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PKM2 recombinant protein :: Tumour Type M2 Pyruvate Kinase Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS142833 PKM2 recombinant protein
Unit / Price
0.002 mg  /  $140 +1 FREE 8GB USB
0.01 mg  /  $205 +1 FREE 8GB USB
1 mg  /  $4,720 +5 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Tumour Type M2 Pyruvate Kinase (PKM2), Recombinant Protein

 Also Known As   

Recombinant Human Tumour Type M2 Pyruvate Kinase

 Product Synonym Names    PKM2 Human; Tumor Type M2 Pyruvate Kinase Human Recombinant; Pyruvate kinase isozymes M1/M2; EC 2.7.1.40; Pyruvate kinase muscle isozyme; Pyruvate kinase 2/3; Cytosolic thyroid hormone-binding protein; CTHBP; THBP1; M2PK; PKM2; PK3; PK2; PKM; TCB; OIP3; MGC3932; Tumor Type M2 Pyruvate Kinase
 Product Gene Name   

PKM2 recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    179050
 3D Structure    ModBase 3D Structure for P14618
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 Host    E Coli
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 Purity/Purification    Greater than 95.0% as determined by: (a)Analysis by RP-HPLC. (b)Analysis by SDS-PAGE.
 Form/Format    PKM2-His is supplied in 1x PBS and 50% glycerol.
Sterile Filtered clear solution.
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 Preparation and Storage    Store at 4 degree C if entire vial will be used within 2-4 weeks. Store, frozen at -20 degree C for longer periods of time. Please avoid freeze thaw cycles.
 Other Notes    Small volumes of PKM2 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for PKM2 recombinant protein

   Description: PKM2 Human Recombinant is produced in E Coli is a single, non-glycosylated, polypeptide chain having a molecular mass of 62400 Dalton with an amino-terminal hexahistidine tag. The PKM2 is purified by standard chromatographic techniques.

Introduction: Pyruvate kinase is a key enzyme in the glycolytic pathway. The M2 isoenzyme of pyruvate kinase is specifically expressed at high levels in tumor cells, and can be measured in plasma of patients with advanced breast cancer. The marker is useful for measuring disease activity, sensitivity to chemotherapy and recurrence.
 Product Categories/Family for PKM2 recombinant protein    PROTEIN KINASES; Enzymes; Protein Kinases
NCBI/Uniprot data below describe general gene information for PKM2. It may not necessarily be applicable to this product.
 NCBI GI #    332164775
 NCBI GeneID    5315
 NCBI Accession #    NP_001193725.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001206796.1 [Other Products]
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 UniProt Primary Accession #    P14618 [Other Products]
 UniProt Secondary Accession #    P14786; Q53GK4; Q96E76; Q9BWB5; Q9UCV6; Q9UPF2; A6NFK3; B2R5N8; B3KRY0; B4DFX8; B4DUU6 [Other Products]
 UniProt Related Accession #    P14618 [Other Products]
 Molecular Weight    56,273 Da
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 NCBI Official Full Name    pyruvate kinase PKM isoform c
 NCBI Official Synonym Full Names    pyruvate kinase, muscle
 NCBI Official Symbol    PKM [Similar Products]
 NCBI Official Synonym Symbols   
PK3; TCB; OIP3; PKM2; CTHBP; THBP1; HEL-S-30
[Similar Products]
 NCBI Protein Information    pyruvate kinase PKM; OIP-3; OPA-interacting protein 3; PK, muscle type; cytosolic thyroid hormone-binding protein; epididymis secretory protein Li 30; p58; pyruvate kinase 2/3; pyruvate kinase isozymes M1/M2; pyruvate kinase muscle isozyme; thyroid hormone-binding protein 1; thyroid hormone-binding protein, cytosolic; tumor M2-PK
 UniProt Protein Name    Pyruvate kinase PKM
 UniProt Synonym Protein Names   
Cytosolic thyroid hormone-binding protein; CTHBP; Opa-interacting protein 3; OIP-3; Pyruvate kinase 2/3; Pyruvate kinase muscle isozyme; Thyroid hormone-binding protein 1; THBP1; Tumor M2-PK; p58
 UniProt Gene Name    PKM [Similar Products]
 UniProt Synonym Gene Names    OIP3; PK2; PK3; PKM2; CTHBP; OIP-3; THBP1 [Similar Products]
 UniProt Entry Name    KPYM_HUMAN
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 NCBI Summary for PKM2    This gene encodes a protein involved in glycolysis. The encoded protein is a pyruvate kinase that catalyzes the transfer of a phosphoryl group from phosphoenolpyruvate to ADP, generating ATP and pyruvate. This protein has been shown to interact with thyroid hormone and may mediate cellular metabolic effects induced by thyroid hormones. This protein has been found to bind Opa protein, a bacterial outer membrane protein involved in gonococcal adherence to and invasion of human cells, suggesting a role of this protein in bacterial pathogenesis. Several alternatively spliced transcript variants encoding a few distinct isoforms have been reported. [provided by RefSeq, May 2011]
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 UniProt Comments for PKM2    PKM2: one of three rate-limiting enzymes in glycolysis. It catalyzes the transfer of a phosphate group from phosphoenolpyruvate (PEP) to ADP, yielding one molecule ATP and a pyruvate molecule, which is a central metabolic intermediate that can be used as a building block or oxidized further. Overexpressed in a variety of cancers. Interacts with thyroid hormone, and thus may mediate cellular metabolic effects induced by thyroid hormones. Binds Opa protein, a bacterial outer membrane protein involved in gonococcal adherence to and invasion of human cells, suggesting a role of this protein in bacterial pathogens is. There are several mammalian isozymes of pyruvate kinase encoded by different genes. The L type predominates in liver, and the M type in muscle and brain. Two alternatively spliced human isoforms of PKM2 have been reported.

Protein type: EC 2.7.1.40; Carbohydrate Metabolism - glycolysis and gluconeogenesis; Carbohydrate Metabolism - pyruvate; Nucleotide Metabolism - purine; Kinase, other; Mitochondrial

Chromosomal Location of Human Ortholog: 15q22

Cellular Component: extracellular matrix; mitochondrion; cytoplasm; plasma membrane; nucleus; cytosol; vesicle; cilium

Molecular Function: potassium ion binding; protein binding; magnesium ion binding; pyruvate kinase activity; ATP binding

Biological Process: glycolysis; carbohydrate metabolic process; programmed cell death; glucose metabolic process; pathogenesis; phosphorylation
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 Research Articles on PKM2    1. Only the dimeric PKM2 possess the activity in promoting tumor angiogenesis, which is consistent with the observations that PKM2 in circulation of cancer patients is a dimer form.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with PKM2 recombinant proteinDiseases associated with PKM2 recombinant protein
 Products by Pathway  Pathway Diagram
 Adenine Ribonucleotide Biosynthesis, IMP => ADP,ATP Pathway antibodies  Adenine Ribonucleotide Biosynthesis, IMP => ADP,ATP Pathway Diagram
 Adenine Ribonucleotide Biosynthesis, IMP => ADP,ATP Pathway antibodies  Adenine Ribonucleotide Biosynthesis, IMP => ADP,ATP Pathway Diagram
 Biosynthesis Of Amino Acids Pathway antibodies  Biosynthesis Of Amino Acids Pathway Diagram
 Biosynthesis Of Amino Acids Pathway antibodies  Biosynthesis Of Amino Acids Pathway Diagram
 Carbon Metabolism Pathway antibodies  Carbon Metabolism Pathway Diagram
 Carbon Metabolism Pathway antibodies  Carbon Metabolism Pathway Diagram
 Central Carbon Metabolism In Cancer Pathway antibodies  Central Carbon Metabolism In Cancer Pathway Diagram
 Central Carbon Metabolism In Cancer Pathway antibodies  Central Carbon Metabolism In Cancer Pathway Diagram
 Disease Pathway antibodies  Disease Pathway Diagram
 Glucose Metabolism Pathway antibodies  Glucose Metabolism Pathway Diagram
 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >11 publications with PKM2 and Nervous System Diseases
 Lung Diseases Antibodies  >8 publications with PKM2 and Lung Diseases
 Brain Diseases Antibodies  >8 publications with PKM2 and Brain Diseases
 Fibrosis Antibodies  >8 publications with PKM2 and Fibrosis
 Inflammation Antibodies  >6 publications with PKM2 and Inflammation
 Cardiovascular Diseases Antibodies  >6 publications with PKM2 and Cardiovascular Diseases
 Cell Transformation, Neoplastic Antibodies  >5 publications with PKM2 and Cell Transformation, Neoplastic
 Congenital Abnormalities Antibodies  >4 publications with PKM2 and Congenital Abnormalities
 Necrosis Antibodies  >4 publications with PKM2 and Necrosis
 Liver Diseases Antibodies  >4 publications with PKM2 and Liver Diseases
Organs/Tissues associated with PKM2 recombinant protein
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >56 publications with PKM2 and Brain
 Blood Antibodies  >41 publications with PKM2 and Blood
 Muscle Antibodies  >25 publications with PKM2 and Muscle
 Kidney Antibodies  >15 publications with PKM2 and Kidney
 Liver Antibodies  >14 publications with PKM2 and Liver
 Heart Antibodies  >11 publications with PKM2 and Heart
 Nerve Antibodies  >10 publications with PKM2 and Nerve
 Vascular Antibodies  >9 publications with PKM2 and Vascular
 Lung Antibodies  >7 publications with PKM2 and Lung
 Intestine Antibodies  >5 publications with PKM2 and Intestine
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