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TGF-B1 recombinant protein :: Transforming Growth Factor Beta - 1 (TGF-B1) Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS343178
SDS-PAGE
Unit / Price
0.01 mg  /  $215 +1 FREE 8GB USB
0.1 mg  /  $545 +1 FREE 8GB USB
1 mg  /  $2,500 +3 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Transforming Growth Factor Beta - 1 (TGF-B1), Recombinant Protein

 Also Known As   

Transforming Growth Factor Beta - 1 (TGF-B1)

 Product Synonym Names    TGF?-1; TGF?; TGF beta 1; TGF-b1., CED, DPD1, LAP
 Product Gene Name   

TGF-B1 recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 3D Structure    ModBase 3D Structure for P50414
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 Purity/Purification    >95% by SDS-PAGE
 Form/Format    Liquid
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 Buffer    Buffered 50% glycerol
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 ISO Certification    Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
 Other Notes    Small volumes of TGF-B1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for TGF-B1 recombinant protein

   TGF beta 1 is a member of the larger TGF beta superfamily of cytokines produced by a wide variety of cells that are involved in the regulation of cell proliferation, differentiation, apoptosis, cellular homeostasis and a wide variety of other cellular functions. TGF beta 1 has been shown to regulate the actions of many other growth factors involved in a range of human diseases including renal disease, hepatic disease, heart failure and cardiomyopathies. Recombinant TGF beta-1 comprises a 112 amino acid fragment (279-390) corresponding to the mature TGF- beta protein sequence and is expressed in E Coli with an amino-terminal hexahistidine tag. This product is not intended for therapeutic use.
 Product Categories/Family for TGF-B1 recombinant protein    Recombinant Proteins; Transforming Growth Factor Beta - 1
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 SDS-PAGE of TGF-B1 recombinant protein    TGF-B1 recombinant protein SDS-PAGE image
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NCBI/Uniprot data below describe general gene information for TGF-B1. It may not necessarily be applicable to this product.
 NCBI GI #    57164399
 NCBI GeneID    443417
 NCBI Accession #    NP_001009400.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001009400.1 [Other Products]
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 UniProt Primary Accession #    P50414 [Other Products]
 UniProt Related Accession #    P50414 [Other Products]
 Molecular Weight    44,291 Da
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 NCBI Official Full Name    transforming growth factor beta-1
 NCBI Official Symbol    TGFB1 [Similar Products]
 NCBI Protein Information    transforming growth factor beta-1
 UniProt Protein Name    Transforming growth factor beta-1
 UniProt Gene Name    TGFB1 [Similar Products]
 UniProt Synonym Gene Names    TGF-beta-1; LAP [Similar Products]
 UniProt Entry Name    TGFB1_SHEEP
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 UniProt Comments for TGF-B1    Multifunctional protein that controls proliferation, differentiation and other functions in many cell types. Many cells synthesize TGFB1 and have specific receptors for it. It positively and negatively regulates many other growth factors. It plays an important role in bone remodeling as it is a potent stimulator of osteoblastic bone formation, causing chemotaxis, proliferation and differentiation in committed osteoblasts (). Stimulates sustained production of collagen through the activation of CREB3L1 by regulated intramembrane proteolysis (RIP) (). Can promote either T-helper 17 cells (Th17) or regulatory T-cells (Treg) lineage differentiation in a concentration-dependent manner. At high concentrations, leads to FOXP3-mediated suppression of RORC and down-regulation of IL-17 expression, favoring Treg cell development. At low concentrations in concert with IL-6 and IL-21, leads to expression of the IL-17 and IL-23 receptors, favoring differentiation to Th17 cells. Mediates SMAD2/3 activation by inducing its phosphorylation and subsequent translocation to the nucleus. Can induce epithelial-to-mesenchymal transition (EMT) and cell migration in various cell types ().
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Product References and Citations for TGF-B1 recombinant protein

   Sporn MB et al., (1986) Science 233 (4763) 532-534
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 Research Articles on TGF-B1    1. Mutations in transforming Growth Factor beta is associated with ovulation
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with TGF-B1 recombinant proteinDiseases associated with TGF-B1 recombinant protein
 Products by Pathway  Pathway Diagram
 AGE-RAGE Signaling Pathway In Diabetic Complications antibodies  AGE-RAGE Signaling Pathway In Diabetic Complications Diagram
 AGE-RAGE Signaling Pathway In Diabetic Complications antibodies  AGE-RAGE Signaling Pathway In Diabetic Complications Diagram
 Amoebiasis Pathway antibodies  Amoebiasis Pathway Diagram
 Amoebiasis Pathway antibodies  Amoebiasis Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram
 Chagas Disease (American Trypanosomiasis) Pathway antibodies  Chagas Disease (American Trypanosomiasis) Pathway Diagram
 Chagas Disease (American Trypanosomiasis) Pathway antibodies  Chagas Disease (American Trypanosomiasis) Pathway Diagram
 Chronic Myeloid Leukemia Pathway antibodies  Chronic Myeloid Leukemia Pathway Diagram
 Chronic Myeloid Leukemia Pathway antibodies  Chronic Myeloid Leukemia Pathway Diagram
 Disease Name  Pubmed Publications
 Fibrosis Antibodies  >6108 publications with TGF-B1 and Fibrosis
 Lung Diseases Antibodies  >1907 publications with TGF-B1 and Lung Diseases
 Liver Cirrhosis Antibodies  >1033 publications with TGF-B1 and Liver Cirrhosis
 Pulmonary Fibrosis Antibodies  >985 publications with TGF-B1 and Pulmonary Fibrosis
 Hypertension Antibodies  >826 publications with TGF-B1 and Hypertension
 Diabetic Nephropathies Antibodies  >571 publications with TGF-B1 and Diabetic Nephropathies
 Proteinuria Antibodies  >553 publications with TGF-B1 and Proteinuria
 Hypersensitivity Antibodies  >533 publications with TGF-B1 and Hypersensitivity
 Asthma Antibodies  >494 publications with TGF-B1 and Asthma
 Neoplasm Metastasis Antibodies  >492 publications with TGF-B1 and Neoplasm Metastasis
Organs/Tissues associated with TGF-B1 recombinant protein
 Organ/Tissue Name  Pubmed Publications
 Bone Antibodies  >2741 publications with TGF-B1 and Bone
 Digestive Antibodies  >1807 publications with TGF-B1 and Digestive
 Skin Antibodies  >1419 publications with TGF-B1 and Skin
 Female Genital Antibodies  >303 publications with TGF-B1 and Female Genital
 Lymphoreticular Antibodies  >1 publications with TGF-B1 and Lymphoreticular
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