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TRIM5 recombinant protein :: Tripartite motif-containing protein 5 (TRIM5) Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS1419648
SDS-Page
Unit / Price
0.01 mg (E-Coli)  /  $110 +1 FREE 8GB USB
0.05 mg (E-Coli)  /  $190 +1 FREE 8GB USB
0.1 mg (E-Coli)  /  $285 +1 FREE 8GB USB
0.2 mg (E-Coli)  /  $460 +1 FREE 8GB USB
0.5 mg (E-Coli)  /  $750 +1 FREE 8GB USB
0.05 mg (Yeast)  /  $990 +1 FREE 8GB USB
0.05 mg (Baculovirus)  /  $1,120 +1 FREE 8GB USB
1 mg (E-Coli)  /  $1,180 +1 FREE 8GB USB
0.2 mg (Yeast)  /  $1,345 +1 FREE 8GB USB
0.05 mg (Mammalian-Cell)  /  $1,370 +1 FREE 8GB USB
0.1 mg (Baculovirus)  /  $1,425 +1 FREE 8GB USB
0.5 mg (Yeast)  /  $1,520 +1 FREE 8GB USB
0.5 mg (Baculovirus)  /  $2,040 +2 FREE 8GB USB
0.1 mg (Mammalian-Cell)  /  $2,070 +2 FREE 8GB USB
1 mg (Yeast)  /  $2,310 +2 FREE 8GB USB
1 mg (Baculovirus)  /  $2,685 +3 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Tripartite motif-containing protein 5 (TRIM5), Recombinant Protein

★Popular Item★
 Also Known As   

Recombinant Human Tripartite motif-containing protein 5 (TRIM5)

 Product Synonym Names    Tripartite motif-containing protein 5; EC=6.3.2.-; RING finger protein 88
 Product Gene Name   

TRIM5 recombinant protein

[Similar Products]
 Product Synonym Gene Name    TRIM5; RNF88 [Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence Positions    1-493aa; Full Length
 Sequence    MASGILVNVK EEVTCPICLE LLTQPLSLDC GHSFCQACLT ANHKKSMLDK GESSCPVCRI SYQPENIRPN RHVANIVEKL REVKLSPEGQ KVDHCARHGE KLLLFCQEDG KVICWLCERS QEHRGHHTFL TEEVAREYQV KLQAALEMLR QKQQEAEELE ADIREEKASW KTQIQYDKTN VLADFEQLRD ILDWEESNEL QNLEKEEEDI LKSLTNSETE MVQQTQSLRE LISDLEHRLQ GSVMELLQGV DGVIKRTENV TLKKPETFPK NQRRVFRAPD LKGMLEVFRE LTDVRRYWVD VTVAPNNISC AVISEDKRQV SSPKPQIIYG ARGTRYQTFV NFNYCTGILG SQSITSGKHY WEVDVSKKTA WILGVCAGFQ PDAMCNIEKN ENYQPKYGYW VIGLEEGVKC SAFQDSSFHT PSVPFIVPLS VIICPDRVGV FLDYEACTVS FFNITNHGFL IYKFSHCSFS QPVFPYLNPR KCGVPMTLCS PSS
 OMIM    608487
 3D Structure    ModBase 3D Structure for Q9C035
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 Host    E Coli or Yeast or Baculovirus or Mammalian Cell
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 Purity/Purification    >=90% (lot specific)
 Form/Format    Liquid containing glycerol
 Tag Information    This protein contains an N-terminal tag and may also contain a C-terminal Myc-tag. N-terminal host tags may vary (His, His-SUMO, His-B2M, GST). Tag types are determined by various factors including tag-protein stability and, therefore, are subject to change; please inquire for tag information.
 Sterility    Sterile filter available upon request.
 Endotoxin    Low endotoxin available upon request.
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 Species    Homo sapiens (Human)
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 Preparation and Storage    Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of TRIM5 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for TRIM5 recombinant protein

   Capsid-specific restriction factor that prevents infection from non-host-adapted retroviruses. Blocks viral replication early in the life cycle, after viral entry but before reverse transcription. In addition to acting as a capsid-specific restriction factor, also acts as a pattern recognition receptor that activates innate immune signaling in response to the retroviral capsid lattice. Binding to the viral capsid triggers its E3 ubiquitin ligase activity, and in concert with the heterodimeric ubiquitin conjugating enzyme complex UBE2V1-UBE2N (also known as UBC13-UEV1A complex) generates 'Lys-63'-linked polyubiquitin chains, which in turn are catalysts in the autophosphorylation of the MAP3K7/TAK1 complex (includes TAK1, TAB2, and TAB3). Activation of the MAP3K7/TAK1 complex by autophosphorylation results in the induction and expression of NF-kappa-B and MAPK-responsive inflammatory genes, thereby leading to an innate immune response in the infected cell. Restricts infection by N-tropic murine leukemia virus (N-MLV), equine infectious anemia virus (EIAV), simian immunodeficiency virus of macaques (SIVmac), feline immunodeficiency virus (FIV), and bovine immunodeficiency virus (BIV) (PubMed:17156811). Plays a role in regulating autophagy through activation of autophagy regulator BECN1 by causing its dissociation from its inhibitors BCL2 and TAB2 (PubMed:25127057). Also plays a role in autophagy by acting as a selective autophagy receptor which recognizes and targets HIV-1 capsid protein p24 for autophagic destruction
 Product Categories/Family for TRIM5 recombinant protein    Cell Biology
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 SDS-Page of TRIM5 recombinant protein    TRIM5 recombinant protein SDS-Page image
(Note: Representative image, actual molecular weight may vary depending on Tag type and expression host)
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NCBI/Uniprot data below describe general gene information for TRIM5. It may not necessarily be applicable to this product.
 NCBI GI #    283046694
 NCBI GeneID    85363
 NCBI Accession #    NP_149023.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_033034.2 [Other Products]
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 UniProt Primary Accession #    Q9C035 [Other Products]
 UniProt Secondary Accession #    Q2MLV4; Q2MLV8; Q2MLV9; Q2MLW1; Q2MLW3; Q2MLW4; A6NGQ1; A8WFA8; D3DQS8; D3DQS9; G3GJY1 [Other Products]
 UniProt Related Accession #    Q9C035 [Other Products]
 Molecular Weight    29,677 Da
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 NCBI Official Full Name    tripartite motif-containing protein 5 isoform alpha
 NCBI Official Synonym Full Names    tripartite motif containing 5
 NCBI Official Symbol    TRIM5 [Similar Products]
 NCBI Official Synonym Symbols   
RNF88; TRIM5alpha
[Similar Products]
 NCBI Protein Information    tripartite motif-containing protein 5; ring finger protein 88; tripartite motif protein TRIM5; tripartite motif containing 5 transcript variant iota; tripartite motif containing 5 transcript variant kappa
 UniProt Protein Name    Tripartite motif-containing protein 5
 UniProt Synonym Protein Names   
RING finger protein 88
 Protein Family    Tripartite motif-containing protein
 UniProt Gene Name    TRIM5 [Similar Products]
 UniProt Synonym Gene Names    RNF88 [Similar Products]
 UniProt Entry Name    TRIM5_HUMAN
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 NCBI Summary for TRIM5    The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The protein forms homo-oligomers via the coilel-coil region and localizes to cytoplasmic bodies. It appears to function as a E3 ubiquitin-ligase and ubiqutinates itself to regulate its subcellular localization. It may play a role in retroviral restriction. Multiple alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Dec 2009]
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 UniProt Comments for TRIM5    TRIM5: Isoform Alpha is a retrovirus restriction factor, which mediates species-specific, early block to retrovirus infection. Targets retroviral capsid soon after entry into the cell, and prevents reverse transcription of the virus RNA genome. Isoform Alpha trimers may make multiple contacts with the hexameric lattice of CA proteins which constitute the surface of retrovirion core, and somehow inactivate the virus. Restricts efficiently infection by N-MLV, but not HIV-1. May have E3 ubiquitin-protein ligase activity. Belongs to the TRIM/RBCC family. 6 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 6.3.2.19; EC 6.3.2.-; Ubiquitin conjugating system; Ligase; Ubiquitin ligase

Chromosomal Location of Human Ortholog: 11p15

Cellular Component: cytoplasm; cytosol

Molecular Function: identical protein binding; protein binding; protein homodimerization activity; zinc ion binding; ubiquitin-protein ligase activity; pattern recognition receptor activity; ligase activity

Biological Process: positive regulation of I-kappaB kinase/NF-kappaB cascade; viral reproduction; positive regulation of MAPKKK cascade; negative regulation of virion penetration into host cell; cytokine and chemokine mediated signaling pathway; innate immune response; positive regulation of transcription factor activity; pattern recognition receptor signaling pathway; activation of innate immune response; regulation of lipopolysaccharide-mediated signaling pathway; defense response to virus; activation of NF-kappaB transcription factor
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 Research Articles on TRIM5    1. TRIM5alpha and TRIM22 have differential transcriptional regulation and distinct anti-HIV roles according to infection phase.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Diseases associated with TRIM5 recombinant proteinOrgans/Tissues associated with TRIM5 recombinant protein
 Disease Name  Pubmed Publications
 HIV Infections Antibodies  >156 publications with TRIM5 and HIV Infections
 Disease Models, Animal Antibodies  >18 publications with TRIM5 and Disease Models, Animal
 Inflammation Antibodies  >7 publications with TRIM5 and Inflammation
 Nervous System Diseases Antibodies  >3 publications with TRIM5 and Nervous System Diseases
 Kidney Diseases Antibodies  >2 publications with TRIM5 and Kidney Diseases
 Necrosis Antibodies  >2 publications with TRIM5 and Necrosis
 Hepatitis Antibodies  >1 publications with TRIM5 and Hepatitis
 Acidosis Antibodies  >1 publications with TRIM5 and Acidosis
 Mental Disorders Antibodies  >1 publications with TRIM5 and Mental Disorders
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >49 publications with TRIM5 and Blood
 Kidney Antibodies  >8 publications with TRIM5 and Kidney
 Bone Marrow Antibodies  >3 publications with TRIM5 and Bone Marrow
 Bone Antibodies  >3 publications with TRIM5 and Bone
 Intestine Antibodies  >2 publications with TRIM5 and Intestine
 Heart Antibodies  >2 publications with TRIM5 and Heart
 Prostate Antibodies  >2 publications with TRIM5 and Prostate
 Embryonic Tissue Antibodies  >1 publications with TRIM5 and Embryonic Tissue
 Connective Tissue Antibodies  >1 publications with TRIM5 and Connective Tissue
 Placenta Antibodies  >1 publications with TRIM5 and Placenta
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