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TPS recombinant protein :: Tryptase (TPS) Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS2010007 (SPECIAL PROMOTION: Get FREE $5 Starbucks gift card (Maximum 5 gift cards/product). Gift card(s) will be included with shipment)
SDS-PAGE
Unit / Price
0.01 mg  /  $140 +1 FREE 8GB USB
0.05 mg  /  $260 +1 FREE 8GB USB
0.1 mg  /  $400 +1 FREE 8GB USB
0.2 mg  /  $495 +1 FREE 8GB USB
0.5 mg  /  $955 +1 FREE 8GB USB
1 mg  /  $1,415 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Tryptase (TPS), Recombinant Protein

★Popular Item★
 Also Known As   

Recombinant Tryptase (TPS)

 Product Gene Name   

TPS recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence    The target protein is fused with two N-terminal Tags, His-tag and GST-tag, its sequence is listed below.
MSPILGYWKI KGLVQPTRLL LEYLEEKYEE HLYERDEGDK WRNKKFELGL EFPNLPYYID GDVKLTQSMA IIRYIADKHN MLGGCPKERA EISMLEGAVL DIRYGVSRIA YSKDFETLKV DFLSKLPEML KMFEDRLCHK TYLNGDHVTH PDFMLYDALD VVLYMDPMCL DAFPKLVCFK KRIEAIPQID KYLKSSKYIA WPLQGWQATF GGGDHPPKSD GSTSGSGHHH HHHSAGLVPR GSTAIGMKET AAAKFERQHM DSPDLGTLEV LFQGPLGSEF - GDVDNDERLP PPFPLKQVKV PIMENHICDA KYHLGAYTGD DVRIVRDDML CAGNTRRDSC QGDSGGPLVC KVNGTWLQAG VVSWGEGCAQ PNRPGIYTRV TY
 Chromosome Location    Chromosome: 16; NC_000016.9 (1290678..1292555). Location: 16p13.3
 OMIM    191080
 3D Structure    ModBase 3D Structure for Q15661
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 Host    E Coli
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 Purity/Purification    > 95%
 Form/Format    Supplied as lyophilized form in PBS,pH7.4, containing 5% sucrose, 0.01% sarcosyl.
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 Organism    Homo sapiens (Human)
 Expression System    Prokaryotic expression
 Residues    Gly161~Tyr262 (Accession # Q15661) with two N-terminal Tags, His-tag and GST-tag
 Subcellular Location    Secreted
 Endotoxin Level    <1.0EU per 1ug (determined by the LAL method)
 Predicted Isoelectric Point    6
 Reconstitution    Reconstitute in sterile PBS, pH7.2-pH7.4.
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 Preparation and Storage    Avoid repeated freeze/thaw cycles. Store at 2-8 degree C for one month. Aliquot and store at -80 degree C for 12 months.
Stability Test: The thermal stability is described by the loss rate of the targetprotein. The loss rate was determined by accelerated thermal degradation test,that is, incubate the protein at 37 degree C for 48h, and no obvious degradation andprecipitation were observed. (Referring from China Biological Products Standard,which was calculated by the Arrhenius equation.) The loss of this protein is lessthan 5% within the expiration date under appropriate storage condition.
 Other Notes    Small volumes of TPS recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for TPS recombinant protein

   About the Marker: Effective Size Range: 10kDa to 70kDa.
Protein bands: 10kDa, 14kDa, 18kDa, 22kDa, 26kDa, 33kDa, 44kDa and70kDa.
Double intensity bands: The 26kDa, 18kDa, 10kDa bands are at doubleintensity to make location and size approximation of proteins of interestquick and easy.
Ready-to-use: No need to heat, dilute or add reducing agents before use.
 Applications Tested/Suitable for TPS recombinant protein   

SDS-PAGE, Western Blot (WB), ELISA (EIA), Immunoprecipitation (IP)

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 SDS-PAGE of TPS recombinant protein    TPS recombinant protein SDS-PAGE image
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NCBI/Uniprot data below describe general gene information for TPS. It may not necessarily be applicable to this product.
 NCBI GI #    13775595
 NCBI GeneID    7177
 NCBI Accession #    NP_003285.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_003294.3 [Other Products]
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 UniProt Primary Accession #    Q15661 [Other Products]
 UniProt Secondary Accession #    P15157; Q15663; Q6B052; Q9H2Y4; Q9H2Y5; Q9UQI1; D2E6R9; D2E6S1 [Other Products]
 UniProt Related Accession #    Q15661 [Other Products]
 Molecular Weight    43.1kDa
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 NCBI Official Full Name    tryptase alpha/beta-1
 NCBI Official Synonym Full Names    tryptase alpha/beta 1
 NCBI Official Symbol    TPSAB1 [Similar Products]
 NCBI Official Synonym Symbols   
TPS1; TPS2; TPSB1
[Similar Products]
 NCBI Protein Information    tryptase alpha/beta-1; tryptase I; tryptase-1; tryptase-I; tryptase-III; tryptase beta 1; tryptase beta I; tryptase beta-1; tryptase alpha-1; tryptase alpha II; mast cell beta I tryptase; mast cell alpha II tryptase
 UniProt Protein Name    Tryptase alpha/beta-1
 UniProt Synonym Protein Names   
Tryptase I; Tryptase alpha-1
 Protein Family    Development-specific protein
 UniProt Gene Name    TPSAB1 [Similar Products]
 UniProt Synonym Gene Names    TPS1; TPS2; TPSB1; Tryptase-1 [Similar Products]
 UniProt Entry Name    TRYB1_HUMAN
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 NCBI Summary for TPS    Tryptases comprise a family of trypsin-like serine proteases, the peptidase family S1. Tryptases are enzymatically active only as heparin-stabilized tetramers, and they are resistant to all known endogenous proteinase inhibitors. Several tryptase genes are clustered on chromosome 16p13.3. These genes are characterized by several distinct features. They have a highly conserved 3' UTR and contain tandem repeat sequences at the 5' flank and 3' UTR which are thought to play a role in regulation of the mRNA stability. These genes have an intron immediately upstream of the initiator Met codon, which separates the site of transcription initiation from protein coding sequence. This feature is characteristic of tryptases but is unusual in other genes. The alleles of this gene exhibit an unusual amount of sequence variation, such that the alleles were once thought to represent two separate genes, alpha and beta 1. Beta tryptases appear to be the main isoenzymes expressed in mast cells; whereas in basophils, alpha tryptases predominate. Tryptases have been implicated as mediators in the pathogenesis of asthma and other allergic and inflammatory disorders. [provided by RefSeq, Jul 2008]
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 UniProt Comments for TPS    TPSAB1: Tryptase is the major neutral protease present in mast cells and is secreted upon the coupled activation-degranulation response of this cell type. Belongs to the peptidase S1 family. Tryptase subfamily. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Secreted; Secreted, signal peptide; EC 3.4.21.59; Protease

Chromosomal Location of Human Ortholog: 16p13.3

Cellular Component: extracellular matrix; extracellular space; extracellular region

Molecular Function: protein binding; serine-type peptidase activity; serine-type endopeptidase activity

Biological Process: extracellular matrix disassembly; extracellular matrix organization and biogenesis; defense response; proteolysis
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 Research Articles on TPS    1. As much as 82% of the variation in serum tryptase is due to genetics factors, and genetic effects overlap serum tryptase and body mass index.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with TPS recombinant proteinPathways associated with TPS recombinant protein
 Reference Product  PubMed Publications
 TPSB2 recombinant protein  >4 publications with TPS and TPSB2
 CPA3 recombinant protein  >2 publications with TPS and CPA3
 RAC1 recombinant protein  >1 publications with TPS and RAC1
 RAC2 recombinant protein  >1 publications with TPS and RAC2
 CTSC recombinant protein  >1 publications with TPS and CTSC
 Products by Pathway  Pathway Diagram
 Activation Of Matrix Metalloproteinases Pathway antibodies  Activation Of Matrix Metalloproteinases Pathway Diagram
 Degradation Of The Extracellular Matrix Pathway antibodies  Degradation Of The Extracellular Matrix Pathway Diagram
 Extracellular Matrix Organization Pathway antibodies  Extracellular Matrix Organization Pathway Diagram
Diseases associated with TPS recombinant proteinOrgans/Tissues associated with TPS recombinant protein
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >28 publications with TPS and Inflammation
 Fibrosis Antibodies  >7 publications with TPS and Fibrosis
 Disease Models, Animal Antibodies  >5 publications with TPS and Disease Models, Animal
 Necrosis Antibodies  >5 publications with TPS and Necrosis
 Hyperplasia Antibodies  >4 publications with TPS and Hyperplasia
 Edema Antibodies  >3 publications with TPS and Edema
 Skin Abnormalities Antibodies  >3 publications with TPS and Skin Abnormalities
 Heart Diseases Antibodies  >1 publications with TPS and Heart Diseases
 Kidney Diseases Antibodies  >1 publications with TPS and Kidney Diseases
 Weight Loss Antibodies  >1 publications with TPS and Weight Loss
 Organ/Tissue Name  Pubmed Publications
 Skin Antibodies  >22 publications with TPS and Skin
 Bone Antibodies  >21 publications with TPS and Bone
 Bone Marrow Antibodies  >20 publications with TPS and Bone Marrow
 Lung Antibodies  >20 publications with TPS and Lung
 Connective Tissue Antibodies  >16 publications with TPS and Connective Tissue
 Intestine Antibodies  >9 publications with TPS and Intestine
 Nerve Antibodies  >5 publications with TPS and Nerve
 Stomach Antibodies  >3 publications with TPS and Stomach
 Kidney Antibodies  >3 publications with TPS and Kidney
 Testis Antibodies  >2 publications with TPS and Testis
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