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TGF b 3 recombinant protein :: Transforming Growth Factor-Beta 3 Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS144136 TGF b 3 recombinant protein
Unit / Price
0.001 mg  /  $140 +1 FREE 8GB USB
0.005 mg  /  $205 +1 FREE 8GB USB
0.1 mg  /  $1,510 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Transforming Growth Factor-Beta 3 (TGF b 3), Recombinant Protein

 Also Known As   

Recombinant Human Transforming Growth Factor-Beta 3, Plant

 Product Synonym Names    TGF b 3 Human, Plant; Transforming Growth Factor-Beta 3 Human Recombinant, Plant; Transforming Growth Factor-beta3; TGFB3; ARVD; FLJ16571; TGF-beta3; TGF b 3 Plant
 Product Gene Name   

TGF b 3 recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence    HHHHHALDTN YCFRNLEENC CVRPLYIDFR QDLGWKWVHE PKGYYANFCS GPCPYLRSAD TTHSTVLGLY NTLNPEASAS PCCVPQDLEP LTILYYVGRT PKVEQLSNMV VKSCKCS
 OMIM    107970
 3D Structure    ModBase 3D Structure for P10600
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 Host    Nicotiana benthamiana
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 Purity/Purification    Greater than 95.0% as determined by SDS-PAGE.
 Form/Format    Lyophilized from a concentrated (1mg/ml) solution containing 50mM Tris-HCl pH-7.4.
Sterile Filtered White lyophilized (freeze-dried) powder.
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 Solubility    It is recommended to reconstitute the lyophilized TGFB3 in sterile 5mM HCl & 50ug/ml BSA at a concentration of 0.05mg/ml, which can then be further diluted to other aqueous solutions.
 Biological Activity    The biological activity of TGFB3 is measured in culture by its ability to inhibit the mink lung epithelial (Mv1Lu) cells proliferation. ED50 ? 40ng/ml corresponding to a specific activity of 25,000 Units/mg.
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 Preparation and Storage    Lyophilized TGFB3 although stable at room temperature for 3 weeks, should be stored desiccated below -18 degree C. Upon reconstitution TGFB3 Human should be stored at 4 degree C between 2-7 days and for future use below -18 degree C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please prevent freeze-thaw cycles.
 Other Notes    Small volumes of TGF b 3 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for TGF b 3 recombinant protein

   Description: TGFB3 Human Recombinant produced in plant is a disulfide-linked homodimeric, glycosylated, polypeptide chain containing 118 amino acids and having a molecular mass of 27.2kDa. The TGFB3 is fused to 6xHis tag at N-terminus and purified by standard chromatographic techniques.

Introduction: Transforming growth factor betas (TGF Betas) mediate many cell-cell interactions that occur during embryonic development. Three TGF Betas have been identified in mammals. TGF Beta 1, TGF Beta 2 and TGF Beta 3 are each synthesized as precursor proteins that are very similar in that each is cleaved to yield a 112 amino acid polypeptide that remains associated with the latent portion of the molecule.
 Product Categories/Family for TGF b 3 recombinant protein    CYTOKINES AND GROWTH FACTORS; Growth Factors; Transforming Growth Factor
NCBI/Uniprot data below describe general gene information for TGF b 3. It may not necessarily be applicable to this product.
 NCBI GI #    4507465
 NCBI GeneID    7043
 NCBI Accession #    NP_003230.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_003239.3 [Other Products]
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 UniProt Primary Accession #    P10600 [Other Products]
 UniProt Secondary Accession #    Q8WV88 [Other Products]
 UniProt Related Accession #    P10600 [Other Products]
 Molecular Weight    35,708 Da
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 NCBI Official Full Name    transforming growth factor beta-3 preproprotein
 NCBI Official Synonym Full Names    transforming growth factor, beta 3
 NCBI Official Symbol    TGFB3 [Similar Products]
 NCBI Official Synonym Symbols   
ARVD; RNHF; ARVD1; TGF-beta3
[Similar Products]
 NCBI Protein Information    transforming growth factor beta-3; TGF-beta-3; prepro-transforming growth factor beta-3
 UniProt Protein Name    Transforming growth factor beta-3
 UniProt Gene Name    TGFB3 [Similar Products]
 UniProt Synonym Gene Names    TGF-beta-3; LAP [Similar Products]
 UniProt Entry Name    TGFB3_HUMAN
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 NCBI Summary for TGF b 3    This gene encodes a member of the TGF-beta family of proteins. The encoded protein is secreted and is involved in embryogenesis and cell differentiation. Defects in this gene are a cause of familial arrhythmogenic right ventricular dysplasia 1. [provided by RefSeq, Mar 2009]
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 UniProt Comments for TGF b 3    TGFB3: Involved in embryogenesis and cell differentiation. Homodimer; disulfide-linked. Interacts with ASPN. Belongs to the TGF-beta family.

Protein type: Ligand, receptor tyrosine kinase; Secreted; Motility/polarity/chemotaxis; Cell development/differentiation; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 14q24

Cellular Component: extracellular matrix; extracellular space; cell surface; cell soma; T-tubule; plasma membrane; extracellular region; nucleus

Molecular Function: identical protein binding; protein binding; growth factor activity; protein heterodimerization activity; transforming growth factor beta binding; punt binding; cytokine activity

Biological Process: extracellular matrix organization and biogenesis; activation of MAPK activity; positive regulation of apoptosis; positive regulation of transcription, DNA-dependent; positive regulation of collagen biosynthetic process; palate development; female pregnancy; SMAD protein nuclear translocation; odontogenesis; regulation of apoptosis; negative regulation of cell proliferation; platelet degranulation; mammary gland development; transforming growth factor beta receptor signaling pathway; salivary gland morphogenesis; embryonic neurocranium morphogenesis; negative regulation of neuron apoptosis; cell growth; inner ear development; aging; uterine wall breakdown; positive regulation of filopodium formation; platelet activation; intercellular junction assembly and maintenance; in utero embryonic development; positive regulation of bone mineralization; regulation of cell proliferation; gut development; positive regulation of protein secretion; response to estrogen stimulus; negative regulation of DNA replication; regulation of MAPKKK cascade; positive regulation of cell division; response to hypoxia; positive regulation of transcription from RNA polymerase II promoter; response to progesterone stimulus; blood coagulation; negative regulation of transforming growth factor beta receptor signaling pathway; alveolus development; positive regulation of DNA replication

Disease: Arrhythmogenic Right Ventricular Dysplasia, Familial, 1; Rienhoff Syndrome
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 Research Articles on TGF b 3    1. Crystal structures, mutations and peptide-affinity measurements show that alpahVbeta6 binds with high affinity to a RGDLXXL/I motif within the prodomains of TGF-beta1 and TGF-beta3.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with TGF b 3 recombinant proteinPathways associated with TGF b 3 recombinant protein
 Reference Product  PubMed Publications
 TGFB2 recombinant protein  >575 publications with TGF b 3 and TGFB2
 EGF recombinant protein  >22 publications with TGF b 3 and EGF
 SERPINE1 recombinant protein  >16 publications with TGF b 3 and SERPINE1
 TGFBR2 recombinant protein  >10 publications with TGF b 3 and TGFBR2
 TGFBR1 recombinant protein  >9 publications with TGF b 3 and TGFBR1
 SMAD5 recombinant protein  >2 publications with TGF b 3 and SMAD5
 TIMP1 recombinant protein  >2 publications with TGF b 3 and TIMP1
 FN1 recombinant protein  >2 publications with TGF b 3 and FN1
 ACVRL1 recombinant protein  >1 publications with TGF b 3 and ACVRL1
 Products by Pathway  Pathway Diagram
 ALK1 Signaling Events Pathway antibodies  ALK1 Signaling Events Pathway Diagram
 Amoebiasis Pathway antibodies  Amoebiasis Pathway Diagram
 Amoebiasis Pathway antibodies  Amoebiasis Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram
 Chagas Disease (American Trypanosomiasis) Pathway antibodies  Chagas Disease (American Trypanosomiasis) Pathway Diagram
 Chagas Disease (American Trypanosomiasis) Pathway antibodies  Chagas Disease (American Trypanosomiasis) Pathway Diagram
 Chronic Myeloid Leukemia Pathway antibodies  Chronic Myeloid Leukemia Pathway Diagram
 Chronic Myeloid Leukemia Pathway antibodies  Chronic Myeloid Leukemia Pathway Diagram
 Colorectal Cancer Pathway antibodies  Colorectal Cancer Pathway Diagram
Diseases associated with TGF b 3 recombinant proteinOrgans/Tissues associated with TGF b 3 recombinant protein
 Disease Name  Pubmed Publications
 Fibrosis Antibodies  >192 publications with TGF b 3 and Fibrosis
 Cleft Palate Antibodies  >108 publications with TGF b 3 and Cleft Palate
 Disease Models, Animal Antibodies  >107 publications with TGF b 3 and Disease Models, Animal
 Cardiovascular Diseases Antibodies  >88 publications with TGF b 3 and Cardiovascular Diseases
 Inflammation Antibodies  >82 publications with TGF b 3 and Inflammation
 Necrosis Antibodies  >65 publications with TGF b 3 and Necrosis
 Heart Diseases Antibodies  >54 publications with TGF b 3 and Heart Diseases
 Breast Neoplasms Antibodies  >40 publications with TGF b 3 and Breast Neoplasms
 Lung Diseases Antibodies  >39 publications with TGF b 3 and Lung Diseases
 Hypertrophy Antibodies  >39 publications with TGF b 3 and Hypertrophy
 Organ/Tissue Name  Pubmed Publications
 Bone Antibodies  >365 publications with TGF b 3 and Bone
 Connective Tissue Antibodies  >255 publications with TGF b 3 and Connective Tissue
 Embryonic Tissue Antibodies  >147 publications with TGF b 3 and Embryonic Tissue
 Bone Marrow Antibodies  >130 publications with TGF b 3 and Bone Marrow
 Mouth Antibodies  >122 publications with TGF b 3 and Mouth
 Heart Antibodies  >81 publications with TGF b 3 and Heart
 Lung Antibodies  >79 publications with TGF b 3 and Lung
 Eye Antibodies  >68 publications with TGF b 3 and Eye
 Brain Antibodies  >68 publications with TGF b 3 and Brain
 Liver Antibodies  >53 publications with TGF b 3 and Liver
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