NP_001074856.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
75.1 kDa
NCBI Official Full Name
transcriptional repressor CTCFL
NCBI Official Synonym Full Names
CCCTC-binding factor (zinc finger protein)-like
NCBI Protein Information
transcriptional repressor CTCFL
UniProt Protein Name
Transcriptional repressor CTCFL
UniProt Synonym Protein Names
Brother of the regulator of imprinted sites; CCCTC-binding factor; CTCF paralog; CTCF-like protein
UniProt Synonym Gene Names
UniProt Entry Name
CTCFL_MOUSE
UniProt Comments for Ctcfl
BORIS: Testis-specific DNA binding protein responsible for insulator function, nuclear architecture and transcriptional control, which probably acts by recruiting epigenetic chromatin modifiers. Plays a key role in gene imprinting in male germline, by participating in the establishment of differential methylation at the IGF2/H19 imprinted control region (ICR). Directly binds the unmethylated H19 ICR and recruits the PRMT7 methyltransferase, leading to methylate histone H4 'Arg-3' to form H4R3sme2. This probably leads to recruit de novo DNA methyltransferases at these sites. Seems to act as tumor suppressor. In association with DNMT1 and DNMT3B, involved in activation of BAG1 gene expression by binding to its promoter. Required for dimethylation of H3 lysine 4 (H3K4me2) of MYC and BRCA1 promoters. Interacts with histones, PRMT7 and SETD1A. Interacts (via N-terminus) with BAG6/BAT3. Testis specific. Specifically expressed in primary spermatocytes. Belongs to the CTCF zinc-finger protein family.
Protein type: Cancer Testis Antigen (CTA); C2H2-type zinc finger protein; DNA-binding
Cellular Component: cytoplasm; nucleus
Molecular Function: DNA binding; histone binding; metal ion binding; nucleic acid binding; protein binding; sequence-specific DNA binding
Biological Process: chromatin modification; DNA methylation during gametogenesis; genetic imprinting; histone methylation; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; regulation of histone H3-K4 methylation; regulation of transcription, DNA-dependent; transcription from RNA polymerase II promoter; transcription, DNA-dependent
Product References and Citations for Ctcfl recombinant protein
BORIS, a novel male germ-line-specific protein associated with epigenetic reprogramming events, shares the same 11-zinc-finger domain with CTCF, the insulator protein involved in reading imprinting marks in the soma.Loukinov D.I., Pugacheva E., Vatolin S., Pack S.D., Moon H., Chernukhin I., Mannan P., Larsson E., Kanduri C., Vostrov A.A., Cui H., Niemitz E.L., Rasko J.E.J., Docquier F.M., Kistler M., Breen J.J., Zhuang Z., Quitschke W.W., Renkawitz R., Klenova E.M., Feinberg A.P., Ohlsson R., Morse H.C. III, Lobanenkov V.V.Proc. Natl. Acad. Sci. U.S.A. 99:6806-6811(2002)
Lineage-specific biology revealed by a finished genome assembly of the mouse.Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S., Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P.PLoS Biol. 7:E1000112-E1000112(2009)
The testis-specific factor CTCFL cooperates with the protein methyltransferase PRMT7 in H19 imprinting control region methylation.Jelinic P., Stehle J.-C., Shaw P.PLoS Biol. 4:E355-E355(2006)
Research Articles on Ctcfl
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Products associated with Ctcfl recombinant protein
Diseases associated with Ctcfl recombinant protein
Organs/Tissues associated with Ctcfl recombinant protein
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