NP_033478.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Related Accession #
Molecular Weight
22,255 Da
NCBI Official Full Name
tumor necrosis factor ligand superfamily member 4
NCBI Official Synonym Full Names
tumor necrosis factor (ligand) superfamily, member 4
NCBI Official Synonym Symbols
Ath1; gp34; Ath-1; Ox40l; TXGP1; CD134L; OX-40L; Txgp1l [Similar Products]
NCBI Protein Information
tumor necrosis factor ligand superfamily member 4; OX40 ligand; atherosclerosis 1; tax-transcriptionally activated glycoprotein 1 ligand
UniProt Protein Name
Tumor necrosis factor ligand superfamily member 4
UniProt Synonym Protein Names
OX40 ligand; OX40L; CD_antigen: CD252
UniProt Synonym Gene Names
UniProt Entry Name
TNFL4_MOUSE
UniProt Comments for Tnfsf4
TNFSF4: Cytokine that binds to TNFRSF4. Co-stimulates T-cell proliferation and cytokine production. Genetic variations in TNFSF4 influence susceptibility to systemic lupus erythematosus (SLE). SLE is a chronic, inflammatory and often febrile multisystemic disorder of connective tissue. It affects principally the skin, joints, kidneys and serosal membranes. It is thought to represent a failure of the regulatory mechanisms of the autoimmune system. The upstream region of TNFSF4 contains a single risk haplotype for SLE, which is correlated with increased expression of both cell-surface TNFSF4 and TNFSF4 transcripts. Increased levels of TNFSF4 are thought to augment T-cell-APC interaction and the functional consequences of T-cell activation, thereby destabilizing peripheral tolerance. Belongs to the tumor necrosis factor family.
Protein type: Cell cycle regulation; Cytokine; Membrane protein, integral
Cellular Component: extracellular space; cell surface; membrane; integral to membrane
Molecular Function: cytokine activity; tumor necrosis factor receptor superfamily binding; tumor necrosis factor receptor binding
Biological Process: negative regulation of T-helper 1 cell differentiation; positive regulation of interleukin-12 production; negative regulation of cytokine secretion; positive regulation of T cell cytokine production; positive regulation of activated T cell proliferation; defense response to nematode; positive regulation of interleukin-10 production; T cell proliferation; positive regulation of interleukin-4 production; positive regulation of immune effector process; regulation of adaptive immune response; positive regulation of T-helper 2 cell differentiation; negative regulation of regulatory T cell differentiation; negative regulation of interferon-gamma production; positive regulation of interleukin-13 production; inflammatory response; positive regulation of memory T cell differentiation; cholesterol metabolic process; blood vessel development; positive regulation of T-helper 2 type immune response; negative regulation of transcription factor activity; response to virus; positive regulation of immunoglobulin mediated immune response; cytokine production; positive regulation of interleukin-6 production; positive regulation of CD4-positive, alpha beta T cell differentiation; positive regulation of immunoglobulin secretion; positive regulation of interferon-gamma production; negative regulation of interleukin-17 production; positive regulation of B cell activation; regulation of inflammatory response; positive regulation of interleukin-2 production; innate immune response; immune response; positive regulation of alpha-beta T cell proliferation; negative regulation of transcription, DNA-dependent; acute inflammatory response; positive regulation of inflammatory response
Research Articles on Tnfsf4
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Pathways associated with Tnfsf4 recombinant protein
Diseases associated with Tnfsf4 recombinant protein
Organs/Tissues associated with Tnfsf4 recombinant protein
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