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TNNI2 recombinant protein :: Troponin I Type 2 Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS142896 TNNI2 recombinant protein
Unit / Price
0.005 mg  /  $140 +1 FREE 8GB USB
0.02 mg  /  $205 +1 FREE 8GB USB
1 mg  /  $2,940 +3 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Troponin I Type 2 (TNNI2), Recombinant Protein

★Popular Item★
 Also Known As   

Recombinant Human Troponin I Type 2

 Product Synonym Names    TNNI2 Human; Troponin I Type 2 Human Recombinant; Troponin I fast skeletal muscle; Troponin I fast-twitch isoform; TNNI2; DA2B; FSSV; fsTnI; AMCD2B
 Product Gene Name   

TNNI2 recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    191043
 3D Structure    ModBase 3D Structure for P48788
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 Host    E Coli
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 Purity/Purification    Greater than 85.0% as determined by SDS-PAGE.
 Form/Format    The protein solution contains 20mM Tris-HCl, 500mM NaCl and 10mM b-ME, pH 7.5.
Sterile Filtered colourless liquid formualtion.
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 Preparation and Storage    TNNI2 Human although stable at 10 degree C for 7 days, should be stored below -18 degree C.Please prevent freeze-thaw cycles.
 Other Notes    Small volumes of TNNI2 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for TNNI2 recombinant protein

   Description: Skeletal isoforms of Troponin I were suggested to be used as markers of acute and chronic skeletal muscle injuries. In skeletal muscles Troponin I is presented by two forms, slow (21.6 kDa) and fast (21.2 kDa) skeletal. The protein (Fast Skeletal Troponin I) migrates on SDS-PAGE to approximately 26.5kDa.

Introduction: TNNI2 is a fast-twitch skeletal muscle protein, belongs to the troponin I gene family, and is part of the troponin complex including troponin T, troponin C and troponin I subunits. The troponin complex, together with tropomyosin, is responsible for the calcium-dependent regulation of striated muscle contraction. TNNI2 is also present in vascular smooth muscle and may play a role in regulation of smooth muscle function. Other than muscle tissues, TNNI2 is found in corneal epithelium, cartilage where it is an inhibitor of angiogenesis to inhibit tumor growth and metastasis, and mammary gland where it functions as a coactivator of estrogen receptor-related receptor alpha. Furthermore, TNNI2 suppresses tumor growth in human ovarian carcinoma. Mutations in the TNNI2 gene cause myopathy and distal arthrogryposis type 2B.
 Product Categories/Family for TNNI2 recombinant protein    RECOMBINANT & NATURAL PROTEINS; Recombinant Proteins; Cardiac Troponin
NCBI/Uniprot data below describe general gene information for TNNI2. It may not necessarily be applicable to this product.
 NCBI GI #    224967057
 NCBI GeneID    7136
 NCBI Accession #    NP_001139301.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001145829.1 [Other Products]
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 UniProt Primary Accession #    P48788 [Other Products]
 UniProt Secondary Accession #    A6NIV8; A6NJU5 [Other Products]
 UniProt Related Accession #    P48788 [Other Products]
 Molecular Weight    21,355 Da
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 NCBI Official Full Name    troponin I, fast skeletal muscle isoform 1
 NCBI Official Synonym Full Names    troponin I type 2 (skeletal, fast)
 NCBI Official Symbol    TNNI2 [Similar Products]
 NCBI Official Synonym Symbols   
DA2B; FSSV; fsTnI; AMCD2B
[Similar Products]
 NCBI Protein Information    troponin I, fast skeletal muscle; troponin I fast twitch 2; troponin I, fast-twitch isoform; troponin I, fast-twitch skeletal muscle isoform; troponin I, skeletal, fast
 UniProt Protein Name    Troponin I, fast skeletal muscle
 UniProt Synonym Protein Names   
Troponin I, fast-twitch isoform
 Protein Family    Troponin
 UniProt Gene Name    TNNI2 [Similar Products]
 UniProt Entry Name    TNNI2_HUMAN
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 NCBI Summary for TNNI2    This gene encodes a fast-twitch skeletal muscle protein, a member of the troponin I gene family, and a component of the troponin complex including troponin T, troponin C and troponin I subunits. The troponin complex, along with tropomyosin, is responsible for the calcium-dependent regulation of striated muscle contraction. Mouse studies show that this component is also present in vascular smooth muscle and may play a role in regulation of smooth muscle function. In addition to muscle tissues, this protein is found in corneal epithelium, cartilage where it is an inhibitor of angiogenesis to inhibit tumor growth and metastasis, and mammary gland where it functions as a co-activator of estrogen receptor-related receptor alpha. This protein also suppresses tumor growth in human ovarian carcinoma. Mutations in this gene cause myopathy and distal arthrogryposis type 2B. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Mar 2009]
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 UniProt Comments for TNNI2    TNNI2: Troponin I is the inhibitory subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity. Defects in TNNI2 are a cause of distal arthrogryposis type 2B (DA2B); also known as arthrogryposis multiplex congenita, distal, type 2B (AMCD2B). DA2B is a form of inherited multiple congenital contractures. Affected individuals have vertical talus, ulnar deviation in the hands, severe camptodactyly, and a distinctive face characterized by a triangular shape, prominent nasolabial folds, small mouth and a prominent chin. Belongs to the troponin I family.

Protein type: Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 11p15.5

Cellular Component: troponin complex; cytosol; nucleus

Molecular Function: troponin T binding; protein binding; actin binding

Biological Process: skeletal muscle contraction; regulation of muscle contraction; positive regulation of transcription, DNA-dependent; muscle filament sliding

Disease: Arthrogryposis, Distal, Type 2b
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 Research Articles on TNNI2    1. report the first TNNI2 mutation in classical FSS and describe an atypical adult FSS case with only facial contractures resulting from somatic mosaicism
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with TNNI2 recombinant proteinPathways associated with TNNI2 recombinant protein
 Reference Product  PubMed Publications
 TPM2 recombinant protein  >14 publications with TNNI2 and TPM2
 TNNT3 recombinant protein  >14 publications with TNNI2 and TNNT3
 MYH3 recombinant protein  >9 publications with TNNI2 and MYH3
 TNNT1 recombinant protein  >3 publications with TNNI2 and TNNT1
 TNNC2 recombinant protein  >3 publications with TNNI2 and TNNC2
 TPM1 recombinant protein  >2 publications with TNNI2 and TPM1
 TNNC1 recombinant protein  >1 publications with TNNI2 and TNNC1
 MYL1 recombinant protein  >1 publications with TNNI2 and MYL1
 TNNT2 recombinant protein  >1 publications with TNNI2 and TNNT2
 Products by Pathway  Pathway Diagram
 Muscle Contraction Pathway antibodies  Muscle Contraction Pathway Diagram
 Striated Muscle Contraction Pathway antibodies  Striated Muscle Contraction Pathway Diagram
 Striated Muscle Contraction Pathway antibodies  Striated Muscle Contraction Pathway Diagram
Diseases associated with TNNI2 recombinant proteinOrgans/Tissues associated with TNNI2 recombinant protein
 Disease Name  Pubmed Publications
 Muscular Diseases Antibodies  >17 publications with TNNI2 and Muscular Diseases
 Distal arthrogryposis type 2B Antibodies  >6 publications with TNNI2 and Distal arthrogryposis type 2B
 Cardiovascular Diseases Antibodies  >4 publications with TNNI2 and Cardiovascular Diseases
 Heart Diseases Antibodies  >4 publications with TNNI2 and Heart Diseases
 Disease Models, Animal Antibodies  >2 publications with TNNI2 and Disease Models, Animal
 Heart Defects, Congenital Antibodies  >1 publications with TNNI2 and Heart Defects, Congenital
 Cognition Disorders Antibodies  >1 publications with TNNI2 and Cognition Disorders
 Hypertrophy Antibodies  >1 publications with TNNI2 and Hypertrophy
 Kidney Diseases Antibodies  >1 publications with TNNI2 and Kidney Diseases
 Prenatal Exposure Delayed Effects Antibodies  >1 publications with TNNI2 and Prenatal Exposure Delayed Effects
 Organ/Tissue Name  Pubmed Publications
 Muscle Antibodies  >31 publications with TNNI2 and Muscle
 Heart Antibodies  >12 publications with TNNI2 and Heart
 Embryonic Tissue Antibodies  >3 publications with TNNI2 and Embryonic Tissue
 Mouth Antibodies  >3 publications with TNNI2 and Mouth
 Connective Tissue Antibodies  >2 publications with TNNI2 and Connective Tissue
 Eye Antibodies  >2 publications with TNNI2 and Eye
 Lung Antibodies  >2 publications with TNNI2 and Lung
 Bone Antibodies  >1 publications with TNNI2 and Bone
 Kidney Antibodies  >1 publications with TNNI2 and Kidney
 Pancreas Antibodies  >1 publications with TNNI2 and Pancreas
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