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BZLF1 recombinant protein :: Trans-activator protein BZLF1 Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS1146552
SDS-Page
Unit / Price
0.05 mg (E-Coli)  /  $190 +1 FREE 8GB USB
0.2 mg (E-Coli)  /  $460 +1 FREE 8GB USB
0.5 mg (E-Coli)  /  $750 +1 FREE 8GB USB
0.05 mg (Baculovirus)  /  $995 +1 FREE 8GB USB
1 mg (E-Coli)  /  $1,180 +1 FREE 8GB USB
0.5 mg (Yeast)  /  $1,225 +1 FREE 8GB USB
0.05 mg (Mammalian-Cell)  /  $1,225 +1 FREE 8GB USB
0.1 mg (Baculovirus)  /  $1,520 +1 FREE 8GB USB
1 mg (Yeast)  /  $1,985 +2 FREE 8GB USB
0.1 mg (Mammalian-Cell)  /  $1,985 +2 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Trans-activator protein BZLF1, Recombinant Protein

 Also Known As   

Recombinant Trans-activator protein BZLF1

 Product Synonym Names    Zebra
 Product Gene Name   

BZLF1 recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence Positions    1-245
 Sequence    MMDPNSTSED VKFTPDPYQV PFVQAFDQAT RVYQDLGGPS QAPLPCVLWP VLPEPLPQGQ LTAYHVSTAP TGSWFSAPQP APENAYQAYA APQLFPVSDI TQNQQTNQAG GEAPQPGDNS TVQTAAAVVF ACPGANQGQQ LADIGVPQPA PVAAPARRTR KPQQPESLEE CDSELEIKRY KNRVASRKCR AKFKQLLQHY REVAAAKSSE NDRLRLLLKQ MCPSLDVDSI IPRTPDVLHE DLLNF
 3D Structure    ModBase 3D Structure for P03206
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 Host    E Coli or Yeast or Baculovirus or Mammalian Cell
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 Purity/Purification    Greater than 90% as determined by SDS-PAGE.
 Form/Format    Liquid containing glycerol; lyophilization may be available upon request.
 Tag Information    This protein contains an N-terminal tag and may also contain a C-terminal Myc-tag. N-terminal host tags may vary (His, His-SUMO, His-B2M, GST). Tag types are determined by various factors including tag-protein stability and, therefore, are subject to change; please inquire for tag information. Additional charge for Tag removal. Tag removal service standardly refers to removal of N-terminal Tag. Any C-terminal Myc-tag may remain intact unless removal of the C-terminal Myc-tag is specifically requested. In most cases tags can be successfully removed. If the lab concludes the protein is no longer stable after tag removal then your protein will be supplied with the tag intact, and you will not be charged for tag removal service.
 Sterility    Sterile filter available upon request.
 Endotoxin    Low endotoxin available upon request.
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 Preparation and Storage    Store at -20 degree C, for extended storage, conserve at -20 degree C or -80 degree C.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of BZLF1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for BZLF1 recombinant protein

   Plays a key role in the switch from latent infection to lytic cycle producing new virions. Acts as a transcription factor, inducing early lytic cycle genes, and as a origin binding protein for genome replication. BZLF1 activates the promoter of another EBV gene (BSLF2+BMLF1).
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 SDS-Page of BZLF1 recombinant protein    BZLF1 recombinant protein SDS-Page image
(Note: Representative image, actual molecular weight may vary depending on Tag type and expression host)
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NCBI/Uniprot data below describe general gene information for BZLF1. It may not necessarily be applicable to this product.
 NCBI GI #    82503229
 NCBI GeneID    3783744
 NCBI Accession #    YP_401673.1 [Other Products]
 NCBI GenBank Nucleotide #    NC_007605.1 [Other Products]
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 UniProt Primary Accession #    P03206 [Other Products]
 UniProt Secondary Accession #    Q69127; Q777E5 [Other Products]
 UniProt Related Accession #    S03634 [Other Products]
 Molecular Weight    42.8kD
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 NCBI Official Full Name    BZLF1
 NCBI Official Symbol    BZLF1 [Similar Products]
 NCBI Protein Information    BZLF1
 UniProt Protein Name    Trans-activator protein BZLF1
 UniProt Synonym Protein Names   
Zebra
 Protein Family    Trans-activator protein
 UniProt Gene Name    BZLF1 [Similar Products]
 UniProt Synonym Gene Names    EB1 [Similar Products]
 UniProt Entry Name    BZLF1_EBVB9
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 UniProt Comments for BZLF1    Plays a key role in the switch from latent infection to lytic cycle producing new virions. Acts as a transcription factor, inducing early lytic cycle genes, and as a origin binding protein for genome replication. BZLF1 activates the promoter of another EBV gene (BSLF2+BMLF1).
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Product References and Citations for BZLF1 recombinant protein

   DNA sequence and expression of the B95-8 Epstein-Barr virus genome.Baer R., Bankier A.T., Biggin M.D., Deininger P.L., Farrell P.J., Gibson T.J., Hatfull G., Hudson G.S., Satchwell S.C., Seguin C., Tuffnell P.S., Barrell B.G.Nature 310:207-211(1984) Epstein-Barr virus gene expression in P3HR1-superinfected Raji cells.Biggin M., Bodescot M., Perricaudet M., Farrel P.J. Virol. 61:3120-3132(1987) Epstein-Barr virus BZLF1 trans-activator specifically binds to a consensus AP-1 site and is related to c-fos.Farrel P.J., Rowe D.T., Rooney C.M., Kouzarides T.EMBO J. 8:127-132(1989) Structure and function of the Epstein-Barr virus BZLF1 protein.Packham G., Economou A., Rooney C.M., Rowe D.T., Farrel P.J.J. Virol. 64:2110-2116(1990) The BZLF1 protein of EBV has a coiled coil dimerisation domain without a heptad leucine repeat but with homology to the C/EBP leucine zipper.Kouzarides T., Packham G., Cook A., Farrell P.J.Oncogene 6:195-204(1991) A transcription factor with homology to the AP-1 family links RNA transcription and DNA replication in the lytic cycle of Epstein-Barr virus.Schepers A., Pich D., Hammerschmidt W.EMBO J. 12:3921-3929(1993) The PKC targeting protein RACK1 interacts with the Epstein-Barr virus activator protein BZLF1.Baumann M., Gires O., Kolch W., Mischak H., Zeidler R., Pich D., Hammerschmidt W.Eur. J. Biochem. 267:3891-3901(2000) Ubinuclein, a novel nuclear protein interacting with cellular and viral transcription factors.Aho S., Buisson M., Pajunen T., Ryoo Y.W., Giot J.-F., Gruffat H., Sergeant A., Uitto J.J. Cell Biol. 148:1165-1176(2000) Epstein-Barr virus BZLF1 gene, a switch from latency to lytic infection, is expressed as an immediate-early gene after primary infection of B lymphocytes.Wen W., Iwakiri D., Yamamoto K., Maruo S., Kanda T., Takada K.J. Virol. 81:1037-1042(2007) TORC2, a coactivator of cAMP-response element-binding protein, promotes Epstein-Barr virus reactivation from latency through interaction with viral BZLF1 protein.Murata T., Sato Y., Nakayama S., Kudoh A., Iwahori S., Isomura H., Tajima M., Hishiki T., Ohshima T., Hijikata M., Shimotohno K., Tsurumi T.J. Biol. Chem. 284:8033-8041(2009) Interaction of Epstein-Barr virus BZLF1 C-terminal tail structure and core zipper is required for DNA replication but not for promoter transactivation.McDonald C.M., Petosa C., Farrell P.J.J. Virol. 83:3397-3401(2009) Structural basis of lytic cycle activation by the Epstein-Barr virus ZEBRA protein.Petosa C., Morand P., Baudin F., Moulin M., Artero J.B., Muller C.W.Mol. Cell 21:565-572(2006)
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 Research Articles on BZLF1    1. Rta autoregulates BRLF1 transcription via its interaction with USF1 on E1.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products related to Recombinant Trans-activator protein BZLF1
 Catalog #  Product Name  Catalog #  Product Name
 MBS1459739  Recombinant Epstein-Barr virus Trans-activator protein BZLF1 (BZLF1)  MBS1146552  Recombinant Trans-activator protein BZLF1
 MBS1306048  Recombinant Epstein-Barr virus Trans-activator protein BZLF1 (BZLF1)
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