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TGFBI recombinant protein :: Transforming Growth Factor Beta Induced Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS143119 TGFBI recombinant protein
Unit / Price
0.005 mg  /  $140 +1 FREE 8GB USB
0.02 mg  /  $205 +1 FREE 8GB USB
1 mg  /  $2,750 +3 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Transforming Growth Factor Beta Induced (TGFBI), Recombinant Protein

★Popular Item★
 Also Known As   

Recombinant Human Transforming Growth Factor Beta Induced

 Product Synonym Names    TGFBI Human; Transforming Growth Factor Beta Induced Human Recombinant; Transforming growth factor-beta-induced protein ig-h3; Beta ig-h3; Kerato-epithelin; RGD-containing collagen-associated protein; RGD-CAP; TGFBI; BIGH3; CSD; CDB1; CDG2; CSD1; CSD2; CSD3; EBMD; LCD1; CDGG1
 Product Gene Name   

TGFBI recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence    MGTVMDVLKG DNRFSMLVAA IQSAGLTETL NREGVYTVFA PTNEAFRALP PRERSRLLGD AKELANILKY HIGDEILVSG GIGALVRLKS LQGDKLEVSL KNNVVSVNKE PVAEPDIMAT NGVVHVITNV LQPPA
 OMIM    121820
 3D Structure    ModBase 3D Structure for Q15582
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 Host    E Coli
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 Purity/Purification    Greater than 95.0% as determined by: (a) Analysis by RP-HPLC. (b) Analysis by SDS-PAGE.
 Form/Format    The TGFBI recombinant Human is formulated 20mM Tris pH-8.
Sterile filtered liquid formulation.
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 Preparation and Storage    Transforming Growth Factor Beta Induced protein Recombinant Human although stable at 4 degree C for 30 days, should be stored below -20 degree C for periods greater than 30 days. Please avoid Freeze/Thaw cycles.
 Other Notes    Small volumes of TGFBI recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for TGFBI recombinant protein

   Description: TGFBI Human Recombinant (fourth FAS domain) produced in E Coli is a single, non-glycosylated, polypeptide containing 135 amino acids (502-636) and having a molecular mass of 14.5 kDa. The TGFBI recombinant Human protein is purified by proprietary chromatographic techniques.

Introduction: Transforming Growth Factor Beta Induced protein also known as TGFBI is an extracellular matrix protein induced by transforming growth factor (TGF)-beta 1. TGFBI protein is involved in cell growth, cell differentiation, wound healing and cell adhesion. In addition, some missense mutations of TGFBI were identified in families affected with human autosomal dominant corneal dystrophies. TGFBI gene encodes for a 683 amino-acid protein containing an RGD motif and four internal repeated domains which have highly conserved sequences founded in several species (Fasciclin domain).
 Product Categories/Family for TGFBI recombinant protein    RECOMBINANT & NATURAL PROTEINS; Recombinant Proteins; Transforming Growth Factor Beta Induced
NCBI/Uniprot data below describe general gene information for TGFBI. It may not necessarily be applicable to this product.
 NCBI GI #    4507467
 NCBI GeneID    7045
 NCBI Accession #    NP_000349.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_000358.2 [Other Products]
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 UniProt Primary Accession #    Q15582 [Other Products]
 UniProt Secondary Accession #    O14471; O14472; O14476; O43216; O43217; O43218; O43219; Q53XM1; D3DQB1 [Other Products]
 UniProt Related Accession #    Q15582 [Other Products]
 Molecular Weight    74,681 Da
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 NCBI Official Full Name    transforming growth factor-beta-induced protein ig-h3
 NCBI Official Synonym Full Names    transforming growth factor, beta-induced, 68kDa
 NCBI Official Symbol    TGFBI [Similar Products]
 NCBI Official Synonym Symbols   
CSD; CDB1; CDG2; CSD1; CSD2; CSD3; EBMD; LCD1; BIGH3; CDGG1
[Similar Products]
 NCBI Protein Information    transforming growth factor-beta-induced protein ig-h3; RGD-CAP; RGD-containing collagen-associated protein; beta ig-h3; kerato-epithelin; transforming growth factor, beta-induced, 68kD
 UniProt Protein Name    Transforming growth factor-beta-induced protein ig-h3
 UniProt Synonym Protein Names   
Kerato-epithelin; RGD-containing collagen-associated protein; RGD-CAP
 Protein Family    Transforming growth factor-beta-induced protein
 UniProt Gene Name    TGFBI [Similar Products]
 UniProt Synonym Gene Names    BIGH3; Beta ig-h3; RGD-CAP [Similar Products]
 UniProt Entry Name    BGH3_HUMAN
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 NCBI Summary for TGFBI    This gene encodes an RGD-containing protein that binds to type I, II and IV collagens. The RGD motif is found in many extracellular matrix proteins modulating cell adhesion and serves as a ligand recognition sequence for several integrins. This protein plays a role in cell-collagen interactions and may be involved in endochondrial bone formation in cartilage. The protein is induced by transforming growth factor-beta and acts to inhibit cell adhesion. Mutations in this gene are associated with multiple types of corneal dystrophy. [provided by RefSeq, Jul 2008]
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 UniProt Comments for TGFBI    betaIG-H3: Binds to type I, II, and IV collagens. This adhesion protein may play an important role in cell-collagen interactions. In cartilage, may be involved in endochondral bone formation. By TGFB1. Highly expressed in the corneal epithelium.

Protein type: Secreted, signal peptide; Cell adhesion; Extracellular matrix; Secreted

Chromosomal Location of Human Ortholog: 5q31

Cellular Component: extracellular matrix; extracellular space; proteinaceous extracellular matrix; plasma membrane; extracellular region; basement membrane; trans-Golgi network

Molecular Function: collagen binding; integrin binding; protein binding; extracellular matrix binding

Biological Process: cell proliferation; extracellular matrix organization and biogenesis; visual perception; response to stimulus; chondrocyte differentiation; negative regulation of cell adhesion; angiogenesis; cell adhesion

Disease: Corneal Dystrophy, Epithelial Basement Membrane; Corneal Dystrophy, Lattice Type Iiia; Corneal Dystrophy, Avellino Type; Corneal Dystrophy Of Bowman Layer, Type Ii; Corneal Dystrophy, Lattice Type I; Corneal Dystrophy Of Bowman Layer, Type I; Corneal Dystrophy, Groenouw Type I
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 Research Articles on TGFBI    1. These results reveal betaig-h3 enhances the metastasis potentials of human osteosarcoma cells via integrin alpha2beta1-mediated PI3K/AKT signal pathways.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with TGFBI recombinant proteinPathways associated with TGFBI recombinant protein
 Reference Product  PubMed Publications
 TGFB1 recombinant protein  >52 publications with TGFBI and TGFB1
 COL1A2 recombinant protein  >6 publications with TGFBI and COL1A2
 CTGF recombinant protein  >4 publications with TGFBI and CTGF
 FN1 recombinant protein  >3 publications with TGFBI and FN1
 SMAD3 recombinant protein  >2 publications with TGFBI and SMAD3
 SMAD2 recombinant protein  >2 publications with TGFBI and SMAD2
 SMAD7 recombinant protein  >1 publications with TGFBI and SMAD7
 VEGFA recombinant protein  >1 publications with TGFBI and VEGFA
 DCN recombinant protein  >1 publications with TGFBI and DCN
 Products by Pathway  Pathway Diagram
 Amyloids Pathway antibodies  Amyloids Pathway Diagram
 Disease Pathway antibodies  Disease Pathway Diagram
Diseases associated with TGFBI recombinant proteinOrgans/Tissues associated with TGFBI recombinant protein
 Disease Name  Pubmed Publications
 Lattice corneal dystrophy type 1 Antibodies  >9 publications with TGFBI and Lattice corneal dystrophy type 1
 Lung Diseases Antibodies  >9 publications with TGFBI and Lung Diseases
 Corneal Dystrophy, Lattice Type IIIA Antibodies  >9 publications with TGFBI and Corneal Dystrophy, Lattice Type IIIA
 Inflammation Antibodies  >8 publications with TGFBI and Inflammation
 Kidney Diseases Antibodies  >8 publications with TGFBI and Kidney Diseases
 Corneal dystrophy Avellino type Antibodies  >8 publications with TGFBI and Corneal dystrophy Avellino type
 Lung Neoplasms Antibodies  >7 publications with TGFBI and Lung Neoplasms
 Groenouw type I corneal dystrophy Antibodies  >5 publications with TGFBI and Groenouw type I corneal dystrophy
 Pancreatic Neoplasms Antibodies  >5 publications with TGFBI and Pancreatic Neoplasms
 Disease Models, Animal Antibodies  >5 publications with TGFBI and Disease Models, Animal
 Organ/Tissue Name  Pubmed Publications
 Eye Antibodies  >127 publications with TGFBI and Eye
 Blood Antibodies  >54 publications with TGFBI and Blood
 Bone Antibodies  >17 publications with TGFBI and Bone
 Lung Antibodies  >12 publications with TGFBI and Lung
 Brain Antibodies  >10 publications with TGFBI and Brain
 Kidney Antibodies  >9 publications with TGFBI and Kidney
 Skin Antibodies  >7 publications with TGFBI and Skin
 Muscle Antibodies  >7 publications with TGFBI and Muscle
 Bone Marrow Antibodies  >7 publications with TGFBI and Bone Marrow
 Liver Antibodies  >7 publications with TGFBI and Liver
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