NP_418348.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
Molecular Weight
26,312 Da
NCBI Official Full Name
response regulator in two-component regulatory system with CpxA
NCBI Protein Information
response regulator in two-component regulatory system with CpxA
UniProt Protein Name
Transcriptional regulatory protein CpxR
UniProt Synonym Gene Names
NCBI Summary for cpxR
CpxR is the response regulator that mediates a response by activating the transcription of stress-combative genes (csgBA, csgDEFG, degP, and cpxP). [More information is available at EcoCyc: EG10020].
UniProt Comments for cpxR
Response regulator member of the two-component regulatory system CpxA/CpxR which responds to envelope stress response by activating expression of downstream genes including cpxP, degP, dsbA and ppiA (PubMed:7883164, PubMed:9401031). Required for efficient binding of stationary phase cells to hydrophobic surfaces, part of the process of biofilm formation (PubMed:11830644). Induced upon cell surface binding, subsequently induces genes it controls (cpxP, dsbA and spy, degP is only partially induced) (PubMed:11830644). Binds and activates transcription from the degP promoter (PubMed:7883164); binding is enhanced by phosphorylation (PubMed:9401031). This system combats a variety of extracytoplasmic protein-mediated toxicities by increasing the transcription of the periplasmic protease, DegP in concert with sigma factor E (PubMed:7883164), as well as that of CpxP protein. Other downstream effectors may include SrkA (PubMed:23416055).
Research Articles on cpxR
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Products associated with cpxR recombinant protein
Pathways associated with cpxR recombinant protein
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