NP_001029241.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
28,718 Da
NCBI Official Full Name
tropomyosin alpha-1 chain isoform Tpm1.6cy
NCBI Official Synonym Full Names
tropomyosin 1
NCBI Protein Information
tropomyosin alpha-1 chain
UniProt Protein Name
Tropomyosin alpha-1 chain
UniProt Synonym Protein Names
Alpha-tropomyosin; Tropomyosin-1
UniProt Synonym Gene Names
NCBI Summary for Tpm1
This gene is a member of the tropomyosin family and encodes a protein that heterodimerizes with a beta subunit, binding actin in both muscle and nonmuscle cells. In both smooth and striated muscle cells, it plays a role in calcium dependent-regulation of muscle contraction. In nonmuscle cells, it stabilizes cytoskeleton actin filaments. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]
UniProt Comments for Tpm1
Binds to actin filaments in muscle and non-muscle cells (PubMed:7568216, PubMed:22812662). Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction (PubMed:22812662). Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments.
Research Articles on Tpm1
Precautions
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Disclaimer
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Pathways associated with Tpm1 recombinant protein
Diseases associated with Tpm1 recombinant protein
Disease Name |
Pubmed Publications |
Cardiovascular Diseases Antibodies |
>74 publications with Tpm1 and Cardiovascular Diseases |
Heart Diseases Antibodies |
>73 publications with Tpm1 and Heart Diseases |
Cardiomyopathy, Hypertrophic, Familial Antibodies |
>27 publications with Tpm1 and Cardiomyopathy, Hypertrophic, Familial |
Hypertrophy Antibodies |
>27 publications with Tpm1 and Hypertrophy |
Breast Neoplasms Antibodies |
>16 publications with Tpm1 and Breast Neoplasms |
Cell Transformation, Neoplastic Antibodies |
>12 publications with Tpm1 and Cell Transformation, Neoplastic |
Fibrosis Antibodies |
>10 publications with Tpm1 and Fibrosis |
Disease Models, Animal Antibodies |
>10 publications with Tpm1 and Disease Models, Animal |
Cardiomyopathy, Familial Hypertrophic, 3 Antibodies |
>9 publications with Tpm1 and Cardiomyopathy, Familial Hypertrophic, 3 |
Kidney Diseases Antibodies |
>5 publications with Tpm1 and Kidney Diseases |
Organs/Tissues associated with Tpm1 recombinant protein
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