Antibody Protein ELISA Kit from MyBioSource header Telephone 1.858.633.0165          
1.855.MyBioSource
Fax 1.858.633.0166    Email sales@mybiosource.com 
tel/fax
menu1 Home Products Ordering Company Help menu7
bottom
   MyBioSource rightarrow Recombinant Protein rightarrow TNFAIP3  rightarrow LOG IN  rightarrow MY ACCOUNT  rightarrow CART CONTENTS  rightarrow CHECKOUT 
horiz bar
MyBioSource Menu separator
separator
ELISA Kit ELISA Kit
CLIA Kit CLIA Kit
PCR Kit PCR Kit
Monoclonal Antibody Monoclonal Antibody
Polyclonal Antibody Polyclonal Antibody
Secondary Antibody Secondary Antibody
Antigen Antigen
Biochemical Biochemical
cDNA Clone cDNA Clone
siRNA siRNA
Peptide Peptide
Recombinant/Purified Protein Rec./Purified Protein

Custom ELISA Kit Custom ELISA Kit
Custom Protein Custom Protein
Custom Antibody Custom Antibody
Antibody Matched Pairs Antibody Matched Pairs
Antibody & Corresponding Blocking Peptide Pairs Antibody Peptide Pairs
Phospho-Specific Antibodies Phospho Antibodies
Products by Disease Products by Disease
Products by Pathway Products by Pathway
Products by Tissue Products by Tissue

arrow Advanced Search
arrow Submit Technical Q&A
arrow International Distributors
arrow Contact Us
separator
Our Best Sellers moreseparator
separator
 • IL2 Antibody
 • Coagulation Factor VIII (F8) Recombinant Protein
 • DEFA1-3 precursor Antibody
 • HEATR9 Antibody
 • GATA Binding Protein 4 (GATA4) Antibody
 • TFR2 ELISA Kit
 • FAM53B Antibody
 • complement factor H-related 1 (CFHR1) ELISA Kit
 • HNF4A Antibody
 • HK3 Antibody
 • p47-phox Antibody
 • LAG-3 Antibody
 • C3orf14 Antibody
 • Insulin (INS) Antibody
 downarrow more ...
separator
separator
DatasheetFull DatasheetPrinter Friendly DatasheetPrint This DatasheetAdd to Compare ListHave Questions? Ask UsRequest for a Quotation today

TNFAIP3 recombinant protein :: Tumor necrosis factor alpha-induced protein 3 (TNFAIP3) Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS950476 TNFAIP3 recombinant protein
Unit / Price
0.05 mg (E-Coli)  /  $1,225 +1 FREE 8GB USB
0.05 mg (Baculovirus)  /  $1,355 +1 FREE 8GB USB
0.05 mg (Mammalian-Cell)  /  $1,605 +2 FREE 8GB USB
0.2 mg (E-Coli)  /  $1,655 +2 FREE 8GB USB
0.2 mg (Yeast)  /  $1,685 +2 FREE 8GB USB
0.1 mg (Baculovirus)  /  $1,720 +2 FREE 8GB USB
0.5 mg (E-Coli)  /  $1,830 +2 FREE 8GB USB
0.5 mg (Yeast)  /  $1,905 +2 FREE 8GB USB
0.1 mg (Mammalian-Cell)  /  $2,410 +3 FREE 8GB USB
0.5 mg (Baculovirus)  /  $2,450 +3 FREE 8GB USB
1 mg (E-Coli)  /  $2,580 +3 FREE 8GB USB
1 mg (Yeast)  /  $2,880 +3 FREE 8GB USB
1 mg (Baculovirus)  /  $3,200 +4 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Tumor necrosis factor alpha-induced protein 3 (TNFAIP3), Recombinant Protein

 Also Known As   

Recombinant Human Tumor necrosis factor alpha-induced protein 3 (TNFAIP3)

 Product Gene Name   

TNFAIP3 recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
Table BarTOPTable Bar
 Sequence Positions    2-790aa, Full Length of Mature Protein
 Sequence    AEQVLPQALY LSNMRKAVKI RERTPEDIFK PTNGIIHHFK TMHRYTLEMF RTCQFCPQFR EIIHKALIDR NIQATLESQK KLNWCREVRK LVALKTNGDG NCLMHATSQY MWGVQDTDLV LRKALFSTLK ETDTRNFKFR WQLESLKSQE FVETGLCYDT RNWNDEWDNL IKMASTDTPM ARSGLQYNSL EEIHIFVLCN ILRRPIIVIS DKMLRSLESG SNFAPLKVGG IYLPLHWPAQ ECYRYPIVLG YDSHHFVPLV TLKDSGPEIR AVPLVNRDRG RFEDLKVHFL TDPENEMKEK LLKEYLMVIE IPVQGWDHGT THLINAAKLD EANLPKEINL VDDYFELVQH EYKKWQENSE QGRREGHAQN PMEPSVPQLS LMDVKCETPN CPFFMSVNTQ PLCHECSERR QKNQNKLPKL NSKPGPEGLP GMALGASRGE AYEPLAWNPE ESTGGPHSAP PTAPSPFLFS ETTAMKCRSP GCPFTLNVQH NGFCERCHNA RQLHASHAPD HTRHLDPGKC QACLQDVTRT FNGICSTCFK RTTAEASSSL STSLPPSCHQ RSKSDPSRLV RSPSPHSCHR AGNDAPAGCL SQAARTPGDR TGTSKCRKAG CVYFGTPENK GFCTLCFIEY RENKHFAAAS GKVSPTASRF QNTIPCLGRE CGTLGSTMFE GYCQKCFIEA QNQRFHEAKR TEEQLRSSQR RDVPRTTQST SRPKCARASC KNILACRSEE LCMECQHPNQ RMGPGAHRGE PAPEDPPKQR CRAPACDHFG NAKCNGYCNE CFQFKQMYG
 OMIM    191163
 3D Structure    ModBase 3D Structure for P21580
Section Bar
 Host    E Coli or Yeast or Baculovirus or Mammalian Cell
Section Bar
 Purity/Purification    >85% (SDS-PAGE) (lot specific)
 Form/Format    Liquid containing glycerol
 Tag Information    This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
 Sterility    Sterile filter available upon request.
 Endotoxin    Low endotoxin available upon request.
Section Bar
 Species    Human
 Storage Buffer    Tris-based buffer, 50% glycerol
 Tag Information    Tag type will be determined during the manufacturing process
Section Bar
 Preparation and Storage    Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of TNFAIP3 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Table BarTOPTable Bar
 

Related Product Information for TNFAIP3 recombinant protein

   This gene was identified as a gene whose expression is rapidly induced by the tumor necrosis factor (TNF). This protein is a zinc finger protein, and has been shown to inhibit NF-kappa B activation as well as TNF-mediated apoptosis. Knockout studies of a similar gene in mice suggested that this gene is critical for limiting inflammation by terminating TNF-induced NF-kappa B responses.
NCBI/Uniprot data below describe general gene information for TNFAIP3. It may not necessarily be applicable to this product.
 NCBI GI #    395393995
 NCBI GeneID    7128
 NCBI Accession #    NP_001257436.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001270507.1 [Other Products]
Section Bar
 UniProt Primary Accession #    P21580 [Other Products]
 UniProt Secondary Accession #    Q2HIX9; Q5VXQ7; Q9NSR6; B2R767; E1P588 [Other Products]
 UniProt Related Accession #    P21580 [Other Products]
 Molecular Weight    89,614 Da
Table BarTOPTable Bar
 NCBI Official Full Name    tumor necrosis factor alpha-induced protein 3
 NCBI Official Synonym Full Names    TNF alpha induced protein 3
 NCBI Official Symbol    TNFAIP3 [Similar Products]
 NCBI Official Synonym Symbols   
A20; AISBL; OTUD7C; TNFA1P2
[Similar Products]
 NCBI Protein Information    tumor necrosis factor alpha-induced protein 3
 UniProt Protein Name    Tumor necrosis factor alpha-induced protein 3
 UniProt Synonym Protein Names   
OTU domain-containing protein 7C; Putative DNA-binding protein A20; Zinc finger protein A20
 Protein Family    Tumor necrosis factor alpha-induced protein
 UniProt Gene Name    TNFAIP3 [Similar Products]
 UniProt Synonym Gene Names    OTUD7C; TNF alpha-induced protein 3 [Similar Products]
Section Bar
 NCBI Summary for TNFAIP3    This gene was identified as a gene whose expression is rapidly induced by the tumor necrosis factor (TNF). The protein encoded by this gene is a zinc finger protein and ubiqitin-editing enzyme, and has been shown to inhibit NF-kappa B activation as well as TNF-mediated apoptosis. The encoded protein, which has both ubiquitin ligase and deubiquitinase activities, is involved in the cytokine-mediated immune and inflammatory responses. Several transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2012]
Section Bar
 UniProt Comments for TNFAIP3    Ubiquitin-editing enzyme that contains both ubiquitin ligase and deubiquitinase activities. Involved in immune and inflammatory responses signaled by cytokines, such as TNF-alpha and IL-1 beta, or pathogens via Toll-like receptors (TLRs) through terminating NF-kappa-B activity. Essential component of a ubiquitin-editing protein complex, comprising also RNF11, ITCH and TAX1BP1, that ensures the transient nature of inflammatory signaling pathways. In cooperation with TAX1BP1 promotes disassembly of E2-E3 ubiquitin protein ligase complexes in IL-1R and TNFR-1 pathways; affected are at least E3 ligases TRAF6, TRAF2 and BIRC2, and E2 ubiquitin-conjugating enzymes UBE2N and UBE2D3. In cooperation with TAX1BP1 promotes ubiquitination of UBE2N and proteasomal degradation of UBE2N and UBE2D3. Upon TNF stimulation, deubiquitinates 'Lys-63'-polyubiquitin chains on RIPK1 and catalyzes the formation of 'Lys-48'-polyubiquitin chains. This leads to RIPK1 proteasomal degradation and consequently termination of the TNF- or LPS-mediated activation of NF-kappa-B. Deubiquitinates TRAF6 probably acting on 'Lys-63'-linked polyubiquitin. Upon T-cell receptor (TCR)-mediated T-cell activation, deubiquitinates 'Lys-63'-polyubiquitin chains on MALT1 thereby mediating disassociation of the CBM (CARD11:BCL10:MALT1) and IKK complexes and preventing sustained IKK activation. Deubiquitinates NEMO/IKBKG; the function is facilitated by TNIP1 and leads to inhibition of NF-kappa-B activation. Upon stimulation by bacterial peptidoglycans, probably deubiquitinates RIPK2. Can also inhibit I-kappa-B-kinase (IKK) through a non-catalytic mechanism which involves polyubiquitin; polyubiquitin promotes association with IKBKG and prevents IKK MAP3K7-mediated phosphorylation. Targets TRAF2 for lysosomal degradation. In vitro able to deubiquitinate 'Lys-11'-, 'Lys-48'- and 'Lys-63' polyubiquitin chains. Inhibitor of programmed cell death. Has a role in the function of the lymphoid system. Required for LPS-induced production of proinflammatory cytokines and IFN beta in LPS-tolerized macrophages.
Table BarTOPTable Bar
 Research Articles on TNFAIP3    1. we demonstrate that a pathological reduction in TNFAIP3 levels induced NF-kappaB/SMAD7 pathway activation, causing a deficiency in MSCs in ITP patients. The ability of ITP-MSCs to support megakaryocytic differentiation and thrombopoiesis of CD34(+) cells was impaired.
Table BarTOPTable Bar
 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Table BarTOPTable Bar
Products associated with TNFAIP3 recombinant proteinPathways associated with TNFAIP3 recombinant protein
 Reference Product  PubMed Publications
 TRAF1 recombinant protein  >35 publications with TNFAIP3 and TRAF1
 TNIP1 recombinant protein  >34 publications with TNFAIP3 and TNIP1
 IKBKB recombinant protein  >29 publications with TNFAIP3 and IKBKB
 TRAF6 recombinant protein  >25 publications with TNFAIP3 and TRAF6
 TRAF2 recombinant protein  >22 publications with TNFAIP3 and TRAF2
 TAX1BP1 recombinant protein  >11 publications with TNFAIP3 and TAX1BP1
 CHUK recombinant protein  >11 publications with TNFAIP3 and CHUK
 RIPK1 recombinant protein  >9 publications with TNFAIP3 and RIPK1
 RNF11 recombinant protein  >7 publications with TNFAIP3 and RNF11
 IKBKG recombinant protein  >4 publications with TNFAIP3 and IKBKG
 Products by Pathway  Pathway Diagram
 CD40/CD40L Signaling Pathway antibodies  CD40/CD40L Signaling Pathway Diagram
 Canonical NF-kappaB Pathway antibodies  Canonical NF-kappaB Pathway Diagram
 Epstein-Barr Virus Infection Pathway antibodies  Epstein-Barr Virus Infection Pathway Diagram
 Epstein-Barr Virus Infection Pathway antibodies  Epstein-Barr Virus Infection Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram
 Innate Immune System Pathway antibodies  Innate Immune System Pathway Diagram
 Measles Pathway antibodies  Measles Pathway Diagram
 Measles Pathway antibodies  Measles Pathway Diagram
 NF-kappa B Signaling Pathway antibodies  NF-kappa B Signaling Pathway Diagram
 NOD-like Receptor Signaling Pathway antibodies  NOD-like Receptor Signaling Pathway Diagram
Diseases associated with TNFAIP3 recombinant proteinOrgans/Tissues associated with TNFAIP3 recombinant protein
 Disease Name  Pubmed Publications
 Necrosis Antibodies  >178 publications with TNFAIP3 and Necrosis
 Inflammation Antibodies  >128 publications with TNFAIP3 and Inflammation
 Neoplasms Antibodies  >101 publications with TNFAIP3 and Neoplasms
 Arthritis, Rheumatoid Antibodies  >66 publications with TNFAIP3 and Arthritis, Rheumatoid
 Cardiovascular Diseases Antibodies  >44 publications with TNFAIP3 and Cardiovascular Diseases
 Lupus Erythematosus, Systemic Antibodies  >41 publications with TNFAIP3 and Lupus Erythematosus, Systemic
 Psoriasis Antibodies  >27 publications with TNFAIP3 and Psoriasis
 Carcinoma Antibodies  >19 publications with TNFAIP3 and Carcinoma
 Drug Toxicity Antibodies  >15 publications with TNFAIP3 and Drug Toxicity
 Heart Diseases Antibodies  >14 publications with TNFAIP3 and Heart Diseases
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >81 publications with TNFAIP3 and Blood
 Vascular Antibodies  >44 publications with TNFAIP3 and Vascular
 Muscle Antibodies  >25 publications with TNFAIP3 and Muscle
 Heart Antibodies  >19 publications with TNFAIP3 and Heart
 Liver Antibodies  >19 publications with TNFAIP3 and Liver
 Skin Antibodies  >17 publications with TNFAIP3 and Skin
 Intestine Antibodies  >17 publications with TNFAIP3 and Intestine
 Kidney Antibodies  >14 publications with TNFAIP3 and Kidney
 Lung Antibodies  >13 publications with TNFAIP3 and Lung
 Brain Antibodies  >10 publications with TNFAIP3 and Brain
Table BarTOPTable Bar
horiz bar
 SSL   Follow us on Facebook Follow us onTwitter Follow us on Google Plus Connect us on LinkedIn Subscribe to our RSS Feed for latest products and special promotions