Antibody Protein ELISA Kit from MyBioSource header Telephone 1.858.633.0165          
1.855.MyBioSource
Fax 1.858.633.0166    Email sales@mybiosource.com 
tel/fax
menu1 Home Products Ordering Company Help menu7
bottom
   MyBioSource rightarrow Recombinant Protein rightarrow TNFSF10  rightarrow LOG IN  rightarrow MY ACCOUNT  rightarrow CART CONTENTS  rightarrow CHECKOUT 
horiz bar
MyBioSource Menu separator
separator
ELISA Kit ELISA Kit
CLIA Kit CLIA Kit
PCR Kit PCR Kit
Monoclonal Antibody Monoclonal Antibody
Polyclonal Antibody Polyclonal Antibody
Secondary Antibody Secondary Antibody
Antigen Antigen
Biochemical Biochemical
cDNA Clone cDNA Clone
siRNA siRNA
Peptide Peptide
Recombinant/Purified Protein Rec./Purified Protein

Custom ELISA Kit Custom ELISA Kit
Custom Protein Custom Protein
Custom Antibody Custom Antibody
Antibody Matched Pairs Antibody Matched Pairs
Antibody & Corresponding Blocking Peptide Pairs Antibody Peptide Pairs
Phospho-Specific Antibodies Phospho Antibodies
Products by Disease Products by Disease
Products by Pathway Products by Pathway
Products by Tissue Products by Tissue

arrow Advanced Search
arrow Submit Technical Q&A
arrow International Distributors
arrow Contact Us
separator
Our Best Sellers moreseparator
separator
 • alpha Smooth Muscle Actin (alpha-SMA) ELISA Kit
 • Clock Homolog (CLOCK) ELISA Kit
 • Sarcolipin (SLN) ELISA Kit
 • Griffonia Antibody
 • IL1RN cDNA Clone
 • Ret Antibody
 • insulin-like 5 (INSL5) ELISA Kit
 • Neutrophil Activating Protein-2 (NAP 2) Recombinant Protein
 • Cofilin 1 (CFL1) Antibody
 • FAM62A Peptide
 • Fc EPSILON R1 ALPHA (FCER1A) Antibody
 • Microtubule Associated Protein Tau (MAPtau) ELISA Kit
 • mucin 2, oligomeric mucus-gel-forming (MUC2) ELISA Kit
 • IGF BP4 Recombinant Protein
 downarrow more ...
separator
separator
DatasheetFull DatasheetPrinter Friendly DatasheetPrint This DatasheetAdd to Compare ListHave Questions? Ask UsRequest for a Quotation today

TNFSF10 recombinant protein :: Tumor necrosis factor ligand superfamily member 10 Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS717233
SDS-PAGE
Unit / Price
0.01 mg  /  $110 +1 FREE 8GB USB
0.05 mg  /  $190 +1 FREE 8GB USB
0.1 mg  /  $285 +1 FREE 8GB USB
0.2 mg  /  $460 +1 FREE 8GB USB
0.5 mg  /  $750 +1 FREE 8GB USB
1 mg  /  $1,180 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Tumor necrosis factor ligand superfamily member 10 (TNFSF10), Recombinant Protein

 Also Known As   

Recombinant Human Tumor necrosis factor ligand superfamily member 10

 Product Synonym Names    Apo-2 ligand; Apo-2; LTNF-related apoptosis-inducing ligand; Protein TRAIL; CD253
 Product Gene Name   

TNFSF10 recombinant protein

[Similar Products]
 Product Synonym Gene Name    APO2L; TRAIL [Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
Table BarTOPTable Bar
 Sequence Positions    39-281aa; Extracellular Domain
 Sequence    TNELKQMQDK YSKSGIACFL KEDDSYWDPN DEESMNSPCW QVKWQLRQLV RKMILRTSEE TISTVQEKQQ NISPLVRERG PQRVAAHITG TRGRSNTLSS PNSKNEKALG RKINSWESSR SGHSFLSNLH LRNGELVIHE KGFYYIYSQT YFRFQEEIKE NTKNDKQMVQ YIYKYTSYPD PILLMKSARN SCWSKDAEYG LYSIYQGGIF ELKENDRIFV SVTNEHLIDM DHEASFFGAF LVG
 OMIM    603598
 3D Structure    ModBase 3D Structure for P50591
Section Bar
 Host    E Coli
Section Bar
 Purity/Purification    Greater than 90% as determined by SDS-PAGE. (lot specific)
 Form/Format    Liquid containing glycerol
 Tag Information    This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
 Sterility    Sterile filter available upon request.
 Endotoxin    Low endotoxin available upon request.
Section Bar
Section Bar
 Preparation and Storage    Store at -20 degree C, for extended storage, conserve at -20 degree C or -80 degree C.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of TNFSF10 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Table BarTOPTable Bar
 

Related Product Information for TNFSF10 recombinant protein

   Cytokine that binds to TNFRSF10A/TRAILR1, TNFRSF10B/TRAILR2, TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4 and possibly also to TNFRSF11B/OPG. Induces apoptosis. Its activity may be modulated by binding to the decoy receptors TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4 and TNFRSF11B/OPG that cannot induce apoptosis.
 Product Categories/Family for TNFSF10 recombinant protein    Apoptosis
Section Bar
 SDS-PAGE of TNFSF10 recombinant protein    TNFSF10 recombinant protein SDS-PAGE image
(Note: Representative image, actual molecular weight may vary depending on Tag type and expression host)
Table BarTOPTable Bar
NCBI/Uniprot data below describe general gene information for TNFSF10. It may not necessarily be applicable to this product.
 NCBI GI #    300193032
 NCBI GeneID    8743
 NCBI Accession #    NP_001177871.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001190942.1 [Other Products]
Section Bar
 UniProt Primary Accession #    P50591 [Other Products]
 UniProt Secondary Accession #    A1Y9B3 [Other Products]
 UniProt Related Accession #    P50591 [Other Products]
 Molecular Weight    55.8kD
Table BarTOPTable Bar
 NCBI Official Full Name    tumor necrosis factor ligand superfamily member 10 isoform 2
 NCBI Official Synonym Full Names    tumor necrosis factor superfamily member 10
 NCBI Official Symbol    TNFSF10 [Similar Products]
 NCBI Official Synonym Symbols   
TL2; APO2L; CD253; TRAIL; Apo-2L; TNLG6A
[Similar Products]
 NCBI Protein Information    tumor necrosis factor ligand superfamily member 10
 UniProt Protein Name    Tumor necrosis factor ligand superfamily member 10
 UniProt Synonym Protein Names   
Apo-2 ligand; Apo-2L; TNF-related apoptosis-inducing ligand; Protein TRAIL; CD_antigen: CD253
 Protein Family    Tumor necrosis factor ligand superfamily
 UniProt Gene Name    TNFSF10 [Similar Products]
 UniProt Synonym Gene Names    APO2L; TRAIL; Apo-2L; Protein TRAIL [Similar Products]
 UniProt Entry Name    TNF10_HUMAN
Section Bar
 NCBI Summary for TNFSF10    The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This protein preferentially induces apoptosis in transformed and tumor cells, but does not appear to kill normal cells although it is expressed at a significant level in most normal tissues. This protein binds to several members of TNF receptor superfamily including TNFRSF10A/TRAILR1, TNFRSF10B/TRAILR2, TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4, and possibly also to TNFRSF11B/OPG. The activity of this protein may be modulated by binding to the decoy receptors TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4, and TNFRSF11B/OPG that cannot induce apoptosis. The binding of this protein to its receptors has been shown to trigger the activation of MAPK8/JNK, caspase 8, and caspase 3. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2010]
Section Bar
 UniProt Comments for TNFSF10    TRAIL: Cytokine that binds to TNFRSF10A/TRAILR1, TNFRSF10B/TRAILR2, TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4 and possibly also to TNFRSF11B/OPG. Induces apoptosis. Its activity may be modulated by binding to the decoy receptors TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4 and TNFRSF11B/OPG that cannot induce apoptosis. Homotrimer. Widespread; most predominant in spleen, lung and prostate. Belongs to the tumor necrosis factor family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Cytokine; Membrane protein, integral

Chromosomal Location of Human Ortholog: 3q26

Cellular Component: extracellular region; extracellular space; integral to plasma membrane

Molecular Function: cytokine activity; metal ion binding; protein binding; receptor binding; tumor necrosis factor receptor binding

Biological Process: apoptosis; caspase activation; cell surface receptor linked signal transduction; cell-cell signaling; immune response; negative regulation of caspase activity; positive regulation of apoptosis; positive regulation of caspase activity; positive regulation of I-kappaB kinase/NF-kappaB cascade; programmed cell death; signal transduction
Table BarTOPTable Bar
 

Product References and Citations for TNFSF10 recombinant protein

   Identification and characterization of a new member of the TNF family that induces apoptosis.Wiley S.R., Schooley K., Smolak P.J., Din W.S., Huang C.-P., Nicholl J.K., Sutherland G.R., Davis-Smith T., Rauch C., Smith C.A., Goodwin R.G.Immunity 3:673-682(1995) Induction of apoptosis by Apo-2 ligand, a new member of the tumor necrosis factor cytokine family.Pitti R.M., Marsters S.A., Ruppert S., Donahue C.J., Moore A., Ashkenazi A.J. Biol. Chem. 271:12687-12690(1996) Isolation of a TRAIL antagonist from the serum of HIV-infected patients.Schnepple D.J., Shepard B., Bren G.D., Cummins N.W., Natesampillai S., Trushin S., Algeciras-Schimnich A., Meng X.W., Sainski A.M., Rizza S.A., Kaufmann S.H., Badley A.D.J. Biol. Chem. 286:35742-35754(2011) Novel TRAIL splice variant TRAIL-delta.Woods D.C., Haugen M.J., Johnson A.L.Complete sequencing and characterization of 21,243 full-length human cDNAs.Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S., Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.Nat. Genet. 36:40-45(2004) The DNA sequence, annotation and analysis of human chromosome 3.Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.Nature 440:1194-1198(2006) A secreted tyrosine kinase acts in the extracellular environment.Bordoli M.R., Yum J., Breitkopf S.B., Thon J.N., Italiano J.E. Jr., Xiao J., Worby C., Wong S.K., Lin G., Edenius M., Keller T.L., Asara J.M., Dixon J.E., Yeo C.Y., Whitman M.Cell 158:1033-1044(2014) Triggering cell death the crystal structure of Apo2L/TRAIL in a complex with death receptor 5.Hymowitz S.G., Christinger H.W., Fuh G., Ultsch M., O'Connell M., Kelley R.F., Ashkenazi A., de Vos A.M.Mol. Cell 4:563-571(1999) Structure of the TRAIL-DR5 complex reveals mechanisms conferring specificity in apoptotic initiation.Mongkolsapaya J., Grimes J.M., Chen N., Xu X.-N., Stuart D.I., Jones E.Y., Screaton G.R.Nat. Struct. Biol. 6:1048-1053(1999) 2.8 A resolution crystal structure of human TRAIL, a cytokine with selective antitumor activity.Cha S.-S., Kim M.S., Choi Y.H., Sung B.J., Shin N.K., Shin H.C., Sung Y.C., Oh B.-H.Immunity 11:253-261(1999)
Section Bar
 Research Articles on TNFSF10    1. PARP1 acts as a prominent upstream regulator of high mobility group box 1-mediated autophagy and maintains a homeostatic balance between apoptosis and autophagy, which provides new insight into the mechanism of TNFSF10 resistance
Table BarTOPTable Bar
 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Table BarTOPTable Bar
Products associated with TNFSF10 recombinant proteinPathways associated with TNFSF10 recombinant protein
 Reference Product  PubMed Publications
 TNFRSF10B recombinant protein  >1336 publications with TNFSF10 and TNFRSF10B
 CASP8 recombinant protein  >750 publications with TNFSF10 and CASP8
 CASP3 recombinant protein  >473 publications with TNFSF10 and CASP3
 FADD recombinant protein  >372 publications with TNFSF10 and FADD
 TNFRSF10A recombinant protein  >337 publications with TNFSF10 and TNFRSF10A
 CFLAR recombinant protein  >181 publications with TNFSF10 and CFLAR
 TNFRSF10C recombinant protein  >84 publications with TNFSF10 and TNFRSF10C
 TNFRSF10D recombinant protein  >28 publications with TNFSF10 and TNFRSF10D
 RIPK1 recombinant protein  >23 publications with TNFSF10 and RIPK1
 CASP10 recombinant protein  >19 publications with TNFSF10 and CASP10
 Products by Pathway  Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Apoptosis Modulation And Signaling Pathway antibodies  Apoptosis Modulation And Signaling Pathway Diagram
 CASP8 Activity Is Inhibited Pathway antibodies  CASP8 Activity Is Inhibited Pathway Diagram
 Caspase Activation Via Extrinsic Apoptotic Signalig Pathway antibodies  Caspase Activation Via Extrinsic Apoptotic Signalig Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Death Receptor Signalling Pathway antibodies  Death Receptor Signalling Pathway Diagram
Diseases associated with TNFSF10 recombinant proteinOrgans/Tissues associated with TNFSF10 recombinant protein
 Disease Name  Pubmed Publications
 Necrosis Antibodies  >2369 publications with TNFSF10 and Necrosis
 Leukemia Antibodies  >258 publications with TNFSF10 and Leukemia
 Liver Diseases Antibodies  >194 publications with TNFSF10 and Liver Diseases
 Colorectal Neoplasms Antibodies  >188 publications with TNFSF10 and Colorectal Neoplasms
 Breast Neoplasms Antibodies  >172 publications with TNFSF10 and Breast Neoplasms
 Liver Neoplasms Antibodies  >167 publications with TNFSF10 and Liver Neoplasms
 Prostatic Neoplasms Antibodies  >153 publications with TNFSF10 and Prostatic Neoplasms
 Inflammation Antibodies  >149 publications with TNFSF10 and Inflammation
 Neoplasms, Experimental Antibodies  >144 publications with TNFSF10 and Neoplasms, Experimental
 Lung Neoplasms Antibodies  >141 publications with TNFSF10 and Lung Neoplasms
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >692 publications with TNFSF10 and Blood
 Liver Antibodies  >255 publications with TNFSF10 and Liver
 Lung Antibodies  >193 publications with TNFSF10 and Lung
 Prostate Antibodies  >187 publications with TNFSF10 and Prostate
 Brain Antibodies  >139 publications with TNFSF10 and Brain
 Vascular Antibodies  >96 publications with TNFSF10 and Vascular
 Kidney Antibodies  >89 publications with TNFSF10 and Kidney
 Skin Antibodies  >74 publications with TNFSF10 and Skin
 Bone Marrow Antibodies  >71 publications with TNFSF10 and Bone Marrow
 Muscle Antibodies  >49 publications with TNFSF10 and Muscle
Table BarTOPTable Bar
horiz bar
 SSL   Follow us on Facebook Follow us onTwitter Follow us on Google Plus Connect us on LinkedIn Subscribe to our RSS Feed for latest products and special promotions