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PRSS1 recombinant protein :: Trypsin-1 (PRSS1) Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS965593 PRSS1 recombinant protein
Unit / Price
0.05 mg (E-Coli)  /  $625 +1 FREE 8GB USB
0.05 mg (Yeast)  /  $770 +1 FREE 8GB USB
0.2 mg (E-Coli)  /  $840 +1 FREE 8GB USB
0.05 mg (Baculovirus)  /  $920 +1 FREE 8GB USB
0.5 mg (E-Coli)  /  $925 +1 FREE 8GB USB
0.2 mg (Yeast)  /  $1,035 +1 FREE 8GB USB
0.1 mg (Baculovirus)  /  $1,155 +1 FREE 8GB USB
0.05 mg (Mammalian-Cell)  /  $1,155 +1 FREE 8GB USB
0.5 mg (Yeast)  /  $1,170 +1 FREE 8GB USB
1 mg (E-Coli)  /  $1,300 +1 FREE 8GB USB
0.5 mg (Baculovirus)  /  $1,670 +2 FREE 8GB USB
0.1 mg (Mammalian-Cell)  /  $1,760 +2 FREE 8GB USB
1 mg (Yeast)  /  $1,775 +2 FREE 8GB USB
1 mg (Baculovirus)  /  $2,230 +2 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Trypsin-1 (PRSS1), Recombinant Protein

★Popular Item★
 Also Known As   

Recombinant Human Trypsin-1 (PRSS1)

 Product Synonym Names    Trypsin-1; EC=3.4.21.4; Beta-trypsin; Cationic trypsinogen; Serine protease 1; Trypsin ICleaved into the following 2 chains:; 1. Alpha-trypsin chain 1; 2. Alpha-trypsin chain 2
 Product Gene Name   

PRSS1 recombinant protein

[Similar Products]
 Product Synonym Gene Name    PRSS1; TRP1; TRY1; TRYP1 [Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence Positions    24-247aa; Full length protein
 Sequence    IVGGYNC EENSVPYQVS LNSGYHFCGG SLINEQWVVS AGHCYKSRIQ VRLGEHNIEV LEGNEQFINA AKIIRHPQYD RKTLNNDIML IKLSSRAVIN ARVSTISLPT APPATGTKCL ISGWGNTASS GADYPDELQC LDAPVLSQAK CEASYPGKIT SNMFCVGFLE GGKDSCQGDS GGPVVCNGQL QGVVSWGDGC AQKNKPGVYT KVYNYVKWIK NTIAANS
 OMIM    276000
 3D Structure    ModBase 3D Structure for P07477
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 Host    E Coli or Yeast or Baculovirus or Mammalian Cell
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 Purity/Purification    >=90% (lot specific)
 Form/Format    Liquid containing glycerol
 Tag Information    This protein contains an N-terminal tag and may also contain a C-terminal Myc-tag. N-terminal host tags may vary (His, His-SUMO, His-B2M, GST). Tag types are determined by various factors including tag-protein stability and, therefore, are subject to change; please inquire for tag information.
 Sterility    Sterile filter available upon request.
 Endotoxin    Low endotoxin available upon request.
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 Species    Homo sapiens (Human)
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 Preparation and Storage    Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of PRSS1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for PRSS1 recombinant protein

   This gene encodes a trypsinogen, which is a member of the trypsin family of serine proteases. This enzyme is secreted by the pancreas and cleaved to its active form in the small intestine. It is active on peptide linkages involving the carboxyl group of lysine or arginine. Mutations in this gene are associated with hereditary pancreatitis. This gene and several other trypsinogen genes are localized to the T cell receptor beta locus on chromosome 7.
NCBI/Uniprot data below describe general gene information for PRSS1. It may not necessarily be applicable to this product.
 NCBI GI #    4506145
 NCBI GeneID    5644
 NCBI Accession #    NP_002760.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_002769.4 [Other Products]
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 UniProt Primary Accession #    P07477 [Other Products]
 UniProt Secondary Accession #    Q5NV57; Q7M4N3; Q7M4N4; Q92955; Q9HAN4; Q9HAN5; Q9HAN6; Q9HAN7; A1A509; A6NJ71; B2R5I5 [Other Products]
 UniProt Related Accession #    P07477 [Other Products]
 Molecular Weight    26,558 Da
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 NCBI Official Full Name    trypsin-1 preproprotein
 NCBI Official Synonym Full Names    protease, serine, 1 (trypsin 1)
 NCBI Official Symbol    PRSS1 [Similar Products]
 NCBI Official Synonym Symbols   
TRP1; TRY1; TRY4; TRYP1
[Similar Products]
 NCBI Protein Information    trypsin-1; beta-trypsin; trypsinogen 1; trypsinogen A; digestive zymogen; cationic trypsinogen; nonfunctional trypsin 1
 UniProt Protein Name    Trypsin-1
 UniProt Synonym Protein Names   
Beta-trypsin; Cationic trypsinogen; Serine protease 1; Trypsin ICleaved into the following 2 chains:Alpha-trypsin chain 1; Alpha-trypsin chain 2
 Protein Family    Anionic trypsin
 UniProt Gene Name    PRSS1 [Similar Products]
 UniProt Synonym Gene Names    TRP1; TRY1; TRYP1 [Similar Products]
 UniProt Entry Name    TRY1_HUMAN
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 NCBI Summary for PRSS1    This gene encodes a trypsinogen, which is a member of the trypsin family of serine proteases. This enzyme is secreted by the pancreas and cleaved to its active form in the small intestine. It is active on peptide linkages involving the carboxyl group of lysine or arginine. Mutations in this gene are associated with hereditary pancreatitis. This gene and several other trypsinogen genes are localized to the T cell receptor beta locus on chromosome 7. [provided by RefSeq, Jul 2008]
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 UniProt Comments for PRSS1    trypsin 1: Has activity against the synthetic substrates Boc-Phe- Ser-Arg-Mec, Boc-Leu-Thr-Arg-Mec, Boc-Gln-Ala-Arg-Mec and Boc-Val- Pro-Arg-Mec. The single-chain form is more active than the two- chain form against all of these substrates. Defects in PRSS1 are a cause of pancreatitis (PCTT). A disease characterized by the presence of calculi in pancreatic ducts. It causes severe abdominal pain attacks. Belongs to the peptidase S1 family.

Protein type: Secreted; EC 3.4.21.4; Secreted, signal peptide; Protease

Chromosomal Location of Human Ortholog: 7q34

Cellular Component: extracellular region

Molecular Function: metal ion binding; serine-type endopeptidase activity

Biological Process: extracellular matrix disassembly; extracellular matrix organization and biogenesis; vitamin metabolic process; cobalamin metabolic process; digestion; proteolysis; water-soluble vitamin metabolic process

Disease: Trypsinogen Deficiency; Pancreatitis, Hereditary
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 Research Articles on PRSS1    1. The p.G208A variant of PRSS1, previously only found in Asian patients, was found in 3 generations of a European family, one of whom had chronic pancreatitis.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with PRSS1 recombinant proteinPathways associated with PRSS1 recombinant protein
 Reference Product  PubMed Publications
 FLNA recombinant protein  >12 publications with PRSS1 and FLNA
 Products by Pathway  Pathway Diagram
 Activation Of Matrix Metalloproteinases Pathway antibodies  Activation Of Matrix Metalloproteinases Pathway Diagram
 Cobalamin (Cbl, Vitamin B12) Transport And Metabolism Pathway antibodies  Cobalamin (Cbl, Vitamin B12) Transport And Metabolism Pathway Diagram
 Defective AMN Causes Hereditary Megaloblastic Anemia 1 Pathway antibodies  Defective AMN Causes Hereditary Megaloblastic Anemia 1 Pathway Diagram
 Defective BTD Causes Biotidinase Deficiency Pathway antibodies  Defective BTD Causes Biotidinase Deficiency Pathway Diagram
 Defective CD320 Causes Methylmalonic Aciduria Pathway antibodies  Defective CD320 Causes Methylmalonic Aciduria Pathway Diagram
 Defective CUBN Causes Hereditary Megaloblastic Anemia 1 Pathway antibodies  Defective CUBN Causes Hereditary Megaloblastic Anemia 1 Pathway Diagram
 Defective GIF Causes Intrinsic Factor Deficiency Pathway antibodies  Defective GIF Causes Intrinsic Factor Deficiency Pathway Diagram
 Defective HLCS Causes Multiple Carboxylase Deficiency Pathway antibodies  Defective HLCS Causes Multiple Carboxylase Deficiency Pathway Diagram
 Defective LMBRD1 Causes Methylmalonic Aciduria And Homocystinuria Type CblF Pathway antibodies  Defective LMBRD1 Causes Methylmalonic Aciduria And Homocystinuria Type CblF Pathway Diagram
 Defective MMAA Causes Methylmalonic Aciduria Type CblA Pathway antibodies  Defective MMAA Causes Methylmalonic Aciduria Type CblA Pathway Diagram
Diseases associated with PRSS1 recombinant proteinOrgans/Tissues associated with PRSS1 recombinant protein
 Disease Name  Pubmed Publications
 Pancreatitis Antibodies  >225 publications with PRSS1 and Pancreatitis
 Pancreatitis, Chronic Antibodies  >176 publications with PRSS1 and Pancreatitis, Chronic
 Hereditary pancreatitis Antibodies  >100 publications with PRSS1 and Hereditary pancreatitis
 Fibrosis Antibodies  >98 publications with PRSS1 and Fibrosis
 Inflammation Antibodies  >25 publications with PRSS1 and Inflammation
 Carcinoma Antibodies  >19 publications with PRSS1 and Carcinoma
 Immune System Diseases Antibodies  >12 publications with PRSS1 and Immune System Diseases
 Gastrointestinal Diseases Antibodies  >11 publications with PRSS1 and Gastrointestinal Diseases
 Necrosis Antibodies  >6 publications with PRSS1 and Necrosis
 Breast Neoplasms Antibodies  >4 publications with PRSS1 and Breast Neoplasms
 Organ/Tissue Name  Pubmed Publications
 Pancreas Antibodies  >92 publications with PRSS1 and Pancreas
 Liver Antibodies  >10 publications with PRSS1 and Liver
 Muscle Antibodies  >2 publications with PRSS1 and Muscle
 Heart Antibodies  >1 publications with PRSS1 and Heart
 Testis Antibodies  >1 publications with PRSS1 and Testis
 Intestine Antibodies  >1 publications with PRSS1 and Intestine
 Prostate Antibodies  >1 publications with PRSS1 and Prostate
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