLR7-mediated recognition of single-stranded RNA.Diebold S.S., Kaisho T., Hemmi H., Akira S., Reis e Sousa C.Science 303:1529-1531(2004) The interaction between the ER membrane protein UNC93B and TLR3, 7, and 9 is crucial for TLR signaling.Brinkmann M.M., Spooner E., Hoebe K., Beutler B., Ploegh H.L., Kim Y.M.J. Cell Biol. 177:265-275(2007) UNC93B1 delivers nucleotide-sensing toll-like receptors to endolysosomes.Kim Y.M., Brinkmann M.M., Paquet M.E., Ploegh H.L.Nature 452:234-238(2008)
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 Research Articles on Tlr7    1. Our data show that TLR7 excess influences the selection, expansion and diversification of B cells in the germinal center, independent of other genes in the Yaa locus.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with Tlr7 recombinant proteinPathways associated with Tlr7 recombinant protein
 Reference Product  PubMed Publications
 Tlr9 recombinant protein  >813 publications with Tlr7 and Tlr9
 Tlr3 recombinant protein  >595 publications with Tlr7 and Tlr3
 Tlr8 recombinant protein  >500 publications with Tlr7 and Tlr8
 Myd88 recombinant protein  >279 publications with Tlr7 and Myd88
 Unc93b1 recombinant protein  >35 publications with Tlr7 and Unc93b1
 Ctss recombinant protein  >2 publications with Tlr7 and Ctss
 Products by Pathway  Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram
 Influenza A Pathway antibodies  Influenza A Pathway Diagram
 Influenza A Pathway antibodies  Influenza A Pathway Diagram
 Innate Immune System Pathway antibodies  Innate Immune System Pathway Diagram
 Measles Pathway antibodies  Measles Pathway Diagram
 Measles Pathway antibodies  Measles Pathway Diagram
 MyD88 Dependent Cascade Initiated On Endosome Pathway antibodies  MyD88 Dependent Cascade Initiated On Endosome Pathway Diagram
 TRAF6 Mediated IRF7 Activation In TLR7/8 Or 9 Signaling Pathway antibodies  TRAF6 Mediated IRF7 Activation In TLR7/8 Or 9 Signaling Pathway Diagram
 TRAF6 Mediated Induction Of NFkB And MAP Kinases Upon TLR7/8 Or 9 Activation Pathway antibodies  TRAF6 Mediated Induction Of NFkB And MAP Kinases Upon TLR7/8 Or 9 Activation Pathway Diagram
 Toll Like Receptor 7/8 (TLR7/8) Cascade Pathway antibodies  Toll Like Receptor 7/8 (TLR7/8) Cascade Pathway Diagram
Diseases associated with Tlr7 recombinant proteinOrgans/Tissues associated with Tlr7 recombinant protein
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >395 publications with Tlr7 and Inflammation
 Necrosis Antibodies  >233 publications with Tlr7 and Necrosis
 Disease Models, Animal Antibodies  >171 publications with Tlr7 and Disease Models, Animal
 Skin Diseases Antibodies  >114 publications with Tlr7 and Skin Diseases
 Lung Diseases Antibodies  >94 publications with Tlr7 and Lung Diseases
 Liver Diseases Antibodies  >85 publications with Tlr7 and Liver Diseases
 Nervous System Diseases Antibodies  >77 publications with Tlr7 and Nervous System Diseases
 Hypersensitivity Antibodies  >77 publications with Tlr7 and Hypersensitivity
 Kidney Diseases Antibodies  >47 publications with Tlr7 and Kidney Diseases
 Cardiovascular Diseases Antibodies  >34 publications with Tlr7 and Cardiovascular Diseases
 Organ/Tissue Name  Pubmed Publications
 Skin Antibodies  >142 publications with Tlr7 and Skin
 Spleen Antibodies  >124 publications with Tlr7 and Spleen
 Bone Antibodies  >120 publications with Tlr7 and Bone
 Lymph Node Antibodies  >88 publications with Tlr7 and Lymph Node
 Kidney Antibodies  >74 publications with Tlr7 and Kidney
 Embryonic Tissue Antibodies  >15 publications with Tlr7 and Embryonic Tissue
 Eye Antibodies  >13 publications with Tlr7 and Eye
 Thymus Antibodies  >12 publications with Tlr7 and Thymus
 Uncharacterized Tissue Antibodies  >1 publications with Tlr7 and Uncharacterized Tissue
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