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TEAD2 recombinant protein :: Transcriptional enhancer factor TEF-4 (TEAD2) Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS1456298 TEAD2 recombinant protein
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 Product Name   

Transcriptional enhancer factor TEF-4 (TEAD2), Recombinant Protein

★Popular Item★
 Also Known As   

Recombinant Human Transcriptional enhancer factor TEF-4 (TEAD2)

 Product Synonym Names    TEA domain family member 2
 Product Gene Name   

TEAD2 recombinant protein

[Similar Products]
 Product Synonym Gene Name    TEAD2 [Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 MBS1456298 COA    COA PDF
 Sequence Positions    1-447aa, Full Length
 Sequence    MGEPRAGAAL DDGSGWTGSE EGSEEGTGGS EGAGGDGGPD AEGVWSPDIE QSFQEALAIY PPCGRRKIIL SDEGKMYGRN ELIARYIKLR TGKTRTRKQV SSHIQVLARR KSREIQSKLK DQVSKDKAFQ TMATMSSAQL ISAPSLQAKL GPTGPQASEL FQFWSGGSGP PWNVPDVKPF SQTPFTLSLT PPSTDLPGYE PPQALSPLPP PTPSPPAWQA RGLGTARLQL VEFSAFVEPP DAVDSYQRHL FVHISQHCPS PGAPPLESVD VRQIYDKFPE KKGGLRELYD RGPPHAFFLV KFWADLNWGP SGEEAGAGGS ISSGGFYGVS SQYESLEHMT LTCSSKVCSF GKQVVEKVET ERAQLEDGRF VYRLLRSPMC EYLVNFLHKL RQLPERYMMN SVLENFTILQ VVTNRDTQEL LLCTAYVFEV STSERGAQHH IYRLVRD
 OMIM    601729
 3D Structure    ModBase 3D Structure for Q15562
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 Host    E Coli or Yeast or Baculovirus or Mammalian Cell
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 Purity/Purification    >85% (SDS-PAGE) (lot specific)
 Form/Format    Liquid containing glycerol
 Tag Information    This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
 Sterility    Sterile filter available upon request.
 Endotoxin    Low endotoxin available upon request.
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 Species    Homo sapiens (Human)
 Storage Buffer    Tris-based buffer, 50% glycerol
 Tag Information    Tag type will be determined during the manufacturing process
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 Preparation and Storage    Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of TEAD2 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for TEAD2 recombinant protein

   Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1
MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1
2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1
TAZ. Acts by mediating gene expression of YAP1 and WWTR1
TAZ, thereby regulating cell proliferation, migration and epithelial mesenchymal transition (EMT) induction. Binds to the SPH and GT-IIC 'enhansons' (5'-GTGGAATGT-3'). May be involved in the gene regulation of neural development. Binds to the M-CAT motif.
 Product Categories/Family for TEAD2 recombinant protein    Epigenetics and Nuclear Signaling
NCBI/Uniprot data below describe general gene information for TEAD2. It may not necessarily be applicable to this product.
 NCBI GI #    375331915
 NCBI GeneID    8463
 NCBI Accession #    NP_001243587.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001256658.1 [Other Products]
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 UniProt Primary Accession #    Q15562 [Other Products]
 UniProt Secondary Accession #    Q8NA25; Q96IG3; B4DTJ6; M0R1T9 [Other Products]
 UniProt Related Accession #    Q15562 [Other Products]
 Molecular Weight    65.62kDa
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 NCBI Official Full Name    transcriptional enhancer factor TEF-4 isoform 1
 NCBI Official Synonym Full Names    TEA domain transcription factor 2
 NCBI Official Symbol    TEAD2 [Similar Products]
 NCBI Official Synonym Symbols   
ETF; TEF4; TEF-4; TEAD-2
[Similar Products]
 NCBI Protein Information    transcriptional enhancer factor TEF-4
 UniProt Protein Name    Transcriptional enhancer factor TEF-4
 UniProt Synonym Protein Names   
TEA domain family member 2; TEAD-2
 Protein Family    Transcriptional enhancer factor
 UniProt Gene Name    TEAD2 [Similar Products]
 UniProt Synonym Gene Names    TEF4; TEAD-2 [Similar Products]
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 UniProt Comments for TEAD2    Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell proliferation, migration and epithelial mesenchymal transition (EMT) induction. Binds to the SPH and GT-IIC 'enhansons' (5'-GTGGAATGT-3'). May be involved in the gene regulation of neural development. Binds to the M-CAT motif.
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Product References and Citations for TEAD2 recombinant protein

   "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."The MGC Project Team Genome Res. 14:2121-2127(2004)
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 Research Articles on TEAD2    1. TAZ negatively regulate transcription of DeltaNp63 through TEAD1,2,3 and 4 transcription factors.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with TEAD2 recombinant proteinPathways associated with TEAD2 recombinant protein
 Reference Product  PubMed Publications
 YAP1 recombinant protein  >2 publications with TEAD2 and YAP1
 NCOA1 recombinant protein  >1 publications with TEAD2 and NCOA1
 Products by Pathway  Pathway Diagram
 Fatty Acid, Triacylglycerol, And Ketone Body Metabolism Pathway antibodies  Fatty Acid, Triacylglycerol, And Ketone Body Metabolism Pathway Diagram
 Gene Expression Pathway antibodies  Gene Expression Pathway Diagram
 Generic Transcription Pathway antibodies  Generic Transcription Pathway Diagram
 Hippo Signaling Pathway antibodies  Hippo Signaling Pathway Diagram
 Hippo Signaling Pathway antibodies  Hippo Signaling Pathway Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram
 Metabolism Of Lipids And Lipoproteins Pathway antibodies  Metabolism Of Lipids And Lipoproteins Pathway Diagram
 PPARA Activates Gene Expression Pathway antibodies  PPARA Activates Gene Expression Pathway Diagram
 Regulation Of Lipid Metabolism By Peroxisome Proliferator-activated Receptor Alpha (PPARalpha) Pathway antibodies  Regulation Of Lipid Metabolism By Peroxisome Proliferator-activated Receptor Alpha (PPARalpha) Pathway Diagram
 YAP1- And WWTR1 (TAZ)-stimulated Gene Expression Pathway antibodies  YAP1- And WWTR1 (TAZ)-stimulated Gene Expression Pathway Diagram
Diseases associated with TEAD2 recombinant proteinOrgans/Tissues associated with TEAD2 recombinant protein
 Disease Name  Pubmed Publications
 Death Antibodies  >2 publications with TEAD2 and Death
 Nervous System Diseases Antibodies  >2 publications with TEAD2 and Nervous System Diseases
 Nervous System Malformations Antibodies  >1 publications with TEAD2 and Nervous System Malformations
 Lung Neoplasms Antibodies  >1 publications with TEAD2 and Lung Neoplasms
 Liver Diseases Antibodies  >1 publications with TEAD2 and Liver Diseases
 Hepatomegaly Antibodies  >1 publications with TEAD2 and Hepatomegaly
 Inflammation Antibodies  >1 publications with TEAD2 and Inflammation
 Congenital Abnormalities Antibodies  >1 publications with TEAD2 and Congenital Abnormalities
 Organ/Tissue Name  Pubmed Publications
 Embryonic Tissue Antibodies  >9 publications with TEAD2 and Embryonic Tissue
 Muscle Antibodies  >7 publications with TEAD2 and Muscle
 Brain Antibodies  >4 publications with TEAD2 and Brain
 Lung Antibodies  >3 publications with TEAD2 and Lung
 Liver Antibodies  >3 publications with TEAD2 and Liver
 Prostate Antibodies  >1 publications with TEAD2 and Prostate
 Uterus Antibodies  >1 publications with TEAD2 and Uterus
 Placenta Antibodies  >1 publications with TEAD2 and Placenta
 Heart Antibodies  >1 publications with TEAD2 and Heart
 Bone Antibodies  >1 publications with TEAD2 and Bone
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