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TNFRSF1A recombinant protein :: Tumor Necrosis Factor Receptor 1, Soluble Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS650997 TNFRSF1A recombinant protein
Unit / Price
0.005 mg  /  $280 +1 FREE 8GB USB
0.02 mg  /  $355 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Tumor Necrosis Factor Receptor 1, Soluble (TNFRSF1A), Recombinant Protein

 Also Known As   

Tumor Necrosis Factor Receptor 1, Soluble, Recombinant, Human (sTNFR1)

 Product Gene Name   

TNFRSF1A recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence    MDSVCPQGKY IHPQNNSICC TKCHKGTYLY NDCPGPGQDT DCRECESGSF TASENHLRHC LSCSKCRKEM GQVEISSCTV DRDTVCGCRK NQYRHYWSEN LFQCFNCSLC LNGTVHLSCQ EKQNTVCTCH AGFFLRENEC VSCSNCKKSL ECTKLCLPQI EN
 Chromosome Location    Chromosome: 12; NC_000012.11 (6437923..6451283, complement). Location: 12p13.2
 OMIM    142680
 3D Structure    ModBase 3D Structure for P19438
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 Purity/Purification    98% by SDS-PAGE and HPLC analyses.
 Form/Format    Supplied as a lyophilized powder from 10mM Tris, pH 8.0, 20mM sodium chloride. Reconstitute in sterile 5mM Tris, pH 8.0 to a concentration of 0.1-1mg/ml. Do not vortex.
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 Biological Activity    Determined by its inhibitory effect of the TNF-alpha mediated cytotoxicity in murine L-929 cells. The ED50 for this effect in the presence of 0.25ng/ml of recombinant human TNF-alpha, is 0.05ug/ml.
 Country of Origin    USA
 Source    Recombinant corresponding to 162aa from the cysteine rich ligand binding portion of the extracellular domain of the human TNFR1 protein expressed in E. coli.
 Endotoxin    0.1ng/ug (1EU/ug).
 Important Note    This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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 Preparation and Storage    Lyophilized powder may be stored at -20 degree C. Stable for 12 months at -20 degree C. Reconstitute with 5mM Tris, pH 8.0. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Reconstituted product is stable for 6 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
 Other Notes    Small volumes of TNFRSF1A recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for TNFRSF1A recombinant protein

   TNFR1 belongs to the TNFR superfamily of transmembrane proteins, and is expressed in most cell types. Binding of either TNF-alpha or TNF-beta to TNFR1 initiates a signal transduction pathway that results in the activation of the transduction factor NFkappaB, whose target genes are involved in the regulation of inflammatory responses, and, in certain cells induce apoptosis. Soluble TNF Receptor I (sTNFR1) is capable of inhibiting TNF-alpha and TNF-beta activities by acting as a decoy receptor that serves as a sink for the TNF ligands. Recombinant human sTNFR1 is an 18.3kD protein (162 amino acid residues) comprising the cysteine rich ligand binding portion of the extracellular domain of the TNFR1 protein.
 Product Categories/Family for TNFRSF1A recombinant protein    Growth Factors, Cytokines; Growth Factors-TNF
NCBI/Uniprot data below describe general gene information for TNFRSF1A. It may not necessarily be applicable to this product.
 NCBI GI #    339750
 NCBI GeneID    7132
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 UniProt Primary Accession #    P19438 [Other Products]
 UniProt Secondary Accession #    Q9UCA4; A8K4X3; B2RDE4; B3KPQ1; B4DQB7; B4E309; D3DUR1 [Other Products]
 UniProt Related Accession #    P19438; Q6Y4Q7 [Other Products]
 Molecular Weight    50,495 Da [Similar Products]
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 NCBI Official Full Name    tumor necrosis factor receptor 1
 NCBI Official Synonym Full Names    tumor necrosis factor receptor superfamily, member 1A
 NCBI Official Symbol    TNFRSF1A [Similar Products]
 NCBI Official Synonym Symbols   
FPF; p55; p60; TBP1; TNF-R; TNFAR; TNFR1; p55-R; CD120a; TNFR55; TNFR60; TNF-R-I; TNF-R55; MGC19588
[Similar Products]
 NCBI Protein Information    tumor necrosis factor receptor superfamily member 1A; TNF-R1; TNF-RI; TNFR-I; OTTHUMP00000238438; OTTHUMP00000238440; OTTHUMP00000238441; tumor necrosis factor-alpha receptor; tumor necrosis factor receptor type 1; tumor necrosis factor binding protein 1; tumor necrosis factor receptor 1A isoform beta
 UniProt Protein Name    Tumor necrosis factor receptor superfamily member 1A
 UniProt Synonym Protein Names   
Tumor necrosis factor receptor 1; TNF-R1; Tumor necrosis factor receptor type I; TNF-RI; TNFR-I; p55; p60
 Protein Family    Tumor necrosis factor receptor superfamily
 UniProt Gene Name    TNFRSF1A [Similar Products]
 UniProt Synonym Gene Names    TNFAR; TNFR1 [Similar Products]
 UniProt Entry Name    TNR1A_HUMAN
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 NCBI Summary for TNFRSF1A    The protein encoded by this gene is a member of the TNF-receptor superfamily. This protein is one of the major receptors for the tumor necrosis factor-alpha. This receptor can activate NF-kappaB, mediate apoptosis, and function as a regulator of inflammation. Antiapoptotic protein BCL2-associated athanogene 4 (BAG4/SODD) and adaptor proteins TRADD and TRAF2 have been shown to interact with this receptor, and thus play regulatory roles in the signal transduction mediated by the receptor. Germline mutations of the extracellular domains of this receptor were found to be associated with the autosomal dominant periodic fever syndrome. The impaired receptor clearance is thought to be a mechanism of the disease. [provided by RefSeq]
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 UniProt Comments for TNFRSF1A    Function: Receptor for TNFSF2/TNF-alpha and homotrimeric TNFSF1/lymphotoxin-alpha. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Contributes to the induction of non-cytocidal TNF effects including anti-viral state and activation of the acid sphingomyelinase.

Subunit structure: Binding of TNF to the extracellular domain leads to homotrimerization. The aggregated death domains provide a novel molecular interface that interacts specifically with the death domain of TRADD. Various TRADD-interacting proteins such as TRAFS, RIPK1 and possibly FADD, are recruited to the complex by their association with TRADD. This complex activates at least two distinct signaling cascades, apoptosis and NF-kappa-B signaling. Interacts with BAG4, BRE, FEM1B, GRB2, SQSTM1 and TRPC4AP. Interacts with HCV core protein. Ref.13 Ref.14 Ref.15 Ref.16 Ref.17 Ref.18

Subcellular location: Cell membrane; Single-pass type I membrane protein. Secreted.

Domain: The domain that induces A-SMASE is probably identical to the death domain. The N-SMASE activation domain (NSD) is both necessary and sufficient for activation of N-SMASE.Both the cytoplasmic membrane-proximal region and the C-terminal region containing the death domain are involved in the interaction with TRPC4AP

Post-translational modification: The soluble form is produced from the membrane form by proteolytic processing.

Involvement in disease: Defects in TNFRSF1A are the cause of familial hibernian fever (FHF) [

MIM:142680]; also known as tumor necrosis factor receptor-associated periodic syndrome (TRAPS). FHF is a hereditary periodic fever syndrome characterized by recurrent fever, abdominal pain, localized tender skin lesions and myalgia. Reactive amyloidosis is the main complication and occurs in 25% of cases. Ref.21 Ref.22 Ref.23 Ref.24 Ref.25

Sequence similarities: Contains 1 death domain.Contains 4 TNFR-Cys repeats.
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 Research Articles on TNFRSF1A    1. Although all six TNFRSF1A mutations show enhance NF-kappa B activity, different mutations stimulate distinct NF-kappa B family subunit activitites, reulting in the gereation of unique cytokine secretory profiles.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with TNFRSF1A recombinant proteinPathways associated with TNFRSF1A recombinant protein
 Reference Product  PubMed Publications
 TNF recombinant protein  >302 publications with TNFRSF1A and TNF
 TRADD recombinant protein  >11 publications with TNFRSF1A and TRADD
 IKBKB recombinant protein  >8 publications with TNFRSF1A and IKBKB
 TRAF2 recombinant protein  >8 publications with TNFRSF1A and TRAF2
 RIPK1 recombinant protein  >5 publications with TNFRSF1A and RIPK1
 LTA recombinant protein  >5 publications with TNFRSF1A and LTA
 JAK2 recombinant protein  >4 publications with TNFRSF1A and JAK2
 CHUK recombinant protein  >4 publications with TNFRSF1A and CHUK
 TNFRSF25 recombinant protein  >4 publications with TNFRSF1A and TNFRSF25
 MAPK1 recombinant protein  >4 publications with TNFRSF1A and MAPK1
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 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
Diseases associated with TNFRSF1A recombinant proteinOrgans/Tissues associated with TNFRSF1A recombinant protein
 Disease Name  Pubmed Publications
 Necrosis Antibodies  >363 publications with TNFRSF1A and Necrosis
 Inflammation Antibodies  >118 publications with TNFRSF1A and Inflammation
 Fever Antibodies  >106 publications with TNFRSF1A and Fever
 Pain Antibodies  >42 publications with TNFRSF1A and Pain
 Skin Diseases Antibodies  >37 publications with TNFRSF1A and Skin Diseases
 Vascular Diseases Antibodies  >37 publications with TNFRSF1A and Vascular Diseases
 Arthritis, Rheumatoid Antibodies  >24 publications with TNFRSF1A and Arthritis, Rheumatoid
 Neoplasms Antibodies  >24 publications with TNFRSF1A and Neoplasms
 Heart Diseases Antibodies  >23 publications with TNFRSF1A and Heart Diseases
 Drug Toxicity Antibodies  >22 publications with TNFRSF1A and Drug Toxicity
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >132 publications with TNFRSF1A and Blood
 Skin Antibodies  >36 publications with TNFRSF1A and Skin
 Brain Antibodies  >31 publications with TNFRSF1A and Brain
 Liver Antibodies  >30 publications with TNFRSF1A and Liver
 Lung Antibodies  >20 publications with TNFRSF1A and Lung
 Kidney Antibodies  >15 publications with TNFRSF1A and Kidney
 Intestine Antibodies  >11 publications with TNFRSF1A and Intestine
 Eye Antibodies  >9 publications with TNFRSF1A and Eye
 Connective Tissue Antibodies  >8 publications with TNFRSF1A and Connective Tissue
 Embryonic Tissue Antibodies  >5 publications with TNFRSF1A and Embryonic Tissue
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