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TEAD4 recombinant protein :: Transcriptional enhancer factor TEF-3 Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS1439777
SDS-Page
Unit / Price
0.05 mg (E-Coli)  /  $770 +1 FREE 8GB USB
0.05 mg (Yeast)  /  $885 +1 FREE 8GB USB
0.05 mg (Baculovirus)  /  $1,020 +1 FREE 8GB USB
0.2 mg (E-Coli)  /  $1,030 +1 FREE 8GB USB
0.5 mg (E-Coli)  /  $1,140 +1 FREE 8GB USB
0.2 mg (Yeast)  /  $1,190 +1 FREE 8GB USB
0.05 mg (Mammalian-Cell)  /  $1,265 +1 FREE 8GB USB
0.1 mg (Baculovirus)  /  $1,290 +1 FREE 8GB USB
0.5 mg (Yeast)  /  $1,345 +1 FREE 8GB USB
1 mg (E-Coli)  /  $1,615 +2 FREE 8GB USB
0.5 mg (Baculovirus)  /  $1,860 +2 FREE 8GB USB
0.1 mg (Mammalian-Cell)  /  $1,915 +2 FREE 8GB USB
1 mg (Yeast)  /  $2,050 +2 FREE 8GB USB
1 mg (Baculovirus)  /  $2,470 +3 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Transcriptional enhancer factor TEF-3 (TEAD4), Recombinant Protein

★Popular Item★
 Also Known As   

Recombinant Human Transcriptional enhancer factor TEF-3

 Product Synonym Names    TEA domain family member 4; TEAD-4; Transcription factor 13-like 1; Transcription factor RTEF-1
 Product Gene Name   

TEAD4 recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 MBS1439777 COA    COA PDF
 Sequence Positions    74-434aa; Partial
 Sequence    MYGRNELIAR YIKLRTGKTR TRKQVSSHIQ VLARRKAREI QAKLKDQAAK DKALQSMAAM SSAQIISATA FHSSMALARG PGRPAVSGFW QGALPGQAGT SHDVKPFSQQ TYAVQPPLPL PGFESPAGPA PSPSAPPAPP WQGRSVASSK LWMLEFSAFL EQQQDPDTYN KHLFVHIGQS SPSYSDPYLE AVDIRQIYDK FPEKKGGLKD LFERGPSNAF FLVKFWADLN TNIEDEGSSF YGVSSQYESP ENMIITCSTK VCSFGKQVVE KVETEYARYE NGHYSYRIHR SPLCEYMINF IHKLKHLPEK YMMNSVLENF TILQVVTNRD TQETLLCIAY VFEVSASEHG AQHHIYRLVK E
 OMIM    601714
 3D Structure    ModBase 3D Structure for Q15561
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 Host    E Coli or Yeast or Baculovirus or Mammalian Cell
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 Purity/Purification    Greater than 90% as determined by SDS-PAGE. (lot specific)
 Form/Format    Liquid containing glycerol
 Tag Information    This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
 Sterility    Sterile filter available upon request.
 Endotoxin    Low endotoxin available upon request.
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 Preparation and Storage    Store at -20 degree C, for extended storage, conserve at -20 degree C or -80 degree C.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of TEAD4 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for TEAD4 recombinant protein

   Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell proliferation, migration and epithelial mesenchymal transition (T) induction. Binds specifically and non-cooperatively to the Sph and GT-IIC 'enhansons' (5'-GTGGAATGT-3') and activates transcription. Binds to the M-CAT motif.
 Product Categories/Family for TEAD4 recombinant protein    Transcription
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 SDS-Page of TEAD4 recombinant protein    TEAD4 recombinant protein SDS-Page image
(Note: Representative image, actual molecular weight may vary depending on Tag type and expression host)
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NCBI/Uniprot data below describe general gene information for TEAD4. It may not necessarily be applicable to this product.
 NCBI GI #    46411152
 NCBI GeneID    7004
 NCBI Accession #    NP_003204.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_003213.3 [Other Products]
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 UniProt Primary Accession #    Q15561 [Other Products]
 UniProt Secondary Accession #    Q6MZR9; Q8NEV5; Q92883; Q96BK2; H0Y308 [Other Products]
 UniProt Related Accession #    Q15561 [Other Products]
 Molecular Weight    56.6kD
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 NCBI Official Full Name    transcriptional enhancer factor TEF-3 isoform 1
 NCBI Official Synonym Full Names    TEA domain transcription factor 4
 NCBI Official Symbol    TEAD4 [Similar Products]
 NCBI Official Synonym Symbols   
TEF3; RTEF1; TEF-3; EFTR-2; TEFR-1; TCF13L1; hRTEF-1B
[Similar Products]
 NCBI Protein Information    transcriptional enhancer factor TEF-3
 UniProt Protein Name    Transcriptional enhancer factor TEF-3
 UniProt Synonym Protein Names   
TEA domain family member 4; TEAD-4; Transcription factor 13-like 1; Transcription factor RTEF-1
 Protein Family    Transcriptional enhancer factor
 UniProt Gene Name    TEAD4 [Similar Products]
 UniProt Synonym Gene Names    RTEF1; TCF13L1; TEF3; TEAD-4 [Similar Products]
 UniProt Entry Name    TEAD4_HUMAN
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 NCBI Summary for TEAD4    This gene product is a member of the transcriptional enhancer factor (TEF) family of transcription factors, which contain the TEA/ATTS DNA-binding domain. It is preferentially expressed in the skeletal muscle, and binds to the M-CAT regulatory element found in promoters of muscle-specific genes to direct their gene expression. Alternatively spliced transcripts encoding distinct isoforms, some of which are translated through the use of a non-AUG (UUG) initiation codon, have been described for this gene. [provided by RefSeq, Jul 2008]
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 UniProt Comments for TEAD4    TEAD4: Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell proliferation, migration and epithelial mesenchymal transition (EMT) induction. Binds specifically and non-cooperatively to the Sph and GT-IIC 'enhansons' (5'-GTGGAATGT-3') and activates transcription. Binds to the M-CAT motif. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: DNA-binding; Transcription factor

Chromosomal Location of Human Ortholog: 12p13.3-p13.2

Cellular Component: nucleoplasm

Molecular Function: DNA binding; protein binding; transcription factor activity

Biological Process: gene expression; muscle development; positive regulation of defense response to virus by host; regulation of transcription from RNA polymerase II promoter; skeletal development; transcription initiation from RNA polymerase II promoter
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Product References and Citations for TEAD4 recombinant protein

   Cloning of human RTEF-1, a transcriptional enhancer factor-1-related gene preferentially expressed in skeletal muscle evidence for an ancient multigene family.Stewart A.F.R., Richard C.W. III, Suzow J., Stephan D., Weremowicz S., Morton C.C., Adra C.N.Genomics 37:68-76(1996) The full-ORF clone resource of the German cDNA consortium.Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I.BMC Genomics 8:399-399(2007) The finished DNA sequence of human chromosome 12.Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Montgomery K.T., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H., Draper H., Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S., Kelly S.H., Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J.H., Santibanez J., Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q., Williams G.A., Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V., Bailey M., Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E., Burkett C.E., Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K., Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D., Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M., Dathorne S.R., David R., Davis C.M., Davy-Carroll L., Deshazo D.R., Donlin J.E., D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J., Escotto M., Flagg N., Forbes L.D., Gabisi A.M., Garza M., Hamilton C., Henderson N., Hernandez O., Hines S., Hogues M.E., Huang M., Idlebird D.G., Johnson R., Jolivet A., Jones S., Kagan R., King L.M., Leal B., Lebow H., Lee S., LeVan J.M., Lewis L.C., London P., Lorensuhewa L.M., Loulseged H., Lovett D.A., Lucier A., Lucier R.L., Ma J., Madu R.C., Mapua P., Martindale A.D., Martinez E., Massey E., Mawhiney S., Meador M.G., Mendez S., Mercado C., Mercado I.C., Merritt C.E., Miner Z.L., Minja E., Mitchell T., Mohabbat F., Mohabbat K., Montgomery B., Moore N., Morris S., Munidasa M., Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O., Nwokenkwo S., Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J., Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A., Perrin W., Pickens A., Primus E.L., Pu L.-L., Puazo M., Quiles M.M., Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I., Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A., Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D., Trejos Z.Y., Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I., Vera V.A., Villasana D.M., Wang L., Ward-Moore S., Warren J.T., Wei X., White F., Williamson A.L., Wleczyk R., Wooden H.S., Wooden S.H., Yen J., Yoon L., Yoon V., Zorrilla S.E., Nelson D., Kucherlapati R., Weinstock G., Gibbs R.A.Nature 440:346-351(2006) Mural R.J., Istrail S., Sutton G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. A novel family of developmentally regulated mammalian transcription factors containing the TEA/ATTS DNA binding domain.Jacquemin P., Hwang J.-J., Martial J.A., Dolle P., Davidson I.J. Biol. Chem. 271:21775-21785(1996) Role of MCAT binding factors during muscle hypertrophy.Tsika R.W., Karasseva N.G., Tsika G.L.TEAD mediates YAP-dependent gene induction and growth control.Zhao B., Ye X., Yu J., Li L., Li W., Li S., Yu J., Lin J.D., Wang C.Y., Chinnaiyan A.M., Lai Z.C., Guan K.L.Genes Dev. 22:1962-1971(2008) TEAD transcription factors mediate the function of TAZ in cell growth and epithelial-mesenchymal transition.Zhang H., Liu C.Y., Zha Z.Y., Zhao B., Yao J., Zhao S., Xiong Y., Lei Q.Y., Guan K.L.J. Biol. Chem. 284:13355-13362(2009) Structural basis of YAP recognition by TEAD4 in the hippo pathway.Chen L., Chan S.W., Zhang X., Walsh M., Lim C.J., Hong W., Song H.Genes Dev. 24:290-300(2010)
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 Research Articles on TEAD4    1. TAZ negatively regulate transcription of DeltaNp63 through TEAD1,2,3 and 4 transcription factors.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with TEAD4 recombinant proteinPathways associated with TEAD4 recombinant protein
 Reference Product  PubMed Publications
 CDX2 recombinant protein  >22 publications with TEAD4 and CDX2
 YAP1 recombinant protein  >11 publications with TEAD4 and YAP1
 CTGF recombinant protein  >5 publications with TEAD4 and CTGF
 VGLL1 recombinant protein  >2 publications with TEAD4 and VGLL1
 WWTR1 recombinant protein  >2 publications with TEAD4 and WWTR1
 VGLL2 recombinant protein  >1 publications with TEAD4 and VGLL2
 Products by Pathway  Pathway Diagram
 Fatty Acid, Triacylglycerol, And Ketone Body Metabolism Pathway antibodies  Fatty Acid, Triacylglycerol, And Ketone Body Metabolism Pathway Diagram
 Gene Expression Pathway antibodies  Gene Expression Pathway Diagram
 Generic Transcription Pathway antibodies  Generic Transcription Pathway Diagram
 Hippo Signaling Pathway antibodies  Hippo Signaling Pathway Diagram
 Hippo Signaling Pathway antibodies  Hippo Signaling Pathway Diagram
 Hippo Signaling Pathway antibodies  Hippo Signaling Pathway Diagram
 Hippo Signaling Pathway antibodies  Hippo Signaling Pathway Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram
 Metabolism Of Lipids And Lipoproteins Pathway antibodies  Metabolism Of Lipids And Lipoproteins Pathway Diagram
 PPARA Activates Gene Expression Pathway antibodies  PPARA Activates Gene Expression Pathway Diagram
Diseases associated with TEAD4 recombinant proteinOrgans/Tissues associated with TEAD4 recombinant protein
 Disease Name  Pubmed Publications
 Cardiovascular Diseases Antibodies  >5 publications with TEAD4 and Cardiovascular Diseases
 Heart Diseases Antibodies  >5 publications with TEAD4 and Heart Diseases
 Cell Transformation, Neoplastic Antibodies  >4 publications with TEAD4 and Cell Transformation, Neoplastic
 Disease Models, Animal Antibodies  >3 publications with TEAD4 and Disease Models, Animal
 Hypertrophy Antibodies  >3 publications with TEAD4 and Hypertrophy
 Nervous System Diseases Antibodies  >3 publications with TEAD4 and Nervous System Diseases
 Kidney Diseases Antibodies  >3 publications with TEAD4 and Kidney Diseases
 Liver Diseases Antibodies  >2 publications with TEAD4 and Liver Diseases
 Fibrosis Antibodies  >2 publications with TEAD4 and Fibrosis
 Congenital Abnormalities Antibodies  >2 publications with TEAD4 and Congenital Abnormalities
 Organ/Tissue Name  Pubmed Publications
 Muscle Antibodies  >71 publications with TEAD4 and Muscle
 Placenta Antibodies  >18 publications with TEAD4 and Placenta
 Vascular Antibodies  >17 publications with TEAD4 and Vascular
 Heart Antibodies  >10 publications with TEAD4 and Heart
 Embryonic Tissue Antibodies  >8 publications with TEAD4 and Embryonic Tissue
 Blood Antibodies  >7 publications with TEAD4 and Blood
 Kidney Antibodies  >5 publications with TEAD4 and Kidney
 Connective Tissue Antibodies  >5 publications with TEAD4 and Connective Tissue
 Lung Antibodies  >5 publications with TEAD4 and Lung
 Eye Antibodies  >3 publications with TEAD4 and Eye
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