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DatasheetFull DatasheetPrinter Friendly DatasheetPrint This DatasheetAdd to Compare ListHave Questions? Ask UsRequest for a Quotation today

CTCF recombinant protein :: Transcriptional repressor CTCF (CTCF) Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS958295
SDS-Page
Unit / Price
0.05 mg (E-Coli)  /  $880 +1 FREE 8GB USB
0.05 mg (Yeast)  /  $970 +1 FREE 8GB USB
0.05 mg (Baculovirus)  /  $1,100 +1 FREE 8GB USB
0.2 mg (E-Coli)  /  $1,180 +1 FREE 8GB USB
0.5 mg (E-Coli)  /  $1,300 +1 FREE 8GB USB
0.2 mg (Yeast)  /  $1,305 +1 FREE 8GB USB
0.05 mg (Mammalian-Cell)  /  $1,345 +1 FREE 8GB USB
0.1 mg (Baculovirus)  /  $1,395 +1 FREE 8GB USB
0.5 mg (Yeast)  /  $1,480 +1 FREE 8GB USB
1 mg (E-Coli)  /  $1,850 +2 FREE 8GB USB
0.5 mg (Baculovirus)  /  $1,995 +2 FREE 8GB USB
0.1 mg (Mammalian-Cell)  /  $2,035 +2 FREE 8GB USB
1 mg (Yeast)  /  $2,250 +2 FREE 8GB USB
1 mg (Baculovirus)  /  $2,630 +3 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Transcriptional repressor CTCF (CTCF), Recombinant Protein

★Popular Item★
 Also Known As   

Recombinant Human Transcriptional repressor CTCF (CTCF)

 Product Gene Name   

CTCF recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 MBS958295 COA    COA PDF
 Sequence Positions    1-727aa; Full length protein
 Sequence    MEGDAVEAIV EESETFIKGK ERKTYQRRRE GGQEEDACHL PQNQTDGGEV VQDVNSSVQM VMMEQLDPTL LQMKTEVMEG TVAPEAEAAV DDTQIITLQV VNMEEQPINI GELQLVQVPV PVTVPVATTS VEELQGAYEN EVSKEGLAES EPMICHTLPL PEGFQVVKVG ANGEVETLEQ GELPPQEDPS WQKDPDYQPP AKKTKKTKKS KLRYTEEGKD VDVSVYDFEE EQQEGLLSEV NAEKVVGNMK PPKPTKIKKK GVKKTFQCEL CSYTCPRRSN LDRHMKSHTD ERPHKCHLCG RAFRTVTLLR NHLNTHTGTR PHKCPDCDMA FVTSGELVRH RRYKHTHEKP FKCSMCDYAS VEVSKLKRHI RSHTGERPFQ CSLCSYASRD TYKLKRHMRT HSGEKPYECY ICHARFTQSG TMKMHILQKH TENVAKFHCP HCDTVIARKS DLGVHLRKQH SYIEQGKKCR YCDAVFHERY ALIQHQKSHK NEKRFKCDQC DYACRQERHM IMHKRTHTGE KPYACSHCDK TFRQKQLLDM HFKRYHDPNF VPAAFVCSKC GKTFTRRNTM ARHADNCAGP DGVEGENGGE TKKSKRGRKR KMRSKKEDSS DSENAEPDLD DNEDEEEPAV EIEPEPEPQP VTPAPPPAKK RRGRPPGRTN QPKQNQPTAI IQVEDQNTGA IENIIVEVKK EPDAEPAEGE EEEAQPAATD APNGDLTPEM ILSMMDR
 OMIM    604167
 3D Structure    ModBase 3D Structure for P49711
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 Host    E Coli or Yeast or Baculovirus or Mammalian Cell
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 Purity/Purification    >85% (SDS-PAGE) (lot specific)
 Form/Format    Liquid containing glycerol
 Tag Information    This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
 Sterility    Sterile filter available upon request.
 Endotoxin    Low endotoxin available upon request.
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 Storage Buffer    Tris-based buffer, 50% glycerol
 Tag Information    Tag type will be determined during the manufacturing process
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 Preparation and Storage    Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of CTCF recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 SDS-Page of CTCF recombinant protein    CTCF recombinant protein SDS-Page image
(Note: Representative image, actual molecular weight may vary depending on Tag type and expression host)
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NCBI/Uniprot data below describe general gene information for CTCF. It may not necessarily be applicable to this product.
 NCBI GI #    300388142
 NCBI GeneID    10664
 NCBI Accession #    NP_001177951.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001191022.1 [Other Products]
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 UniProt Primary Accession #    P49711 [Other Products]
 UniProt Secondary Accession #    Q53XI7; Q59EL8; B5MC38 [Other Products]
 UniProt Related Accession #    P49711 [Other Products]
 Molecular Weight    45,998 Da [Similar Products]
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 NCBI Official Full Name    transcriptional repressor CTCF isoform 2
 NCBI Official Synonym Full Names    CCCTC-binding factor
 NCBI Official Symbol    CTCF [Similar Products]
 NCBI Official Synonym Symbols   
MRD21
[Similar Products]
 NCBI Protein Information    transcriptional repressor CTCF
 UniProt Protein Name    Transcriptional repressor CTCF
 UniProt Synonym Protein Names   
11-zinc finger protein; CCCTC-binding factor; CTCFL paralog
 Protein Family    Transcriptional repressor
 UniProt Gene Name    CTCF [Similar Products]
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 NCBI Summary for CTCF    This gene is a member of the BORIS + CTCF gene family and encodes a transcriptional regulator protein with 11 highly conserved zinc finger (ZF) domains. This nuclear protein is able to use different combinations of the ZF domains to bind different DNA target sequences and proteins. Depending upon the context of the site, the protein can bind a histone acetyltransferase (HAT)-containing complex and function as a transcriptional activator or bind a histone deacetylase (HDAC)-containing complex and function as a transcriptional repressor. If the protein is bound to a transcriptional insulator element, it can block communication between enhancers and upstream promoters, thereby regulating imprinted expression. Mutations in this gene have been associated with invasive breast cancers, prostate cancers, and Wilms' tumors. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2010]
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 UniProt Comments for CTCF    Chromatin binding factor that binds to DNA sequence specific sites. Involved in transcriptional regulation by binding to chromatin insulators and preventing interaction between promoter and nearby enhancers and silencers. Acts as transcriptional repressor binding to promoters of vertebrate MYC gene and BAG1 gene. Also binds to the PLK and PIM1 promoters. Acts as a transcriptional activator of APP. Regulates APOA1/C3/A4/A5 gene cluster and controls MHC class II gene expression. Plays an essential role in oocyte and preimplantation embryo development by activating or repressing transcription. Seems to act as tumor suppressor. Plays a critical role in the epigenetic regulation. Participates in the allele-specific gene expression at the imprinted IGF2/H19 gene locus. On the maternal allele, binding within the H19 imprinting control region (ICR) mediates maternally inherited higher-order chromatin conformation to restrict enhancer access to IGF2. Plays a critical role in gene silencing over considerable distances in the genome. Preferentially interacts with unmethylated DNA, preventing spreading of CpG methylation and maintaining methylation-free zones. Inversely, binding to target sites is prevented by CpG methylation. Plays a important role in chromatin remodeling. Can dimerize when it is bound to different DNA sequences, mediating long-range chromatin looping. Mediates interchromosomal association between IGF2/H19 and WSB1/NF1 and may direct distant DNA segments to a common transcription factory. Causes local loss of histone acetylation and gain of histone methylation in the beta-globin locus, without affecting transcription. When bound to chromatin, it provides an anchor point for nucleosomes positioning. Seems to be essential for homologous X-chromosome pairing. May participate with Tsix in establishing a regulatable epigenetic switch for X chromosome inactivation. May play a role in preventing the propagation of stable methylation at the escape genes from X- inactivation. Involved in sister chromatid cohesion. Associates with both centromeres and chromosomal arms during metaphase and required for cohesin localization to CTCF sites. Regulates asynchronous replication of IGF2/H19. Plays a role in the recruitment of CENPE to the pericentromeric/centromeric regions of the chromosome during mitosis (PubMed:26321640).
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 Research Articles on CTCF    1. The MeCP2, a protein whose mutated forms are involved in Rett syndrome; and CTCF, a constitutive transcriptional insulator.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with CTCF recombinant proteinPathways associated with CTCF recombinant protein
 Reference Product  PubMed Publications
 MYC recombinant protein  >57 publications with CTCF and MYC
 SUZ12 recombinant protein  >11 publications with CTCF and SUZ12
 CDKN2A recombinant protein  >10 publications with CTCF and CDKN2A
 GATA1 recombinant protein  >9 publications with CTCF and GATA1
 SMAD4 recombinant protein  >4 publications with CTCF and SMAD4
 SIN3A recombinant protein  >3 publications with CTCF and SIN3A
 SMAD3 recombinant protein  >3 publications with CTCF and SMAD3
 YBX1 recombinant protein  >2 publications with CTCF and YBX1
 POLR2A recombinant protein  >1 publications with CTCF and POLR2A
 Products by Pathway  Pathway Diagram
 Activation Of HOX Genes During Differentiation Pathway antibodies  Activation Of HOX Genes During Differentiation Pathway Diagram
 Activation Of Anterior HOX Genes In Hindbrain Development During Early Embryogenesis Pathway antibodies  Activation Of Anterior HOX Genes In Hindbrain Development During Early Embryogenesis Pathway Diagram
 Developmental Biology Pathway antibodies  Developmental Biology Pathway Diagram
 SIDS Susceptibility Pathways antibodies  SIDS Susceptibility Pathways Diagram
 TGF-beta Receptor Signaling Pathway antibodies  TGF-beta Receptor Signaling Pathway Diagram
Diseases associated with CTCF recombinant proteinOrgans/Tissues associated with CTCF recombinant protein
 Disease Name  Pubmed Publications
 Carcinoma Antibodies  >55 publications with CTCF and Carcinoma
 Kidney Diseases Antibodies  >33 publications with CTCF and Kidney Diseases
 Abnormalities, Multiple Antibodies  >30 publications with CTCF and Abnormalities, Multiple
 Adenocarcinoma Antibodies  >16 publications with CTCF and Adenocarcinoma
 Lung Diseases Antibodies  >13 publications with CTCF and Lung Diseases
 Cell Transformation, Neoplastic Antibodies  >11 publications with CTCF and Cell Transformation, Neoplastic
 Lung Neoplasms Antibodies  >10 publications with CTCF and Lung Neoplasms
 Fibrosis Antibodies  >9 publications with CTCF and Fibrosis
 Carcinoma, Hepatocellular Antibodies  >9 publications with CTCF and Carcinoma, Hepatocellular
 Neoplasms, Experimental Antibodies  >8 publications with CTCF and Neoplasms, Experimental
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >99 publications with CTCF and Blood
 Brain Antibodies  >62 publications with CTCF and Brain
 Liver Antibodies  >44 publications with CTCF and Liver
 Kidney Antibodies  >43 publications with CTCF and Kidney
 Testis Antibodies  >37 publications with CTCF and Testis
 Embryonic Tissue Antibodies  >32 publications with CTCF and Embryonic Tissue
 Eye Antibodies  >29 publications with CTCF and Eye
 Lung Antibodies  >27 publications with CTCF and Lung
 Muscle Antibodies  >23 publications with CTCF and Muscle
 Heart Antibodies  >23 publications with CTCF and Heart
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