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TNFR recombinant protein :: Tumor Necrosis Factor Receptor Type Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS143878 TNFR recombinant protein
Unit / Price
0.005 mg  /  $140 +1 FREE 8GB USB
0.02 mg  /  $205 +1 FREE 8GB USB
1 mg  /  $4,665 +5 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Tumor Necrosis Factor Receptor Type (TNFR), Recombinant Protein

★Popular Item★
 Also Known As   

Recombinant Human Tumor Necrosis Factor Receptor Type His Tag

 Product Synonym Names    TNFR Human, His; Tumor Necrosis Factor Receptor Type Human Recombinant, His Tag; Tumor necrosis factor receptor superfamily member 1A; Tumor necrosis factor receptor 1; Tumor necrosis factor receptor type I; TNF-R1; TNF-RI; TNFR-I; p60; p55; CD120a; TNFRSF1A; TNFAR; TNFR1; FPF; TBP1; TNF-R; p55-R; TNFR55; TNFR60; TNF-R-I; TNF-R55; MGC19588; TNFR His
 Product Gene Name   

TNFR recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence    DSVCPQGKYI HPQNNSICCT KCHKGTYLYN DCPGPGQDTD CRECESGSFT ASENHLRHCL SCSKCRKEMG QVEISSCTVD RDTVCGCRKN QYRHYWSENL FQCFNCSLCL NGTVHLSCQE KQNTVCTCHA GFFLRENECV SCSNCKKSLE CTKLCLPQIE N
 OMIM    142680
 3D Structure    ModBase 3D Structure for P19438
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 Host    E Coli
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 Purity/Purification    Greater than 95.0% as determined by SDS-PAGE.
 Form/Format    TNFR His Tag protein is supplied in 1xPBS, 50% glycerol.
Sterile Filtered clear solution.
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 Source    E.coli
 Physical Appearance    Sterile Filtered clear solution (0.1mg/ml)
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 Preparation and Storage    Store at 4 degree C if entire vial will be used within 2-4 weeks. Store, frozen at -20 degree C for longer periods of time. Please avoid freeze thaw cycles.
 Other Notes    Small volumes of TNFR recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for TNFR recombinant protein

   Description: TNFR Human Recombinant produced in E Coli is a single, non-glycosylated, Polypeptide chain containing 161 amino acids fragment (41-201) having a molecular weight of 22.68kDa and fused with a 4.5kDa amino-terminal hexahistidine tag. The TNFR His Tag is purified by proprietary chromatographic techniques.

Introduction: TNFR1 belongs to the TNF-receptor superfamily. TNFR1 is a receptor for TNFSF2/TNF-alpha and homotrimeric TNFSF1/lymphotoxin-alpha. There are 2 types of soluble TNF receptors: sTNFR-I and sTNFR-II, which act to neutralize the biological activities of TNF alpha and TNF beta. The levels of these soluble receptors seem to increase as a result of shedding of the extracellular domains of the membrane bound receptors. TNF-a, TNFR1 and TNFR2 have roles in cellular differentiation. TNFR1 and TNFR2 function in cell type-specific renal injury.TNFR1 is capable of signaling both cell survival and apoptosis. TNFR1-induced apoptosis requires 2 sequential signaling complexes. TNFR1 is capable of activating NF-kappaB, mediate apoptosis, and function as a regulator of inflammation. Oxidative stress promotes TNFR1 and TNFR2 self-interaction, ligand-independent and enhanced ligand-dependent TNF signaling. TNFR1 contributes to the induction of non-cytocidal TNF effects including anti-viral state and activation of the acid sphingomyelinase. Human TNFR1 has a major region which controls cell surface expression. High levels of soluble TNF receptors are found in the amniotic fluid of pregnant women.Germline mutations of the extracellular domains of TNFR1 are linked to the autosomal dominant periodic fever syndrome. The impaired receptor clearance is believed to be a mechanism of the disease. Familial hibernian fever (FHF) is caused by defects in TNFRSF1A gene.
 Product Categories/Family for TNFR recombinant protein    CYTOKINES AND GROWTH FACTORS; Cytokines; Tumor Necrosis Factor
NCBI/Uniprot data below describe general gene information for TNFR. It may not necessarily be applicable to this product.
 NCBI GI #    4507575
 NCBI GeneID    7132
 NCBI Accession #    NP_001056.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001065.3 [Other Products]
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 UniProt Primary Accession #    P19438 [Other Products]
 UniProt Secondary Accession #    Q9UCA4; A8K4X3; B2RDE4; B3KPQ1; B4DQB7; B4E309; B5M0B5; D3DUR1 [Other Products]
 UniProt Related Accession #    P19438 [Other Products]
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 NCBI Official Full Name    tumor necrosis factor receptor superfamily member 1A
 NCBI Official Synonym Full Names    tumor necrosis factor receptor superfamily, member 1A
 NCBI Official Symbol    TNFRSF1A [Similar Products]
 NCBI Official Synonym Symbols   
FPF; MS5; p55; p60; TBP1; TNF-R; TNFAR; TNFR1; p55-R; CD120a; TNFR55; TNFR60; TNF-R-I; TNF-R55; TNFR1-d2
[Similar Products]
 NCBI Protein Information    tumor necrosis factor receptor superfamily member 1A; TNF-R1; TNF-RI; TNFR-I; tumor necrosis factor binding protein 1; tumor necrosis factor receptor 1A isoform beta; tumor necrosis factor receptor type 1; tumor necrosis factor-alpha receptor
 UniProt Protein Name    Tumor necrosis factor receptor superfamily member 1A
 UniProt Synonym Protein Names   
Tumor necrosis factor receptor 1; TNF-R1; Tumor necrosis factor receptor type I; TNF-RI; TNFR-I; p55; p60; CD_antigen: CD120aCleaved into the following 2 chains:Tumor necrosis factor receptor superfamily member 1A, membrane form; Tumor necrosis factor-binding protein 1; TBPI
 Protein Family    Tumor necrosis factor receptor type 1-associated DEATH domain protein
 UniProt Gene Name    TNFRSF1A [Similar Products]
 UniProt Synonym Gene Names    TNFAR; TNFR1; TNF-R1; TNF-RI; TNFR-I; TBPI [Similar Products]
 UniProt Entry Name    TNR1A_HUMAN
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 NCBI Summary for TNFR    The protein encoded by this gene is a member of the TNF-receptor superfamily. This protein is one of the major receptors for the tumor necrosis factor-alpha. This receptor can activate NF-kappaB, mediate apoptosis, and function as a regulator of inflammation. Antiapoptotic protein BCL2-associated athanogene 4 (BAG4/SODD) and adaptor proteins TRADD and TRAF2 have been shown to interact with this receptor, and thus play regulatory roles in the signal transduction mediated by the receptor. Germline mutations of the extracellular domains of this receptor were found to be associated with the autosomal dominant periodic fever syndrome. The impaired receptor clearance is thought to be a mechanism of the disease. [provided by RefSeq, Jul 2008]
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 UniProt Comments for TNFR    TNF-R1: Receptor for TNFSF2/TNF-alpha and homotrimeric TNFSF1/lymphotoxin-alpha. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate- specific cysteine proteases) mediating apoptosis. Contributes to the induction of non-cytocidal TNF effects including anti-viral state and activation of the acid sphingomyelinase. Binding of TNF to the extracellular domain leads to homotrimerization. The aggregated death domains provide a novel molecular interface that interacts specifically with the death domain of TRADD. Various TRADD-interacting proteins such as TRAFS, RIPK1 and possibly FADD, are recruited to the complex by their association with TRADD. This complex activates at least two distinct signaling cascades, apoptosis and NF-kappa-B signaling. Interacts with BAG4, BRE, FEM1B, GRB2, SQSTM1 and TRPC4AP. Interacts with HCV core protein. Interacts with human cytomegalovirus/HHV-5 protein UL138. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Receptor, cytokine

Chromosomal Location of Human Ortholog: 12p13.2

Cellular Component: Golgi membrane; extracellular space; cell surface; mitochondrion; axon; integral to plasma membrane; plasma membrane; extracellular region; synapse; nucleus; cytosol; receptor complex; lipid raft

Molecular Function: protein binding; tumor necrosis factor receptor activity; protease binding; protein complex binding; tumor necrosis factor binding

Biological Process: response to alkaloid; viral reproduction; protein heterooligomerization; response to lipopolysaccharide; tumor necrosis factor-mediated signaling pathway; positive regulation of neuron apoptosis; response to wounding; negative regulation of interleukin-6 production; tetrapyrrole metabolic process; inflammatory response; positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of protein import into nucleus, translocation; cytokine and chemokine mediated signaling pathway; positive regulation of tumor necrosis factor production; response to amino acid stimulus; prostaglandin metabolic process; positive regulation of angiogenesis; positive regulation of tyrosine phosphorylation of Stat1 protein; response to ethanol; induction of apoptosis via death domain receptors; DNA damage response, signal transduction resulting in induction of apoptosis; negative regulation of inflammatory response; defense response to bacterium; response to hypoxia; positive regulation of transcription from RNA polymerase II promoter; positive regulation of inflammatory response; negative regulation of apoptosis

Disease: Periodic Fever, Familial, Autosomal Dominant; Multiple Sclerosis, Susceptibility To, 5
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 Research Articles on TNFR    1. Dendritic cell maturation and survival are differentially regulated by TNFR1 and TNFR2.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with TNFR recombinant proteinPathways associated with TNFR recombinant protein
 Reference Product  PubMed Publications
 TNF recombinant protein  >429 publications with TNFR and TNF
 FADD recombinant protein  >15 publications with TNFR and FADD
 TRADD recombinant protein  >15 publications with TNFR and TRADD
 TRAF2 recombinant protein  >13 publications with TNFR and TRAF2
 IKBKB recombinant protein  >12 publications with TNFR and IKBKB
 RIPK1 recombinant protein  >11 publications with TNFR and RIPK1
 LTA recombinant protein  >8 publications with TNFR and LTA
 TRAF1 recombinant protein  >3 publications with TNFR and TRAF1
 BIRC2 recombinant protein  >2 publications with TNFR and BIRC2
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 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
Diseases associated with TNFR recombinant proteinOrgans/Tissues associated with TNFR recombinant protein
 Disease Name  Pubmed Publications
 Necrosis Antibodies  >615 publications with TNFR and Necrosis
 Inflammation Antibodies  >206 publications with TNFR and Inflammation
 Fever Antibodies  >158 publications with TNFR and Fever
 Autoimmune Diseases Antibodies  >97 publications with TNFR and Autoimmune Diseases
 Disease Models, Animal Antibodies  >86 publications with TNFR and Disease Models, Animal
 Pain Antibodies  >67 publications with TNFR and Pain
 Cardiovascular Diseases Antibodies  >66 publications with TNFR and Cardiovascular Diseases
 Heart Diseases Antibodies  >39 publications with TNFR and Heart Diseases
 Multiple Sclerosis Antibodies  >35 publications with TNFR and Multiple Sclerosis
 Liver Diseases Antibodies  >32 publications with TNFR and Liver Diseases
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >214 publications with TNFR and Blood
 Brain Antibodies  >61 publications with TNFR and Brain
 Liver Antibodies  >52 publications with TNFR and Liver
 Skin Antibodies  >49 publications with TNFR and Skin
 Vascular Antibodies  >48 publications with TNFR and Vascular
 Muscle Antibodies  >47 publications with TNFR and Muscle
 Bone Antibodies  >44 publications with TNFR and Bone
 Lung Antibodies  >37 publications with TNFR and Lung
 Nerve Antibodies  >31 publications with TNFR and Nerve
 Bone Marrow Antibodies  >31 publications with TNFR and Bone Marrow
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