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PTPN6 recombinant protein :: Tyrosine Phosphatase Non Receptor Type-6 Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS142767 PTPN6 recombinant protein
Unit / Price
0.005 mg  /  $140 +1 FREE 8GB USB
0.02 mg  /  $205 +1 FREE 8GB USB
1 mg  /  $2,750 +3 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Tyrosine Phosphatase Non Receptor Type-6 (PTPN6), Recombinant Protein

★Popular Item★
 Also Known As   

Recombinant Human Protein Tyrosine Phosphatase Non Receptor Type-6

 Product Synonym Names    PTPN6 Human; Protein Tyrosine Phosphatase Non Receptor Type-6 Human Recombinant; Tyrosine-protein phosphatase non-receptor type 6; EC 3.1.3.48; Protein-tyrosine phosphatase 1C; PTP-1C; Hematopoietic cell protein-tyrosine phosphatase; SH-PTP1; Protein-tyrosine phosphatase SHP-1; PTPN6; HCP; HCPH; SHP1; HPTP1C; SHP-1L
 Product Gene Name   

PTPN6 recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence    Mgfweefes lqkqevknlh qrlegqrpen kgknryknil pfdhsrvilq grdsnipgsd yinanyiknq llgpdenakt yiasqgclea tvndfwqmaw qensrvivmt trevekgrnk cvpywpevgm qraygpysvt ncgehdttey klrtlqvspl dngdlireiw hyqylswpdh gvpsepggvl sfldqinqrq eslphagpii vhcsagigrt gtiividmlm enistkgldc didiqktiqm vraqrsgmvq teaqykfiyv aiaqfiettk kklevlqsqk gqeseygnit y.
 OMIM    176883
 3D Structure    ModBase 3D Structure for P29350
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 Host    E Coli
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 Purity/Purification    Greater than 95.0% as determined by SDS-PAGE.
 Form/Format    The protein contains 25mM Tris-HCl, pH 7.5, 2mM b-mercaptoethanol, 1mM EDTA, 1mMDTT and 20%Glycerol.
Sterile filtered colorless solution.
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 Unit Defenition    One unit will hydrolyze 1nanomole of p-nitrophenylphosphatate per minute at pH 7.5 at 37 degree C using 10mM of substrate.
 Activity    >5,000 U/mg of PTPN6.
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 Preparation and Storage    Store at 4 degree C if entire vial will be used within 2-4 weeks. Store, frozen at -20 degree C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Avoid multiple freeze-thaw cycles.
 Other Notes    Small volumes of PTPN6 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for PTPN6 recombinant protein

   Description: PTPN6 Human Recombinant produced in E Coli is a single,non-glycosylated polypeptide chain containing 300 amino acids and having a molecular mass of 34.3 kDa. The protein coding region of the catalytic domain of PTPN6 (amino acids 243-541). The catalytic domain of PTPN6 was overexpressed as insoluble protein aggregates (inclusion bodies). The recombinant PTPN6 protein was purified by FPLC gel-filtration chromatography, after refolding of the isolated inclusion bodies in a redox buffer. Additional amino acid(Met) is attached at N-terminus.

Introduction: PTPN6 is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. N-terminal part of this PTP contains two tandem Src homolog (SH2) domains, which act as protein phospho-tyrosine binding domains, and mediate the interaction of this PTP with its substrates. This PTP is expressed primarily in hematopoietic cells, and functions as an important regulator of multiple signaling pathways in hematopoietic cells. This PTP has been shown to interact with, and dephosphorylate a wide spectrum of phospho-proteins involved in hematopoietic cell signaling. Multiple alternatively spliced variants of this gene, which encode distinct isoforms, have been reported.
 Product Categories/Family for PTPN6 recombinant protein    PROTEIN KINASES; Enzymes; Phosphatase
NCBI/Uniprot data below describe general gene information for PTPN6. It may not necessarily be applicable to this product.
 NCBI GI #    18104989
 NCBI GeneID    5777
 NCBI Accession #    NP_002822.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_002831.5 [Other Products]
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 UniProt Primary Accession #    P29350 [Other Products]
 UniProt Secondary Accession #    Q969V8; Q9UK67; A8K306; G3V0F8 [Other Products]
 UniProt Related Accession #    P29350 [Other Products]
 Molecular Weight    70,131 Da
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 NCBI Official Full Name    tyrosine-protein phosphatase non-receptor type 6 isoform 1
 NCBI Official Synonym Full Names    protein tyrosine phosphatase, non-receptor type 6
 NCBI Official Symbol    PTPN6 [Similar Products]
 NCBI Official Synonym Symbols   
HCP; HCPH; SHP1; SHP-1; HPTP1C; PTP-1C; SHP-1L; SH-PTP1
[Similar Products]
 NCBI Protein Information    tyrosine-protein phosphatase non-receptor type 6; hematopoietic cell phosphatase; hematopoietic cell protein-tyrosine phosphatase; protein-tyrosine phosphatase 1C; protein-tyrosine phosphatase SHP-1
 UniProt Protein Name    Tyrosine-protein phosphatase non-receptor type 6
 UniProt Synonym Protein Names   
Hematopoietic cell protein-tyrosine phosphatase; Protein-tyrosine phosphatase 1C; PTP-1C; Protein-tyrosine phosphatase SHP-1; SH-PTP1
 Protein Family    Tyrosine-protein phosphatase non-receptor
 UniProt Gene Name    PTPN6 [Similar Products]
 UniProt Synonym Gene Names    HCP; PTP1C; PTP-1C [Similar Products]
 UniProt Entry Name    PTN6_HUMAN
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 NCBI Summary for PTPN6    The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. N-terminal part of this PTP contains two tandem Src homolog (SH2) domains, which act as protein phospho-tyrosine binding domains, and mediate the interaction of this PTP with its substrates. This PTP is expressed primarily in hematopoietic cells, and functions as an important regulator of multiple signaling pathways in hematopoietic cells. This PTP has been shown to interact with, and dephosphorylate a wide spectrum of phospho-proteins involved in hematopoietic cell signaling. Multiple alternatively spliced variants of this gene, which encode distinct isoforms, have been reported. [provided by RefSeq, Jul 2008]
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 UniProt Comments for PTPN6    SHP-1: an SH2-containing ubiquitously expressed tyrosine-specific protein phosphatase. Plays a key role in hematopoiesis. Directly links growth factor receptors and other signaling proteins through protein-tyrosine phosphorylation. The SH2 regions may interact with other cellular components to modulate its own phosphatase activity against interacting substrates. Three alternatively spliced isoforms have been described.

Protein type: Motility/polarity/chemotaxis; Protein phosphatase, tyrosine (non-receptor); EC 3.1.3.48

Chromosomal Location of Human Ortholog: 12p13

Cellular Component: membrane; cytoplasm; nucleolus; alpha-beta T cell receptor complex; intercellular junction; nucleus; cytosol

Molecular Function: protein binding; phosphotyrosine binding; transmembrane receptor protein tyrosine phosphatase activity; protein tyrosine phosphatase activity; SH2 domain binding; protein kinase binding; SH3 domain binding

Biological Process: negative regulation of MAP kinase activity; peptidyl-tyrosine phosphorylation; apoptosis; protein amino acid dephosphorylation; negative regulation of humoral immune response mediated by circulating immunoglobulin; negative regulation of cell proliferation; B cell receptor signaling pathway; negative regulation of T cell proliferation; negative regulation of B cell receptor signaling pathway; positive regulation of cell proliferation; abortive mitotic cell cycle; cell differentiation; negative regulation of peptidyl-tyrosine phosphorylation; natural killer cell mediated cytotoxicity; cytokine and chemokine mediated signaling pathway; negative regulation of T cell receptor signaling pathway; positive regulation of cell adhesion mediated by integrin; regulation of release of sequestered calcium ion into cytosol; positive regulation of phosphoinositide 3-kinase cascade; cell proliferation; G-protein coupled receptor protein signaling pathway; T cell costimulation; regulation of B cell differentiation; platelet formation; blood coagulation; leukocyte migration
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 Research Articles on PTPN6    1. decreased expression levels of SHP-1 caused by aberrant promoter hypermethylation may play a key role in the progression of CML by dysregulating BCR-ABL1, AKT, MAPK, MYC and JAK2/STAT5 signaling.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with PTPN6 recombinant proteinPathways associated with PTPN6 recombinant protein
 Reference Product  PubMed Publications
 JAK2 recombinant protein  >86 publications with PTPN6 and JAK2
 SYK recombinant protein  >53 publications with PTPN6 and SYK
 LCK recombinant protein  >41 publications with PTPN6 and LCK
 CD22 recombinant protein  >37 publications with PTPN6 and CD22
 EGFR recombinant protein  >15 publications with PTPN6 and EGFR
 EPOR recombinant protein  >14 publications with PTPN6 and EPOR
 CD72 recombinant protein  >10 publications with PTPN6 and CD72
 KDR recombinant protein  >5 publications with PTPN6 and KDR
 Products by Pathway  Pathway Diagram
 Adaptive Immune System Pathway antibodies  Adaptive Immune System Pathway Diagram
 Adherens Junction Pathway antibodies  Adherens Junction Pathway Diagram
 Adherens Junction Pathway antibodies  Adherens Junction Pathway Diagram
 B Cell Receptor Signaling Pathway antibodies  B Cell Receptor Signaling Pathway Diagram
 B Cell Receptor Signaling Pathway antibodies  B Cell Receptor Signaling Pathway Diagram
 B Cell Receptor Signaling Pathway antibodies  B Cell Receptor Signaling Pathway Diagram
 BCR Signaling Pathway antibodies  BCR Signaling Pathway Diagram
 CXCR4-mediated Signaling Events Pathway antibodies  CXCR4-mediated Signaling Events Pathway Diagram
 Cell Surface Interactions At The Vascular Wall Pathway antibodies  Cell Surface Interactions At The Vascular Wall Pathway Diagram
 Cell-Cell Communication Pathway antibodies  Cell-Cell Communication Pathway Diagram
Diseases associated with PTPN6 recombinant proteinOrgans/Tissues associated with PTPN6 recombinant protein
 Disease Name  Pubmed Publications
 Immune System Diseases Antibodies  >128 publications with PTPN6 and Immune System Diseases
 Inflammation Antibodies  >74 publications with PTPN6 and Inflammation
 Death Antibodies  >59 publications with PTPN6 and Death
 Necrosis Antibodies  >42 publications with PTPN6 and Necrosis
 Nervous System Diseases Antibodies  >27 publications with PTPN6 and Nervous System Diseases
 Cell Transformation, Neoplastic Antibodies  >27 publications with PTPN6 and Cell Transformation, Neoplastic
 Liver Diseases Antibodies  >20 publications with PTPN6 and Liver Diseases
 Liver Neoplasms Antibodies  >19 publications with PTPN6 and Liver Neoplasms
 Carcinoma, Hepatocellular Antibodies  >18 publications with PTPN6 and Carcinoma, Hepatocellular
 Breast Neoplasms Antibodies  >16 publications with PTPN6 and Breast Neoplasms
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >436 publications with PTPN6 and Blood
 Bone Antibodies  >87 publications with PTPN6 and Bone
 Bone Marrow Antibodies  >81 publications with PTPN6 and Bone Marrow
 Liver Antibodies  >56 publications with PTPN6 and Liver
 Brain Antibodies  >48 publications with PTPN6 and Brain
 Muscle Antibodies  >43 publications with PTPN6 and Muscle
 Spleen Antibodies  >36 publications with PTPN6 and Spleen
 Kidney Antibodies  >33 publications with PTPN6 and Kidney
 Lung Antibodies  >32 publications with PTPN6 and Lung
 Skin Antibodies  >27 publications with PTPN6 and Skin
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