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CD176 recombinant protein :: Transferrin / CD176 / Serotransferrin Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS2546773
SDS-PAGE
Unit / Price
0.05 mg  /  $475 +1 FREE 8GB USB
0.1 mg  /  $775 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Transferrin / CD176 / Serotransferrin, Recombinant Protein

★Popular Item★
 Also Known As   

Recombinant Mouse Transferrin / CD176 / Serotransferrin Protein (Fc tag)

 Product Synonym Names    TRF, Tf
 Product Gene Name   

CD176 recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 MBS2546773 Technical Datasheet    Technical Datasheet PDF
 3D Structure    ModBase 3D Structure for Q921I1
 Host    Human Cells
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 Purity/Purification    > 90 % as determined by SDS-PAGE
 Form/Format    Lyophilized from sterile PBS, pH7.4, 5% Trehalose, 5% mannitol, 0.01% Tween-80
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 Predicted N Terminal    Val 20
 Endotoxin    < 1.0 EU per ug of the protein as determined by the LAL method
 Reconstitution    It is recommended that sterile water (400 ?l) be added to the vial to prepare a stock solution of 0.25 mg/mL. Concentration is measured by UV-Vis.
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 Preparation and Storage    Store it under sterile conditions at -20 degree C to -80 degree C upon receiving. Recommend to aliquot the protein into smaller quantities for optimal storage.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of CD176 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for CD176 recombinant protein

   Background: Transferrin is a glycoprotein with an approximate molecular weight of 76.5 kDa. This glycoprotein is thought to have been created as a result of an ancient gene duplication event that led to generation of homologous C and N-terminal domains each of which binds one ion of ferric iron. The function of Transferrin is to transport iron from the intestine, reticuloendothelial system, and liver parenchymal cells to all proliferating cells in the body. This protein may also have a physiologic role as granulocyte / pollen-binding protein (GPBP) involved in the removal of certain organic matter and allergens from serum. Transferrins are iron binding transport proteins which bind Fe3+ ion in association with the binding of an anion, usually bicarbonate. This transferrin binds only one Fe3+ ion per protein molecule. Transports iron ions from the hemolymph into the eggs during the vitellogenic stage. Transferrins are iron binding transport proteins which can bind two Fe (3+) ions in association with the binding of an anion, usually bicarbonate. It is responsible for the transport of iron from sites of absorption and heme degradation to those of storage and utilization. Serum transferrin may also have a further role in stimulating cell proliferation. When a transferrin loaded with iron encounters with a transferring receptor on cell surface, transferring binds to it and, as a consequence, is transported into the cell in a visicle by receptor-mediated endocytosis. The PH is reduced by hydrogen iron pumps. The lower pH causes transferrin to release its iron ions. The receptor is then transported through the endocytic cycle back to the cell surface, ready for another round of iron uptake. Each transferrin molecule has the ability to carry two iron ions in the ferric form.

Description: A DNA sequence encoding the mouse TRF (Q921I1) (Met1-His697) was expressed with the Fc region of human IgG1 at the C-terminus.
 Application Notes for CD176 recombinant protein    The recombinant mouse TRF/Fc is a disulfide-linked homodimer. The reduced monomer comprises 919 amino acids and has a predicted molecular mass of 101.9 kDa. The apparent molecular mass of the protein is approximately 102 kDa in SDS-PAGE under reducing conditions due to glycosylation.
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 SDS-PAGE of CD176 recombinant protein    CD176 recombinant protein SDS-PAGE image
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NCBI/Uniprot data below describe general gene information for CD176. It may not necessarily be applicable to this product.
 NCBI GI #    20330802
 NCBI GeneID    22041
 NCBI Accession #    NP_598738.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_133977.2 [Other Products]
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 UniProt Primary Accession #    Q921I1 [Other Products]
 UniProt Secondary Accession #    O35421; Q3UBW7; Q58E69; Q61803; Q62357; Q62358; Q62359; Q63915; Q64515; Q8VII5; Q922C0 [Other Products]
 UniProt Related Accession #    Q921I1 [Other Products]
 Molecular Weight    76,724 Da
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 NCBI Official Full Name    serotransferrin
 NCBI Official Synonym Full Names    transferrin
 NCBI Official Symbol    Trf [Similar Products]
 NCBI Official Synonym Symbols   
HP; Tf; Tfn; hpx; Cd176; AI266983
[Similar Products]
 NCBI Protein Information    serotransferrin
 UniProt Protein Name    Serotransferrin
 UniProt Synonym Protein Names   
Beta-1 metal-binding globulin; Siderophilin
 UniProt Gene Name    Tf [Similar Products]
 UniProt Synonym Gene Names    Trf; Transferrin [Similar Products]
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 UniProt Comments for CD176    TF: Transferrins are iron binding transport proteins which can bind two Fe(3+) ions in association with the binding of an anion, usually bicarbonate. It is responsible for the transport of iron from sites of absorption and heme degradation to those of storage and utilization. Serum transferrin may also have a further role in stimulating cell proliferation. Defects in TF are the cause of atransferrinemia (ATRAF). Atransferrinemia is rare autosomal recessive disorder characterized by iron overload and hypochromic anemia. Belongs to the transferrin family.

Protein type: Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 9 F1|9 55.03 cM

Cellular Component: apical plasma membrane; basal plasma membrane; basement membrane; cell surface; coated pit; cytoplasmic vesicle; early endosome; endocytic vesicle; endosome; extracellular region; extracellular space; extrinsic to external side of plasma membrane; late endosome; membrane; perinuclear region of cytoplasm; recycling endosome; vesicle

Molecular Function: ferric iron binding; ferrous iron binding; protein binding

Biological Process: actin filament organization; activation of JNK activity; ferric iron transport; iron ion transport; osteoclast differentiation; positive regulation of bone resorption; positive regulation of myelination; positive regulation of phosphorylation; positive regulation of receptor-mediated endocytosis; positive regulation of transcription, DNA-dependent
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 Research Articles on CD176    1. Identification of multiple transferrin species in the spleen and serum from mice with collagen-induced arthritis which may reflect changes in transferrin glycosylation associated with disease activity: The role of CD38.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with CD176 recombinant proteinPathways associated with CD176 recombinant protein
 Reference Product  PubMed Publications
 Tfrc recombinant protein  >2 publications with CD176 and Tfrc
 Products by Pathway  Pathway Diagram
 Cargo Recognition For Clathrin-mediated Endocytosis Pathway antibodies  Cargo Recognition For Clathrin-mediated Endocytosis Pathway Diagram
 Clathrin-mediated Endocytosis Pathway antibodies  Clathrin-mediated Endocytosis Pathway Diagram
 HIF-1 Signaling Pathway antibodies  HIF-1 Signaling Pathway Diagram
 Hemostasis Pathway antibodies  Hemostasis Pathway Diagram
 Iron Homeostasis Pathway antibodies  Iron Homeostasis Pathway Diagram
 Iron Uptake And Transport Pathway antibodies  Iron Uptake And Transport Pathway Diagram
 Membrane Trafficking Pathway antibodies  Membrane Trafficking Pathway Diagram
 Mineral Absorption Pathway antibodies  Mineral Absorption Pathway Diagram
 Mineral Absorption Pathway antibodies  Mineral Absorption Pathway Diagram
 Platelet Activation, Signaling And Aggregation Pathway antibodies  Platelet Activation, Signaling And Aggregation Pathway Diagram
Diseases associated with CD176 recombinant proteinOrgans/Tissues associated with CD176 recombinant protein
 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >126 publications with CD176 and Nervous System Diseases
 Immune System Diseases Antibodies  >88 publications with CD176 and Immune System Diseases
 Brain Diseases Antibodies  >68 publications with CD176 and Brain Diseases
 Kidney Diseases Antibodies  >66 publications with CD176 and Kidney Diseases
 Inflammation Antibodies  >53 publications with CD176 and Inflammation
 Death Antibodies  >44 publications with CD176 and Death
 Hypertension Antibodies  >35 publications with CD176 and Hypertension
 Disease Models, Animal Antibodies  >32 publications with CD176 and Disease Models, Animal
 Liver Diseases Antibodies  >31 publications with CD176 and Liver Diseases
 Neurobehavioral Manifestations Antibodies  >25 publications with CD176 and Neurobehavioral Manifestations
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >597 publications with CD176 and Blood
 Brain Antibodies  >202 publications with CD176 and Brain
 Pituitary Gland Antibodies  >86 publications with CD176 and Pituitary Gland
 Kidney Antibodies  >77 publications with CD176 and Kidney
 Liver Antibodies  >74 publications with CD176 and Liver
 Heart Antibodies  >59 publications with CD176 and Heart
 Spleen Antibodies  >59 publications with CD176 and Spleen
 Bone Antibodies  >40 publications with CD176 and Bone
 Muscle Antibodies  >38 publications with CD176 and Muscle
 Skin Antibodies  >30 publications with CD176 and Skin
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