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TuBB3 recombinant protein

Scan QR to view Datasheet Catalog #    MBS204798
SDS-PAGE
Unit / Price
0.05 mg  /  $375 +1 FREE 8GB USB
0.25 mg  /  $925 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

TuBB3, Recombinant Protein

 Also Known As   

TuBB3, 1-450aa, Human, His tag, E Coli

 Product Synonym Names    Tubulin; beta 3 class III; beta-4; CDCBM; CFEOM3A; TuBB4
 Product Gene Name   

TuBB3 recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence    MGSSHHHHHH SSGLVPRGSH MGSMREIVHI QAGQCGNQIG AKFWEVISDE HGIDPSGNYV GDSDLQLERI SVYYNEASSH KYVPRAILVD LEPGTMDSVR SGAFGHLFRP DNFIFGQSGA GNNWAKGHYT EGAELVDSVL DVVRKECENC DCLQGFQLTH SLGGGTGSGM GTLLISKVRE EYPDRIMNTF SVVPSPKVSD TVVEPYNATL SIHQLVENTD ETYCIDNEAL YDICFRTLKL ATPTYGDLNH LVSATMSGVT TSLRFPGQLN ADLRKLAVNM VPFPRLHFFM PGFAPLTARG SQQYRALTVP ELTQQMFDAK NMMAACDPRH GRYLTVATVF RGRMSMKEVD EQMLAIQSKN SSYFVEWIPN NVKVAVCDIP PRGLKMSSTF IGNSTAIQEL FKRISEQFTA MFRRKAFLHW YTGEGMDEME FTEAESNMND LVSEYQQYQD ATAEEEGEMY EDDEEESEAQ GPK
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 Purity/Purification    > 90% by SDS - PAGE
 Form/Format    Liquid. In 20mM Tris-HCl buffer (pH 8.0) containing 0.15M NaCl,10% glycerol, 1mM DTT
 Concentration    0.25 mg/ml (determined by Bradford assay) (lot specific)
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 Antigen Species    Human
 Tag    His-tag
 Expression System    E Coli
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 Preparation and Storage    Can be stored at 4 degree C short term (1-2 weeks). For long term storage, aliquot and store at -20 degree C or -70 degree C. Avoid repeated freezing and thawing cycles.
 Other Notes    Small volumes of TuBB3 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for TuBB3 recombinant protein

   Tubulin, beta 3 class III, also known as TuBB3, is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha-chain. TuBB3 plays a critical role in proper axon guidance and mantainance. Recombinant human TuBB3 protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques.
 Product Categories/Family for TuBB3 recombinant protein    Cytoskeleton
 Applications Tested/Suitable for TuBB3 recombinant protein   

SDS-PAGE

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 SDS-PAGE of TuBB3 recombinant protein    TuBB3 recombinant protein SDS-PAGE image
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NCBI/Uniprot data below describe general gene information for TuBB3. It may not necessarily be applicable to this product.
 NCBI GI #    50592996
 NCBI GeneID    10381
 NCBI Accession #    NP_006077 [Other Products]
 NCBI GenBank Nucleotide #    NM_006086.3 [Other Products]
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 UniProt Secondary Accession #    Q9BTZ0; Q9BW10; A8K854 [Other Products]
 UniProt Related Accession #    Q13509 [Other Products]
 Molecular Weight    52.8 kDa (473aa)
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 NCBI Official Full Name    tubulin beta-3 chain isoform 1
 NCBI Official Synonym Full Names    tubulin, beta 3 class III
 NCBI Official Symbol    TUBB3 [Similar Products]
 NCBI Official Synonym Symbols   
CDCBM; FEOM3; TUBB4; CDCBM1; CFEOM3; beta-4; CFEOM3A
[Similar Products]
 NCBI Protein Information    tubulin beta-3 chain; class III beta-tubulin; tubulin beta-4 chain; tubulin beta-III
 UniProt Protein Name    Tubulin beta-3 chain
 UniProt Synonym Protein Names   
Tubulin beta-4 chain; Tubulin beta-III
 Protein Family    Tubulin
 UniProt Gene Name    TUBB3 [Similar Products]
 UniProt Synonym Gene Names    TUBB4 [Similar Products]
 UniProt Entry Name    TBB3_HUMAN
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 NCBI Summary for TuBB3    This gene encodes a class III member of the beta tubulin protein family. Beta tubulins are one of two core protein families (alpha and beta tubulins) that heterodimerize and assemble to form microtubules. This protein is primarily expressed in neurons and may be involved in neurogenesis and axon guidance and maintenance. Mutations in this gene are the cause of congenital fibrosis of the extraocular muscles type 3. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 6. [provided by RefSeq, Oct 2010]
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 UniProt Comments for TuBB3    TUBB3: Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha-chain. TUBB3 plays a critical role in proper axon guidance and mantainance. Dimer of alpha and beta chains. Expression is primarily restricted to central and peripheral nervous system. Greatly increased expression in most cancerous tissues. Belongs to the tubulin family.

Protein type: Motility/polarity/chemotaxis; Cytoskeletal

Chromosomal Location of Human Ortholog: 16q24.3

Cellular Component: microtubule; cell soma; axon; cytoplasm; dendrite; nucleus

Molecular Function: GTPase activity; protein binding; GTP binding; structural constituent of cytoskeleton; peptide binding

Biological Process: protein polymerization; mitosis; 'de novo' posttranslational protein folding; axon guidance; cellular protein metabolic process; protein folding; transmembrane transport; microtubule-based process

Disease: Fibrosis Of Extraocular Muscles, Congenital, 3a, With Or Without Extraocular Involvement; Cortical Dysplasia, Complex, With Other Brain Malformations 1
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Product References and Citations for TuBB3 recombinant protein

   Katsetos C.D., et al. (2003) J. Child Neurol. 18:851-866
Tischfield M.A., et al. (2010) Cell. 140:74-87
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 Research Articles on TuBB3    1. evidence for a direct linkage between HIF-2alpha and increased expression of betaIII-t by hypoxia
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with TuBB3 recombinant proteinPathways associated with TuBB3 recombinant protein
 Reference Product  PubMed Publications
 POMC recombinant protein  >3 publications with TuBB3 and POMC
 Products by Pathway  Pathway Diagram
 Chaperonin-mediated Protein Folding Pathway antibodies  Chaperonin-mediated Protein Folding Pathway Diagram
 Cooperation Of Prefoldin And TriC/CCT In Actin And Tubulin Folding Pathway antibodies  Cooperation Of Prefoldin And TriC/CCT In Actin And Tubulin Folding Pathway Diagram
 Diurnally Regulated Genes With Circadian Orthologs Pathway antibodies  Diurnally Regulated Genes With Circadian Orthologs Pathway Diagram
 Formation Of Tubulin Folding Intermediates By CCT/TriC Pathway antibodies  Formation Of Tubulin Folding Intermediates By CCT/TriC Pathway Diagram
 Gap Junction Pathway antibodies  Gap Junction Pathway Diagram
 Gap Junction Pathway antibodies  Gap Junction Pathway Diagram
 Metabolism Of Proteins Pathway antibodies  Metabolism Of Proteins Pathway Diagram
 Orphan Transporters Pathway antibodies  Orphan Transporters Pathway Diagram
 Parkin-Ubiquitin Proteasomal System Pathway antibodies  Parkin-Ubiquitin Proteasomal System Pathway Diagram
 Pathogenic Escherichia Coli Infection Pathway antibodies  Pathogenic Escherichia Coli Infection Pathway Diagram
Diseases associated with TuBB3 recombinant proteinOrgans/Tissues associated with TuBB3 recombinant protein
 Disease Name  Pubmed Publications
 Fibrosis Of Extraocular Muscles, Congenital, 3A, with or without Extraocular Involvement Antibodies  >575 publications with TuBB3 and Fibrosis Of Extraocular Muscles, Congenital, 3A, with or without Extraocular Involvement
 Nervous System Diseases Antibodies  >73 publications with TuBB3 and Nervous System Diseases
 Brain Diseases Antibodies  >40 publications with TuBB3 and Brain Diseases
 Breast Neoplasms Antibodies  >30 publications with TuBB3 and Breast Neoplasms
 Ovarian Neoplasms Antibodies  >25 publications with TuBB3 and Ovarian Neoplasms
 Eye Diseases Antibodies  >19 publications with TuBB3 and Eye Diseases
 Disease Models, Animal Antibodies  >19 publications with TuBB3 and Disease Models, Animal
 Fibrosis Antibodies  >17 publications with TuBB3 and Fibrosis
 Neoplasms, Experimental Antibodies  >10 publications with TuBB3 and Neoplasms, Experimental
 Nerve Degeneration Antibodies  >9 publications with TuBB3 and Nerve Degeneration
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >125 publications with TuBB3 and Brain
 Nerve Antibodies  >90 publications with TuBB3 and Nerve
 Lung Antibodies  >63 publications with TuBB3 and Lung
 Eye Antibodies  >39 publications with TuBB3 and Eye
 Embryonic Tissue Antibodies  >31 publications with TuBB3 and Embryonic Tissue
 Blood Antibodies  >29 publications with TuBB3 and Blood
 Muscle Antibodies  >28 publications with TuBB3 and Muscle
 Bone Antibodies  >17 publications with TuBB3 and Bone
 Ganglia Antibodies  >16 publications with TuBB3 and Ganglia
 Vascular Antibodies  >16 publications with TuBB3 and Vascular
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